Article
Biochemistry & Molecular Biology
Tuomo Laitinen, Theres Meili, Maria Koyioni, Panayiotis A. Koutentis, Antti Poso, Regina Hofmann-Lehmann, Christopher R. M. Asquith
Summary: In this study, a series of potent anti-viral compounds derived from 4,5-dichloro-1,2,3-dithiazolium chloride were synthesized through a concise approach. Screening against FIV infected cells led to the discovery of sub-micromolar anti-viral compounds with reduced toxicity. Mechanistic understanding was gained through advanced QM-MM modeling.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Review
Microbiology
Mathieu Long, Johan Toesca, Christophe Guillon
Summary: The Gag polyprotein plays crucial roles in the budding and replication of retroviruses, with structural data on FIV Gag subunits emerging in recent years. Understanding the structure-function relationships is essential for developing anti-FIV molecules.
Article
Agriculture, Dairy & Animal Science
Supita Sunpongsri, Attawit Kovitvadhi, Jatuporn Rattanasrisomporn, Viphavee Trisaksri, Nichakorn Jensirisak, Tassanee Jaroensong
Summary: Feline leukemia virus (FeLV) infection is a poor prognostic factor for feline lymphoma. This retrospective study investigated the prevalence, clinical signs, adverse events, and survival time of cats with FeLV-infected lymphoma treated with COP chemotherapy. All 92 cats diagnosed with mediastinal or mediastinal plus other sites of lymphoma were FeLV-antigen-positive. Clinical signs improved after the 3rd induction of COP chemotherapy, with a response rate of 96.74%. The overall median survival time was 338 days. Cats aged <4 years had longer survival, while anemia, azotemia, and elevated alanine aminotransferase were associated with increased mortality.
Article
Veterinary Sciences
Xinyu Chi, Kexin Fang, Liza Koster, Jevan Christie, Chaoqun Yao
Summary: The study collected fecal samples from feral cats on St. Kitts and found a significantly higher prevalence of FIV-positive cats, which was associated with male and adult cats. However, no T. gondii DNA was detected in the feces of either FIV-positive or FIV-negative cats. Further research with a larger sample size is needed to confirm or refute the hypothesis that FIV-positive cats have a higher prevalence of shedding T. gondii oocysts than FIV-negative cats.
VETERINARY SCIENCES
(2021)
Article
Microbiology
Alex Moskaluk, Mary Nehring, Sue VandeWoude
Summary: The study evaluated the specificity of ELISA for detecting FIV and FFV infections in domestic cats, showing that exposure to off-target pathogens may affect the test results. SPF cat sera experimentally infected with the corresponding virus had lower background in ELISA, while FIV-specific background absorbance was higher than that of FFV.
Article
Virology
Yusuke Kosugi, Keiya Uriu, Narumi Suzuki, Keisuke Yamamoto, Shumpei Nagaoka, Izumi Kimura, Yoriyuki Konno, Hirofumi Aso, Brian J. Willett, Tomoko Kobayashi, Yoshio Koyanagi, Mahoko Takahashi Ueda, Jumpei Ito, Kei Sato
Summary: The interaction between feline APOBEC3 and FIV Vif was investigated, revealing the role of specific residues in multiple feline APOBEC3Z3 proteins in counteracting FIV transmission. This study provides insights into both the cross-species transmissions of FIVs in felids and the evolutionary interaction between mammals and lentiviruses.
JOURNAL OF VIROLOGY
(2021)
Article
Veterinary Sciences
Ashley Cheang, Mark E. Westman, Jennifer Green
Summary: This study evaluated the accuracy of a commercial FIV test kit in Australian pet cats and found it to be highly accurate in determining the FIV status. This is important for veterinarians, animal shelters, and researchers in accurately diagnosing FIV infection.
VETERINARY SCIENCES
(2022)
Article
Virology
Brian G. Murphy, Diego Castillo, Sarah Cook, Christina Eckstrand, Samantha Evans, Ellen Sparger, Chris K. Grant
Summary: FIV is a lentivirus that infects domestic cats and causes immunodeficiency. The clinical effects of FIV infection on morbidity and mortality are still debated. In this study, we monitored a cohort of FIV-infected cats for more than thirteen years to investigate the immunopathogenesis and clinical disease of FIV infection.
Article
Microbiology
P. Capozza, E. Lorusso, V. Colella, J. C. Thibault, D. Y. Tan, J. P. Tronel, L. Halos, F. Beugnet, G. Elia, V. L. Nguyen, L. Occhiogrosso, V. Martella, D. Otranto, N. Decaro
Summary: This study assessed the circulation of feline leukaemia virus (FeLV) in cats from different countries in Southeast Asia and Taiwan, revealing varying prevalence rates and significant associations with the origins, age, lifestyle, and oral mucosa abnormalities of the cats. Further in-depth studies are needed to enhance understanding of FeLV epidemiology in Southeast Asia.
