Article
Oncology
Hironobu Hata, Kenji Imamachi, Michihiro Ueda, Masashi Matsuzaka, Hiroaki Hiraga, Toshihisa Osanai, Toru Harabayashi, Katsuya Fujimoto, Satoshi Oizumi, Masato Takahashi, Kazuhito Yoshikawa, Jun Sato, Yutaka Yamazaki, Yoshimasa Kitagawa
Summary: The study aimed to clarify the incidence of MRONJ and the corresponding survival rate of patients treated with zoledronic acid for different types of cancer. The results showed that patients with shorter survival times did not develop MRONJ, and dentists need to be aware of prognosis-related factors to predict MRONJ risk for effective dental management planning.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Immunology
Weidong Zhang, Ling Gao, Wenhao Ren, Shaoming Li, Jingjing Zheng, Shasha Li, Chunmiao Jiang, Shuying Yang, Keqian Zhi
Summary: Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious adverse drug effect, with hypotheses involving reduced bone remodeling, infection, inflammation, and bisphosphonates-induced immune dysfunction. Treatment with bisphosphonates disrupts mucosal and osteo immune homeostasis, impairing the body's ability to resist infection and repair from injury, contributing to the development of MRONJ.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Wen Pan, Jianyu Gu, Shihan Xu, Chunmei Zhang, Jinsong Wang, Songlin Wang, Junji Xu
Summary: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication in patients with osteoporosis or metastatic bone cancer. The study found that dietary nitrate, abundant in green vegetables, can protect against BRONJ-like lesions in mice. Nitrate intake increased plasma nitric oxide levels, reducing monocyte necrosis and inflammatory cytokine production. The findings suggest that dietary nitrate can inhibit monocyte necroptosis in BRONJ and promote bone remodeling after injury.
CELL PROLIFERATION
(2023)
Article
Medicine, General & Internal
Gabor Kammerhofer, Daniel Vegh, Dorottya Banyai, Adam Vegh, Arpad Joob-Fancsaly, Peter Hermann, Zoltan Geczi, Tamas Hegedus, Kata Sara Somogyi, Bulcsu Bencze, Zita Biczo, Donat Huba Juhasz, Peter Zaborszky, Marta Ujpal, Mihaly Tamas Vaszilko, Zsolt Nemeth
Summary: This study aimed to evaluate the association between hyperglycemia and medication-related osteonecrosis of the jaw (MRONJ). The results showed a significant association between hyperglycemia and MRONJ, suggesting that hyperglycemia may lead to vascular anomaly and immune dysfunction, resulting in necrosis after tooth extraction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Krzysztof Wrobel, Maciej Sikora, Maciej Checinski, Maria Jas, Dariusz Chlubek
Summary: MRONJ is a condition that is becoming more common in dental and maxillofacial practice, requiring comprehensive, accessible, and up-to-date data. Besides bisphosphonates, angiogenesis inhibitors and anti-RANKL monoclonal antibodies can also increase the risk of the disease. Thorough physical examination, periodic correction of dental prostheses, and adequate preparation for oral procedures can prevent or minimize the risk of MRONJ.
