Article
Biochemical Research Methods
Maria-Pilar Martinez-Moral, Kurunthachalam Kannan
Summary: This study presents a novel methodology for determining 19 biomarkers of health effects associated with environmental factors. By analyzing these biomarkers in urine, it is possible to assess the direct effects of chemical exposure and their precursors to adverse health outcomes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Neurosciences
Josiane Silva Silveira, Osmar Vieira Ramires Junior, Felipe Schmitz, Fernanda Silva Ferreira, Fabiana Cristina Rodrigues, Robson Coutinho Silva, Luiz Eduardo Baggio Savio, Angela T. S. Wyse
Summary: Supplementing with 4 mg/kg of folic acid during pregnancy can negatively affect the behavior and biochemical indicators of offspring.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Chemistry, Medicinal
Monazza Shahab, Samson Jamesdaniel
Summary: The article discusses the induction and therapeutic value of targeting nitrate stress in auditory tissue.
Review
Biochemistry & Molecular Biology
Celia Maria Curieses Andres, Jose Manuel Perez de la Lastra, Celia Andres Juan, Francisco J. Plou, Eduardo Perez-Lebena
Summary: This review focuses on the DNA damage caused by various oxidizing, alkylating, and nitrating species, which may play a crucial role in the pathophysiology of inflammation, cancer, and degenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Brittney Lacy, Md Sadequr Rahman, Md Saydur Rahman
Summary: This study investigated the dose-dependent effects of an environmentally relevant pesticide cocktail and temperature change on protein expressions in the gills of goldfish. The results showed that combined exposure to heat and pesticides caused cellular damage, upregulated oxidative/nitrative stress biomarkers, increased apoptotic cells, and downregulated Na+/K+-ATPase expression in the gills.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Cell Biology
Andreas Goette, Uwe Lendeckel
Summary: This article summarizes the underlying pathophysiology and remodeling processes observed in the development of atrial cardiomyopathy, thrombogenesis, and atrial fibrillation, focusing particularly on the impact of oxidative stress, inflammation, diabetes, and obesity.
Article
Respiratory System
Bin Liu, Yi Peng, Dan Yi, Narsa Machireddy, Daoyin Dong, Karina Ramirez, Jingbo Dai, Rebecca Vanderpool, Maggie M. Zhu, Zhiyu Dai, You-Yang Zhao
Summary: This study found that nitrative stress is significantly elevated in the lungs of patients with vascular remodeling and severe pulmonary arterial hypertension. Through a series of experiments, it was discovered that antioxidants and Cav1 gene restoration can inhibit obliterative vascular remodeling and attenuate pulmonary arterial hypertension. These findings suggest that nitrative stress plays an important role in the pathogenesis of obliterative vascular remodeling and severe pulmonary arterial hypertension.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Camila Aguilar Delgado, Tatiane Hammerschmidt, Jessica Lamberty Faverzini, Franciele Lopes, Roberto Giugliani, Guilherme Baldo, Carmen Regla Vargas
Summary: This study aimed to investigate the mechanisms of oxidative/nitrative stress and inflammation in MPS IVA patients under long-term enzyme replacement therapy (ERT). The results showed that there was no overproduction of reactive nitrogen species, protein damage, DNA/RNA oxidative damage, or alteration in non-enzymatic antioxidant capacity in these patients. Additionally, no significant difference was observed in the production of proinflammatory cytokines or the genic expression of factors involved in oxidative stress and inflammatory pathways. In conclusion, this study demonstrated the protective effect of long-term ERT in MPS IVA patients and emphasized the importance of early treatment.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Medicine, Research & Experimental
Mohammad Reza Sepand, Armin Salek Maghsoudi, Amir Shadboorestan, Kayvan Mirnia, Mehdi Aghsami, Mohammad Raoufi
Summary: Although numerous studies have been conducted on the mechanisms of cigarette smoking toxicity in the past three decades, there are still some aspects that remain unclear. Recent developments have raised hopeful indicators that enhance our understanding of cigarette-induced cell death, proposing suggestions for detoxification and therapeutic interventions.
Article
Biochemistry & Molecular Biology
Pablo Balino, Ricard Romero-Cano, Maria Muriach
Summary: Ethanol abuse and metabolic syndrome both have negative impacts on the central nervous system, but their combined effects have not been fully elucidated. This study aims to determine the effects of ethanol intake on a mouse model of metabolic syndrome at the behavioral and biochemical levels. Ethanol intake modulated the insulin response and impaired the oxidative status in the ob mouse brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Anmol Gupta, Priya Dubey, Manoj Kumar, Aditi Roy, Deeksha Sharma, Mohammad Mustufa Khan, Atal Bihari Bajpai, Ravi Prakash Shukla, Neelam Pathak, Mirza Hasanuzzaman
Summary: Arsenic contamination is a severe problem with toxic effects on the environment and human health. Mycoremediation approaches, using specific fungi, have potential for reducing arsenic levels and mitigating its detrimental effects. This review explores the relationship between arsenic exposure, oxidative stress, and signaling pathways, and discusses the mechanisms involved in mycoremediation.
Review
Immunology
Monika Groth, Elzbieta Skrzydlewska, Marta Dobrzynska, Slawomir Pancewicz, Anna Moniuszko-Malinowska
Summary: Vector-borne diseases, including tick-borne diseases, are a growing global health problem. Oxidative stress, inflammation, and metabolic effects play key roles in the pathogenesis of these diseases, impacting the structure and function of phospholipids and proteins. Finding diagnostic biomarkers related to redox imbalance and phospholipid metabolites can help in monitoring disease progression and treatment efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tian Liu, Yi-Fei Lv, Jing-Long Zhao, Qi-Dong You, Zheng-Yu Jiang
Summary: NRF2 is involved in antioxidant pathways and physiological processes, dysregulation is linked to diseases, phosphorylation by kinases is critical in regulating NRF2 activity. Various kinases positively or negatively regulate NRF2 activity through phosphorylation of different sites.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Chemistry, Inorganic & Nuclear
Mohammad Reza Sepand, Banafsheh Bigdelou, Armin Salek Maghsoudi, Nima Sanadgol, Jim Q. Ho, Prashant Chauhan, Mohammad Raoufi, Atefeh Kermanian, Rahim Esfandyarpour, Mohammad Javad Hajipour, Steven Zanganeh
Summary: Ferroptosis is an iron-mediated cell death that combines cell metabolism, redox status, and human disease. Excessive reactive oxygen species (ROS) can lead to cellular oxidative changes, suppress protein activity, and trigger cell death. This review summarizes the effects of environmental chemical exposure on cellular redox signaling, ferroptosis, and cell death, providing critical information to mitigate the impact of ferroptosis on human health.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Shabnoor Iqbal, Farhat Jabeen, Cheng Peng, Muhammad Ajmal Shah, Muhammad Umar Ijaz, Azhar Rasul, Shujat Ali, Abdur Rauf, Gaber E. S. Batiha, Ewa Klodzinska
Summary: The study on Nickel nanoparticles (Ni NPs) induced liver toxicity in Sprague Dawley rats revealed a dose-dependent increase in Ni NPs concentration leading to liver dysfunction and pathologies. Oxidative stress and inflammatory pathways were identified as key toxicological mechanisms, providing insight for health risk management and preventive measures related to the use of Ni-NPs materials.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2021)