Article
Cardiac & Cardiovascular Systems
Bradley J. Gardiner, Sue J. Lee, Allisa N. Robertson, Yvonne Cristiano, Gregory I. Snell, C. Orla Morrissey, Anton Y. Peleg, Glen P. Westall
Summary: This study reviewed the application of Quantiferon-Cytomegalovirus (QF-CMV) testing in lung transplant recipients and found a strong correlation between QF-CMV results and serostatus. D+/R- patients were unlikely to test positive while receiving prophylaxis. Extended prophylaxis was associated with delayed, reduced, and milder CMV infection. However, the incremental predictive value of QF-CMV was limited after accounting for serostatus.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Hematology
Po-Hsien Li, Cheng-Hsien Lin, Yu-Hui Lin, Tsung-Chih Chen, Chiann-Yi Hsu, Chieh-Lin Jerry Teng
Summary: The study suggests that low-dose valganciclovir prophylaxis may be an effective strategy to prevent CMV infection in patients undergoing allo-HSCT, particularly in resource-limited countries.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2021)
Article
Transplantation
Rachel Hellemans, Daniel Abramowicz
Summary: CMV-related complications after kidney transplantation present a significant challenge. Tailoring preventive strategies based on individual patient risk levels can improve outcomes. CMV-specific T-cell assays can help predict CMV risk pre-transplantation. Immunosuppressive regimens including mammalian target of rapamycin inhibitors can reduce CMV risk. New antiviral agents and adoptive T-cell therapy hold promise for future treatment options.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Virology
Andrea Gilioli, Andrea Messerotti, Paola Bresciani, Angela Cuoghi, Valeria Pioli, Corrado Colasante, Francesca Bettelli, Davide Giusti, Fabio Forghieri, Leonardo Potenza, Francesca Donatelli, Rachele Giubbolini, Laura Galassi, Roberto Marasca, Federico Banchelli, Roberto D'Amico, Monica Pecorari, William Gennari, Tommaso Trenti, Patrizia Comoli, Mario Luppi, Franco Narni
Summary: The study retrospectively analyzed a cohort of patients who underwent HSCT and found that CMV clinically significant infection (CS-CMVi) occurred in 48% of prophylactically treated patients, but it did not impact relapse incidence or overall survival. Additionally, the use of CMV-IG alone as prophylactic therapy did not effectively prevent CMV reactivation.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, General & Internal
Sarah Mafi, Marie Essig, Jean-Philippe Rerolle, Gisele Lagathu, Romain Crochette, Veronique Brodard, Betoul Schvartz, Stephanie Gouarin, Nicolas Bouvier, Ilka Engelmann, Antoine Garstka, Celine Bressollette-Bodin, Diego Cantarovitch, Raphaele Germi, Benedicte Janbon, Christine Archimbaut, Anne-Elizabeth Heng, Francoise Garnier, Melissa Gomes-Mayeras, Anais Labrunie, Sebastien Hantz, Sophie Alain
Summary: Cytomegalovirus (CMV) is a common infectious complication following solid organ transplantation. Torque teno viruses (TTV) viremia and QuantiFERON((R))-CMV (QF-CMV) assay markers have shown potential in predicting CMV reactivation in kidney transplant recipients (KTR). The combination of TTV load and QF-Ag or TTV load and QF-Mg may help stratify the risk of CMV reactivation and impact the duration of prophylaxis in these patients.
FRONTIERS IN MEDICINE
(2023)
Article
Urology & Nephrology
Tomas Reischig, Tomas Vlas, Martin Kacer, Kristyna Pivovarcikova, Daniel Lysak, Jana Nemcova, Petr Drenko, Jana Machova, Mirko Bouda, Monika Sedivcova, Stanislav Kormunda
Summary: This study compared the efficacy of valganciclovir prophylaxis and preemptive therapy in preventing CMV infection in kidney transplant recipients. The results showed that both regimens had similar effectiveness in preventing CMV disease, but preemptive therapy had a higher incidence of CMV DNAemia.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Immunology
Narisa Ruenroengbun, Tunlanut Sapankaew, Kamolpat Chaiyakittisopon, Pakpoom Phoompoung, Thundon Ngamprasertchai
Summary: This study evaluated and ranked the drugs for allograft rejection prevention following CMV prophylaxis in high-risk kidney transplant patients. Valganciclovir was considered the most effective and safest drug, while valacyclovir was the optimal alternative. Dose-related toxicities and patient compliance should be closely monitored.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biology
Markus J. Barten, Fausto Baldanti, Alexander Staus, Christian M. Hueber, Kyriaki Glynou, Andreas Zuckermann
Summary: This meta-analysis suggests that prophylactic CMVIG treatment in solid organ transplantation patients can reduce the risk of CMV infection. This is particularly beneficial for patients at high risk of CMV infection or disease.
Article
Microbiology
Victor M. Mora, Piedad Ussetti, Alicia de Pablo, David Iturbe, Rosalia Laporta, Rodrigo Alonso, Myriam Aguilar, Carlos A. Quezada, Jose M. Cifrian
Summary: This study compared the risk of CMV infection in lung transplant recipients between two CMV-Ig prophylaxis regimens, and found that extending the CMV-Ig prophylaxis to one year did not provide additional clinical benefits.
Review
Immunology
Dipesh Kumar Yadav, Vishnu Prasad Adhikari, Rajesh Kumar Yadav, Alina Singh, Xing Huang, Qi Zhang, Prabesh Pandit, Qi Ling, Tingbo Liang
Summary: This meta-analysis compared the outcomes of antiviral prophylaxis and preemptive therapy for the prevention of cytomegalovirus (CMV) infection in liver transplant recipients. The results showed that antiviral prophylaxis reduced the incidence of CMV infection in the high-risk group, while preemptive therapy reduced the incidence of late-onset CMV disease. There were no significant differences in other outcomes between the two interventions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Elodie Cheyssac, Hamidou Savadogo, Nathan Lagoutte, Veronique Baudouin, Marina Charbit, Robert Novo, Anne-Laure Sellier-Leclerc, Marc Fila, Stephane Decramer, Elodie Merieau, Ariane Zaloszyc, Jerome Harambat, Gwenaelle Roussey
Summary: In this retrospective study, the effectiveness of valganciclovir (VGC) prophylaxis in preventing Epstein-Barr Virus (EBV) infection in pediatric kidney transplant recipients was investigated. The results showed that VGC prophylaxis did not decrease the incidence of EBV infection, but increased the risk of adverse effects such as neutropenia.
FRONTIERS IN PEDIATRICS
(2023)
Article
Immunology
Hugoline Boulay, Emmanuel Oger, Diego Cantarovich, Philippe Gatault, Antoine Thierry, Yannick Le Meur, Agnes Duveau, Cecile Vigneau, Nolwenn Lorcy
Summary: The study results indicate that the absence of prophylaxis did not appear to have a deleterious effect on CMV diseases among CMV R+ recipients receiving non-depleting induction.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Microbiology
A. Facchin, N. Benyoub, V. Elie, S. Magreault, E. Jacqz-Aigrain
Summary: Valganciclovir is an antiviral agent used to prevent cytomegalovirus infection in renal transplant children. Therapeutic drug monitoring is still necessary to ensure optimal pharmacokinetic variability. This study developed and validated a limited sampling strategy for individualizing valganciclovir dosage in renal transplant children.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Immunology
Moritz B. Immohr, Payam Akhyari, Charlotte Bottger, Arash Mehdiani, Hannan Dalyanoglu, Ralf Westenfeld, Daniel Oehler, Igor Tudorache, Hug Aubin, Artur Lichtenberg, Udo Boeken
Summary: CMV infections are associated with complications following heart transplantation. The impact of serologic mismatch and the necessity of prophylactic virostatic medication remain concerns. Different serologic CMV matching did not significantly affect postoperative morbidity, but seropositive recipients had a higher risk for CMV-DNAemia.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Infectious Diseases
Eleftheria Kampouri, Danniel Zamora, Erika S. Kiem, Winnie Liu, Sarah Ibrahimi, Rachel L. Blazevic, Erika A. Lovas, Louise E. Kimball, Meei-Li Huang, Keith R. Jerome, Masumi Ueda Oshima, Marco Mielcarek, Danielle M. Zerr, Michael J. Boeckh, Elizabeth M. Krantz, Joshua A. Hill
Summary: The use of letermovir for cytomegalovirus (CMV) prophylaxis has led to a decrease in broad-spectrum anti-CMV therapy. However, the impact of letermovir on human herpesvirus-6 (HHV-6) epidemiology remains unknown. This retrospective cohort study aimed to assess changes in HHV-6 detection and disease after the routine use of prophylactic letermovir in CMV-seropositive allogeneic hematopoietic cell transplant recipients.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Multidisciplinary Sciences
K. Griffiths, D. M. Habiel, J. Jaffar, U. Binder, W. G. Darby, C. G. Hosking, A. Skerra, G. P. Westall, C. M. Hogaboam, M. Foley
SCIENTIFIC REPORTS
(2018)
Article
Pharmacology & Pharmacy
Christine R. Keenan, Shenna Y. Langenbach, Fernando Jativa, Trudi Harris, Meina Li, Qianyu Chen, Yuxiu Xia, Bryan Gao, Michael J. Schuliga, Jade Jaffar, Danica Prodanovic, Yan Tu, Asres Berhan, Peter V. S. Lee, Glen P. Westall, Alastair G. Stewart
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Immunology
Sneha Sant, Ludiyine Grzelak, Zhongfang Wang, Angela Pizzollal, Manbs Koutsakos, Jane Crowe, Thomas Loudoyaris, Stuart I. Mannering, Glen P. Westall, Linda M. Wakiml, Jamie Rossjohn, Stephanie Gras, Michael Richards, Jianqing Xu, Paul G. Thomas, Liyen Loh, Thi H. Nguyen, Katherine Kedzierska
