Article
Multidisciplinary Sciences
Andras Gyorgy, Amor Menezes, Murat Arcak
Summary: The authors develop a genetic optimizer based on common synthetic biology parts to ensure optimal and robust cellular performance in diverse contexts. By presenting the blueprint of a genetic feedback module, they propose a method to dynamically fine-tune and optimize cellular performance. The optimizer can be easily implemented and integrated with existing pathways and biosensors.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Kexin Yuan, Pei Zhao, Lili Wang
Summary: The study investigated the expression levels of miRNA-1 and miRNA-21 in atrial tissues of AF patients and found significant differences compared to patients with sinus rhythm. The down-regulation of miRNA-1 and up-regulation of miRNA-21 were observed in AF patients, indicating their role in molecular remodeling of aging AF.
Article
Medicine, General & Internal
Fuxing Tang, Xiaohong Jiang, Shijie Liao, Yun Liu, Maolin He
Summary: This study investigates the potential regulatory mechanism of transcription factor (TF)-miRNA-mRNA in osteosarcoma using bioinformatics methods and validates the findings through qRT-PCR. The study identifies differentially expressed miRNAs and genes and constructs a TF-miRNA-mRNA regulatory network. Two genes, LAMC1 and THBS1, in the network are found to have prognostic value. Survival analysis and experimental validation establish a TF-miRNA-mRNA sub-network, providing insights into the pathological mechanisms of osteosarcoma for diagnosis and treatment.
Article
Plant Sciences
Malgorzata Majewska, Lukasz Kuzma, Piotr Szymczyk
Summary: Salvia miltiorrhiza synthesises tanshinones with multidirectional therapeutic effects. In this study, a new sequence of the HMGR4 gene in S. miltiorrhiza was isolated and characterised, providing valuable information for understanding the transcription regulation of this gene and further exploring the medicinal value of S. miltiorrhiza.
Article
Biotechnology & Applied Microbiology
Jingyi Cai, Chaoyuan Li, Shun Li, Jianru Yi, Jun Wang, Ke Yao, Xinyan Gan, Yu Shen, Pu Yang, Dian Jing, Zhihe Zhao
Summary: This research aims to uncover potential lncRNAs related to mechanical input and their interaction with bone-related cells. By constructing competing endogenous RNA networks and pathway-lncRNA networks, signaling pathways and factors possibly involved in bone remodeling and mechanotransduction are revealed. This study introduces a novel bioinformatic analysis approach integrating sequencing data, literature retrieval, and computational algorithm.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biology
Kendall E. Martin, Padmapriyadarshini Ravisankar, Manu Beerens, Calum A. MacRae, Joshua S. Waxman
Summary: This study reveals that the zebrafish transcription factor Nr2f1a prevents the progressive acquisition of ventricular and pacemaker cardiomyocyte identities within distinct regions of the atrium by maintaining the expression of nkx2.5. The findings provide insights into the molecular etiology of congenital heart defects and associated arrhythmias.
Article
Virology
Urs F. Greber, Alfonso Gomez-Gonzalez
Summary: The article discusses the mechanisms by which human adenoviruses deliver their double-stranded DNA genome into the cell nucleus, as well as their effects on lytic cell killing, non-lytic persistent infection, or vector gene expression.
