Article
Multidisciplinary Sciences
Reuben Agada, Dluya Thagriki, D. Esther Lydia, Ameer Khusro, Jawaher Alkahtani, Manal M. Al Shaqha, Mona S. Alwahibi, Mohamed Soliman Elshikh
Summary: The study aimed to evaluate the antioxidant and anti-diabetic activities of bioactive fractions from Carica papaya seed extracts. Ethyl acetate fractions showed strong inhibition of alpha-amylase and alpha-glucosidase, indicating their potential as effective antioxidant and anti-diabetic agents.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2021)
Review
Food Science & Technology
Rebecca A. Haber, Reicelle D. Garcia, Jamie N. Hernandez, Sarah Jamieson, Arijit Mondal, Anupam Bishayee
Summary: This paper provides a comprehensive analysis of the cancer-preventive potential of Carica papaya extracts, fractions, and isolated phytochemicals. It discusses the cellular and molecular mechanisms of action, bioavailability, pharmacokinetics, and safety profiles of these phytochemicals, as well as the limitations, challenges, and future directions of research.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Horticulture
Ruining Zhang, Jinhui Lv, Jing Yu, Hailin Xiong, Ping Chen, Hongxing Cao, Jerome Jeyakumar John Martin
Summary: This study compared the antioxidant properties of different organs and cultivars of papaya. The results showed that the leaves and roots of papaya exhibited higher antioxidant properties, while the leaves and flowers of the Daqing cultivar had the strongest antioxidant ability. These findings suggest that papaya has the potential to be a natural antioxidant resource.
INTERNATIONAL JOURNAL OF FRUIT SCIENCE
(2022)
Article
Chemistry, Physical
Mageshwaran Maran, Sanjay Gangadharan, Isaac Arnold Emerson
Summary: Breast cancer is a deadly cancer and flavonoids from Carica papaya leaf, especially quercetin, have shown inhibitory properties against molecular targets, particularly COX2, which may lead to the development of anti-breast cancer agents from natural compounds.
CHEMICAL PHYSICS LETTERS
(2022)
Review
Genetics & Heredity
Ziwei Zhou, Rebecca Ford, Ido Bar, Chutchamas Kanchana-udomkan
Summary: The papaya industry faces challenges in fruit quality consistency and flavor, necessitating a better understanding of genetic and biochemical mechanisms for breeding new varieties with improved taste. Research methods such as studying sugar components, volatile compounds, and genomics are used to identify the flavor profile of papaya.
Article
Biochemistry & Molecular Biology
Laura Pastare, Marta Berga, Liene Kienkas, Martins Boroduskis, Anna Ramata-Stunda, Dace Reihmane, Maris Senkovs, Gundars Skudrins, Ilva Nakurte
Summary: This study investigated the potential of using supercritical fluid extracts from Matricaria chamomilla white ray florets as a source of bioactive cosmetic ingredients. The extracts contained a diverse range of phytochemical classes and had cytotoxic, proliferation-reducing, and antimicrobial activities, making them potentially useful in cosmetic formulations.
Review
Chemistry, Medicinal
V. L. Maruthanila, Elancheran Ramakrishnan, Mirunalini Sankaran
Summary: Carica papaya is an essential medicinal plant with anticancer activities, containing phenolic compounds like Caffeic acid, Quinic acid and Chlorogenic acid, which play significant roles in cancer prevention and treatment mechanisms.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Lauren Lett, Michael George, Rachael Slater, Ben De Lacy Costello, Norman Ratcliffe, Marta Garcia-Finana, Henry Lazarowicz, Chris Probert
Summary: This study compared the VOC profiles of patients with and without UBC and found that UBC patients have distinct VOC profiles. These VOC profiles can be used for the diagnosis and surveillance of UBC.
BRITISH JOURNAL OF CANCER
(2022)
Article
Plant Sciences
Wanwisa Siriwan, Sittiruk Roytrakul, Srimek Chowpongpang, Aroonothai Sawwa
Summary: PRSV interactions with host proteins play a significant role in virus replication and understanding cellular responses against viruses. Analysis shows that host proteins interact with PRSV coat protein, impacting processes such as cellular metabolism, transcription, and stress response, indicating the importance of studying virus-host interactions for better understanding of virus replication and host defense mechanisms.
