Type IV secretion system of Brucella spp. and its effectors

Recent advances in the structural and molecular biology of type IV secretion systems

(2014) Martina Trokter et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Staphylococcus aureus TIR Domain Protein Virulence Factor Blocks TLR2-Mediated NF-κB Signaling

(2014) Fatemeh Askarian et al.   Journal of Innate Immunity

Structure of a type IV secretion system

(2014) Harry H. Low et al.   NATURE

Molecular Structure of the Brucella abortus Metalloprotein RicA, a Rab2-Binding Virulence Effector

(2013) Julien Herrou et al.   BIOCHEMISTRY

Identification of a type IV secretion substrate ofBrucella abortusthat participates in the early stages of intracellular survival

(2013) Peter H. Döhmer et al.   CELLULAR MICROBIOLOGY

BtaE, an Adhesin That Belongs to the Trimeric Autotransporter Family, Is Required for Full Virulence and Defines a Specific Adhesive Pole of Brucella suis

(2013) Verónica Ruiz-Ranwez et al.   INFECTION AND IMMUNITY

A Lysozyme-Like Protein in Brucella abortus Is Involved in the Early Stages of Intracellular Replication

(2013) Mariela G. Del Giudice et al.   INFECTION AND IMMUNITY

Interplay between Clathrin and Rab5 Controls the Early Phagocytic Trafficking and Intracellular Survival ofBrucella abortuswithin HeLa cells

(2013) Jin Ju Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from theBrucellaProtein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry

(2013) Greg A. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Bacterial Interference with TLR4 Signaling byBrucellaToll/Interleukin-1 Receptor Domain-containing Protein TcpB

(2013) Mohammed Alaidarous et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular pathogenesis of the obligate intracellular bacterium Coxiella burnetii

(2013) Erin J. van Schaik et al.   NATURE REVIEWS MICROBIOLOGY

Systems Biology Analysis of Brucella Infected Peyer's Patch Reveals Rapid Invasion with Modest Transient Perturbations of the Host Transcriptome

(2013) Carlos A. Rossetti et al.   PLoS One

Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal

(2013) Z. Lifshitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli

(2013) G. A. Snyder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of betaine aldehyde dehydrogenase (BetB) as an essential virulence factor of Brucella abortus

(2013) Jin Ju Lee et al.   VETERINARY MICROBIOLOGY

Sensing of Bacterial Type IV Secretion via the Unfolded Protein Response

(2013) M. F. de Jong et al.   mBio

Brucella Modulates Secretory Trafficking via Multiple Type IV Secretion Effector Proteins

(2013) Sebenzile Myeni et al.   PLoS Pathogens

BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions

(2013) Suzana P. Salcedo et al.   Frontiers in Cellular and Infection Microbiology

Structural analysis of Brucella abortus RicA substitutions that do not impair interaction with human Rab2 GTPase

(2012) Bernard Nkengfac et al.   BMC BIOCHEMISTRY

Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle

(2012) Tregei Starr et al.   Cell Host & Microbe

BmaC, a novel autotransporter of Brucella suis, is involved in bacterial adhesion to host cells

(2012) Diana M. Posadas et al.   CELLULAR MICROBIOLOGY

Identification of the Binding Site of Brucella VirB8 Interaction Inhibitors

(2012) Mark A. Smith et al.   CHEMISTRY & BIOLOGY

Quorum-Sensing and BvrR/BvrS Regulation, the Type IV Secretion System, Cyclic Glucans, and BacA in the Virulence of Brucella ovis: Similarities to and Differences from Smooth Brucellae

(2012) Ana I. Martín-Martín et al.   INFECTION AND IMMUNITY

A MarR-Type Regulator Directly Activates Transcription from the Brucella abortus virB Promoter by Sharing a Redundant Role with HutC

(2012) Rodrigo Sieira et al.   JOURNAL OF BACTERIOLOGY

Brucella melitensis MucR, an Orthologue of Sinorhizobium meliloti MucR, Is Involved in Resistance to Oxidative, Detergent, and Saline Stresses and Cell Envelope Modifications

(2012) A. Mirabella et al.   JOURNAL OF BACTERIOLOGY

Protective effects of recombinantBrucella abortusOmp28 against infection with a virulent strain ofBrucella abortus544 in mice

(2012) Jeong Ju Lim et al.   Journal of Veterinary Science

Bacterial TIR-containing proteins and host innate immune system evasion

(2012) Rohini R. Rana et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

The virB-encoded type IV secretion system is critical for establishment of infection and persistence of Brucella ovis infection in mice

(2012) Joicy C. Sá et al.   VETERINARY MICROBIOLOGY

Brucella β 1,2 Cyclic Glucan Is an Activator of Human and Mouse Dendritic Cells

(2012) Anna Martirosyan et al.   PLoS Pathogens

Legionella secreted effectors and innate immune responses

(2011) Zhao-Qing Luo   CELLULAR MICROBIOLOGY

In search of Brucella abortus type IV secretion substrates: screening and identification of four proteins translocated into host cells through VirB system