APPLIED SCIENCES-BASEL
(2021)
Review
Toxicology
Bhumrapee Srivichit, Chanisa Thonusin, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Bisphosphonates are commonly used in the treatment of bone and joint diseases, but long-term use can lead to osteonecrosis. Osteonecrosis is characterized by cell death and impaired cell functions, with medication-related osteonecrosis of the jaw being the most concerning condition. In addition to surgical treatment, non-surgical interventions have been explored to mitigate bisphosphonate-induced osteonecrosis.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Judith Everts-Graber, Daniel Lehmann, John-Patrik Burkard, Benoit Schaller, Brigitta Gahl, HansJoerg Haeuselmann, Ueli Studer, Hans-Rudolf Ziswiler, Stephan Reichenbach, Thomas Lehmann
Summary: This study aimed to determine the risk of ONJ in a real-world population, showing a higher incidence rate in patients receiving denosumab therapy compared to those receiving BPs, with previous BP therapy potentially being an additional risk factor for ONJ development.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Jessica Pepe, Nicola Napoli, Andrea Palermo, Christos Magopoulos, Aliya A. Khan, M. Carola Zillikens, Jean-Jacques Body
Summary: This study evaluates the differences of MRONJ among different patient categories and provides recommendations on how to mitigate the risk and optimally manage MRONJ. The results indicate that patients with advanced malignancies are at a higher risk for MRONJ compared to those with benign bone diseases, but the overall risk is considerably lower than the benefits of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jie Liu, Nikos Mattheos, Chuanxi Deng, Cheng Su, Zekun Wang, Nanyu Luo, Hua Tang
Summary: Icariin benefits MRONJ by improving soft tissue wound area and empty bone lacuna ratio, while teriparatide activates RANKL expression and reduces bone necrosis area and empty lacuna ratio. These findings suggest potential therapeutic benefits for patients with MRONJ.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Endocrinology & Metabolism
Guang Yang, Roy Williams, Lishu Wang, Nosha Farhadfar, Yiqing Chen, Alexander T. Loiacono, Jiang Bian, Lexie Shannon Holliday, Joseph Katz, Yan Gong
Summary: This study evaluated the incidence and risk factors for medication-related osteonecrosis of the jaw (MRONJ) related to bisphosphonates (BPs) or denosumab in cancer patients. The results showed that the rates of MRONJ associated with BPs and denosumab were similar, but patients receiving sequential treatment of these two drug classes had a much higher risk of MRONJ.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Sakiko Soutome, Mitsunobu Otsuru, Saki Hayashida, Maho Murata, Souichi Yanamoto, Shunsuke Sawada, Yuka Kojima, Madoka Funahara, Hiroshi Iwai, Masahiro Umeda, Toshiyuki Saito
Summary: Tooth extraction is not a risk factor for medication-related osteonecrosis of the jaw (MRONJ) in cancer patients receiving bone-modifying agents (BMAs), but rather helps reduce the risk of MRONJ development. Infected teeth and longer duration of BMA administration are independent risk factors for MRONJ.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Xiao-Hong Wu, Shi-Wei Chen
Summary: This report presents a case of multiple myeloma (MM) identified in a surgical specimen previously diagnosed as medication-related osteonecrosis of the jaw (MRONJ) in a patient with MM. The patient exhibited symptoms of both MRONJ and MM, suggesting that MM and MRONJ can occur simultaneously at the same site.
Article
Environmental Sciences
Guillermo Pardo-Zamora, Yanet Martinez, Jose Antonio Moreno, Antonio J. Ortiz-Ruiz
Summary: MRONJ is a rare and severe disease with unclear exact cause and potential multifactorial origins. A case series of three stage 2 MRONJ patients showed complete healing within 12 months of therapeutic protocol application, with radiography demonstrating slow but progressive healing with normal bone structure. Conservative treatment and minimally invasive surgical intervention are effective for stage 2 MRONJ, while application of PRF-L in refractory cases can improve outcomes in soft tissue healing and bone regeneration, though further research is needed to confirm effectiveness.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Se Hwa Kim, Young-Kyun Lee, Tae-Young Kim, Yong-Chan Ha, Sunmee Jang, Ha Young Kim
Summary: The study aimed to estimate the incidence of osteonecrosis of the jaw (ONJ) in Korean osteoporosis patients treated with bisphosphonates (BPs) and identified clinical risk factors such as advanced age, diabetes, and rheumatoid arthritis that increase the risk for ONJ.
Article
Biotechnology & Applied Microbiology
Stephane Odet, Christophe Meyer, Camille Gaudet, Elise Weber, Julie Quenot, Stephane Derruau, Sebastien Laurence, Lisa Bompy, Marine Girodon, Brice Chatelain, Cedric Mauprivez, Esteban Brenet, Halima Kerdjoudj, Narcisse Zwetyenga, Philippe Marchetti, Anne-Sophie Hatzfeld, David Toubeau, Fabienne Pouthier, Xavier Lafarge, Heinz Redl, Mathilde Fenelon, Jean-Christophe Fricain, Roberta Di Pietro, Charlotte Ledouble, Thomas Gualdi, Anne-Laure Parmentier, Aurelien Louvrier, Florelle Gindraux
Summary: The use of human amniotic membrane (hAM) can promote tissue regeneration and healing in patients with medication-related osteonecrosis of the jaw (MRONJ). By using cryopreserved hAM, MRONJ can be effectively treated, leading to improved quality of life for patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Urology & Nephrology
Ioannis Mykoniatis, Nikolaos Pyrgidis, Ioannis Sokolakis, Petros Sountoulides, Georgios Hatzichristodoulou, Apostolos Apostolidis, Dimitrios Hatzichristou
Summary: This study confirmed the efficacy and safety of low-intensity shockwave therapy for patients with chronic prostatitis/chronic pelvic pain syndrome through a systematic review and meta-analysis, showing significant improvements in pain and quality of life for patients.