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
David W. Waters, Kaj E. C. Blokland, Prabuddha S. Pathinayake, Lan Wei, Michael Schuliga, Jade Jaffar, Glen P. Westall, Philip M. Hansbro, Cecilia M. Prele, Steven E. Mutsaers, Nathan W. Bartlett, Janette K. Burgess, Christopher L. Grainge, Darryl A. Knight
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Article
Surgery
Megan Kummrow, Steven Hiho, Fiona Hudson, Linda Cantwell, William R. Mulley, Lloyd D'Orsogna, Adam Testro, Julie Pavlovic, Peter MacDonald, Lucy C. Sullivan, Gregory I. Snell, Glen P. Westall
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Immunology
Christopher M. Harpur, Sanda Stankovic, Abbie Kanagarajah, Jacqueline M. L. Widjaja, Bronwyn J. Levvey, Yvonne Cristiano, Greg I. Snell, Andrew G. Brooks, Glen P. Westall, Lucy C. Sullivan
Article
Cardiac & Cardiovascular Systems
Kieran M. Halloran, Michael D. Parkes, Jessica Chang, Irina L. Timofte, Gregory Snell, Glen P. Westall, Ramsey Hachem, Daniel Kreisel, Elbert Trulock, Antoine Roux, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Philip F. Halloran
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Article
Immunology
Marios Koutsakos, Patricia T. Illing, Thi H. O. Nguyen, Nicole A. Mifsud, Jeremy Chase Crawford, Simone Rizzetto, Auda A. Eltahla, E. Bridie Clemens, Sneha Sant, Brendon Y. Chua, Chinn Yi Wong, E. Kaitlynn Allen, Don Teng, Pradyot Dash, David F. Boyd, Ludivine Grzelak, Weiguang Zeng, Aeron C. Hurt, Ian Barr, Steve Rockman, David C. Jackson, Tom C. Kotsimbos, Allen C. Cheng, Michael Richards, Glen P. Westall, Thomas Loudovaris, Stuart I. Mannering, Michael Elliott, Stuart G. Tangye, Linda M. Wakim, Jamie Rossjohn, Dhanasekaran Vijaykrishna, Fabio Luciani, Paul G. Thomas, Stephanie Gras, Anthony W. Purcell, Katherine Kedzierska
Review
Immunology
Jonathan E. H. Ling, Michael Fink, Glen Westall, Peter Macdonald, Philip A. Clayton, Rhonda Holdsworth, Helen Opdam, Kevan R. Polkinghorne, John Kanellis
Article
Cardiac & Cardiovascular Systems
Gregory I. Snell, Bronwyn J. Levvey, Aimee Henriksen, Helen M. Whitford, Kovi Levin, Miranda Paraskeva, Sakhee Kotecha, Trevor Williams, Glen P. Westall, David McGiffin
HEART LUNG AND CIRCULATION
(2020)
Article
Cardiac & Cardiovascular Systems
Gregory Snell, Bronwyn Levvey, Miranda Paraskeva, Helen Whitford, Kovi Levin, Trevor Williams, David McGiffin, Glen Westall
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Gregory Snell, Steven Hiho, Bronwyn Levvey, Lucy Sullivan, Glen Westall
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2019)
Article
Immunology
Blandine Rammaert, Mathieu Puyade, Oliver A. Cornely, Danila Seidel, Paolo Grossi, Shahid Husain, Clement Picard, Cornelia Lass-Floerl, Oriol Manuel, Jerome Le Pavec, Olivier Lortholary, Claudia Nagel, Glen Westall, Orla Morrissey, Daniel Chambers, Stephan Eschertzhuber, Julien Coussement, ChristianeKnoop, Robin Vos, Lieven Dupont, Michel Dumonceaux, Silvia Vidal Campos, Dima Kabbani, Carlos Cervera, Me-Linh Luong, Elodie Blanchard, Agathe Senechal, Olivier Brugiere, Veronique Boussaud, Romain Guillemain, Jean-Francois Bervar, Johanna Claustre, Alain Haloun, Sandrine Hirschi, Martine Reynaud, Nikolaus Kneidinger, Jens Gottlieb, Emmanuel Roilides, Hossein Zarrinfar, Lorenzo Rosso, Letizia Corinna Morlacchi, Andrea Dell'Amore, Monica Loy, Claudy Oliveira dos Santos, JordiRello, Victor Monforte, Maria Teresa Martin-Gomez, Francisco Lopez Medrano, Mario Fernandez-Ruiz, Amparo Sole, Jose M. Cifrian, Dionysios Neofytos, Nicolas Mueller, Christian Benden, Anne Kathrin Brill, Esen Kiyan, Kate Gould, Effrossyni Gkrania-Klotsas, Miruna David, Sam Weigt, Eun Jeong Kwak, Femanda Silveira, Denis Hadjiliadis, John Baddley, Lara Danziger-Isakov, Sangeeta Bhorade, Michael Ison, Cameron Wolfe, Saima Aslam, Marie Budem, Ana Musetti
TRANSPLANT INFECTIOUS DISEASE
(2019)
Article
Medicine, Research & Experimental
Laila S. Al Yazidi, Julie Huynh, Philip N. Britton, C. Orla Morrissey, Tony Lai, Glen P. Westall, Hiran Selvadurai, Alison Kesson
MEDICAL MYCOLOGY CASE REPORTS
(2019)