Article
Cardiac & Cardiovascular Systems
Kina Jeon, Darae Kim, Jin-Oh Choi, Yang Hyun Cho, Kiick Sung, Jaewon Oh, Hyun Jai Cho, Sung-Ho Jung, Hae-Young Lee, Jin Joo Park, Dong-Ju Choi, Seok-Min Kang, Jae-Joong Kim, Eun-Seok Jeon
Summary: This study found no significant differences in efficacy between EC-MPS and MMF in heart transplant patients. Overall survival, all-cause mortality, and rejection rates were comparable between the two groups during the follow-up period.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Annelies E. de Weerd, Zainab Al Fatly, Marieken Boer-Verschragen, Judith A. Kal-van Gestel, Dave L. Roelen, Marjolein Dieterich, Michiel G. H. Betjes
Summary: This randomized-controlled pilot study evaluated the feasibility and safety of tacrolimus monotherapy in immunologically low-risk kidney transplant recipients. The results suggest that tacrolimus monotherapy may be safe and effective in reducing infections in these patients.
TRANSPLANT INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Pierluigi Toniutto, Edmondo Falleti, Sara Cmet, Annarosa Cussigh, Laura Veneto, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Carlo Fabris, Assunta Sartor, Roberto Peressutti, Francesco Curcio, Laura Regattin, Lucrezia Grillone
Summary: This study explores the long-term antibody response and failure mechanism of COVID-19 vaccines in liver transplant recipients, revealing significantly lower antibody titers after vaccination compared to controls and identifying MMF as a major predictor of vaccination failure.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Qianying Zhang, Peng Xing, Hong Ren, Xiaonong Chen, Jingyuan Xie, Wen Zhang, Pingyan Shen, Xiao Li, Nan Chen
Summary: This study compared the efficacy and safety of mycophenolate mofetil (MMF) and tacrolimus (TAC) with azathioprine (AZA) as maintenance therapy for active lupus nephritis (ALN). The study found that long-term maintenance therapies with MMF or TAC have similarly low rates of renal relapse and similar safety profiles compared with AZA.
FRONTIERS OF MEDICINE
(2022)
Article
Immunology
Ibrahim Tawhari, Patrick Hallak, Sofia Bin, Fatmah Yamani, Maria Safar-Boueri, Aazib Irshad, Joseph Leventhal, Mohammed Javeed Ansari, Paolo Cravedi, Lorenzo Gallon
Summary: This study evaluated the use of Belatacept in kidney transplant recipients and found a higher rate of biopsy-proven acute rejection in the Bela+MPA treatment group, while the Bela+low-dose Tac group showed an increase in eGFR.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Klaus Nunes Ficher, Yasmin Dreige, Paulo Ricardo Gessolo Lins, Alexandra Nicolau Ferreira, Juliana Toniato de Rezende Freschi, Kamilla Linhares, Suelen Stopa Martins, Luciana Custodio, Marina Cristelli, Laila Viana, Daniel Wagner Santos, Renato de Marco, Maria Gerbase-DeLima, Henrique Proenca, Wilson Aguiar, Monica Nakamura, Claudia Rosso Felipe, Jose Medina Pestana, Helio Tedesco Silva Jr
Summary: This study analyzed the long-term efficacy and safety of everolimus or mycophenolate in combination with tacrolimus for kidney transplant recipients. The results showed that in de novo low/moderate immunologic risk patients, using a single dose of rabbit antithymocyte globulin followed by reduced tacrolimus concentrations and everolimus resulted in similar effectiveness and renal function compared to the standard immunosuppressive regimen.
Article
Medicine, General & Internal
Deok Gie Kim, Sung Hwa Kim, Shin Hwang, Suk Kyun Hong, Je Ho Ryu, Bong-Wan Kim, Young Kyoung You, Donglak Choi, Dong-Sik Kim, Yang Won Nah, Jai Young Cho, Tae-Seok Kim, Geun Hong, Dong Jin Joo, Myoung Soo Kim, Jong Man Kim, Jae Geun Lee
Summary: Tacrolimus monotherapy is considered a viable option for early post-liver transplantation, but its effects in the recent era of reduced tacrolimus and mycophenolate mofetil remain unclear. This study compared the outcomes of liver recipients who received tacrolimus monotherapy or continued tacrolimus/mycophenolate mofetil therapy within 12 months after transplantation. The results showed similar rates of rejection and graft failure between the two groups, but a greater decline in renal function and higher required tacrolimus dose in the monotherapy group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qi Wang, Manna Li, Xuexin Cheng, Gaosi Xu
Summary: This retrospective study compared the efficacy and safety of different tacrolimus concentrations in the treatment of IMN patients, showing that the C-TAC>5 ng/ml group had better treatment response and improved some indicators compared to the C-TAC <= 5 ng/ml group, but there was no significant difference in the complete remission rate at 12 months between the two groups.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
M. Quaresma, L. S. Azevedo, N. Pereira, M. G. Saldanha, E. David-Neto, M. N. Sotto
Summary: This study evaluated the effect of different immunosuppression regimens on skin immunity in renal transplant recipients (RTRs). The results showed that RTRs treated with mTOR inhibitors had preserved skin immune surveillance, while those treated with mycophenolic acid or azathioprine exhibited suppressed skin immunity. These findings are important for the prevention and treatment of skin cancer in RTRs.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Veterinary Sciences
Jae-Eun Hyun, Yeong-Hun Kang, