Article
Chemistry, Multidisciplinary
Edgar Uhl, Friederike Wolff, Sriyash Mangal, Henry Dube, Esther Zanin
Summary: The research reveals that the versatile proteasome inhibitor MG132, inactivated with a photolabile protection group, can be restored with blue light irradiation, causing cancer cells to arrest during metaphase of the cell cycle or undergo apoptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Mohummad Aminur Rahman, Agnete S. T. Engelsen, Shahin Sarowar, Christian Bindesboll, Even Birkeland, Dorota Goplen, Maria L. L. Lotsberg, Stian Knappskog, Anne Simonsen, Martha Chekenya
Summary: The study found that bortezomib can enhance the efficacy of temozolomide by inhibiting autophagic flux, thereby increasing the treatment effect on glioblastoma and increasing the occurrence of cell apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhen Hua, Rongfang Wei, Mengjie Guo, Zigen Lin, Xichao Yu, Xinying Li, Chunyan Gu, Ye Yang
Summary: This study highlights the role of the YTHDF2/STAT5A/MAP2K2/p-ERK axis in the proliferation of multiple myeloma (MM), and targeting YTHDF2 may be a promising therapeutic strategy.
Article
Chemistry, Medicinal
Romina A. Guedes, Jorge H. Grilo, Andreia N. Carvalho, Pedro M. P. Fernandes, Ana S. Ressurreicao, Vanessa Brito, Adriana O. Santos, Samuel Silvestre, Eleonora Gallerani, Maria Joao Gama, Riccardo Gavioli, Jorge A. R. Salvador, Rita C. Guedes
Summary: The purpose of this study was to discover novel proteasome inhibitors with anticancer activity to overcome the limitations of existing inhibitors. A structure-based virtual screening protocol was developed using the human 20S proteasome structure, and 246 compounds were selected for in vitro evaluation. Compound 4 (JHG58) was shortlisted as the best hit compound based on its proteasome inhibitory activity and ability to induce cell death. Molecular docking studies revealed its interactions with key residues at the catalytic active site.
Article
Oncology
Xianyun Qin, Jilan Liu, Dongfeng Pan, Wenyuan Ma, Panpan Cheng, Feng Jin
Summary: Research has shown that corilagin, a primary active constituent of the matsumura leafflower herb, has a significant antitumor effect on glioma, promoting apoptosis of U251 cells and synergizing with temozolomide. The study found that decreased proteasome activity and expression levels play an important role in corilagin-induced apoptosis of glioma U251 cells.
Article
Chemistry, Analytical
Ying Sun, Qimeng Wu, Quanyou Fu, Hailin Cong, Youqing Shen, Bing Yu, Hao Hu
Summary: Combination chemotherapy is a common strategy to enhance treatment effectiveness and avoid multidrug resistance. Integrating synergistic drugs into a nanocarrier can improve drug stability, targeting, and loading, ensuring that the drugs work together at the intended destination.
Article
Multidisciplinary Sciences
Zhijie Cao, Ning Kon, Yajing Liu, Wenbin Xu, Jia Wen, Han Yao, Mi Zhang, Zhen Wu, Xiaojun Yan, Wei-Guo Zhu, Wei Gu, Donglai Wang
Summary: The study revealed that PD-1 in cancer cells is a direct target of the tumor suppressor p53, with its transcription being influenced by acetylation of p53. Acetylated p53 enhances PD-1 transcription, facilitating activation of cancer cell-intrinsic PD-1 and inhibiting tumor growth.
Review
Medicine, Research & Experimental
Nasreddine El Omari, Saad Bakrim, Asaad Khalid, Mohammed Albratty, Ashraf N. Abdalla, Learn-Han Lee, Khang Wen Goh, Long Chiau Ming, Abdelhakim Bouyahya
Summary: Cancer progression is influenced by epigenetic events, with histone modification playing a key role in gene expression. Belinostat, a pan-HDAC inhibitor, has shown effectiveness in the treatment of T-cell lymphoma and solid malignancies. By indirectly promoting acetylated histone accumulation and restoring normal gene expressions, belinostat exhibits potential anti-cancer therapeutic effects through various pathways. Additionally, it has been found to increase p21WAF1, a cyclin-dependent kinase inhibitor involved in cell cycle arrest and apoptosis. Investigative trials have supported belinostat's potential as a valuable anti-cancer drug.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Hyeon-Jin Kim, Greg Booth, Lauren Saunders, Sanjay Srivatsan, Jose L. McFaline-Figueroa, Cole Trapnell
Summary: This article describes a simple and cost-effective method for normalizing transcript counts and reducing technical variability in single-cell RNA sequencing. By using a mixture of DNA standards, the authors improve the detection of global transcriptome changes.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Yiyi Zhang, Bich-Thuy Doan, Gilles Gasser
Summary: This review systematically summarizes the effects of metal-based photosensitizers (PSs) on different types of regulated cell death (RCD), including ferroptosis, immunogenic cell death (ICD), and pyroptosis. The characteristics and mechanisms of each RCD are explained, and commonalities between different metal-based PSs inducing the same RCD are emphasized. Future perspectives on metal-based PSs inducing novel forms of RCD are also discussed.
