Article
Multidisciplinary Sciences
Nina Hoglund, Petteri Nieminen, Anne-Mari Mustonen, Reijo Kakela, Sylvain Tollis, Ninna Koho, Minna Holopainen, Hanna Ruhanen, Anna Mykkanen
Summary: This study investigates how the respiratory fatty acid (FA) profile reflects airway inflammatory status. The results show that the FA composition differs in samples with different diagnoses, but it is insufficient to predict the health status of uncategorized samples. Specifically, in severe EA horses, the proportion of 16:0 decreases and the proportion of 20:5n-3 increases, while all sample types of asthmatic horses have elevated proportions of 20:3n-6. The study suggests a potential role for extracellular vesicles (EVs) as vehicles for lipid mediators in asthma pathogenesis and EV lipid manifestations can offer translational targets for studying asthma pathophysiology and treatment options.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Amelia Madani, Gabriel Pitollat, Eleonore Sizun, Laura Cardoit, Maud Ringot, Thomas Bourgeois, Nelina Ramanantsoa, Christophe Delclaux, Stephane Dauger, Marie-Pia D'ortho, Muriel Thoby-Brisson, Jorge Gallego, Boris Matrot
Summary: Phox2b(27Ala/+) mutation in mice predisposes them to not only hypoventilation and central apneas, but also obstructive and mixed apneas, likely due to hypoglossal dysgenesis. These findings highlight the importance of paying attention to obstructive events in infants with CCHS.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Immunology
Yun Mao, Sonika Patial, Yogesh Saini
Summary: This study investigated the role of airway epithelium-specific HMGB1 in the pathogenesis of muco-obstructive lung disease in Tg+ mice. The deficiency of HMGB1 in airway epithelial cells in Tg+ mice resulted in increased inflammation and impaired bacterial clearance.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Luca Stucchi, Francesco Ferrucci, Michela Bullone, Raffaele L. Dellaca, Jean Pierre Lavoie
Summary: This study evaluated the sensitivity of within-breath analysis and oscillometry in detecting subclinical airway obstruction in horses with asthma. The results showed that within-breath oscillometry is sensitive in discriminating horses with severe asthma from control horses, and it can identify an increase in expiratory reactance similar to that observed in human asthmatic patients. Evaluating inspiratory and expiratory reactance could be promising in distinguishing between horses with asthma in remission and control horses.
Article
Agriculture, Dairy & Animal Science
Chiara Maria Lo Feudo, Luca Stucchi, Elena Alberti, Bianca Conturba, Enrica Zucca, Francesco Ferrucci
Summary: Equine asthma is a respiratory syndrome similar to human asthma, with mild-moderate and severe classifications. Environmental allergens trigger hypersensitivity responses in asthmatic horses, with insects, Dermatophagoides spp., and dog epithelium being the most common allergens. Type-I hypersensitivity plays a major role in severe equine asthma, while type-IV hypersensitivity is more involved in milder forms. Intradermal testing is effective in identifying hypersensitivity to specific allergens in equine medicine.
Article
Respiratory System
Fernando Guedes, Mariana V. Branquinho, Ana C. Sousa, Rui D. Alvites, Antonio Bugalho, Ana Colette Mauricio
Summary: CAO cases are often under-diagnosed and challenging to manage. This review explores classifications, causes, treatments, and limitations of CAO, focusing on both benign and malignant presentations. Three representative cases are presented to illustrate the clinical problem.
BMC PULMONARY MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Malwina Slowikowska, Joanna Bajzert, Julia Miller, Tadeusz Stefaniak, Artur Niedzwiedz
Summary: This study aimed to evaluate the dynamics of circulating immune complexes (CICs) in equine asthma patients during exacerbation, remission, and treatment. The results showed that CIC levels did not support the diagnosis of equine asthma syndrome but could be useful in monitoring patients' conditions.
