Article
Gastroenterology & Hepatology
Suk Yee Lam, Michiel C. Mommersteeg, Bingting Yu, Linda Broer, Manon C. W. Spaander, Fabian Frost, Stefan Weiss, Henry Voelzke, Markus M. Lerch, Ben Schoettker, Yan Zhang, Hannah Stocker, Hermann Brenner, Daniel Levy, Shih-Jen Hwang, Alexis C. Wood, Stephen S. Rich, Jerome I. Rotter, Kent D. Taylor, Russell P. Tracy, Edmond K. Kabagambe, Marcis Leja, Janis Klovins, Raitis Peculis, Dace Rudzite, Liene Nikitina-Zake, Girts Skenders, Vita Rovite, Andre Uitterlinden, Ernst J. Kuipers, Gwenny M. Fuhler, Georg Homuth, Maikel P. Peppelenbosch
Summary: The association between anti-H pylori IgG titers and the TLR1/6/10 locus was not replicated across different populations, and the variation at this locus affected TLR1-mediated cytokine production and TLR1 surface expression on monocytes and neutrophils.
Article
Immunology
Dongsheng Liu, Jinyun Wang, Yong Xie
Summary: Refractory Helicobacter pylori infection leads to significant alterations in gastric microbiota, inhibiting the growth of beneficial Lactobacillus. Patients with refractory H. pylori infection may be more prone to developing gastric cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biology
Patricio Gonzalez-Hormazabal, Diana Pelaez, Maher Musleh, Marco Bustamante, Juan Stambuk, Raul Pisano, Hector Valladares, Enrique Lanzarini, Hector Chiong, Jose Suazo, Luis A. Quinones, Nelson M. Varela, V. Gonzalo Castro, Lilian Jara, Zoltan Berger
Summary: The study found that the NOD1 gene polymorphism rs2075820 increases the risk of intestinal-type gastric cancer among individuals infected with H. pylori, especially in those harboring the cag pathogenicity island.
BIOLOGICAL RESEARCH
(2021)
Article
Oncology
Xiao-Yu Wang, Li-Li Wang, Shu-Zhen Liang, Chao Yang, Lin Xu, Meng-Chao Yu, Yi-Xuan Wang, Quan-Jiang Dong
Summary: This study evaluated the performance of a polygenic risk score (PRS) based on H. pylori SNPs in predicting the risk of gastric cancer. The PRS model showed good predictive power for gastric cancer risk. It also demonstrated good performance in predicting cancer risk for hpEurope strains.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Genetics & Heredity
Karolina Golabek, Grzegorz Raczka, Jadwiga Gazdzicka, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Lukasz Krakowczyk, Dorota Hudy, Marek Asman, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study is the first to investigate the association between LTF gene polymorphisms and the risk of oral squamous cell carcinoma (OSCC), as well as its influence on TNM staging and histological grading. The G/G genotype of rs2073495 and rs4637321 were found to be associated with an increased risk of OSCC. However, no significant influences were observed between LTF genotype and TNM staging or histological grading.
Article
Oncology
Yoshiyuki Watanabe, Ritsuko Oikawa, Yasuhiro Kodaka, Yoshinori Sato, Shoko Ono, Takeshi Kenmochi, Hideo Suzuki, Seiji Futagami, Mototsugu Kato, Hiroyuki Yamamoto, Fumio Itoh
Summary: H.pylori plays a key role in gastric cancer development, with specific genetic variations identified in genes related to the mitochondrial electron transport system, glycolytic processes, and the TCA cycle. A novel mutation in the Helicobacter outer membrane protein family member hopL was found to be associated with gastric cancer development, indicating its potential as a genetic biomarker for H.pylori virulence and gastric cancer risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Patricia M. R. Pereira, Komal Mandleywala, Sebastien Monette, Melissa Lumish, Kathryn M. Tully, Sandeep Surendra Panikar, Mike Cornejo, Audrey Mauguen, Ashwin Ragupathi, Nai C. Keltee, Marissa Mattar, Yelena Y. Janjigian, Jason S. Lewis
Summary: This study demonstrates that high levels of caveolin-1 (CAV1) reduce the survival benefit of Trastuzumab in HER2-positive gastric cancer patients. Modulating CAV1 levels, particularly with cholesterol-depleting drugs such as statins, can improve the efficacy of antibody drugs.