Review
Urology & Nephrology
Petros Sountoulides, Nikolaos Pyrgidis, Sabine Brookman-May, Ioannis Mykoniatis, Theofilos Karasavvidis, Dimitrios Hatzichristou
Summary: Ureteral stenting in bladder cancer patients may increase the risk of metachronous upper tract urothelial carcinoma compared to no stents, but no significant difference was found compared to nephrostomy. In cases of hydronephrosis, drainage with either nephrostomy or stent is recommended.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Soultana Foutzitzi, Konstantinos Frigkas, Despoina Vitsa, Savas P. Deftereos
Summary: Infections of maxillary teeth commonly spread to the buccal space, while infections originating in the mandible usually spread to the submandibular, pterygomandibular, and buccal spaces. The pterygomandibular space may act as a pathway for spread to zygomatic areas.
CLINICAL CASE REPORTS
(2022)
Article
Medicine, General & Internal
Georgios Tsakaldimis, Zoi Bousiou, Sotiria Dimou-Besikli, Nikolaos Karakasis, Apostolos Papalakis, Stilianos Giannakopoulos, Ioanna Sakellari, Christos Kalaitzis
Summary: We present a rare case of emphysematous cystitis in an immunosuppressed woman with extensive extraperitoneal gas spread up to the mediastinum.
CLINICAL CASE REPORTS
(2022)
Review
Oncology
Evangelos N. Symeonidis, Ka-Lun Lo, Ka-Lun Chui, Ioannis Vakalopoulos, Petros Sountoulides
Summary: En bloc resection of bladder tumor (ERBT) is a feasible, safe, and effective treatment method that provides excellent histological specimens and better staging, but its adoption in the field is still limited.
Review
Medicine, General & Internal
Eliophotos Savvides, Nikolaos Pyrgidis, Georgios Langas, Evangelos N. Symeonidis, Georgios Dimitriadis, Petros Sountoulides
Summary: This study found that concomitant TURBT and endoscopic BPO surgery are oncologically safe and improve the quality of life for patients with lower urinary tract symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Konstantina Bekiaridou, Katerina Kambouri, Alexandra Giatromanolaki, Soultana Foutzitzi, Maria Kouroupi, Ioannis Chrysafis, Savas Deftereos
Summary: This study compares the preoperative ultrasound findings with intraoperative and histopathological findings in children with acute appendicitis, aiming to determine the feasibility of using ultrasound to distinguish between uncomplicated and complicated cases. The results suggest that ultrasound can predict the type of appendicitis in most cases, with parameters like appendiceal diameter, presence of appendicolith, and peritonitis being strong predictors of complicated appendicitis.
Review
Oncology
Nikolaos Pyrgidis, Ioannis Mykoniatis, Lukas Lusuardi, Gerald Bastian Schulz, Ioannis Sokolakis, Christian Stief, Petros Sountoulides
Summary: This study aimed to assess the safety and efficacy of anatomical endoscopic enucleation of the prostate (AEEP) in the retreatment setting after failed previous surgical treatment for benign prostatic obstruction (BPO). Through a systematic review and meta-analysis of 15 studies, it was found that AEEP was equally effective for recurrent or residual BPO compared to primary BPO and can be used after previous surgical treatment failure. However, the overall strength of evidence for all outcomes was deemed very low.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Medicine, General & Internal
Konstantina Bekiaridou, Katerina Kambouri, Alexandra Giatromanolaki, Soultana Foutzitzi, Maria Kouroupi, Maria Aggelidou, Savas Deftereos
Summary: This retrospective study aimed to create a new predictive score for complicated appendicitis in children by combining clinical signs, laboratory values, and ultrasound images. The new score included 10 variables found to be statistically significant, with a cutoff value of ≥4. The sensitivity, specificity, PPV, NPV, and accuracy of the score were 81.1%, 82.4%, 73.2%, approaching 88%, and 81.9%, respectively.
