Article
Medicine, Research & Experimental
Mohamed Abdellah Ibrahim, Walaa Yehia Abdelzaher, Yasmine F. Ibrahim, Amira F. Ahmed, Nermeen N. Welson, Sarah Al-Rashed, Gaber El-Saber Batiha, Asmaa Mohamed Abdel-Aziz
Summary: The study demonstrated that diacerein pretreatment can reduce liver enzyme levels, oxidative stress, and hepatic inflammation by down-regulating the TLR4/NF kappa-B signaling pathway to restore the damaging effects of liver I/R. This hepatoprotective effect is attributed to the antioxidant and anti-inflammatory properties of diacerein, highlighting its potential as a therapeutic agent for liver I/R injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Yitong Pan, Shuna Yu, Jianxin Wang, Wanzhen Li, Huiting Li, Chen Bai, Yaxin Sheng, Ming Li, Chenchen Wang, Jiao Liu, Peitong Xie, Can Wang, Jiying Jiang, Jianguo Li
Summary: The study found that L-NAT alleviates HIRI by regulating the activation of NLRP3 inflammasome, possibly related to the TLR4/NF-κB signaling pathway.
Article
Immunology
Tao Zhang, Wenqi Huang, Yi Ma
Summary: TRPM2 plays a critical role in hepatic ischemia/reperfusion (I/R) injury and oxygen-glucose deprivation/reoxygenation (OGD/R) induced hepatocyte injury, protecting the liver through activation of autophagy and inhibition of the NLRP3 inflammasome pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carlos Andres Pantanali, Vinicius Rocha-Santos, Marcia Saldanha Kubrusly, Inar Alves Castro, Luiz Augusto Carneiro-D'Albuquerque, Flavio Henrique Galvao
Summary: Nutraceuticals are bioactive compounds found in food that can improve health, prevent diseases, and support the normal functioning of the human body. They are able to target multiple pathways, acting as antioxidants, anti-inflammatory agents, and immune response and cell death modulators. This study investigated the effect of a nutraceutical solution on liver ischemia-reperfusion injury (IRI), and found that it decreased apoptosis and histologic injury in liver tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Bo Yu, Yalong Zhang, Tianyu Wang, Jiayu Guo, Chenyang Kong, Zhongbao Chen, Xiaoxiong Ma, Tao Qiu
Summary: The mitogen-activated protein kinase (MAPK) signaling pathway, which can be triggered by various growth factors, cytokines, and hormones, plays a crucial role in regulating cellular activities such as cell proliferation, motility, and differentiation. It has been extensively studied in the context of inflammation and tumor development. Hepatic ischemia-reperfusion injury (HIRI) is a common pathological phenomenon occurring during surgical procedures like lobectomy and liver transplantation, characterized by severe inflammatory reaction following ischemia and reperfusion. This review mainly focuses on discussing the roles of p38, ERK1/2, JNK in the MAPK family, as well as TAK1 and ASK1 in the MAPKKK family, in HIRI, aiming to identify effective treatments for HIRI.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Maurits Roorda, Jan Lj Miljkovic, Harry van Goor, Robert H. Henning, Hjalmar R. Bouma
Summary: Hydrogen sulfide (H2S), previously known as a putrid, toxic gas, is now recognized as the third gasotransmitter alongside nitric oxide (NO) and carbon monoxide (CO) in mammalian systems. H2S plays a critical role in regulating vascular and cellular function in the kidneys, impacting blood flow, glomerular filtration rate, and the renin-angiotensin axis. Furthermore, H2S offers protection against acute kidney injury (AKI) by enhancing ATP production and preventing damage due to free radicals during hypoxia or ischemia-reperfusion injury. Understanding the (sub)cellular signaling mechanisms of H2S can lead to novel therapeutic targets for preventing kidney injury.
