Article
Multidisciplinary Sciences
Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis, William H. Robinson
Summary: This study reveals that cytotoxic CD8(+) T cells targeting ACPA are involved in synovitis and joint tissue destruction in rheumatoid arthritis (RA), contributing to the understanding of the immune mechanisms underlying RA pathogenesis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Adam L. Burrack, Zoe C. Schmiechen, Michael T. Patterson, Ebony A. Miller, Ellen J. Spartz, Meagan R. Rollins, Jackson F. Raynor, Jason S. Mitchell, Tsuneyasu Kaisho, Brian T. Fife, Ingunn M. Stromnes
Summary: We investigated the differential impact of myeloid subsets on immunity to pancreatic ductal adenocarcinoma (PDA). Our study demonstrates that tumor antigenicity shapes the composition and functionality of myeloid cells. The therapeutic effectiveness of adoptive T cell therapy or programmed cell death ligand 1 blockade relies on the presence of type 1 dendritic cells (cDC1), which support the survival and function of antitumor T cells. Our research highlights the essential role of cDC1s in sustaining effective antitumor T cells and reveals differential roles for cDC1s and monocytes/macrophages in guiding T cell fate and immunotherapy response.
Article
Chemistry, Multidisciplinary
Xuedan He, Shiqi Zhou, Wei-Chiao Huang, Amal Seffouh, Moustafa T. Mabrouk, M. Thomas Morgan, Joaquin Ortega, Scott Abrams, Jonathan F. Lovell
Summary: A new vaccine adjuvant system was developed to induce strong cellular immune responses against multiple tumor cell lines, demonstrating durable immunity. The system showed the importance of stable particle formation for effective immune response induction and could control local and metastatic disease in a therapeutic setting.
Article
Multidisciplinary Sciences
Ana Clara Barbosa Antonelli, Vinnycius Pereira Almeida, Fernanda Oliveira Feitosa de Castro, Jacyelle Medeiros Silva, Irmtraut Araci Hoffmann Pfrimer, Edecio Cunha-Neto, Andrea Queiroz Maranhao, Marcelo Macedo Brigido, Renato Oliveira Resende, Anamelia Lorenzetti Bocca, Simone Goncalves Fonseca
Summary: In this study, an in silico universal vaccine against Zika virus was developed, which is predicted to induce broad and high-coverage cellular and humoral immune responses.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Jaume Mora, Shakeel Modak, Joyce Kinsey, Carolyn E. Ragsdale, Hillard M. Lazarus
Summary: Colony-stimulating factors, such as GM-CSF, have been studied extensively for their potential to enhance the effectiveness of anti-GD2 monoclonal antibodies in high-risk neuroblastoma. However, access to these therapies is not uniform, and there is limited clinical data supporting the use of G-CSF as an alternative to GM-CSF. More research is needed to ensure equitable access to these treatments globally.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Immunology
Arne Knoerck, Gertrud Schaefer, Dalia Alansary, Josephine Richter, Lorenz Thurner, Markus Hoth, Eva C. Schwarz
Summary: This study developed a FRET-based single cell fluorescent assay to compare the cytotoxic efficiency of effector memory CD8(+) T cells (T-EM) and central memory CD8(+) T cells (T-CM). The results showed that T-EM had higher cytotoxic efficiency compared to T-CM. This could be attributed to the higher expression levels of perforin and granzyme B in T-EM, which likely mediate the higher cytotoxic efficiency.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Laurie Vaillant, Paul Oster, Brynn McMillan, Eulalia Orozco Fernandez, Dominique Velin
Summary: This study demonstrates the crucial role of GM-CSF, most likely originating from Th17 cells, in the vaccine-induced reduction of H. pylori infection. GM-CSF promotes the production of beta defensin3 by gastric epithelial cells, which exhibits bactericidal activities against H. pylori.
Article
Biochemistry & Molecular Biology
Jianhua Li, Ping Wang, Kevin J. Tracey, Haichao Wang
Summary: SARS-CoV-2, similar to SARS-CoV, uses its spike protein to bind ACE2 receptor for entry, leading to COVID-19 pandemic. Vaccines encoding for SARS-CoV-2 spike protein are being used to boost antibodies inhibiting viral entry.
