Article
Immunology
Katharina Hutter, Thomas Rulicke, Tamas G. Szabo, Lill Andersen, Andreas Villunger, Sebastian Herzog
Summary: MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in the development and function of immune cells. The miR-15 family has been shown to suppress tumors in chronic lymphocytic leukemia. However, its physiological functions are not well understood. This study reveals that the miR-15 family restricts the expansion of progenitor B cells by inhibiting cell cycle regulators and IL-7 receptor expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Kai Guo, Di Qi, Bo Huang
Summary: The study revealed that lncRNA MEG8 plays a critical role in the development of NSCLC by modulating the miR-15a/b-5p/PSAT1 axis, indicating that lncRNA MEG8, miR-15a-5p, miR-15b-5p, and PSAT1 may serve as potential targets for NSCLC therapy.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Dada Wen, Huamin Zhang, Yutong Zhou, Jie Wang
Summary: This article reviews the important role and regulatory mechanisms of miR-15a/16 in fibrotic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katharina Hutter, Thomas Ruelicke, Mathias Drach, Lill Andersen, Andreas Villunger, Sebastian Herzog
Summary: miRNAs are important regulators of gene expression, with miR-15 family playing key roles in conditions like chronic lymphocytic leukemia. While miR-15a/16-1 deficiency affects NK and early B-cell development, miR-497/195 lack of function does not show similar effects. The redundancy of miR-497/195 to other miRNA clusters and its potential role in specific physiological or pathological conditions are suggested by the study.
Article
Hematology
Tomasz Sewastianik, Juerg R. Straubhaar, Jian-Jun Zhao, Mehmet K. Samur, Keith Adler, Helen E. Tanton, Vignesh Shanmugam, Omar Nadeem, Peter S. Dennis, Vinodh Pillai, Jianli Wang, Meng Jiang, Jianhong Lin, Ying Huang, Daniel Brooks, Mary Bouxsein, David M. Dorfman, Geraldine S. Pinkus, Davide F. Robbiani, Irene M. Ghobrial, Bogdan Budnik, Petr Jarolim, Nikhil C. Munshi, Kenneth C. Anderson, Ruben D. Carrasco
Summary: The deletion of miR-15a/16-1 cluster in murine GC B cells induces moderate but widespread molecular and functional changes, leading to the development of mature B-cell neoplasms resembling human extramedullary plasmacytoma and lymphoma. The low expression levels of miR-15a/16 in human primary EP, primarily associated with del(13q) loss, highlights the tumor-suppressor role of this cluster in plasma cell and B-cell malignancies.
Article
Oncology
Weipeng Liu, Yunyun Zhang, Fengdan Huang, Qianli Ma, Chuanyin Li, Shuyuan Liu, Yan Liang, Li Shi, Yufeng Yao
Summary: The expression of EGFL7 and miR-126 is downregulated in non-small cell lung cancer (NSCLC) through methylation. The EGFL7/miR-126 polymorphism rs2297538 is associated with NSCLC risk.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Felice Pepe, Laura Z. Rassenti, Yuri Pekarsky, Jadwiga Labanowska, Tatsuya Nakamura, Giovanni Nigita, Thomas J. Kipps, Veronica Balatti, Carlo M. Croce
Summary: Chronic lymphocytic leukemia (CLL) is a common adult leukemia characterized by chromosomal aberrations. This study found that some CLL patients have undetected microdeletions, which are closely associated with chromosomal alterations in cancer. These findings may have clinical relevance for successful stratification of patients.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lianjun Zhang, Le Xuan Truong Nguyen, Ying-Chieh Chen, Dijiong Wu, Guerry J. Cook, Dinh Hoa Hoang, Casey J. Brewer, Xin He, Haojie Dong, Shu Li, Man Li, Dandan Zhao, Jing Qi, Wei-Kai Hua, Qi Cai, Emily Carnahan, Wei Chen, Xiwei Wu, Piotr Swiderski, Russell C. Rockne, Marcin Kortylewski, Ling Li, Bin Zhang, Guido Marcucci, Ya-Huei Kuo
Summary: The study elucidates that aberrant expression of miR-126 in inv(16) AML is directly induced by the CBFB-MYH11 fusion gene, promoting AML development and maintaining leukemia stem cells. This highlights miR-126 as a therapeutic target for inv(16) AML patients.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Qi Gao, Liming Zhang, Ruiqun Qi, Li Qiu, Xinghua Gao, Ting Xiao, Hongduo Chen
Summary: The study identified miR-126-3p and miR-16-5p as potential serum biomarkers for symptomatic dermographism (SD) with diagnostic capabilities. The two miRNAs were found to show an inverse correlation with serum level of VEGF-A, indicating their potential role in the pathogenesis of SD.
CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiroya Yamada, Koji Suzuki, Ryosuke Fujii, Miyuki Kawado, Shuji Hashimoto, Yoshiyuki Watanabe, Hiroyasu Iso, Yoshihisa Fujino, Kenji Wakai, Akiko Tamakoshi
Summary: This study found that high levels of circulating miR-21 and miR-29a were significantly associated with an increased risk of total death, cancer death, and CVD death, while individuals with low levels of circulating miR-126 were more likely to experience total death. This suggests that circulating miRNAs may serve as potential biomarkers for early detection of high-risk individuals.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Gabriela C. Lopez-Armas, Arailym Yessenbekova, Rocio E. Gonzalez-Castaneda, Kevin J. Arellano-Arteaga, Ana Guerra-Librero, Nurzhanyat Ablaikhanova, Javier Florido, Germaine Escames, Dario Acuna-Castroviejo, Iryna Rusanova
Summary: This study investigates oxidative damage and inflammatory markers in T2DM patients through blood sample analysis. The relative expression levels of c-miR-21 and c-miR-126 are also analyzed. The results show that T2DM patients have increased oxidative damage and inflammatory response, and c-miR-21 and c-miR-126 may be potential markers for VC development in the future.
Article
Biochemistry & Molecular Biology
Xiaoqin Jia, Yingying Wei, Xin Miao, Tao Zhu, Xiangyu Hu, Zhijie Lin, Weiming Xiao, Yu Zhang, Zhengbing Wang, Weijuan Gong
Summary: The miR-15a/16 gene cluster plays a role in cancer development and immune regulation by affecting CD8(+) T cell frequency and NKG2D expression, mediating disease progression and treatment. The study found that miR-16 binds to the NKG2D gene, regulating the number and activity of CD8(+) NKG2D(+) T cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Ping Xue, Guopei Zhang, Hongchao Zhang, Su Cui, Liang Zhang, Tao Yu, Mingyang Xiao, Liuli Li, Xiaobo Lu
Summary: Platinum-based chemotherapy is commonly used for treating non-small cell lung cancer (NSCLC), but drug resistance remains a significant challenge. This study investigated the association between polymorphisms in DNA repair genes and the efficacy of platinum-based chemotherapy in NSCLC patients. The researchers found that a specific polymorphism (rs3212986) in the ERCC1 gene was associated with overall survival and chemosensitivity to platinum-based chemotherapy. This suggests that ERCC1 rs3212986 may serve as a predictive biomarker for NSCLC patients receiving platinum-based chemotherapy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chairmandurai Aravindraja, Syam Jeepipalli, Krishna Mukesh Vekariya, Ruben Botello-Escalante, Edward K. L. Chan, Lakshmyya Kesavalu
Summary: This study aimed to investigate the global miRNA expression kinetics during the progression of periodontitis in mice infected with T. denticola. The results showed that T. denticola infection led to bacterial colonization and increased alveolar bone resorption. A total of 70 miRNAs with differential expression were identified, and miR-486, miR-126-3p, and miR-126-5p were found to be potential invasive biomarkers of T. denticola in periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sanaz Dastghaib, P. Sravan Kumar, Sajjad Aftabi, Gautam Damera, Azadeh Dalvand, Adel Sepanjnia, Mohammad Kiumarsi, Mohamad-Reza Aghanoori, Sukhwinder Singh Sohal, Sudharsana R. Ande, Javad Alizadeh, Pooneh Mokarram, Saeid Ghavami, Pawan Sharma, Amir A. Zeki
Summary: Lung cells are exposed to internal and external stressors, leading to disruption of protein homeostasis and activation of the UPR. Dysregulation of the UPR is associated with disease development and various human conditions. Compounds targeting the UPR pathway show potential for future therapeutic interventions.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Antoni Sureda, Javad Alizadeh, Seyed Fazel Nabavi, Ioana Berindan-Neagoe, Cosmin Andrei Cismaru, Philippe Jeandet, Marek J. Los, Emilio Clementi, Seyed Mohammad Nabavi, Saeid Ghavami
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Mazaher Ahmadi, Shayan Amiri, Stevan Pecic, Filip Machaj, Jakub Rosik, Marek J. Los, Javad Alizadeh, Reza Mahdian, Simone C. da Silva Rosa, Dedmer Schaafsma, Shahla Shojaei, Tayyebeh Madrakian, Amir A. Zeki, Saeid Ghavami
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Review
Oncology
Mehdi Alikhani, Eliette Touati, Morteza Karimipoor, Massoud Vosough, Sana Eybpoosh, Marjan Mohammadi
Summary: The study showed significant alterations in mtDNA-CN in PBL before and after GIT cancer development, particularly in the CRC and GC subgroups. High levels of heterogeneity were observed in tissue analysis. A statistically significant mean difference was found in the CRC subgroup.
CANCER INVESTIGATION
(2021)
Review
Genetics & Heredity
Mahdi Barazesh, Shiva Mohammadi, Yadollah Bahrami, Pooneh Mokarram, Mohammad Hossein Morowvat, Massoud Saidijam, Morteza Karimipoor, Soudabe Kavousipour, Amir Reza Vosoughi, Korosh Khanaki
Summary: Neurodegenerative diseases are often caused by changes in the structures and functions of the Central Nervous System. Animal models are valuable tools for understanding the development of these disorders, with non-human primates serving as particularly suitable models due to their similarity to humans. The emergence of CRISPR/Cas9 technology has made it easier to generate accurate animal models for neurodegenerative disorders, presenting promising opportunities for breakthroughs in therapy and drug discovery.