CURRENT OPINION IN VIROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Gerhild Euler, Jens Kockskaemper, Rainer Schulz, Mariana S. Parahuleva
Summary: HF and AF are major life-threatening diseases worldwide, and recent studies suggest JDP2 as a potential prognostic marker and therapeutic target for these diseases. Studies in genetically modified mice show impressive involvement of JDP2 in HF and AF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yingwei Chen, Xiaojie Chen, Haiyu Li, Yunpeng Li, Dong Cheng, Yi Tang, Haiqiang Sang
Summary: The study revealed that MIAT enriched in serum-derived EVs promotes atrial fibrosis, inflammation, and oxidative stress, exacerbating atrial remodeling and AF. Mechanistically, MIAT binds to miR-485-5p to relieve its inhibition on CXCL10, contributing to the pathogenesis of AF.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Miao Chen, Jiawei Zhong, Zhen Wang, Hongfei Xu, Heng Chen, Xingang Sun, Yunlong Lu, Lu Chen, Xudong Xie, Liangrong Zheng
Summary: Fgf21 administration effectively attenuated atrial remodeling by reducing oxidative stress and improving structural and electrical changes in the atria.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ahmet Demirkiran, Raquel P. Amier, Mark B. M. Hofman, Rob J. van der Geest, Lourens F. H. J. Robbers, Luuk H. G. A. Hopman, Mark J. Mulder, Peter van de Ven, Cornelis P. Allaart, Albert C. van Rossum, Marco J. W. Gotte, Robin Nijveldt
Summary: The study revealed that the global left atrial flow dynamics in patients with paroxysmal atrial fibrillation are impaired even during sinus rhythm, showing lower flow velocities, increased stasis of blood, and decreased kinetic energy compared to patients without cardiac disease. These pathophysiological flow patterns may help explain the increased incidence of thromboembolic events in paroxysmal AF patients, independent of actual AF or left atrial remodeling.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Takashi Shimizu, Yoshiki Higashijima, Yasuharu Kanki, Ryo Nakaki, Takeshi Kawamura, Yoshihiro Urade, Youichiro Wada
Summary: The study revealed that PERK plays a role in PAH pathophysiology in BMPR2 heterozygous mice by regulating the UPR pathway. PERK inhibition resulted in reduced PDGFRD-STAT1 signaling and glycolysis in hypoxic BMPR2 heterozygous PASMCs, ultimately ameliorating pulmonary vascular remodeling in a PAH model. These findings suggest that PERK inhibition could be a promising therapeutic strategy for patients with PAH, regardless of BMPR2 mutation status.
Article
Cardiac & Cardiovascular Systems
Yanyi Sun, Cristina Pinto, Stephane Camus, Vincent Duval, Paul Alayrac, Ivana Zlatanova, Xavier Loyer, Jose Vilar, Mathilde Lemitre, Angelique Levoye, Meritxell Nus, Hafid Ait-Oufella, Ziad Mallat, Jean-Sebastien Silvestre
Summary: This study reveals the important role of follicular B cells and marginal zone B cells in the recovery of cardiac function after acute myocardial infarction (MI). The miR21/HIF-alpha pathway plays a critical role in B-cell functions. Activation of the miR21/HIF-1 alpha pathway in marginal zone B cells is associated with the recruitment of inflammatory monocytes and adverse cardiac remodeling.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sashidar Bandaru, Chandu Ala, Alex-Xianghua Zhou, Levent M. Akyurek
Summary: Filamin A (FLNA) plays a crucial role in cell motility and vascular development by stabilizing actin networks and interacting with transcription factors and cell signaling molecules. Mutations in FLNA can lead to cardiovascular malformations in humans, highlighting its importance in cardiovascular health. The interaction of FLNA with transcription factors and cell signaling molecules dictates its function in vascular cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mathematical & Computational Biology
Shengjue Xiao, Yufei Zhou, Ailin Liu, Qi Wu, Yue Hu, Jie Liu, Hong Zhu, Ting Yin, Defeng Pan
Summary: This study identified novel biomarkers, miRNAs, and pathways associated with persistent atrial fibrillation (pAF) through integrated analyses, revealing that microRNA-34a-5p may regulate pAF through the calcineurin NFAT signaling pathway. Additionally, differences in immune infiltration between pAF patients and normal controls were observed, suggesting potential interactions between immune cells and specific genes in pAF pathogenesis.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Houria Daimi, Estefania Lozano-Velasco, Amelia Aranega, Diego Franco
Summary: This review provides the latest information on the molecular events that regulate the Na(v)1.5 sodium channel and the cardiac channelopathies associated with defects in these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Carlos Garcia-Padilla, Francisco Hernandez-Torres, Estefania Lozano-Velasco, Angel Duenas, Maria del Mar Munoz-Gallardo, Isabel S. Garcia-Valencia, Lledo Palencia-Vincent, Amelia Aranega, Diego Franco
Summary: Bmp and Fgf signaling are involved in embryonic development, and their modulation of microRNAs plays a crucial role in regulating cell fate during cardiomyogenesis and PE/ST development. However, the role of Bmp and Fgf signaling in mouse PE/ST development is different from that in chicken, and their impact on cardiomyogenesis and fibrogenesis is limited. Species-specific differences in regulating PE/ST cardiomyogenic lineage commitment are supported by the data.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell Biology
