Photoreceptor replacement therapy: Challenges presented by the diseased recipient retinal environment

Advances in repairing the degenerate retina by rod photoreceptor transplantation

(2014) Rachael A. Pearson   BIOTECHNOLOGY ADVANCES

An Effective Approach to Prevent Immune Rejection of Human ESC-Derived Allografts

(2014) Zhili Rong et al.   Cell Stem Cell

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina

(2013) Anai Gonzalez-Cordero et al.   NATURE BIOTECHNOLOGY

Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation

(2013) M. S. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The estimated prevalence and incidence of late stage age related macular degeneration in the UK

(2012) Christopher G Owen et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Localization and developmental expression patterns of CSPG-cs56 (aggrecan) in normal and dystrophic retinas in two rat strains

(2012) Li-Feng Chen et al.   EXPERIMENTAL NEUROLOGY

Embryonic stem cell trials for macular degeneration: a preliminary report

(2012) Steven D Schwartz et al.   LANCET

Restoration of vision after transplantation of photoreceptors

(2012) R. A. Pearson et al.   NATURE

Road to Fulfilment: Taming the Immune Response to Restore Vision

(2012) Andrew D. Dick   OPHTHALMIC RESEARCH

Outer Segment Formation of Transplanted Photoreceptor Precursor Cells

(2012) Dominic Eberle et al.   PLoS One

Repair of the degenerate retina by photoreceptor transplantation

(2012) A. C. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the Integration Capacity of Embryonic Stem Cell-Derived Photoreceptor Precursors

(2012) Emma L. West et al.   STEM CELLS

Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells into the Developing Mouse Eye

(2011) Eun-Shil Lee et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations

(2011) Samuel G. Jacobson   ARCHIVES OF OPHTHALMOLOGY

Modelling the prevalence of age-related macular degeneration (2010-2020) in the UK: expected impact of anti-vascular endothelial growth factor (VEGF) therapy

(2011) D. C. Minassian et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Immunogenicity of induced pluripotent stem cells

(2011) Tongbiao Zhao et al.   NATURE

Self-organizing optic-cup morphogenesis in three-dimensional culture

(2011) Mototsugu Eiraku et al.   NATURE

Retinal Degeneration Progression Changes Lentiviral Vector Cell Targeting in the Retina

(2011) Maritza Calame et al.   PLoS One

Targeting lymphocyte co-stimulation: From bench to bedside

(2010) Nathan J. Felix et al.   AUTOIMMUNITY

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology

(2010) Simon J. Clark et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeted Disruption of Outer Limiting Membrane Junctional Proteins (Crb1 and ZO-1) Increases Integration of Transplanted Photoreceptor Precursors into the Adult Wild-Type and Degenerating Retina

(2010) R. A. Pearson et al.   CELL TRANSPLANTATION

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

(2010) Achilleas D. Theocharis et al.   FEBS Journal

Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina

(2010) Simon J. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation, Purification and Transplantation of Photoreceptors Derived from Human Induced Pluripotent Stem Cells

(2010) Deepak A. Lamba et al.   PLoS One

Long-Term Survival of Photoreceptors Transplanted into the Adult Murine Neural Retina Requires Immune Modulation

(2010) Emma L. West et al.   STEM CELLS

Adult Ciliary Epithelial Cells, Previously Identified as Retinal Stem Cells with Potential for Retinal Repair, Fail to Differentiate into New Rod Photoreceptors

(2010) Sara Gualdoni et al.   STEM CELLS

The role of local protein synthesis and degradation in axon regeneration

(2009) Laura F. Gumy et al.   EXPERIMENTAL NEUROLOGY

Stepwise differentiation of pluripotent stem cells into retinal cells

(2009) Fumitaka Osakada et al.   Nature Protocols

Generation of retinal cells from mouse and human induced pluripotent stem cells

(2009) Yasuhiko Hirami et al.   NEUROSCIENCE LETTERS

Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells

(2009) S. A. Cicero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury

(2009) Hyunjung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice

(2008) Udo Bartsch et al.   EXPERIMENTAL EYE RESEARCH

Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors

(2008) E.L. West et al.   EXPERIMENTAL EYE RESEARCH

Neuroretinal xenotransplantation to immunocompetent hosts in a discordant species combination

(2008) F. Ghosh et al.   NEUROSCIENCE

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Gene Therapy on Visual Function in Leber's Congenital Amaurosis

(2008) James W.B. Bainbridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chondroitin Sulfate Proteoglycans and Microglia Prevent Migration and Integration of Grafted Müller Stem Cells into Degenerating Retina

(2008) Shweta Singhal et al.   STEM CELLS

Isolation of Progenitor Cells from GFP-Transgenic Pigs and Transplantation to the Retina of Allorecipients

(2008) Henry Klassen et al.   Cloning Stem Cells