Substituent-Controlled Selective Synthesis of Spirooxindoles and Oxazolyloxindoles via Two Tandem Reactions

Enantioselective Construction of Tetrasubstituted Stereogenic Carbons through Brønsted Base Catalyzed Michael Reactions: α′-Hydroxy Enones as Key Enoate Equivalent

(2014) Eider Badiola et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Double C(sp3)–H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles

(2014) Keiji Mori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Concise synthesis of Didebromohamacanthin A and Demethylaplysinopsine: Addition of Ethylenediamine and Guanidine Derivatives to the Pyrrole-Amino Acid Diketopiperazines in Oxidative Conditions

(2014) Ludmila Ermolenko et al.   ORGANIC LETTERS

TMP–Magnesium and TMP–Zinc Bases for the Regioselective Metalation of the Cinnoline Scaffold

(2014) Thomas Klatt et al.   ORGANIC LETTERS

Exploring the Chemistry of N,N′-Diamidocarbenes with Organophosphorus Compounds

(2014) Daniel T. Chase et al.   ORGANIC LETTERS

Regiodivergent Synthesis of 1- and 2-Arylsulfonyl 1,3-Dienes

(2014) Carissa S. Hampton et al.   ORGANIC LETTERS

Rhodium(III)-Catalyzed C–C Coupling of Arenes with 2-Vinyloxiranes: Synthesis of Allylic Alcohols

(2014) Songjie Yu et al.   ORGANIC LETTERS

A New Strategy To Construct Acyclic Nucleosides via Ag(I)-Catalyzed Addition of Pronucleophiles to 9-Allenyl-9H-purines

(2014) Tao Wei et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Mannich Reactions of 5H-Oxazol-4-ones: Highly Enantio- and Diastereoselective Synthesis of Chiral α-Alkylisoserine Derivatives

(2013) Zhiqiang Han et al.   ADVANCED SYNTHESIS & CATALYSIS

Total Syntheses of (±)-Spiroquinazoline, (−)-Alantryphenone, (+)-Lapatin A, and (−)-Quinadoline B

(2013) Mingyao Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cinchona-based squaramide-catalysed cascade aza-Michael–Michael addition: enantioselective construction of functionalized spirooxindole tetrahydroquinolines

(2013) Wen Yang et al.   CHEMICAL COMMUNICATIONS

Catalytic C–C Bond-Forming Multi-Component Cascade or Domino Reactions: Pushing the Boundaries of Complexity in Asymmetric Organocatalysis

(2013) Chandra M. R. Volla et al.   CHEMICAL REVIEWS

Organocatalytic Asymmetric Michael Addition of 5H-Oxazol-4-ones to Nitroolefins

(2013) Baokun Qiao et al.   ORGANIC LETTERS

Highly Diastereo- and Enantioselective Synthesis of α-Alkyl Norstatine Derivatives: Catalytic Asymmetric Mannich Reactions of 5H-Oxazol-4-ones

(2012) Depeng Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Stereoselective Synthesis of α-Alkyl-α-Hydroxycarboxylic Acid Derivatives Catalyzed by a Dinuclear Zinc Complex

(2012) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereocontrolled Domino Reactions

(2012) Hélène Pellissier   CHEMICAL REVIEWS

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters via Organocatalytic Michael–Henry Cascade Reactions

(2012) Klaus Albertshofer et al.   ORGANIC LETTERS

Phosphorus-containing Lewis base catalyzed highly regioselective cyclization of isatin derived electron-deficient alkenes with but-3-yn-2-one

(2012) Zhong Lian et al.   TETRAHEDRON

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

(2011) Yiming Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly diastereoselective and enantioselective Michael addition of 5H-oxazol-4-ones to α,β-unsaturated ketones catalyzed by a new bifunctional organocatalyst with broad substrate scope and applicability

(2011) Huicai Huang et al.   CHEMICAL COMMUNICATIONS

Domino reactions for the synthesis of bridged bicyclic frameworks: fast access to bicyclo[n.3.1]alkanes

(2011) Miriam Ruiz et al.   CHEMICAL SOCIETY REVIEWS

Core Structure-Based Design of Organocatalytic [3+2]-Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3′-Pyrrolidonyl Spirooxindoles

(2011) Bin Tan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereoselective Access to Tri- and Pentacyclic Spiro-γ-lactam-oxindole Cores through a Tandem Aza-Michael Initiated Ring Closure Sequence

(2011) Iyad Allous et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Chemoselective Reduction of Isatin-Derived Electron-Deficient Alkenes Using Alkylphosphanes as Reduction Reagents