CURRENT GENE THERAPY
(2021)
Review
Immunology
Masoomeh Masoomikarimi, Behzad Garmabi, Javad Alizadeh, Erfan Kazemi, Amirhossein Azari Jafari, Seyyedmohammadsadeq Mirmoeeni, Motahareh Dargahi, Niloofar Taheri, Reza Jafari
Summary: COVID-19 is a global pandemic caused by SARS-COV-2, with immunopathological features including elevated CRP and IL-6 levels, decreased CD4+ and CD8+ T cells, and increased inflammatory cytokines. Specific immunotherapies like CP for COVID-19 lack definitive evidence of effectiveness.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Aida Feiz Barazandeh, Zhirong Mou, Nnamdi Ikeogu, Edgard M. Mejia, Chidalu A. Edechi, Wen-Wei Zhang, Javad Alizadeh, Grant M. Hatch, Saeid Ghavami, Greg Matlashewski, Aaron J. Marshall, Jude E. Uzonna
Summary: PEPCK plays a critical role in the metabolism, virulence, and immune pathology of Leishmania major. Its deletion results in altered metabolic activity and attenuation of virulence.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Biology
Mahmoud Aghaei, Sanaz Dastghaib, Sajjad Aftabi, Mohamad-Reza Aghanoori, Javad Alizadeh, Pooneh Mokarram, Parvaneh Mehrbod, Milad Ashrafizadeh, Ali Zarrabi, Kielan Darcy McAlinden, Mathew Suji Eapen, Sukhwinder Singh Sohal, Pawan Sharma, Amir A. Zeki, Saeid Ghavami
Summary: The disruption of protein homeostasis in lung cells by stressors leads to activation of the unfolded protein response (UPR) to manage the increased functional demands. Dysregulation of UPR and ER stress are implicated in various human diseases. Compounds targeting the UPR pathway are being considered as potential therapies.
Article
Multidisciplinary Sciences
Somayeh Aftabsavad, Zahra Noormohammadi, Ashraf Moini, Morteza Karimipoor
Summary: This study investigated the relationship between follicular fluid BPA concentrations and alterations in ICAM-1 and HLA-G gene and protein expressions in the cumulus cells of POR women. Results showed differential expressions between the two groups, with lifestyle habits potentially affecting methylation patterns and protein levels in cumulus cells, impacting ovulation and clinical pregnancy outcomes.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Medicine, General & Internal
Javad Alizadeh, Shahrokh Lorzadeh, Saeid Ghavami
JOURNAL OF INVESTIGATIVE MEDICINE
(2021)
Article
Neurosciences
Javad Alizadeh, Matthew M. Kochan, Vanessa D. Stewart, Dennis A. Drewnik, Sari S. Hannila, Saeid Ghavami
Summary: The study reveals that TGF beta affects the secretion of CSPGs through autophagy pathways, suggesting a potential new approach to reduce CSPG secretion and improve axonal regeneration after SCI.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Pawan Sharma, Javad Alizadeh, Maya Juarez, Afshin Samali, Andrew J. Halayko, Nicholas J. Kenyon, Saeid Ghavami, Amir A. Zeki
Summary: The study found that cell stress markers in lung tissue of IPF patients are associated with lung function deficits, with co-localization of UPR and autophagy markers positively correlated with increased lung function.
Review
Oncology
Mehdi Alikhani, Eliette Touati, Morteza Karimipoor, Massoud Vosough, Marjan Mohammadi
Summary: Changes in mitochondria have been associated with various cancers, including gastrointestinal tract cancers, but the exact causes of mtDNA-CN alterations are not yet known. This review explored potential factors involved in this process, such as ROS, mtDNA genetic variations, DNA methylation, immune system activation, and discussed their potential impact on cancer initiation and progression. Further research into these mechanisms may allow for the effective use of mtDNA-CN variations as cancer biomarkers and the development of novel cancer therapeutic agents.
JOURNAL OF GASTROINTESTINAL CANCER
(2022)
Editorial Material
Genetics & Heredity
Samira Tarashi, Morteza Karimipoor, Seyed Davar Siadat, Andrea Fuso
Review
Oncology
Javad Alizadeh, Mahboubeh Kavoosi, Navjit Singh, Shahrokh Lorzadeh, Amir Ravandi, Biniam Kidane, Naseer Ahmed, Fatima Mraiche, Michael R. Mowat, Saeid Ghavami
Summary: The metabolism of carbohydrates and lipids is crucial for meeting cellular needs. Autophagy plays a vital role in cellular function and energy supply, especially in cancer cells which have a high rate of proliferation. This review discusses the recent findings on how carbohydrate and lipid metabolism regulate autophagy and affect cancer cells.