Article
Health Care Sciences & Services
Eirini Papachristou, Savas Deftereos, Panagoula Oikonomou, Konstantina Bekiaridou, Soultana Foutzitzi, Ioannis Gogoulis, Xenophon Sinopidis, Konstantinos Romanidis, Alexandra Tsaroucha, Katerina Kambouri
Summary: The COVID-19 pandemic and stay-at-home regulations have led to an increase in child injuries at home in Greece. This study examines the types and frequency of these injuries during the COVID-19 lockdown, as well as parents' suggestions for preventing such injuries. The survey was conducted from November to December 2021 and involved parents completing an anonymous questionnaire. The findings reveal that 39.3% of parents reported an increase in accidents at home, with injuries being the most common type. Most accidents occurred indoors and affected children aged 0-4 years. Rural/island areas or suburbs had a higher proportion of child accidents. Accidents were more likely to happen when children were with their grandparents, nanny, or alone, compared to being with their parents. Parents who had difficulty supervising their children experienced more accidents, while those who knew how to provide a safe home did not report an increase in accidents.
Review
Medicine, Research & Experimental
Ioannis Mykoniatis, Stavros Tsiakaras, Michael Samarinas, Anastasios Anastasiadis, Evangelos N. Symeonidis, Petros Sountoulides
Summary: This review examines the potential autoimmune nature of painful bladder syndrome/interstitial cystitis (PBS/IC) and focuses on the therapeutic role of monoclonal antibodies for PBS/IC patients. The study finds that adalimumab and certolizumab pegol show no significant difference compared to placebo, while tanezumab has mixed efficacy results and fulranumab study was stopped due to adverse events. Further research is needed to determine the potential of monoclonal antibody therapy as a future treatment option for PBS/IC.
BIOLOGICS-TARGETS & THERAPY
(2022)
Letter
Urology & Nephrology
Petros Sountoulides, Linda Metaxa, Irene Asouhidou, Marios Stavropoulos, John Calleary
Summary: This case report describes a rare instance of a healthy 68-year-old female presenting with a pathological fracture caused by a metastatic RCC in the right shoulder and upper arm. Although the primary tumor was a low risk T1a RCC, it led to a large solitary bone metastasis. The patient underwent successful treatment with a laparoscopic radical nephrectomy followed by targeted therapy with oral TKIs, with no recurrence at 12-month follow-up.
Review
Urology & Nephrology
Dimitrios Memmos, Ioannis Mykoniatis, Petros Sountoulides, Anastasios Anastasiadis, Nikolaos Pyrgidis, Francesco Greco, Luca Cindolo, Dimitrios Hatzichristou, Evangelos Liatsikos, Panagiotis Kallidonis
Summary: This review evaluated the effect of antibiotic prophylaxis on asymptomatic bacteriuria and urinary tract infection in patients undergoing ESWL, showing that antibiotic prophylaxis is not necessary for preventing UTI in patients with sterile urine prior to ESWL. Additionally, patients undergoing instrumentation of the urinary tract do not benefit from antibiotic prophylaxis.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Katerina Kambouri, Paschalis Chatzipantelis, Soultana Foutzitzi, Chrysavgi Dimitriadou, Maria Aggelidou, Alexandra Giatromanolaki, Savas Deftereos
Summary: For pediatric soft tissue tumors, surgery should always be performed and biopsies sent for further analysis.
CLINICAL CASE REPORTS
(2021)
Review
Endocrinology & Metabolism
Nikolaos Pyrgidis, Ioannis Vakalopoulos, Petros Sountoulides
Summary: Treatment with ARAT medications in advanced PCa improves overall survival but comes with certain endocrine and metabolic consequences. Abiraterone acetate can induce mineralocorticoid excess, hypokalemia, hypertension, elevated liver function tests, insulin resistance, and hyperglycemia, while enzalutamide may induce or worsen hypertension and increase the risk of falls and fractures. Darolutamide appears to have a somewhat safer endocrine and metabolic profile.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2021)