VETERINARY MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Giovanna Fusco, Luisa Marati, Annamaria Pugliese, Martina Levante, Gianmarco Ferrara, Esterina de Carlo, Maria Grazia Amoroso, Serena Montagnaro
Summary: The study aimed to determine the prevalence of FeLV and FIV infections in domestic cats in southern Italy. The results showed a certain proportion of cats were positive for FeLV and FIV infections, with associations found between year, province, region, and lifestyle.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
Taishi Tanabe, Yurina Fukuda, Kazuhiko Kawashima, Satomi Yamamoto, Takashige Kashimoto, Hisaaki Sato
Summary: The study found that alpha-amanitin has antiviral activity against feline immunodeficiency virus (FIV) by inhibiting the RNA transcription level.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2021)
Article
Virology
Hai-Xiao Shen, Xin Li, De-Quan Yang, Hou-Bin Ju, Fei-Fei Ge, Jian Wang, Hong-jin Zhao
Summary: The study found that H3N2 feline influenza virus and canine influenza virus are closely related with high posterior probability and have certain regional characteristics, while the significance of geographical structure correlation decreased. Intrasubtypic reassortment between FIVs and CIVs were common during epidemics, and under different selection pressures, certain sites in HA, NA, M1, and M2 proteins were under positive selection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Luis A. F. Andrade, Alice F. Versiani, Edel F. Barbosa-Stancioli, Jenner K. P. dos Reis, Jordana Grazziela A. C. dos Reis, Flavio G. da Fonseca
Summary: The feline immunodeficiency virus (FIV) is a global retrovirus that affects both domestic and wild cats, and can lead to death. Currently, there is only one effective vaccine for certain FIV subtypes, while another common subtype is not preventable by vaccination. Researchers have developed a new vaccine prototype and conducted preclinical tests in mice, showing potential for further development and use in cats.
Article
Chemistry, Multidisciplinary
Natchaya Rasri, Lueacha Tabtimmai, Charoenkwan Kraiya, Montarop Yamabhai, Chomdao Sinthuvanich, Jatuporn Rattanasrisomporn, Kiattawee Choowongkomon
Summary: A feline IgG-bound scFv was selected and a scFv-AP platform was developed for feline infectious disease detection.
Article
Veterinary Sciences
Paola Dezubiria, E. Susan Amirian, Keegan Spera, P. Cynda Crawford, Julie K. Levy
Summary: Approximately 5% of cats in US animal shelters are positive for FeLV or FIV, with over 100,000 positive cats in shelters each year. This study focuses on the retroviral management practices in Florida shelters, which are characterized by chronic pet overpopulation and high shelter admissions.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Evangel Kummari, Shirley X. Guo-Ross, Jeffrey B. Eells
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2015)
Article
Biochemistry & Molecular Biology
Jeffrey B. Eells, Josiah Wilcots, Scott Sisk, Shirley X. Guo-Ross
JOURNAL OF MOLECULAR NEUROSCIENCE
(2012)
Article
Neurosciences
Jeffrey B. Eells, Timothy Brown
NEUROTOXICOLOGY AND TERATOLOGY
(2009)
Article
Neurosciences
Talisha M. Moore, Timothy Brown, Mirae Cade, Jeffrey B. Eells
Article
Behavioral Sciences
Heath S. Partington, Jennifer Makenzie Nutter, Jeffrey B. Eells
Summary: Disruption of Nurr1 affects the function of DA neurons and circadian rhythms, while Nurr1 plays an important role in regulating the DA phenotype. Using a Nurr1 deficient model can replicate some DA functional changes found in schizophrenia and PD, and further research is needed to understand the mechanisms regulating circadian rhythms and fluctuations in the DA phenotype.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Medicine, Research & Experimental
Regina F. Fernandez, Andrea S. Pereyra, Victoria Diaz, Emily S. Wilson, Karen A. Litwa, Jonatan Martinez-Gardeazabal, Shelley N. Jackson, J. Thomas Brenna, Brian P. Hermann, Jeffrey B. Eells, Jessica M. Ellis
Summary: The research suggests that ACSL6 plays a crucial role in promoting membrane DHA enrichment in neurons but not in astrocytes; ACSL6 is crucial for maintaining neuronal DHA levels throughout the lifespan; Loss of ACSL6 affects motor function, memory, and age-related neuroinflammation.
Article
Biochemistry & Molecular Biology
Minchan Gil, Cushla McKinney, Mi Kyeong Lee, Jeffrey B. Eells, Marcia A. Phyillaier, Vera M. Nikodem
JOURNAL OF NEUROCHEMISTRY
(2007)
Article
Neurosciences
Jeffrey B. Eells, Jaime A. Misler, Vera M. Nikodem
BRAIN RESEARCH BULLETIN
(2006)
Article
Behavioral Sciences
JB Eells, BK Lipska, SK Yeung, JA Misler, VM Nikodem
BEHAVIOURAL BRAIN RESEARCH
(2002)
Article
Neurosciences
JB Eells, SK Yeung, VM Nikodem
NEUROSCIENCE RESEARCH COMMUNICATIONS
(2002)
Article
Neurosciences
JB Eells, JE Rives, SK Yeung, VM Nikodem
JOURNAL OF NEUROSCIENCE RESEARCH
(2001)
Article
Neurosciences
J. B. Eells, J. A. Misler, V. M. Nikodem
Article
Neurosciences
JB Eells, RW Clough, RA Browning, PC Jobe
Article
Developmental Biology
XB Yu, JJ Shacka, JB Eells, C Suarez-Quian, RM Przygodzki, B Beleslin-Cokic, CS Lin, VM Nikodem, B Hempstead, KC Flanders, F Costantini, CT Noguchi