Human Monocyte Recognition of Adenosine-Based Cyclic Dinucleotides Unveils the A2a GαsProtein-Coupled Receptor Tonic Inhibition of Mitochondrially Induced Cell Death

Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling

(2013) Hiroyasu Konno et al.   CELL

Extracellular Adenosine Sensing—A Metabolic Cell Death Priming Mechanism Downstream of p53

(2013) Jaclyn S. Long et al.   MOLECULAR CELL

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis

(2013) C. J. Desmet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection

(2013) C. E. Witte et al.   mBio

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Determination of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in human plasma and animal tissues by solid phase extraction on silica and liquid chromatography–triple quadrupole mass spectrometry

(2012) Thomas Van Damme et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Istradefylline, an adenosine A2A receptor antagonist, for patients with Parkinson's Disease: A meta-analysis

(2012) Wanqiang Chen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium

(2012) Zhi-hui Chen et al.   NATURE

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

The gene expression profile of phosphoantigen-specific humanγδT lymphocytes is a blend of αβ T-cell and NK-cell signatures

(2011) Fréderic Pont et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A2a adenosine receptor mediates HepG2 cell apoptosis by downregulating Bcl-XL expression and upregulating Bid expression

(2011) Kunihiro Tamura et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cyclic AMP-induced p53 destabilization is independent of EPAC in pre-B acute lymphoblastic leukemia cellsin vitro

(2011) Majid Safa et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Preladenant in patients with Parkinson's disease and motor fluctuations: a phase 2, double-blind, randomised trial

(2011) Robert A Hauser et al.   LANCET NEUROLOGY

Structure tridimensionnelle du récepteur de l’adénosine A2Alié à son agoniste naturel l’adénosine

(2011) Guillaume Lebon et al.   M S-MEDECINE SCIENCES

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

Inhibition of the mitochondrial permeability transition by protein kinase A in rat liver mitochondria and hepatocytes

(2010) Peter Pediaditakis et al.   BIOCHEMICAL JOURNAL

Gene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies

(2010) Anna Andersson et al.   BMC Medical Genomics

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Inhibitory role of cAMP on doxorubicin-induced apoptosis in pre-B ALL cells through dephosphorylation of p53 serine residues

(2009) Majid Safa et al.   APOPTOSIS

Bacterial nucleotide-based second messengers

(2009) Christina Pesavento et al.   CURRENT OPINION IN MICROBIOLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Adenosine A2Areceptor antagonists exert motor and neuroprotective effects by distinct cellular mechanisms

(2008) Liqun Yu et al.   ANNALS OF NEUROLOGY

Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice

(2008) Haruko Shima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adenosine A2A receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC

(2008) Frank Brand et al.   EUROPEAN JOURNAL OF PHARMACOLOGY