Article
Virology
Pei Liu, Yadi Yuan, Bopei Cui, Yaqian Huo, Lianlian Bian, Lei Chen, Siyuan Liu, Chenfei Wang, Yingzhi Xu, Alison Tedcastle, Fan Gao, Qunying Mao, Javier Martin, Zhenglun Liang
Summary: The study confirmed that C4 EV71 vaccines can provide global protection against HFMD, inducing cross-neutralizing antibodies against different sub-genotypes. The results demonstrated that the vaccine can elicit cross-neutralization activities against various sub-genotypes.
Review
Immunology
Vincent Dussupt, Kayvon Modjarrad, Shelly J. Krebs
Summary: The unprecedented Zika outbreak in the Americas from 2015-2016 led to global concern and accelerated the deployment of vaccine and therapeutic countermeasures. Several potent neutralizing antibodies against Zika and related flaviviruses have been discovered in recent years. Structure-based approaches have helped identify species-specific and cross-protective epitopes with therapeutic value.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jiajing Wu, Li Zhang, Yue Zhang, Haixin Wang, Ruxia Ding, Jianhui Nie, Qianqian Li, Shuo Liu, Yongxin Yu, Xiaoming Yang, Kai Duan, Xiaowang Qu, Youchun Wang, Weijin Huang
Summary: In this study, convalescent sera, inactivated virus vaccine-elicited sera, mRNA vaccine-elicited sera were found to still possess neutralizing capability against the top five epidemic SARS-CoV-2 variants in the UK, while different types of vaccines showed varying responses in neutralizing antibody levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Rui Chen, Bing Liu, Xiangmei Zhang, Mengmeng Qin, Jianhui Dong, Guoqian Gu, Chunyan Wu, Jingyu Wang, Yuchen Nan
Summary: Current strategies for porcine reproductive and respiratory syndrome (PRRS) control are insufficient, and mainly rely on vaccination. This study used a novel monoclonal antibody as a vaccine adjuvant and compared its effectiveness with other vaccines. The results showed that the adjuvanted vaccine significantly improved the survival rate and cellular immune response, and reduced viral shedding.
VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Qunying Mao, Miao Xu, Qian He, Changgui Li, Shufang Meng, Yiping Wang, Bopei Cui, Zhenglun Liang, Junzhi Wang
Summary: The outbreak of COVID-19 has brought significant challenges to global health and economy. Vaccines are considered the most effective tool to combat the virus. China has deployed five vaccine platforms, accelerating research and development progress. International collaboration has played a key role in advancing the research and approval process for vaccines.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Cell Biology
Yannic C. Bartsch, Xin Tong, Jaewon Kang, Maria Jose Avendano, Eileen F. Serrano, Tamara Garcia-Salum, Catalina Pardo-Roa, Arnoldo Riquelme, Yongfei Cai, Isabella Renzi, Guillaume Stewart-Jones, Bing Chen, Rafael A. Medina, Galit Alter
Summary: Despite evading neutralizing antibodies, the Omicron variant does not increase death rates in highly vaccinated populations, suggesting the presence of immune mechanisms beyond antibody-mediated virus neutralization. Vaccine-induced Spike protein-specific antibodies continue to drive Fc effector functions, indicating the potential of extraneutralizing antibodies in disease control.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Food Science & Technology
Zhi Li, Hua Xu, Bo Ma, Li Luo, Lei Guo, Pingping Zhang, Yong Zhao, Lili Wang, Jianwei Xie
Summary: Abrin is a highly toxic protein isolated from Abrus precatorious seeds, which has the potential to be used as a bioterrorism agent. Currently, there are no antidotes available for abrin poisoning, and neutralizing antibodies are the most effective therapy. In this study, a high-affinity neutralizing monoclonal antibody 10D8 was prepared and found to have a strong protective effect against abrin-induced toxicity.