Article
Immunology
Yanyao Liu, Zilun Lei, Hao Chai, Song Xiang, Yihua Wang, Ping Yan, Zhenrui Cao, Xingyu Pu, Zhongjun Wu
Summary: This study found that recombinant human thrombomodulin (rTM) can inhibit the formation of neutrophil extracellular traps (NETs), alleviate hepatic ischemia-reperfusion injury (IRI) and improve liver function. rTM blocks multiple signaling pathways to inhibit NETosis. The results suggest that NETs are a potential therapeutic target for hepatic IRI and rTM can be used to prevent liver injury caused by IRI.
Article
Pharmacology & Pharmacy
Lina Zhao, Huanming Li, Qian Gao, Jin Xu, Yongjie Zhu, Meili Zhai, Peijun Zhang, Na Shen, Yanbo Di, Jinhui Wang, Tie Chen, Meina Huang, Jinglai Sun, Chong Liu
Summary: Berberine exerts neuroprotective effects against ischemic stroke by inhibiting neuronal apoptosis induced by CIRI through downregulating the CNPY2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jie Pan, Sanyang Chen, Wenzhi Guo, Shengli Cao, Xiaoyi Shi, Jiakai Zhang, Huapeng Zhang, Shuijun Zhang
Summary: Alpinetin pretreatment alleviates inflammatory response and apoptosis induced by hepatic I/R injury, showing significant protective effects in a mouse model. This protective effect may be attributed to the inhibition of NF-kappa B/MAPK signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dina Zakaria Mohamed, Alaa El-Din El-Sayed El-Sisi, Samia Salim Sokar, Abdelhadi Mohamed Shebl, Sally El-Sayed Abu-Risha
Summary: This study showed that OCT induced protective autophagy to protect liver against HIR injury in rats, while MLT reversed the hepatoprotective effects of OCT by inhibiting autophagy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Jihoon Nah, Eun-Ah Sung, Peiyong Zhai, Daniela Zablocki, Junichi Sadoshima
Summary: Autosis is a unique form of cell death caused by dysregulated autophagy. During the late phase of ischemia/reperfusion in the heart, Tfeb is activated and translocated into the nucleus, leading to the upregulation of genes related to autophagy and lysosomal function, which promotes autosis.
Article
Pharmacology & Pharmacy
Wen An, Ju-Seop Kang
Summary: Metformin can alleviate hepatic and myocardial injury induced by hepatic ischemia-reperfusion by inhibiting oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Qin Huang, Liqun Tian, Xiaoshuai Zhao, Shaoqing Lei, Bo Zhao, Zhen Qiu, Zhong-Yuan Xia
Summary: The complex progression of type-2 diabetes affects the myocardial susceptibility to ischemia-reperfusion (IR) injury. Targeting Rev-erbs and using circadian medicine show potential in mitigating the IR injury. The study finds that SR9009 may alleviate the diabetic myocardial IR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Giuseppina Palladini, Marta Cagna, Laura Giuseppina Di Pasqua, Luciano Adorini, Anna Cleta Croce, Stefano Perlini, Andrea Ferrigno, Clarissa Berardo, Mariapia Vairetti
Summary: This study investigated the ability of the FXR agonist OCA to modulate MMPs in distant organs such as the kidney, and found that OCA can protect the kidney by reducing TNF-alpha-mediated expression of MMPs after liver ischemia/reperfusion.
Article
Immunology
Jiansen Lu, Wen Hou, Shuang Yang, Decheng Chen, Fei Wang, Lei Liu, Zhongyang Shen
Summary: Hepatic ischemia reperfusion injury (IRI) is a common complication in liver transplantation, and there is currently a lack of effective drugs for treatment. Trans-anethole (TA) is a compound with multiple effects that can alleviate liver IRI through anti-inflammation, anti-oxidative stress, and anti-apoptosis. This study confirms that TA pretreatment significantly improves liver function, reduces liver injury, inhibits hepatocyte apoptosis and inflammatory response, attenuates oxidative stress, and attenuates hepatic IRI by inhibiting NLRP3 inflammasome activation via regulation of soluble epoxide hydrolase (sEH).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)