Article
Clinical Neurology
Pauline Samia, Nicholas Odero, Maureen Njoroge, Shem Ochieng, Jacqueline Mavuti, Sheila Waa, Samson Gwer
Summary: In a tertiary hospital in Nairobi, Kenya, a study found that up to a third of children with epilepsy who underwent MRI had abnormal findings, including encephalomalacia, cerebral atrophy, and disorders of neuronal migration. Clinical comorbidity and inter-ictal epileptiform activity on EEG were associated with abnormal imaging findings.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Tzu-Hsin Huang, Ming-Chi Lai, Yu-Shiue Chen, Chin-Wei Huang
Summary: This review focuses on the fundamentals of DWI and its associated techniques, such as apparent diffusion coefficient, diffusion tensor imaging, and tractography, as well as their impact on epilepsy in terms of differential diagnosis, epileptic foci determination, and prognosis prediction.
Article
Clinical Neurology
Soo Jeong Kim, Hyojin Nam, Sang-Ahm Lee, Yong Seo Koo
Summary: This study demonstrates that II-ESI has comparable accuracy to ictal SPECT and brain FDG-PET scan in localizing the epileptogenic zone in MRI-negative epilepsy patients. II-ESI is a simple, noninvasive method for evaluating the epileptogenic zone and guiding iEEG planning.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Neurosciences
Ke Xu, Xiongfei Wang, Jian Zhou, Yuguang Guan, Tianfu Li, Guoming Luan
Summary: This study investigates the clinical discrepancies and predictors of anterior temporal lobectomy (ATL) in children and adults with temporal lobe epilepsy (TLE). Significant differences in clinical manifestations, MRI examinations, number of preoperative AEDs, and pathologies were observed between TLE children and adults. The early complete resection of MRI-detected epileptogenic focus in TLE children predicts favorable seizure outcome, while the concordance of MRI-detected focus with EEG-detected epileptogenic zone predicts favorable seizure outcomes in TLE adults.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Kristin M. Gunnarsdottir, Adam Li, Rachel J. Smith, Joon-Yi Kang, Anna Korzeniewska, Nathan E. Crone, Adam G. Rouse, Jennifer J. Cheng, Michael J. Kinsman, Patrick Landazuri, Utku Uysal, Carol M. Ulloa, Nathaniel Cameron, Iahn Cajigas, Jonathan Jagid, Andres Kanner, Turki Elarjani, Manuel Melo Bicchi, Sara Inati, Kareem A. Zaghloul, Varina L. Boerwinkle, Sarah Wyckoff, Niravkumar Barot, Jorge Gonzalez-Martinez, Sridevi Sarma
Summary: There are over 15 million epilepsy patients worldwide, many of whom have drug-resistant epilepsy. Surgical treatment is often successful, but the success rate varies due to the lack of validated biological markers of the epileptogenic zone. This study aimed to develop a new network-based interictal iEEG marker of the epileptogenic zone by analyzing interictal iEEG data. The algorithm developed in this study showed promising accuracy in identifying epileptogenic regions and predicting surgical outcomes, outperforming clinicians' predictions.
Article
Clinical Neurology
Anca A. Arbune, Pirgit Meritam Larsen, Stephan Wustenhagen, Daniella Terney, Elena Gardella, Sandor Beniczky
Summary: The study found that more than one third of epileptiform EEG discharges showed a decrease in spiking patterns during seizures, suggesting a potential anticonvulsive function, while the majority of discharges increased in association with seizures.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Bianca R. Villa, Dhyey Bhatt, Marshal D. Wolff, Kwaku Addo-Osafo, Jonathan R. Epp, G. Campbell Teskey
Summary: Comorbidities during the period between seizures present a significant challenge for individuals with epilepsy. The pathophysiology of the interictal symptomatology is largely unknown, but postictal severe hypoxia (PIH) has been identified as a potential underlying mechanism. Using a rat model, the study found that repeated seizures led to increasingly severe episodes of PIH and decreased oxygen levels in the hippocampus during the interictal period. These reductions were prevented when PIH was blocked, and the cognitive deficits caused by seizures were alleviated. The study suggests that seizure-induced hypoxia may play a crucial role in epilepsy and targeting and preventing PIH could offer significant benefits.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Biomedical
Rathin K. Joshi, M. Varun Kumar, Megha Agrawal, Avinash Rao, Latika Mohan, M. Jayachandra, Hardik J. Pandya
Summary: This study developed a quick, robust, and accurate algorithm to classify epileptic seizures, reducing the workload of neurologists for epilepsy screening and identifying important features of epileptic activities.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicolin Hainc, Mary Pat McAndrews, Taufik Valiante, Danielle M. Andrade, Richard Wennberg, Timo Krings
Summary: This study provides an updated description of the spectrum and frequency of dedicated 3T MRI findings in adult medically refractory epilepsy (MRE) patients at a tertiary epilepsy center, aiming to familiarize radiologists with potential imaging findings in this population.