Ariadna Bargiela, Francisco Hernandez-Torres
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elena Alonso-Villa, Fernando Bonet, Francisco Hernandez-Torres, Oscar Campuzano, Georgia Sarquella-Brugada, Maribel Quezada-Feijoo, Monica Ramos, Alipio Mangas, Rocio Toro
Summary: Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by ventricular dilation and systolic dysfunction, often leading to heart failure and death. DCM is the final phenotype of various factors such as ischemia, infection, autoimmunity, drugs, or genetic susceptibility. miRNAs play important roles in regulating mechanisms related to inflammation, ER stress, oxidative stress, mitochondrial dysfunction, autophagy, cardiomyocyte apoptosis, and fibrosis in the context of DCM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Carmen Tarifa, Selma A. Serra, Adela Herraiz-Martinez, Estefania Lozano-Velasco, Raul Benitez, Amelia Aranega, Diego Franco, Leif Hove-Madsen
Summary: This study aimed to investigate the relationship between Pitx2c expression and calcium release and electrical activity in atrial myocytes. By using confocal calcium imaging and patch-clamp techniques, it was found that Pitx2c deletion leads to calcium homeostasis imbalance and abnormal electrical activity, which resemble the abnormalities observed in right atrial myocytes from patients with AF.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Francisco Jose Martinez-Amaro, Carlos Garcia-Padilla, Diego Franco, Houria Daimi
Summary: The endoplasmic reticulum (ER) is crucial for protein quality control and maintaining protein homeostasis. ER stress triggers various molecular mechanisms such as ERAD, UPR, and reticulophagy to restore protein balance. Failure to alleviate ER stress leads to apoptosis and cardiovascular diseases. The roles of microRNAs, as well as lncRNAs and circRNAs, in modulating ER stress response and their impact on cardiovascular diseases are discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Sheila Cano-Carrillo, Estefania Lozano-Velasco, Juan Manuel Castillo-Casas, Cristina Sanchez-Fernandez, Diego Franco
Summary: Myocardial infarction is a common cardiovascular disease caused by cardiomyocyte cell death due to lack of oxygen supply. Reactive oxygen species generated during reperfusion lead to cell death, inflammation, and fibrotic scar formation. Non-coding RNAs, including miRNAs, lncRNAs, and circRNAs, play a vital role in modulating cardiac injury and regeneration processes.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Juan Manuel Castillo-Casas, Sheila Cano-Carrillo, Cristina Sanchez-Fernandez, Diego Franco, Estefania Lozano-Velasco
Summary: Cardiovascular diseases, especially ischemic heart disease, are the leading cause of death worldwide. Myocardial infarction, caused by coronary artery occlusion, results in insufficient blood supply to the heart and the limited regenerative ability of the adult mammalian heart cannot fully restore the massive loss of cardiomyocytes. However, lower vertebrate species have the ability to regenerate their hearts after injury, and their study has revealed cell types, molecular mechanisms, and signaling pathways involved in the regenerative process. This two-part review discusses the principal response in heart regeneration and emphasizes the essential processes for the full recovery of cardiac function.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Juan Manuel Castillo-Casas, Sheila Cano-Carrillo, Cristina Sanchez-Fernandez, Diego Franco, Estefania Lozano-Velasco
Summary: This article provides a comprehensive review of the main responses and processes involved in heart regeneration, discussing various cell types, molecular mechanisms, and signaling pathways. Heart regeneration holds significant implications for the treatment of ischemic heart disease.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Cristina Sanchez-Fernandez, Lara Rodriguez-Outeirino, Lidia Matias-Valiente, Felicitas Ramirez de Acuna, Diego Franco, Amelia Eva Aranega
Summary: The epicardium is an essential cell population in the outermost layer of the heart, contributing to the formation of different cell types and providing signals for cardiac development. While quiescent during adulthood, the epicardium can reactivate and play a role in cardiac tissue remodeling after injury. However, it is still unclear whether the epicardium-derived cells come from specific subpopulations or a common progenitor. Further research is needed to understand the complexity of the epicardium.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Carlos Garcia-Padilla, Maria del Mar Munoz-Gallardo, Estefania Lozano-Velasco, Juan Manuel Castillo-Casas, Sheila Cano-Carrillo, Virginio Garcia-Lopez, Amelia Aranega, Diego Franco, Virginio Garcia-Martinez, Carmen Lopez-Sanchez
Summary: The cytoskeleton is crucial for cell architecture and signal transduction in biological processes. It consists of actin filaments, microtubules, and intermediate filaments. Dysregulation of the cytoskeleton is associated with cancer. Long non-coding RNAs (lncRNAs) have been identified as potential regulators of the cytoskeleton and play a role in cancer pathogenesis.
