Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets

Targeting protein palmitoylation: selective inhibitors and implications in disease

(2014) Burzin Chavda et al.   Expert Opinion on Drug Discovery

Control of Ras-Mediated Signaling in Aspergillus fumigatus

(2014) Tiffany S. Norton et al.   MYCOPATHOLOGIA

Small-molecule modulation of Ras signaling

(2014) Jochen Spiegel et al.   Nature Chemical Biology

Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

(2013) Ioannis Manolaridis et al.   NATURE

Crystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design

(2013) Mark F. Mabanglo et al.   PROTEIN SCIENCE

In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida

(2013) Jianjun Qiao et al.   Annals of Clinical Microbiology and Antimicrobials

Plasma Membrane Localization Is Required for RasA-Mediated Polarized Morphogenesis and Virulence of Aspergillus fumigatus

(2012) Jarrod R. Fortwendel et al.   EUKARYOTIC CELL

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Function Relationships of the G Domain, a Canonical Switch Motif

(2011) Alfred Wittinghofer et al.   Annual Review of Biochemistry

Roles of Ras1 Membrane Localization during Candida albicans Hyphal Growth and Farnesol Response

(2011) Amy E. Piispanen et al.   EUKARYOTIC CELL

Structures ofCryptococcus neoformansProtein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

(2011) Michael A. Hast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitors

(2011) Norbert Berndt et al.   Nature Protocols

Regulating the regulator: post-translational modification of RAS

(2011) Ian M. Ahearn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ras trafficking, localization and compartmentalized signalling

(2011) Ian A. Prior et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The intracellular dynamic of protein palmitoylation

(2010) Christine Salaun et al.   JOURNAL OF CELL BIOLOGY

Subcellular Localization Directs Signaling Specificity of theCryptococcus neoformansRas1 Protein

(2008) Connie B. Nichols et al.   EUKARYOTIC CELL

Aspergillus fumigatusRasA Regulates Asexual Development and Cell Wall Integrity

(2008) Jarrod R. Fortwendel et al.   EUKARYOTIC CELL

Thinking Outside the Box about Ras

(2008) John M. Kyriakis   JOURNAL OF BIOLOGICAL CHEMISTRY