(2011) María Inés Marchesini et al.   CELLULAR MICROBIOLOGY

Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2

(2011) Marie de Barsy et al.   CELLULAR MICROBIOLOGY

An evolutionary strategy for a stealthy intracellular Brucella pathogen

(2011) Anna Martirosyan et al.   IMMUNOLOGICAL REVIEWS

The Coxiella burnetii Cryptic Plasmid Is Enriched in Genes Encoding Type IV Secretion System Substrates

(2011) D. E. Voth et al.   JOURNAL OF BACTERIOLOGY

The RNA Chaperone Hfq Independently Coordinates Expression of the VirB Type IV Secretion System and the LuxR-Type Regulator BabR in Brucella abortus 2308

(2011) C. C. Caswell et al.   JOURNAL OF BACTERIOLOGY

The virB Operon Is Essential for Lethality of Brucella microti in the Balb/c Murine Model of Infection

(2011) Nabil Hanna et al.   JOURNAL OF INFECTIOUS DISEASES

Yersinia pestis TIR-domain protein forms dimers that interact with the human adaptor protein MyD88

(2011) Rohini R. Rana et al.   MICROBIAL PATHOGENESIS

Comprehensive Identification of Protein Substrates of the Dot/Icm Type IV Transporter of Legionella pneumophila

(2011) Wenhan Zhu et al.   PLoS One

Interactions of the Human PathogenicBrucellaSpecies with Their Hosts

(2010) Vidya L. Atluri et al.   Annual Review of Microbiology

Biochemical and functional analysis of TIR domain containing protein from Brucella melitensis

(2010) Girish K. Radhakrishnan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AnIn VivoHigh-Throughput Screening Approach Targeting the Type IV Secretion System Component VirB8 Identified Inhibitors ofBrucella abortus2308 Proliferation

(2010) Athanasios Paschos et al.   INFECTION AND IMMUNITY

The Two-Component System BvrR/BvrS Regulates the Expression of the Type IV Secretion System VirB in Brucella abortus

(2010) C. Martinez-Nunez et al.   JOURNAL OF BACTERIOLOGY

Identification of the Quorum-Sensing Target DNA Sequence and N-Acyl Homoserine Lactone Responsiveness of the Brucella abortus virB promoter

(2010) G. M. Arocena et al.   JOURNAL OF BACTERIOLOGY

Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii

(2010) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Antibody Contributes to Host Defense against an Attenuated Brucella abortus virB Mutant

(2009) H. G. Rolan et al.   INFECTION AND IMMUNITY

Metabolic Control of Virulence Genes in Brucella abortus: HutC Coordinates virB Expression and the Histidine Utilization Pathway by Direct Binding to Both Promoters

(2009) R. Sieira et al.   JOURNAL OF BACTERIOLOGY

Molecular Mimicry in Innate Immunity

(2009) Siew Leong Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BrucellaTIR Domain-containing Protein Mimics Properties of the Toll-like Receptor Adaptor Protein TIRAP

(2009) Girish K. Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subversion of Innate Immune Responses by Brucella through the Targeted Degradation of the TLR Signaling Adapter, MAL

(2009) D. Sengupta et al.   JOURNAL OF IMMUNOLOGY

Structure of a Type IV Secretion System Core Complex

(2009) R. Fronzes et al.   SCIENCE

Microbial TIR domains: not necessarily agents of subversion?

(2009) Abigail M. Spear et al.   TRENDS IN MICROBIOLOGY

Inactivation of the Type IV Secretion System Reduces the Th1 Polarization of the Immune Response to Brucella abortus Infection

(2008) H. G. Rolan et al.   INFECTION AND IMMUNITY

Putative Quorum-Sensing Regulator BlxR of Brucella melitensis Regulates Virulence Factors Including the Type IV Secretion System and Flagella

(2008) A. A. Rambow-Larsen et al.   JOURNAL OF BACTERIOLOGY

VirB3 to VirB6 and VirB8 to VirB11, but Not VirB7, Are Essential for Mediating Persistence of Brucella in the Reticuloendothelial System

(2008) A. B. den Hartigh et al.   JOURNAL OF BACTERIOLOGY

Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by theBrucellatype IV secretion system

(2008) Maarten F. de Jong et al.   MOLECULAR MICROBIOLOGY

Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins

(2008) Christine Cirl et al.   NATURE MEDICINE

Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1

(2008) Suzana P. Salcedo et al.   PLoS Pathogens

Brucella Intracellular Replication Requires Trafficking Through the Late Endosomal/Lysosomal Compartment

(2008) Tregei Starr et al.   TRAFFIC