Review
Immunology
Xuan Ying Poh, Fei Kean Loh, Jon S. Friedland, Catherine W. M. Ong
Summary: Tuberculosis (TB) is a major infectious disease worldwide, with central nervous system tuberculosis (CNS-TB) being the most severe form. Neutrophils play a crucial role in CNS-TB by carrying out antimicrobial functions and mediating inflammation and tissue destruction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Michal Senitko, Catherine L. Oberg, George E. Abraham, William B. Hillegass, Israh Akhtar, Erik Folch
Summary: This study presented a pilot study using endobronchial microwave ablation (MWA) via flexible bronchoscopy for the management of malignant central airway obstruction (CAO). The results showed successful airway recanalization in all cases without complications. Endobronchial MWA is a novel technique for tumor destruction while maintaining a patent airway.
Article
Pharmacology & Pharmacy
Lena Wucherpfennig, Felix Wuennemann, Monika Eichinger, Angelika Seitz, Ingo Baumann, Mirjam Stahl, Simon Y. Graeber, Shengkai Zhao, Jaehi Chung, Jens-Peter Schenk, Abdulsattar Alrajab, Hans-Ulrich Kauczor, Marcus A. Mall, Olaf Sommerburg, Mark O. Wielpuetz
Summary: Chronic rhinosinusitis (CRS) in cystic fibrosis (CF) can cause nasal congestion, rhinorrhea, and anosmia, affecting the quality of life. Previous studies using MRI showed early onset and progression of CRS in CF patients from infancy to school age, as well as mid-term improvements in preschool and school-age CF children with lumacaftor/ivacaftor treatment. However, there is a lack of long-term data on the treatment effects on paranasal sinus abnormalities in CF children.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Tingting Yu, Le Sun, Xinmei Liu, Wei Zhu
Summary: Invasive silicone tracheobronchial stenting via rigid bronchoscopy is a viable option for infants with central airway obstruction. Properly choosing the appropriate size of the stent is crucial for the success of the procedure, as reported in this study where satisfactory outcomes were observed in most cases after 6 months of follow-up.
Article
Anesthesiology
Guillaume Gaggini, Link-Mathieu Nkamicaniye, Sabrina Meyer, Philippe E. Dubois
Summary: This case report describes a patient with expiratory central airway collapse that persisted during general anesthesia despite positive pressure ventilation. Fiberoptic bronchoscopy revealed complete collapse of the left main bronchus, which could not be resolved with positive end-expiratory pressure and recruitment maneuvers. The collapse was hypothesized to be due to mechanical bending of the bronchus caused by loss of natural position and thoracic muscle tone under anesthesia.
BMC ANESTHESIOLOGY
(2022)
Review
Dermatology
R. Marsella, S. White, V. A. Fadok, D. Wilson, R. Mueller, C. Outerbridge, W. Rosenkrantz
Summary: This article reviews the current literature on allergic skin diseases in horses and provides consensus on pathogenesis, diagnosis, treatment, and prevention. Insect bite hypersensitivity and atopic dermatitis are the most common forms of allergic skin diseases in horses. Avoiding insect bites is the most effective treatment for insect bite hypersensitivity, while treatment for atopic dermatitis relies largely on glucocorticoids, antihistamines, and allergen-specific immunotherapy.