JOURNAL OF PLANT INTERACTIONS
(2021)
Review
Food Science & Technology
Ting Yi Heung, Jessica Yue Shuen Huong, Wan Yeng Chen, Yi Wen Loh, Kooi Yeong Khaw, Bey-Hing Goh, Yong Sze Ong
Summary: Papaya extracts or their bioactive compounds may serve as a potential broad-spectrum therapy for cancer by targeting multiple characteristics of cancer development.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Ashraf N. E. Hamed, Mohamed E. Abouelela, Ahmed E. El Zowalaty, Mohamed M. Badr, Mohamed S. A. Abdelkader
Summary: The phytochemical investigation of Carica papaya leaves led to the isolation and characterization of ten compounds. Methyl gallate and clitorin showed potent cytotoxic activities and enzyme inhibitory properties, comparable to standard drugs. Molecular docking simulations demonstrated the binding ability of some compounds to their target receptors.
Article
Horticulture
Carlos Lopez Encina, Manuel Lopez Granero, Jose Javier Regalado
Summary: In this article, the authors present a reliable method for the long-term micropropagation of papaya, using microshoots developed from the axillary buds of papaya shoots as primary explants. The proliferation medium (PPRM) was found to maintain papaya shoots under continuous proliferation for 20 years, while the elongation medium (PELM) and rooting medium (PROM) were designed to recover shoots with poor growth and induce high-quality roots from nonrooted shoots, respectively. The main objective of this work was to provide a micropropagation method that can maintain healthy elite genotypes of papaya for long periods of time and produce a high number of good quality plants.
Article
Agronomy
Juan Alberto Cabrera, Axel Ritter, Vanesa Raya, Eudaldo Perez, Maria Gloria Lobo
Summary: To optimize papaya yield and quality, crop phenology studies are necessary, involving measurement of meteorological variables and morphological characteristics, as well as calculation of source-sink ratios and study of fruit quality. Results indicated that better environmental control inside greenhouses and screenhouses is needed to maintain good fruit quality.
Article
Agronomy
Adriana Azevedo Vimercati Pirovani, Helaine Christine Cancela Ramos, Renato Santa-Catarina, Daniel Pereira Miranda, Alex Souza Rodrigues, Julio Cesar Fiorio Vettorazzi, Izaias Rodrigues da Silva Junior, Messias Gonzaga Pereira, Alexandre Pio Viana
Summary: This study aimed to evaluate the parent lines of important papaya hybrids and progress the genetics through self-fertilization. Through selection and analysis, 80 promising genotypes were identified, emphasizing the importance of selecting parent lines with different patterns.
Article
Biochemistry & Molecular Biology
Magdalena Sliwka-Kaszynska, Iwona Anusiewicz, Piotr Skurski
Summary: The retro-Diels-Alder fragmentation mechanism of luteolin was studied using theoretical calculations and experimental results. The reaction paths and energy barriers leading to the formation of fragment ions were described and discussed.
Article
Pharmacology & Pharmacy
H. M. H. N. Bandara, A. K. Hewavitharana, P. N. Shaw, H. D. C. Smyth, L. P. Samaranayake
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Biology
Mareike Bongers, Jordi Perez-Gil, Mark P. Hodson, Lars Schrubbers, Tune Wulff, Morten O. A. Sommer, Lars K. Nielsen, Claudia E. Vickers
Article
Chemistry, Applied
Zhengzheng Zou, Claire Bouchereau-De Pury, Amitha K. Hewavitharana, Saad S. Al-Shehri, John A. Duley, David M. Cowley, Pieter Koorts, Paul N. Shaw, Nidhi Bansal
Summary: A high-throughput fluorescence assay method was developed for determination of oxidase activities in milk samples, showing high sensitivity, good repeatability and reproducibility. The method was successfully applied to survey different animal milk samples and can be adapted for measurements of other oxidase activities.
Article
Chemistry, Applied
Zhengzheng Zou, Julien Bauland, Amitha K. Hewavitharana, Saad S. Al-Shehri, John A. Duley, David M. Cowley, Pieter Koorts, Paul N. Shaw, Nidhi Bansal
Summary: A more sensitive microplate fluorescent assay was developed for measuring LPO activity in milk, which is suitable for both laboratory and commercial scales. The method eliminates the influences of indigenous milk components and has good precision. The assay showed that LPO activities ranked as bovine > goat > camel > human in the four types of milk analyzed.
