Review
Biochemistry & Molecular Biology
Oxana Yu Kytikova, Tatyana P. Novgorodtseva, Yulia K. Denisenko, Denis E. Naumov, Tatyana A. Gvozdenko, Juliy M. Perelman
Summary: Asthma is a chronic disease with a complex etiology, influenced by both natural-climatic and anthropogenic factors. Studies have shown that temperature plays a significant role in airway inflammation, and thermosensory TRP channels are crucial in the pathogenesis of asthma. New treatment methods for asthma exacerbations caused by temperature and humidity should focus on regulating channel activity.
Article
Pharmacology & Pharmacy
Xiao-Yu Cheng, Shu-Fang Li, Yong Chen, Ying-Jie Zhao, Wei Hu, Chao Lu, Ren-Peng Zhou
Summary: TRPM7 is a channel protein located on the cell membrane that regulates the balance of intracellular Mg2+. It plays an important role in cell proliferation, adhesion, migration, and is directly related to disease occurrence and development.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Behavioral Sciences
Qin'yi Xu, Yan Zou, Zeng'li Miao, Lei Jiang, Xu'dong Zhao
Summary: Stroke is a major cause of death and disability, with a rising incidence in developing countries. Transient receptor potential ion channels, expressed in the brain, have been implicated in the pathophysiology of stroke, although the exact mechanisms are still unclear.
BRAIN AND BEHAVIOR
(2023)
Review
Medicine, Research & Experimental
Suwen Bai, Yuan Wei, Rong Liu, Yuhua Chen, Wanling Ma, Minghua Wang, Li Chen, Yumei Luo, Juan Du
Summary: Metastasis, the spread of cancer cells to other parts of the body, is a major factor in tumor treatment failure and death. Transient receptor potential (TRP) channels play a crucial role in various stages of metastasis, including promoting cell migration, angiogenesis, immune regulation, and gene expression changes. This review examines the mechanisms of TRP channels, their involvement in tumor metastasis, inhibitors of TRP channels, and challenges in studying TRP channels in tumor metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Felix Yang, Andy Sivils, Victoria Cegielski, Som Singh, Xiang-Ping Chu
Summary: Pharmacomodulation of membrane channels is a crucial field in understanding physiological conditions and diseases. Transient receptor potential (TRP) channels, especially TRPM, TRPV, and TRPC, have been shown to mediate pain sensation, neuropsychiatric disorders, and epilepsy, providing potential therapeutic targets. This review emphasizes the importance of these TRP channels and their potential for future clinical treatments, giving patients hope for improved care.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Cinder Faith Cohen, Jueun Roh, Sang Hoon Lee, Chul-Kyu Park, Temugin Berta
Summary: Migraine is a neurovascular disorder affecting 12% of the global population. Research suggests that nociceptive neurons in the trigeminal ganglia play a crucial role in migraine pain signals. These neurons innervate the meninges and transmit pain signals to the thalamus. Targeting nociceptive neurons, which express transient receptor potential (TRP) channels, may be a promising approach for migraine treatment. This review discusses the role of nociceptive neurons, challenges with current drugs, and the potential of TRP channels, particularly TRPC4, as novel targets for migraine prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Yuping Zheng, Qingrui Huang, Yanfeng Zhang, Lanxin Geng, Wuqing Wang, Huimin Zhang, Xiang He, Qiannan Li
Summary: This article introduces TRP channels as a class of transmembrane proteins that can sense a variety of physical/chemical stimuli, participate in the pathological processes of various diseases, and have attracted increasing attention from researchers. Recent studies have shown that some TRP channels are involved in the development of pathological scarification (PS) and directly participate in PS fibrosis and re-epithelialization or indirectly activate immune cells to release cytokines and neuropeptides, which is subdivided into immune inflammation, fibrosis, pruritus, and mechanical forces increased. This article elaborates on the characteristics of TRP channels, the mechanism of PS, and how TRP channels mediate the development of PS, summarizes the important role of TRP channels in the different pathogenesis of PS, and proposes that therapeutic strategies targeting TRP will be important for the prevention and treatment of PS. TRP channels are expected to become new targets for PS, which will make further breakthroughs and provide potential pharmacological targets and directions for the in-depth study of PS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jianxiong Jiang, Ying Yu