VETERINARY DERMATOLOGY
(2023)
Review
Critical Care Medicine
Brian D. Shaller, Darius Filsoof, Jorge M. Pineda, Thomas R. Gildea
Summary: Malignant central airway obstruction (MCAO) is a debilitating complication that severely restricts the lives of patients with advanced intrathoracic cancer. The treatment options for MCAO are limited and progress has been slow. However, there is ongoing expansion in the interventions available for MCAO.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Cell Biology
Daniel Holl, Christian Goeritz
Summary: Fibrotic scarring is a common response to various lesions in the central nervous system, where perivascular cells give rise to stromal fibroblasts. This review summarizes the current understanding of fibrotic scar formation and provides an evaluation of perivascular cells using human single-cell gene expression datasets.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Editorial Material
Cell & Tissue Engineering
Francesco De Francesco, Csaba Matta, Michele Riccio, Andrea Sbarbati, Ali Mobasheri
STEM CELLS INTERNATIONAL
(2021)
Article
Orthopedics
Ari Vaarala, Victor Casula, Arttu Peuna, Egor Panfilov, Ali Mobasheri, Marianne Haapea, Eveliina Lammentausta, Miika T. Nieminen
Summary: In this study, a 3D texture analysis method based on gray level co-occurrence matrix was developed for knee cartilage analysis in osteoarthritis studies. The method was able to detect longitudinal changes in cartilage and distinguish different subpopulations based on their progression into radiographically confirmed osteoarthritis. The results showed significant changes in textural features of femoral and tibial cartilages across all groups and tissue layers.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Rheumatology
Vera Francisco, Jesus Pino, Miguel Angel Gonzalez-Gay, Francisca Lago, Jaro Karppinen, Osmo Tervonen, Ali Mobasheri, Oreste Gualillo
Summary: Studies have found that immunometabolic alterations in patients with obesity and type 2 diabetes mellitus are closely related to intervertebral disc degeneration, involving the abnormal production of proteins such as adipokines and exacerbation of inflammatory responses.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Cell & Tissue Engineering
Ignacio Dallo, Riccardo D'Ambrosi, Dawid Szwedowski, Ali Mobasheri, Alberto Gobbi
Summary: Bone marrow lesions (BMLs) are common findings in different knee pathologies, but the etiology and treatment protocol for symptomatic BMLs remain unclear. This study evaluates the clinical outcomes and safety of Osteo Core Plasty technique in treating symptomatic BMLs in the knee, and it shows promising results in reducing pain and improving overall scores.
STEM CELLS AND DEVELOPMENT
(2022)
Review
Orthopedics
Ursule Kalvaityte, Csaba Matta, Eiva Bernotiene, Peter Natesan Pushparaj, Ata M. Kiapour, Ali Mobasheri
Summary: This article reviews the biological roles of clusterin in cartilage, chondrocytes, and other synovial joint tissues, and discusses its potential as a biomarker in synovial and systemic fluids of patients with rheumatoid arthritis (RA) or osteoarthritis (OA). Clusterin has cytoprotective functions and may serve as a biomarker of early repair responses in OA.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Chemistry, Analytical
Almira Ramanaviciene, Anton Popov, Ema Baliunaite, Benediktas Brasiunas, Asta Kausaite-Minkstimiene, Ugur Tamer, Gailute Kirdaite, Eiva Bernotiene, Ali Mobasheri
Summary: This study presents the development of a specific magnetic immunoassay method for the determination of hGH concentration in serum. The method has a low limit of detection, clinically relevant linear range, and negligible non-specific binding. Important technical solutions for the development of this sandwich-type colorimetric magneto-immunoassay are discussed.
Article
Rheumatology
Federico Angelini, Pawel Widera, Ali Mobasheri, Joseph Blair, Andre Struglics, Melanie Uebelhoer, Yves Henrotin, Anne Ca Marijnissen, Margreet Kloppenburg, Francisco J. Blanco, Ida K. Haugen, Francis Berenbaum, Christoph Ladel, Jonathan Larkin, Anne C. Bay-Jensen, Jaume Bacardit
Summary: The study found three dominant endotypes associated with three phenotypes: low tissue turnover, structural damage, and systemic inflammation. Each endotype presented different disease characteristics, indicating the potential for personalized treatment strategies in the future.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Veterinary Sciences
Anne Marie Bakke, Joshua Wood, Carina Salt, David Allaway, Matt Gilham, Gail Kuhlman, Tiffany Bierer, Richard Butterwick, Ciaran O'Flynn
Summary: The study showed that feeding grain-free diets with high inclusion of split peas and lentils may lead to canine diet-induced dilated cardiomyopathy, and the data will help generate hypotheses for future studies.
BMC VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dawid Szwedowski, Ali Mobasheri, Andrzej Moniuszko, Jan Zabrzynski, Slawomir Jeka
Summary: In patients with knee osteoarthritis, it was found that those receiving PRP treatment showed significant functional improvement within 6 months, which was superior to treatment with HA or CS; in terms of pain reduction, the CS group performed the best, but the effect decreased gradually in subsequent visits.