Article
Multidisciplinary Sciences
Danielle L. Michell, Waled A. Shihata, Karen L. Andrews, Nurul Aisha Zainal Abidin, Ann-Maree Jefferis, Amanda K. Sampson, Natalie G. Lumsden, Olivier Huet, Marie-Odile Parat, Garry L. Jennings, Robert G. Parton, Kevin J. Woollard, David M. Kaye, Jaye P. F. Chin-Dusting, Andrew J. Murphy
Summary: High intraluminal pressure can lead to vascular inflammation and subsequent hypertension development; Studies have shown that deficiency of caveolin-1 can reduce pressure-induced inflammatory responses and leukocyte adhesion; These findings demonstrate that Cav1 plays an important role in pressure-induced inflammation.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Thao Nhu Dinh, Marie-Odile Parat, Yong Sze Ong, Kooi Yeong Khaw
Summary: BITC, a common isothiocyanate found in cruciferous vegetables, has shown anticancer activities by modulating various signaling pathways. Further studies are needed to validate its effectiveness in humans for future development.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Oncology
Iqira Saeed, Adam La Caze, Markus W. Hollmann, Paul N. Shaw, Marie-Odile Parat
Summary: Tramadol is considered to possess anti-inflammatory properties and preserve immune responses, including natural killer cell activity, which are important in anti-cancer defences, according to recent clinical evidence.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Biology
Kerrie-Ann Mcmahon, David A. Stroud, Yann Gambin, Vikas Tillu, Michele Bastiani, Emma Sierecki, Mark E. Polinkovsky, Thomas E. Hall, Guillermo A. Gomez, Yeping Wu, Marie-Odile Parat, Nick Martel, Harriet P. Lo, Kum Kum Khanna, Kirill Alexandrov, Roger Daly, Alpha Yap, Michael T. Ryan, Robert G. Parton
Summary: Cavin3 plays a key role in DNA repair and interacts directly with BRCA1. Loss of cavin3 can increase the sensitivity of tumor cells to UV-induced apoptosis, while also affecting DNA repair and cell survival.
Review
Oncology
Mai Mahmoud Gabr, Iqira Saeed, Jared A. Miles, Benjamin P. Ross, Paul Nicholas Shaw, Markus W. Hollmann, Marie-Odile Parat
Summary: Recent evidence suggests that opioids can interact with the Toll-like receptor 4 (TLR4) on innate immune and cancer cells, potentially influencing tumor growth and metastasis. Opioids have been shown to weakly activate TLR4 and can inhibit its activation by lipopolysaccharide (LPS). The interaction of opioids with TLR4 is complex, involving non-competitive mechanisms and downstream effects on NF-kappa B activation.
Review
Oncology
Claudia A. Scroope, Zane Singleton, Markus W. Hollmann, Marie-Odile Parat
Summary: Opioids are commonly used in cancer patients for pain management during tumor excision and to alleviate cancer-related pain. However, the effects of opioids on tumor growth and metastasis, as well as their impact on disease outcomes, are still under debate in literature. It is clear that opioids have direct and indirect effects on solid tumor biology, the anticancer immune response, inflammation, angiogenesis, and the tumor-promoting effects of pain.
FRONTIERS IN ONCOLOGY
(2021)
Article
Food Science & Technology
Zhengzheng Zou, John A. Duley, David M. Cowley, Sarah Reed, Buddhika J. Arachchige, Bhesh Bhandari, Paul N. Shaw, Nidhi Bansal
Summary: This study compared the physicochemical properties and protein profiles of camel milk powders produced by different concentration and dehydration processes. The results showed that direct freeze drying is the most ideal method for preserving bioactive proteins in camel milk powder production, but the freeze-drying technique has limitations in terms of cost and scalability. The current spray-drying technique needs improvement to better retain the bioactivity of camel milk during powder processing.
Review
Polymer Science
Ritu Thapa, Shila Gurung, Marie-Odile Parat, Harendra S. Parekh, Preeti Pandey
Summary: Approaches for effective and sustained drug delivery to the female reproductive tract remain limited, but the development of versatile delivery platforms like sol-gels shows promise. Sol-gels, which transition from solution to gel triggered by physiological conditions, offer advantages for drug formulations and can be used as drug delivery vehicles for diverse drug molecules. The review discusses the challenges and opportunities in optimal drug delivery and highlights the potential of sol-gels for improved treatment of gynaecological conditions.