Article
Biochemistry & Molecular Biology
Rui Chen, Yimin Wen, Enbo Yu, Junpeng Yang, Yixiao Liang, Daili Song, Yiping Wen, Rui Wu, Qin Zhao, Senyan Du, Qigui Yan, Xinfeng Han, Sanjie Cao, Xiaobo Huang
Summary: We identified two monoclonal antibodies that effectively neutralized PDCoV, with one targeting the S280-288 epitope and the other targeting the S506-513 epitope. The S280-288 epitope induced specific neutralizing antibodies and provided partial protection against disease in piglets. This study provides valuable insights for understanding the pathogenic mechanism of PDCoV, vaccine design, and antiviral drug development.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, General & Internal
Summary: In a platform trial involving patients hospitalized with Covid-19, among 314 patients who were also being treated with remdesivir, those who received the monoclonal antibody LY-CoV555 did not have better pulmonary function at day 5 than those who received placebo. The trial was stopped for futility.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jianbo Liu, Hongyan Shi, Jianfei Chen, Xin Zhang, Da Shi, Zhaoyang Ji, Zhaoyang Jing, Li Feng
Summary: A neutralizing monoclonal antibody (mAb), 5F7, against the S2 protein of PEDV was obtained and found to neutralize both new variant genotype 2 and genotype 1 PEDV strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Multidisciplinary Sciences
Katie J. Doores
Summary: Phleboviruses are global zoonotic pathogens that cause severe diseases. There is currently no approved vaccine or treatment for phlebovirus infection. Studying neutralizing antibodies and identifying neutralizing epitopes on viral proteins can inform vaccine development for both known and emerging phleboviruses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Immunology
Li Li, Yufeng Li, Yunhua Bai, Guohua Li, Jing Zhang, Liqing Yang, Weimin Zhao, Wei Zhao, Fengji Luo, Qinhua Zhao, Zheng Zhang, Yanling Liu, Shuping Li, Qiang Lu, Hui Wang, Junnan Zhang, Yanli Zhang, Jian Gao, Nianmin Shi
Summary: This study evaluated the RVNA, safety, and immunogenicity of Ormutivimab + rabies vaccine in Chinese healthy adults. The results showed that the Ormutivimab + vaccine group had higher RVNA levels and lower incidence of adverse reactions compared to the other groups.
Article
Medicine, General & Internal
Jingxin Li, Li Zhang, Linlin Bao, Yuxiao Wang, Lin Qiu, Jialei Hu, Rong Tang, Huiyan Yu, Jun Shan, Yan Li, Chuan Qin, Fengcai Zhu
Summary: This study isolated specific B cells from patients infected with H7N9 and generated a human monoclonal antibody (mAb) called 6-137. mAb 6-137 can recognize and neutralize the H7N9 virus, providing preventive and therapeutic effects in mouse models.
CHINESE MEDICAL JOURNAL
(2022)
Review
Virology
Leonardo F. Ormundo, Carolina T. Barreto, Lilian R. Tsuruta
Summary: Antibody-based passive immunotherapy is effective in treating and preventing infectious diseases. Selecting neutralizing monoclonal antibodies (mAbs) and developing highly effective mAbs have become important strategies in combating emerging arbovirus infections.
Review
Immunology
Qingrui Huang, Xiaonan Han, Jinghua Yan
Summary: The COVID-19 pandemic has led to devastating economic and public health consequences, prompting outstanding efforts from the scientific community and pharmaceutical companies to develop antibody-based therapeutics against SARS-CoV-2. Understanding the antibody neutralizing mechanisms at the molecular and structural levels is critical for optimizing effective antibody-based therapeutics and developing next-generation pan-coronavirus vaccines.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Feixue Wei, Ningshao Xia, Rebeca Ocampo, Marc T. Goodman, Nancy A. Hessol, Beatriz Grinsztejn, Ana P. Ortiz, Fanghui Zhao, Erna M. Kojic, Rupert Kaul, Isabelle Heard, Imran O. Morhason-Bello, Anna-Barbara Moscicki, Alexandra de Pokomandy, Joel M. Palefsky, Luana L. S. Rodrigues, Racheal S. Dube Mandishora, Reshmie A. Ramautarsing, Silvia Franceschi, Sheela Godbole, Fernanda K. Tso, Lynette J. Menezes, Chunqing Lin, Gary M. Clifford
Summary: Age-specific shifts in HPV16 prevalence from cervix to anus suggest that HPV infections may persist longer, or occur later in life, in the anus than cervix. This has important implications for using cervical screening results to direct anal cancer prevention.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Feixue Wei, Marc T. Goodman, Ningshao Xia, Jun Zhang, Anna R. Giuliano, Gypsyamber D'Souza, Nancy A. Hessol, Maarten F. Schim van der Loeff, Jianghong Dai, Karin Neukam, Alexandra de Pokomandy, I. Mary Poynten, Ronald B. Geskus, Joaquin Burgos, Isabelle Etienney, Anna Barbara Moscicki, Maria Gabriella Dona, Maura L. Gillison, Alan G. Nyitray, Rebecca G. Nowak, Evy Yunihastuti, Huachun Zou, Carmen Hidalgo-Tenorio, Nittaya Phanuphak, Jean Michel Molina, Alice M. Schofield, Stephen Kerr, Song Fan, Yong Lu, Jason J. Ong, Admire T. Chikandiwa, Sirinya Teeraananchai, Nicola Squillace, Dorothy J. Wiley, Joel M. Palefsky, Damien Georges, Catharina J. Alberts, Gary M. Clifford
Summary: This study provides a comprehensive analysis of the natural history of anal high-risk HPV infection and identifies differences among different risk groups. These findings are crucial for designing effective anal cancer prevention programs.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Virology
Yang Shi, Zihan Wang, Shengxiang Ge, Ningshao Xia, Quan Yuan
Summary: The HBcAg is a highly immunogenic antigen and the anti-HBc is traditionally considered as a serological marker of HBV infections. However, recent studies have shown the predictive value of quantitative anti-HBc level in the treatment response and clinical outcome of chronic HBV infections. This review summarizes the clinical values of qAnti-HBc in differentiating CHB phases, predicting treatment response, and providing disease prognosis.