MOLECULAR MEDICINE
(2021)
Article
Immunology
Yu-Min Chuang, Liangmei He, Michael L. Pinn, Ya-Chea Tsai, Max A. Cheng, Emily Farmer, Petros C. Karakousis, Chien-Fu Hung
Summary: The study created a novel albumin-fused GM-CSF molecule that could shorten global tuberculosis treatment regimens and enhance GM-CSF stability, increasing dendritic cell populations to effectively treat chronic tuberculosis infections.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Yawei Liu, Robert Bockermann, Mahdieh Hadi, Iman Safari, Belinda Carrion, Marie Kveiborg, Shohreh Issazadeh-Navikas
Summary: ADAM12 is identified as a costimulatory molecule in T cells that mimics CD28 signaling to activate and induce proliferation of Th1 cells. Lack of genomic ADAM12 in T cells diminishes T-bet and IFN gamma production in Th1 cells, providing a potential target for the treatment of Th1-mediated diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Philipp Adams, Gilles Iserentant, Jean-Yves Servais, Linos Vandekerckhove, Guido Vanham, Carole Seguin-Devaux
Summary: This study reveals that HIV controllers show significantly increased suppression at baseline and after peptide stimulation, indicating a positive correlation between IFN-gamma secretion, Ki67 proliferation marker, and viral suppressive capacity (VSC). Furthermore, detailed phenotypes of three distinct multifunctional memory CD8(+) T cell subsets are specific traits of HIV controllers, two of which are convincingly correlated with VSC. Our results underline the importance of multifunctional CD8(+) T cell responses during natural control.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Vanaja Konduri, Damilola Oyewole-Said, Jonathan Vazquez-Perez, Scott A. Weldon, Matthew M. Halpert, Jonathan M. Levitt, William K. Decker
Summary: NK1.1 and its human homolog CD161 are expressed on various immune cells and play different roles in NK cells, T cells, and NKT cells. CD161-expressing CD8(+) T cells, initially studied in viral infections, have potential implications in tumor immunology, although their exact role is not well understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nadia Madrid-Elena, Sergio Serrano-Villar, Carolina Gutierrez, Beatriz Sastre, Matias Morin, Laura Luna, Laura Martin, Javier Santoyo-Lopez, Maria Rosa Lopez-Huertas, Elena Moreno, Maria Laura Garcia-Bermejo, Miguel Angel Moreno-Pelayo, Santiago Moreno
Summary: This study demonstrates that modulation of miRNA expression in T cells enhances specific cytotoxic immune responses to HIV, providing a new approach for achieving HIV remission.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Takuto Nogimori, Koichiro Suzuki, Yuji Masuta, Ayaka Washizaki, Mika Yagoto, Mami Ikeda, Yuki Katayama, Hidenori Kanda, Minoru Takada, Shohei Minami, Takeshi Kobayashi, Shokichi Takahama, Yasuo Yoshioka, Takuya Yamamoto
Summary: Understanding T-cell responses is crucial for combating COVID-19. This study found that the BNT162b2 mRNA vaccine induced long-lasting spike-specific CD8(+) T cells, but TCR usage decreased over time. Additionally, the vaccine elicited a subpopulation of spike-specific CD8(+) T cells expressing GZMA, GZMB, and Perforin, but this subpopulation was not maintained after 12 weeks. Improving vaccine efficacy against variants may require factors that induce CD8(+) T cells with highly cytotoxic activity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Chen Luo, Qianqian Wang, Ruhai Guo, Jingnan Zhang, Jingya Zhang, Riteng Zhang, Xin Ma, Peixin Wang, Fathalrhman Eisa Addoma Adam, Basit Zeshan, Zengqi Yang, Yefei Zhou, Xinglong Wang
Summary: In this study, a TK/gI/gE deleted recombinant PRV expressing GM-CSF was developed using the HDR-CRISPR/Cas9 system. The recombinant PRV showed higher knock-in efficiency and similar properties to the parental strain. Mice vaccinated with the recombinant PRV were completely protected against wild-type PRV challenge and showed improved antibody responses and immune reactions. This study provides a novel approach for recombinant PRV construction and the triple gene-deleted PRV expressing GM-CSF could be a promising vaccine candidate for PR control.