(2011) Shu-Hua Cao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Generation and Reactivity of Aza-Oxyallyl Cationic Intermediates: Aza-[4 + 3] Cycloaddition Reactions for Heterocycle Synthesis

(2011) Christopher S. Jeffrey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HighlyZ-Selective Asymmetric 1,4-Addition Reaction of 5H-Oxazol-4-ones with Alkynyl Carbonyl Compounds Catalyzed by Chiral Guanidines

(2011) Tomonori Misaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Divergent Synthesis and Chemical Reactivity of Bicyclic Lactone Fragments of Complex Rearranged Spongian Diterpenes

(2011) Martin J. Schnermann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Hydrogen-Bonding Catalysis of the Diels–Alder Reaction of 3-Vinylindoles and Methyleneindolinones Provides Carbazolespirooxindole Skeletons

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Core-Structure-Motivated Design of a Phosphine-Catalyzed [3 + 2] Cycloaddition Reaction: Enantioselective Syntheses of Spirocyclopenteneoxindoles

(2011) Bin Tan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral Counteranion Synergistic Organocatalysis under High Temperature: Efficient Construction of Optically Pure Spiro[cyclohexanone-oxindole] Backbone

(2011) Yu-Bao Lan et al.   ORGANIC LETTERS

Noncovalent Organocatalysis: A Powerful Tool for the Nucleophilic Epoxidation of α-Ylideneoxindoles

(2011) Chiara Palumbo et al.   ORGANIC LETTERS

Phosphine- and Nitrogen-Containing Lewis Base Catalyzed Highly Regioselective and Geometric Selective Cyclization of Isatin Derived Electron-Deficient Alkenes with Ethyl 2,3-Butadienoate

(2011) Xiu-Chun Zhang et al.   ORGANIC LETTERS

Highly Regio- and Diastereoselective Construction of Spirocyclopenteneoxindoles through Phosphine-Catalyzed [3 + 2] Annulation of Morita–Baylis–Hillman Carbonates with Isatylidene Malononitriles

(2011) Hong-Ping Deng et al.   ORGANIC LETTERS

Unusual mechanistic pathway for the synthesis of novel spiro-oxindoles via 3-phenyl-5-isoxazolone ring cleavage by secondary amino acids

(2011) Neelakandan Vidhya Lakshmi et al.   TETRAHEDRON LETTERS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Tandem Reaction to Construct Six-Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

(2010) Kun Jiang et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Organocatalytic [3+2] Cyclisation Strategy for the Highly Enantioselective Synthesis of Spirooxindoles

(2010) Arnaud Voituriez et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct Asymmetric Aldol Reaction of 5H-Oxazol-4-ones with Aldehydes Catalyzed by Chiral Guanidines

(2010) Tomonori Misaki et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

(2010) Xianxing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalytic Asymmetric Formal [4 + 2] Cycloaddition for the Synthesis of Spiro[4-cyclohexanone-1,3′-oxindoline] Derivatives in High Optical Purity

(2010) Qiang Wei et al.   ORGANIC LETTERS

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Asymmetric organocatalytic synthesis of γ-nitrocarbonyl compounds through Michael and Domino reactions

(2010) David Roca-Lopez et al.   TETRAHEDRON-ASYMMETRY

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

(2009) Giorgio Bencivenni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic approaches to the bicyclo[2.2.2]diazaoctane ring system common to the paraherquamides, stephacidins and related prenylated indole alkaloids

(2009) Kenneth A. Miller et al.   CHEMICAL SOCIETY REVIEWS

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis

(2009) Shu-Ming Li   NATURAL PRODUCT REPORTS

Asymmetric total syntheses of (+)- and (−)-versicolamide B and biosynthetic implications

(2009) Kenneth A. Miller et al.   Nature Chemistry

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Selected Synthetic Strategies to Spirocyclics

(2009) Sambasivarao Kotha et al.   SYNTHESIS-STUTTGART

Isolation, Structure Elucidation, and Biomimetic Total Synthesis of Versicolamide B, and the Isolation of Antipodal (−)-Stephacidin A and (+)-Notoamide B fromAspergillus versicolor NRRL 35600

(2008) Thomas J. Greshock et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

(2008) Andrew Fensome et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantiospecific Synthesis of (+)-Alstonisine via a Stereospecific Osmylation Process(1)

(2008) Jie Yang et al.   JOURNAL OF NATURAL PRODUCTS

Relative and Absolute Stereochemistry of Quinadoline B, an Inhibitor of Lipid Droplet Synthesis in Macrophages

(2008) Nobuhiro Koyama et al.   ORGANIC LETTERS

Facile and General Synthesis of Quaternary 3-Aminooxindoles

(2008) Stephen P. Marsden et al.   ORGANIC LETTERS