Article
Chemistry, Analytical
Yi-Quan An, Shao-Lei Huang, Bang-Chao Xi, Xiang-Lian Gong, Jun-Hao Ji, You Hu, Yi-Jie Ding, Dong-Xu Zhang, Sheng-Xiang Ge, Jun Zhang, Ning-Shao Xia
Summary: This article proposes a temperature control strategy to significantly increase the ramp rates of solution temperature by switching microfluidic chips between multiple temperature zones and increasing the temperature difference between zones and the solution. A thermocycler with ultrafast nucleic acid amplification capabilities has been designed. The results show that the ramp rates of solution temperature are linearly related to temperature differences, with larger differences resulting in faster ramp rates. The thermocycler achieves 92% reduction in nucleic acid amplification time compared to conventional methods.
Review
Microbiology
Dequan Pan, Wei Wang, Tong Cheng
Summary: Infection with VZV causes chickenpox and shingles, resulting in significant morbidity and mortality worldwide. Detecting serum VZV-specific antibodies is crucial for clinical diagnosis, sero-epidemiological research, and evaluating the efficacy of VZV vaccine. Various methods for VZV antibody detection have been developed, and this review summarizes and compares the current methods while discussing future directions in the field.
Review
Microbiology
Mengling Hao, Jiabao Tang, Shengxiang Ge, Tingdong Li, Ningshao Xia
Summary: Herpesviruses are important pathogens that infect humans and animals. Bacterial artificial chromosome (BAC) technology has advanced the manipulation of herpesvirus genomes, but the efficiency still needs improvement. This review summarizes the advancements and limitations of BAC-based gene editing and its application in viral research.
Article
Immunology
Yue Huang, Jiabao Tang, Huan Yu, Qiaoqiao Song, Mengling Hao, Han Wang, Junxian Liu, Yue Dong, Mufeng Liang, Sijie Zhuang, Caihong Li, Jiangding Wang, Caihong Liang, Yingying Su, Tingdong Li, Ting Wu, Shengxiang Ge, Jun Zhang, Ningshao Xia
Summary: This study examines the value of maternal CMV serological testing in predicting intrauterine transmission in regions with high seropositivity rates. The study found no statistical association between maternal IgM antibodies and IgG avidity during pregnancy and intrauterine transmission. The presence of CMV DNAemia indicated a higher risk of cCMV infection. However, the difference in CMV shedding rates in urine was not significant.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Letter
Biochemistry & Molecular Biology
Yizhen Wang, Feibo Song, Siling Wang, Miaolin Lan, Tingdong Li, Huilin Guo, Yali Zhang, Shengxiang Ge, Zizheng Zheng, Ningshao Xia
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemical Research Methods
Shaolei Huang, Yiquan An, Bangchao Xi, Xianglian Gong, Zhongfu Chen, Shan Shao, Shengxiang Ge, Jun Zhang, Dongxu Zhang, Ningshao Xia
Summary: Nucleic acid detection is a method that directly identifies the presence of pathogenic microorganisms and has advantages of high sensitivity, commendable specificity, and a short window period. A real-time PCR system based on multiple temperature zones was proposed to solve the time-consuming problem, enabling fast detection speed and high sensitivity under extreme conditions.
Article
Biochemical Research Methods
Zihao Chen, Nan Liu, Yang Huang, Xiaoping Min, Xiangxiang Zeng, Shengxiang Ge, Jun Zhang, Ningshao Xia
Summary: In this study, a protein docking evaluation method called PointDE is proposed, which utilizes a 3D point cloud neural network. PointDE is able to capture the geometry of the point cloud and learn the interaction information from the protein interface, showing superior performance on public datasets and an antibody-antigen dataset.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2023)
