The Role of Rho GTPases in Toxicity of Clostridium difficile Toxins

Recurrent Clostridium difficile infection: From colonization to cure

(2015) Kelsey Shields et al.   ANAEROBE

Diagnostic Pitfalls in Clostridium difficile Infection

(2015) Tim Planche et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Diagnosis and Treatment ofClostridium difficilein Adults

(2015) Natasha Bagdasarian et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca 2+ and GTPγS

(2015) Andrea Balletta et al.   TOXICOLOGY

Recombinant Clostridium difficile toxin B induces endoplasmic reticulum stress in mouse colonal carcinoma cells

(2014) Chunli Sun et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Haemorrhagic toxin and lethal toxin fromClostridium sordelliistrain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins

(2014) Harald Genth et al.   CELLULAR MICROBIOLOGY

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Utility of Clostridium difficile Toxin B for Inducing Anti-Tumor Immunity

(2014) Tuxiong Huang et al.   PLoS One

Clostridium Difficile Infection

(2014) Jason A. Luciano et al.   SURGICAL CLINICS OF NORTH AMERICA

Clostridium difficile Modulates Host Innate Immunity via Toxin-Independent and Dependent Mechanism(s)

(2013) Nazila V. Jafari et al.   PLoS One

Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex

(2013) M. A. Farrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Health Care–Associated Infections

(2013) Eyal Zimlichman et al.   JAMA Internal Medicine

A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection

(2012) Haiying Wang et al.   INFECTION AND IMMUNITY

Treatment failure and recurrence of Clostridium difficile infection following treatment with vancomycin or metronidazole: a systematic review of the evidence

(2012) Konstantinos Z. Vardakas et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Clostridium difficile Toxins: Mediators of Inflammation

(2012) Aimee Shen   Journal of Innate Immunity

Clostridium difficile flagellin stimulates toll-like receptor 5, and toxin B promotes flagellin-induced chemokine production via TLR5

(2012) Yusuke Yoshino et al.   LIFE SCIENCES

Modeling the Role of Peroxisome Proliferator-Activated Receptor γ and MicroRNA-146 in Mucosal Immune Responses to Clostridium difficile

(2012) Monica Viladomiu et al.   PLoS One

Rho GTPase regulation by miRNAs and covalent modifications

(2012) Ming Liu et al.   TRENDS IN CELL BIOLOGY

Glutamine and Alanyl-Glutamine Increase RhoA Expression and ReduceClostridium difficileToxin-A-Induced Intestinal Epithelial Cell Damage

(2012) Ana A. Q. A. Santos et al.   Biomed Research International

Protection from Clostridium difficile toxin B-catalysed Rac1/Cdc42 glucosylation by tauroursodeoxycholic acid-induced Rac1/Cdc42 phosphorylation

(2011) Vanessa Brandes et al.   BIOLOGICAL CHEMISTRY

Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B

(2011) Selda Genisyuerek et al.   MOLECULAR MICROBIOLOGY

Rho protein crosstalk: another social network?

(2011) Christophe Guilluy et al.   TRENDS IN CELL BIOLOGY

Direct modifications of Rho proteins: deconstructing GTPase regulation

(2010) Orane Visvikis et al.   BIOLOGY OF THE CELL

Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome

(2010) Jeffrey Ng et al.   GASTROENTEROLOGY

Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A

(2010) Isa Kreimeyer et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Comparative genome-wide analysis of small RNAs of major Gram-positive pathogens: from identification to application

(2010) Mobarak A. Mraheil et al.   Microbial Biotechnology

Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect ofClostridium difficiletoxin A

(2009) Janett Schoentaube et al.   CELLULAR MICROBIOLOGY

Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin

(2009) Ho Kim et al.   EXPERIMENTAL CELL RESEARCH

Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing inClostridium difficileToxin A

(2009) Rory N. Pruitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-α by macrophages

(2009) Xingmin Sun et al.   MICROBIAL PATHOGENESIS

Prevention of the cytopathic effect induced byClostridium difficileToxin B by active Rac1

(2008) Ismael Halabi-Cabezon et al.   FEBS LETTERS

Clostridium difficile toxins: More than mere inhibitors of Rho proteins

(2008) Harald Genth et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells

(2008) R. Gerhard et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Conformational Changes and Reaction of Clostridial Glycosylating Toxins

(2008) Mathias O.P. Ziegler et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and mode of action of clostridial glucosylating toxins: the ABCD model

(2008) Thomas Jank et al.   TRENDS IN MICROBIOLOGY