INSIGHTS INTO IMAGING
(2022)
Article
Clinical Neurology
Joshua M. Diamond, C. Price Withers, Julio Chapeton, Shareena Rahman, Sara K. Inati, Kareem A. Zaghloul
Summary: This study shows that both ictal discharges and interictal epileptiform discharges (IEDs) are traveling waves emerging from common epileptogenic brain regions. The timing and spatial distribution of IEDs are consistent with the receipt of ictal discharges, indicating that both types of discharges spread as traveling waves. The presence and localization of IEDs may provide valuable information for seizure source localization.
Article
Clinical Neurology
Heinz Krestel, David R. Schreier, Elmaze Sakiri, Andreas von Allmen, Yasmina Abukhadra, Arto Nirkko, Maja Steinlin, Felix Rosenow, Rune Markhus, Gaby Schneider, Caroline Jagella, Johannes Mathis, Hal Blumenfeld
Summary: This study evaluated the effects of interictal epileptiform discharges (IEDs) on driving ability, showing that generalized typical IEDs significantly prolonged reaction times and increased the probability of crashes. The study also created a decision aid for assessing fitness-to-drive based on the type and duration of IEDs detected in routine EEGs.
Article
Neurosciences
Anna Witkowska-Wrobel, Kirill Aristovich, Abbe Crawford, Justin D. Perkins, David Holder
Summary: The study successfully reconstructed slow impedance changes evoked by cell swelling using Electrical Impedance Tomography (EIT) in a swine model of epilepsy, demonstrating the potential of combining EIT with intracranial EEG monitoring to improve diagnostic yield in epileptic patients.
Article
Clinical Neurology
Mariana R. Brito, Thiago S. Prado, Marina K. M. Alvim, Lucas S. R. Santos, Marcia Morita-Sherman, Clarissa L. Yasuda, Fernando Cendes
Summary: The study found that in patients with temporal lobe epilepsy and hippocampal sclerosis, the number of ipsilateral interictal epileptiform discharges increased over time, while the number of normal EEGs decreased. Contralateral interictal epileptiform discharges remained stable, which may reflect early abnormalities rather than epilepsy progression.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2021)
Article
Computer Science, Information Systems
Zhuozheng Shi, Zhiqiang Liao, Hitoshi Tabata
Summary: This study proposes a stochastic resonance-effect-based EEG preprocessing module to improve the signal-to-noise ratio by transferring noise to different spectral components. By combining this module with a deep convolutional neural network, an intelligent diagnostic system for predicting seizure onset achieves high accuracy.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Clinical Neurology
Valerio Frazzini, Stephen Whitmarsh, Katia Lehongre, Pierre Yger, Jean-Didier Lemarechal, Bertrand Mathon, Claude Adam, Dominique Hasboun, Virginie Lambrecq, Vincent Navarro
Summary: Periventricular nodular heterotopia (PNH) is a malformation of cortical development that often leads to drug-resistant epilepsy. In this study, consistent interictal patterns were identified within the nodules, with specific patterns associated with seizure generation. The results suggest that PNH nodules may play a significant role in initiating seizures.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Brian K. Kwon, Femke Streijger, Caitlin E. Hill, Aileen J. Anderson, Mark Bacon, Michael S. Beattie, Armin Blesch, Elizabeth J. Bradbury, Arthur Brown, Jacqueline C. Bresnahan, Casey C. Case, Raymond W. Colburn, Samuel David, James W. Fawcett, Adam R. Ferguson, Itzhak Fischer, Candace L. Floyd, John C. Gensel, John D. Houle, Lyn B. Jakeman, Nick D. Jeffery, Linda Ann Truett Jones, Naomi Kleitman, Jeffery Kocsis, Paul Lu, David S. K. Magnuson, Martin Marsala, Simon W. Moore, Andrea J. Mothe, Martin Oudega, Giles W. Plant, Alexander Sasha Rabchevsky, Jan M. Schwab, Jerry Silver, Oswald Steward, Xiao-Ming Xu, James D. Guest, Wolfram Tetzlaff