Summary: Epilepsy is a prevalent and disabling brain disorder characterized by spontaneous seizures. The current medications for epilepsy are not effective for over 30% of patients and have significant adverse effects. Identifying novel drug targets, such as TRP channels, can lead to new therapies for epilepsy.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Cell Biology
Kihwan Lee, Youn Yi Jo, Gehoon Chung, Jung Hoon Jung, Yong Ho Kim, Chul-Kyu Park
Summary: Transient receptor potential (TRP) channels are transmembrane protein complexes that play crucial roles in both the physiology and pathophysiology of the nervous system. These non-selective cation channels are activated by various stimuli and have been implicated in the pathogenesis of multiple organ and neurological disorders, making them promising targets for therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dae Ki Hong, A. Ra Kho, Song Hee Lee, Beom Seok Kang, Min Kyu Park, Bo Young Choi, Sang Won Suh
Summary: Maintaining the correct ionic gradient is crucial for cellular homeostasis, and the TRP channel family and zinc play important roles in brain disease. Dysregulation of ionic gradients in diseases like ischemic stroke and traumatic brain injury leads to excessive release of zinc, causing cell damage. Regulating zinc homeostasis and blocking zinc translocation via TRP channels can protect against brain damage. These findings suggest that targeting zinc and TRP channels could be a potential strategy for treating brain diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyung-Il Kim, Jae-Chul Lee, Dae Won Kim, Myoung Cheol Shin, Jun Hwi Cho, Ji Hyeon Ahn, Soon-Sung Lim, Il Jun Kang, Joon Ha Park, Moo-Ho Won, Tae-Kyeong Lee
Summary: In this study, the neuroprotective effect of oxcarbazepine (OXC) against ischemic injury induced by transient forebrain ischemia was investigated in gerbils. The results showed that post-ischemic treatment with OXC significantly attenuated hyperactivity and cognitive impairment, as well as increased TRPV1 expression in the CA1 region of the hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Fangyan Hu, Xiaohua Song, Dingxin Long
Summary: Calcium is a crucial signaling molecule in all cells, with TRPA1 being a potential target for treating sensory disorders such as pain and pruritus. TRPA1 is the only identified member of the ankyrin subfamily in mammals and has high permeability to calcium ions.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Cell Biology
Theodoros Rizopoulos, Martha Assimakopoulou
Summary: TRPs play a crucial role in the pathogenesis of colorectal cancer and could serve as potential therapeutic targets and prognostic biomarkers.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Review
Immunology
Mengwen Niu, Feng Zhao, Rui Chen, Ping Li, Liqi Bi
Summary: This review summarizes the impact of TRPs on various aspects of rheumatoid arthritis (RA), including joint swelling in vascular endothelial cells, activation and trans-endothelial migration of neutrophils, and the bridging role of TRPs in the formation of citrullinated proteins in the reactive oxygen species/TRPs/Ca2+/peptidyl arginine deiminases networks. It also discusses the distinct functions of TRPs subfamilies expressed in the nervous systems of joints in cold hyperalgesia and neuro-inflammation mutually influenced inflammatory pain in RA, highlighting the potential of TRPs in anti-inflammation and analgesic therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dilara Batan, Douglas K. Peters, Megan E. Schroeder, Brian A. Aguado, Mark W. Young, Robert M. Weiss, Kristi S. Anseth
Summary: This study investigates the role of mechanosensitive calcium channel TRPV4 in stiffness-induced myofibroblast activation in aortic valve stenosis. The results show that TRPV4 regulates VIC proliferation in a stiffness-independent manner, while myofibroblast activation is strongly affected by microenvironmental stiffness. TRPV4 also plays a role in the nuclear localization of Yes-activated protein (YAP). This study suggests TRPV4 as a potential pharmaceutical target for slowing the progression of aortic valve stenosis.