Editorial Material
Immunology
Lawrence Corey
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
L. Corey, P. B. Gilbert, M. Juraska, D. C. Montefiori, L. Morris, S. T. Karuna, S. Edupuganti, N. M. Mgodi, A. C. deCamp, E. Rudnicki, Y. Huang, P. Gonzales, R. Cabello, C. Orrell, J. R. Lama, F. Laher, E. M. Lazarus, J. Sanchez, I. Frank, J. Hinojosa, M. E. Sobieszczyk, K. E. Marshall, P. G. Mukwekwerere, J. Makhema, L. R. Baden, J. I. Mullins, C. Williamson, J. Hural, M. J. McElrath, C. Bentley, S. Takuva, M. M. Gomez Lorenzo, D. N. Burns, N. Espy, A. K. Randhawa, N. Kochar, E. Piwowar-Manning, D. J. Donnell, N. Sista, P. Andrew, J. G. Kublin, G. Gray, J. E. Ledgerwood, J. R. Mascola, M. S. Cohen
Summary: The study found that broadly neutralizing antibodies did not prevent HIV-1 acquisition more effectively than placebo, but analyses of VRC01-sensitive HIV-1 isolates indicated that prophylaxis with broadly neutralizing antibodies may be effective.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Immunology
Glenda E. Gray, Lawrence Corey
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2021)
Editorial Material
Medicine, General & Internal
Lawrence Corey, Chris Beyrer, Myron S. Cohen, Nelson L. Michael, Trevor Bedford, Morgane Rolland
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemical Research Methods
Catherine M. Byrne, Christine Johnston, Jackson Orem, Fred Okuku, Meei-Li Huang, Habibur Rahman, Anna Wald, Lawrence Corey, Joshua T. Schiffer, Corey Casper, Daniel Coombs, Soren Gantt
Summary: Epstein-Barr virus (EBV) is a major cause of cancer transmitted through saliva, particularly in individuals living with HIV/AIDS. A study in Uganda found that HIV-1 coinfected individuals had a higher risk of EBV detection in saliva and higher viral loads compared to those without HIV-1. Mathematical modeling revealed that HIV-1 coinfected individuals had higher rates of B cell reactivation, potentially explaining the more frequent detection of EBV in their saliva.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Matthew D. Gray, Junli Feng, Connor E. Weidle, Kristen W. Cohen, Lamar Ballweber-Fleming, Anna J. MacCamy, Crystal N. Huynh, Josephine J. Trichka, David Montefiori, Guido Ferrari, Marie Pancera, M. Juliana McElrath, Leonidas Stamatatos
Summary: This study demonstrates that the activation of naive B cells is crucial for the development of broadly neutralizing HIV-1 antibodies. Only one antibody displayed homology to VRC01-class antibodies, but required alterations in certain domains to switch epitope recognition. Germ line-targeting Env immunogens efficiently activated VRC01 B cells, highlighting their importance in B cell activation.
Article
Medicine, General & Internal
Dean Follmann, Holly E. Janes, Olive D. Buhule, Honghong Zhou, Bethany Girard, Kristen Marks, Karen Kotloff, Michael Desjardins, Lawrence Corey, Kathleen M. Neuzil, Jacqueline M. Miller, Hana M. El Sahly, Lindsey R. Baden
Summary: This study evaluated the seropositivity of anti-nucleocapsid antibody (anti-N Ab) in mRNA-1273 vaccinees with breakthrough SARS-CoV-2 infection. The results showed a lower seroconversion rate in vaccinees, indicating the importance of considering vaccination status when interpreting seroprevalence and seropositivity data based solely on anti-N Ab testing.
ANNALS OF INTERNAL MEDICINE
(2022)
Review
Immunology
Corey Casper, Lawrence Corey, Jeffrey Cohen, Blossom Damania, Anne A. Gershon, David C. Kaslow, Laurie T. Krug, Jeffrey Martin, Sam M. Mbulaiteye, Edward S. Mocarski, Patrick S. Moore, Javier Gordon Ogembo, Warren Phipps, Denise Whitby, Charles Wood
Summary: This article summarizes the epidemiology and biology of Kaposi sarcoma herpesvirus (KSHV) as an overlooked but potentially vaccine-preventable infection. The unique epidemiology of this virus provides opportunities to prevent its cancers if an effective, inexpensive, and well-tolerated vaccine can be developed and delivered.