EXPERIMENTAL NEUROLOGY
(2015)
Article
Neurosciences
Rae L. Russell, Jonathan M. Levine, Nick D. Jeffery, Colin Young, Armando Mondragon, Bryan Lee, C. Elizabeth Boudreau, C. Jane Welsh, Gwendolyn J. Levine
Editorial Material
Veterinary Sciences
Hilary Z. Hu, Nick D. Jeffery, Jessica Donnelly, Matthew Severs, Tracy Lindquist, Lindsey Gilmour, Heather A. Flaherty, Andrew K. Barker
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2016)
Editorial Material
Veterinary Sciences
Nick Jeffery
JOURNAL OF SMALL ANIMAL PRACTICE
(2016)
Article
Clinical Neurology
Saul Wilson, Kingsley O. Abode-Iyamah, John W. Miller, Chandan G. Reddy, Sina Safayi, Douglas C. Fredericks, Nicholas D. Jeffery, Nicole A. DeVries-Watson, Sara K. Shivapour, Stephanus Viljoen, Brian D. Dalm, Katherine N. Gibson-Corley, Michael D. Johnson, George T. Gillies, Matthew A. Howard
JOURNAL OF SPINAL CORD MEDICINE
(2017)
Review
Veterinary Sciences
H. Z. Hu, N. Granger, N. D. Jeffery
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2016)
Article
Veterinary Sciences
Lindsey J. Gilmour, Nick D. Jeffery, Kristina Miles, Elizabeth Riedesel
VETERINARY RADIOLOGY & ULTRASOUND
(2017)
Article
Neurosciences
Rana S. Dhillon, John Parker, Yasir A. Syed, Steve Edgley, Adam Young, James W. Fawcett, Nick D. Jeffery, Robin J. M. Franklin, Mark R. N. Kotter
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2016)
Review
Critical Care Medicine
Sarah A. Moore, Nicolas Granger, Natasha J. Olby, Ingo Spitzbarth, Nick D. Jeffery, Andrea Tipold, Yvette S. Nout-Lomas, Ronaldo C. da Costa, Veronika M. Stein, Linda J. Noble-Haeusslein, Andrew R. Blight, Robert G. Grossman, D. Michele Basso, Jonathan M. Levine
JOURNAL OF NEUROTRAUMA
(2017)
Article
Veterinary Sciences
P. Freeman, N. D. Jeffery
JOURNAL OF SMALL ANIMAL PRACTICE
(2017)
Article
Veterinary Sciences
M. Charalambous, S. F. M. Bhatti, L. Van Ham, S. Platt, N. D. Jeffery, A. Tipold, J. Siedenburg, H. A. Volk, D. Hasegawa, A. Gallucci, G. Gandini, M. Musteata, E. Ives, A. E. Vanhaesebrouck
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2017)
Article
Veterinary Sciences
Ilyssa L. Meren, Jessica A. Chavera, Cody J. Alcott, Andrew K. Barker, Nick D. Jeffery
VETERINARY SURGERY
(2017)
Article
Multidisciplinary Sciences
Nick D. Jeffery, Andrew K. Barker, Cody J. Alcott, Jon M. Levine, Ilyssa Meren, Jane Wengert, Albert E. Jergens, Jan S. Suchodolski
Article
Veterinary Sciences
Taylor J. Yaw, Nick D. Jeffery, Brandon Cain, Amanda Fales-Williams, Bianca A. Zaffarano
JOURNAL OF AVIAN MEDICINE AND SURGERY
(2016)
Article
Veterinary Sciences
Nick D. Jeffery, Andrew K. Barker, Hilary Z. Hu, Cody J. Alcott, Karl H. Kraus, Elizabeth M. Scanlin, Nicolas Granger, Jonathan M. Levine
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2016)
Article
Veterinary Sciences
L. Alibrandi, R. Tognetti, O. Domenech, M. Croce, M. Giuntoli, G. Grosso, T. Vezzosi
Summary: This study assessed the feasibility and diagnostic reliability of a new smartphone-based ECG device in dogs, and found no significant differences compared to a traditional ECG device. The results suggest that the smartphone-based device is clinically reliable for assessing heart rate and rhythm in dogs.
VETERINARY JOURNAL
(2024)