Article
Biochemistry & Molecular Biology
Jun Lu, Liang-min Fu, Yun Cao, Yong Fang, Jia-zheng Cao, Yi-hui Pan, Jun-jie Cen, Yan-ping Liang, Zhen-hua Chen, Jin-huan Wei, Yong Huang, Mukhtar Adan Mumin, Quan-hui Xu, Ying-han Wang, Jiang-quan Zhu, Hui Liang, Zhu Wang, Qiong Deng, Wei Chen, Xiao-han Jin, Zhi-ping Liu, Jun-hang Luo
Summary: In this study, the tumor suppressive function of LZTFL1 in clear cell renal cell carcinoma (ccRCC) was investigated using bioinformatics analysis and functional studies. LZTFL1 was found to inhibit kidney tumor cell proliferation by destabilizing AKT through the ZNRF1-mediated ubiquitin proteosome pathway and inducing G1 cell cycle arrest. LZTFL1 downregulation was associated with a poor ccRCC outcome and could serve as a prognostic marker. Overexpression of LZTFL1 suppressed tumor growth in a patient-derived xenograft model, suggesting its potential as a therapeutic strategy against ccRCC.
Review
Cell Biology
Zhen Xie, Mengyuan Zhao, Chengxiang Yan, Wei Kong, Fei Lan, Shuxuan Zhao, Qinghu Yang, Zhantao Bai, Hong Qing, Junjun Ni
Summary: Cathepsin B (CatB), a cysteine protease, is primarily located in the subcellular endosomal and lysosomal compartments and is involved in the degradation of intracellular and extracellular proteins. It plays diverse roles in physiological and pathological processes, including programmed cell death (PCD). However, CatB-mediated PCD can lead to disease progression under pathological conditions. This review provides an overview of the critical roles and regulatory pathways of CatB in different types of PCD, and discusses its potential as a therapeutic target in multiple diseases. Current gaps in understanding CatB's involvement in PCD are also highlighted to guide future research directions.
CELL DEATH & DISEASE
(2023)
Review
Cell Biology
Petra Wiedmer, Tobias Jung, Jose Pedro Castro, Laura C. D. Pomatto, Patrick Y. Sun, Kelvin J. A. Davies, Tilman Grune
Summary: Sarcopenia is a muscle-wasting syndrome characterized by progressive loss of skeletal muscle mass, quality, and strength during normal aging. Patients with sarcopenia mainly suffer from loss of muscle strength, leading to mobility disorders, increased risk of morbidity, and mortality. Various molecular mechanisms, including hormone function, muscle fiber composition, and inflammatory pathways, have been identified as causes of sarcopenia.
AGEING RESEARCH REVIEWS
(2021)
Article
Immunology
Rajan Kumar Tiwari, Shiv Govind Rawat, Ajay Kumar
Summary: Research has shown that propranolol exhibits antitumor and chemopotentiating effects in a murine model of T cell lymphoma by altering apoptosis, glycolysis, acidification of the tumor microenvironment, and immunosuppression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Samar S. Fatahala, Amira Sayed, Shahenda Mahgoub, Heba Taha, Mohamed-I Kotb El-Sayed, Mohamed F. El-Shehry, Samir M. Awad, Rania H. Abd El-Hameed
Summary: The designed and synthesized 2-thiouracil-5-sulfonamides derivatives showed promising anticancer activity and significant inhibition of CDK2A in various human cancer cell lines. The most active compound 6e induced cell growth arrest and apoptotic death in different phases of the cell cycle in cancer cells, ultimately leading to potent anticancer effects. Molecular docking of compound 6e confirmed its proper binding to CDK2A, explaining its strong anticancer activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)