Article
Medicine, Research & Experimental
Daniel Corey, Francoise Haeseleer, Joe Hou, Lawrence Corey
Summary: Adoptive therapy using genetically engineered T cells shows promise in treating infectious diseases in immunocompromised individuals. In this study, chimeric engulfment receptor (CER) T cells designed to recognize phosphatidylserine (PS)-expressing cells successfully eliminated SIV-infected cells. The introduction of innate immune functions into T cells enhances the elimination of SIV-infected cells, and further in vivo studies are needed to evaluate their effectiveness.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2023)
Article
Immunology
Deborah Donnell, Fei Gao, James P. Hughes, Brett Hanscom, Lawrence Corey, Myron S. Cohen, Srilatha Edupuganti, Nyaradzo Mgodi, Helen Rees, Jared M. Baeten, Glenda Gray, Linda-Gail Bekker, Mina Hosseinipour, Sinead Delany-Moretlwe
Summary: This study used counterfactual placebo comparisons using other data sources to evaluate the efficacy of antiretroviral agents for HIV pre-exposure prophylaxis. The findings showed that injectable cabotegravir (CAB-LA) and daily oral emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) can significantly reduce the risk of HIV infection compared to no intervention, and the efficacy of FTC/TDF against counterfactual placebo was consistent with previous placebo-controlled trials.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2023)
Article
Medicine, Research & Experimental
Magdalena E. Sobieszczyk, Jill Maaske, Ann R. Falsey, Stephanie Sproule, Merlin L. Robb, Robert W. Frenck, Hong-Van Tieu, Kenneth H. Mayer, Lawrence Corey, Kathleen M. Neuzil, Tina Tong, Margaret Brewinski Isaacs, Holly Janes, Himanshu Bansal, Lindsay M. Edwards, Justin A. Green, Elizabeth J. Kelly, Kathryn Shoemaker, Therese Takas, Tom White, Prakash Bhuyan, Tonya Villafana, Ian Hirsch
Summary: AZD1222 vaccine demonstrated safety, efficacy, and immunogenicity in the ongoing phase 3 trial. The vaccine provided durable protection with a significant reduction in the incidence of symptomatic COVID-19 and showed high efficacy against severe/critical disease. Humoral immune responses induced by AZD1222 waned over time.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Meeting Abstract
Immunology
V. Singh, D. Burgess, A. Dashti, J. McBrien, H. King, R. Mason, J. Safrit, J. Lifson, M. Tuyishime, G. Ferrari, M. Roederer, G. Silvestri, A. Chahroudi
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Meeting Abstract
Immunology
A. Kenny, A. Luedtke, O. Hyrien, Y. Fong, R. Burnham, J. Heptinstall, S. Sawant, S. Stanfield-Oakley, F. L. Omar, S. Khuzwayo, O. Dintwe, E. Borducchi, L. Pattacini, W. Willems, L. Lavreys, J. van Duijn, D. J. Stieh, F. Tomaka, M. G. Pau, G. E. Gray, S. Buchbinder, K. Mngadi, M. J. McElrath, L. Corey, D. H. Barouch, S. C. De Rosa, G. Ferrari, E. Andersen-Nissen, G. Tomaras, P. B. Gilbert
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Meeting Abstract
Immunology
J. L. Nordstrom, C. L. Gay, C. Bohac, A. R. Wahl, T. Morgan, J. L. Schmitz, H. Li, J. Cotshott, J. Gobburu, A. N. Macintyre, R. J. Gorelick, G. Ferrari, D. M. Margolis, J. V. Garcia
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2022)
Article
Multidisciplinary Sciences
Amalio Telenti, Ann Arvin, Lawrence Corey, Davide Corti, Michael S. Diamond, Adolfo Garcia-Sastre, Robert F. Garry, Edward C. Holmes, Phillip S. Pang, Herbert W. Virgin
Summary: This article discusses the future patterns of SARS-CoV-2 infection, the development of variants, and the implications for vaccine deployment. It suggests that the virus may become endemic fueled by pockets of susceptible individuals and waning immunity. Effective surveillance and response are crucial to prevent new epidemic or pandemic patterns.