Article
Veterinary Sciences
David Allaway, Janet E. Alexander, Laura J. Carvell-Miller, Rhiannon M. Reynolds, Catherine L. Winder, Ralf J. M. Weber, Gavin R. Lloyd, Andrew D. Southam, Warwick B. Dunn
Summary: Biomarker discovery using biobank samples collected from veterinary clinics can provide insights into the diverse population of pets and accelerate diagnostic development. Metabolomics analysis of DBS samples is a valuable approach to detect health/disease phenotypes. The study demonstrates that DBS samples are suitable for biomarker discovery.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Clinical Neurology
Ali Mobasheri
Summary: The concept of self-healing through integrative medicine and natural remedies is introduced as a new approach to managing musculoskeletal conditions. This approach highlights the potential for improving patient outcomes by optimizing the body's innate ability to heal itself.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Geriatrics & Gerontology
Carina Salt, Emi K. Saito, Ciaran O'Flynn, David Allaway
Summary: Aging is a complex process involving changes in metabolic processes, immune capacities, and genetic/epigenetic repertoires. With exposure to environmental stresses and deterioration of physiological functions, body systems become more susceptible to chronic inflammation and various pathologies. This study used disease diagnosis data from millions of cats and dogs to define adult life stages based on age clusters and disease patterns, providing valuable information for healthcare recommendations.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Cell Biology
Csaba Matta, Roland Takacs, Laszlo Ducza, Rana Abdelsattar Ebeid, Heonsik Choi, Ali Mobasheri
Summary: Osteoarthritis (OA) is a chronic, progressive, and debilitating musculoskeletal condition with chronic pain as one of its main symptoms. The true source of OA pain is still unclear, despite ongoing research into its pathomechanisms. Ion channels and transporters play a key role in nociceptive pain, and this review article provides an update on their distribution and function in synovial joint tissues. It also proposes directions for the development of future analgesic therapies for OA pain.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ilona Uzieliene, Daiva Bironaite, Rokas Miksiunas, Edvardas Bagdonas, Raminta Vaiciuleviciute, Ali Mobasheri, Eiva Bernotiene
Summary: This study investigated the role of intracellular calcium (iCa(2+)) and its regulation through voltage-operated calcium channels (VOCC) in the chondrogenic differentiation of mesenchymal stem/stromal cells. Results showed that chondrocytes had the highest level of iCa(2+), while MenSCs had the largest iCa(2+) store capacity and proliferation ability. The expression of the CaV1.2 gene was highest in MenSCs during chondrogenic differentiation. Nifedipine, a CaV1.2 antagonist, could suppress iCa(2+) and proliferation in all cells and affect iCa(2+) stores, especially in BMMSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Mehdi Ommati, Ali Mobasheri, Hossein Niknahad, Mohammad Rezaei, Sepideh Alidaee, Abdollah Arjmand, Sahra Mazloomi, Narges Abdoli, Issa Sadeghian, Samira Sabouri, Mohsen Saeed, Khadijeh Mousavi, Asma Najibi, Reza Heidari
Summary: Ammonium ion (NH4+) is suspected to be the main molecule responsible for neurological complications in hepatic encephalopathy. This study investigated the effects of the NMDA receptor antagonist ketamine on hyperammonemic mice and found that it significantly improved locomotor activity, biomarkers of oxidative stress, and decreased proinflammatory cytokines. These findings suggest that ketamine may have neuroprotective mechanisms against NH4+-induced neurotoxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Veterinary Sciences
L. Alibrandi, R. Tognetti, O. Domenech, M. Croce, M. Giuntoli, G. Grosso, T. Vezzosi
Summary: This study assessed the feasibility and diagnostic reliability of a new smartphone-based ECG device in dogs, and found no significant differences compared to a traditional ECG device. The results suggest that the smartphone-based device is clinically reliable for assessing heart rate and rhythm in dogs.
VETERINARY JOURNAL
(2024)