NATURE COMMUNICATIONS
(2022)
Review
Microbiology
Ling Zhang, Ming Zhao, Xiangsheng Fu
Summary: Helicobacter pylori (H. pylori) infection is a common cause of gastric disease, but the increase in antibiotic resistance has made it challenging to eradicate. The stomach has a unique microecology that can have positive, negative, or neutral effects on microbial fitness and function. This article reviews the imbalance of gastric microecology and its relationship with H. pylori, as well as potential methods for modulating gastric microecology to facilitate H. pylori eradication, such as probiotics, prebiotics, postbiotics, synbiotics, and microbiota transplantation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jun Wen, Harry Cheuk-Hay Lau, Maikel Peppelenbosch, Jun Yu
Summary: Gastric cancer is a leading cause of cancer death globally, with Helicobacter pylori being a significant risk factor. Recent studies have shown the presence of a large population of microorganisms in the human stomach, with alterations in microbial composition linked to gastric carcinogenesis.
Article
Oncology
Shanshan Chen, Youjia Duan, Yongchao Zhang, Long Cheng, Liang Cai, Xiaopu Hou, Wei Li
Summary: In this study, the polymorphisms of hypoxia-related genes were found to be correlated with the formation of hepatocellular carcinoma (HCC) capsule and the prognosis of HCC patients. The genetic variants in genes including SLC2A1, STAT1, HIF1A, SERPINE1, IFNG, and CTNNB1 showed significant associations with HCC capsule formation and prognosis.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2023)
Article
Gastroenterology & Hepatology
Nianshuang Li, Xinbo Xu, Yuan Zhan, Xiao Fei, Yaobin Ouyang, Pan Zheng, Yanan Zhou, Cong He, Chuan Xie, Yi Hu, Junbo Hong, Nonghua Lu, Zhongming Ge, Yin Zhu
Summary: This study investigates the crosstalk between the Yes-associated protein 1 (YAP) and beta-catenin pathways in H. pylori-associated gastric tumorigenesis. The findings suggest that YAP and beta-catenin synergistically promote H. pylori-induced gastric carcinogenesis through their physical interaction, and identify CDX2, LGR5, and RUVBL1 as downstream genes shared by both pathways.
Article
Immunology
Kun Zhuang, Hailing Tang, Hanqing Guo, Shanshan Yuan
Summary: Geraniol inhibits H. pylori-induced gastric carcinogen signalling, prevents cytotoxicity, ROS and apoptosis, and protects against H. pylori-induced antioxidant depletion, DNA damage and nuclear fragmentation. It also reduces the expression of phosphorylated MAPK proteins and increases the expression of antioxidant protein Prdx-1 in H. pylori-infected cells. Geraniol thus protects against H. pylori-concomitant infection and may be a potential method for preventing gastric cancer caused by H. pylori.
MICROBIAL PATHOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Wenshuai Zhu, Duanrui Liu, Yi Lu, Jingguo Sun, Jingyu Zhu, Yuanxin Xing, Xiaoli Ma, Yunshan Wang, Mingyu Ji, Yanfei Jia
Summary: In this study, it was found that Helicobacter pylori infection increased the sensitivity of gastric cancer cells to RSL3-induced ferroptosis. The molecular subtypes mediated by ferroptosis-related genes are associated with tumor microenvironment cell infiltration and patient survival. The expression of PHKG2 was remarkably correlated with H. pylori infection, metabolic biological processes, patient survival, and therapy response.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Oncology
Alan Ayoub, Chimaobi M. Anugwom, Jhon Prieto, Domingo Balderramo, Javier Diaz Ferrer, Angelo Z. Mattos, Marco Arrese, Enrique Carrera, Zwier M. A. Groothuismink, Jeffrey Oliveira, Andre Boonstra, Jose D. Debes
Summary: This study investigated the association between the STAT4 rs7574865 genetic variant and the risk of hepatocellular carcinoma (HCC) in Latin American and European populations. The results showed no significant association between the risk allele and HCC development in both populations, but Latin Americans of European ancestry were more likely to carry the risk allele.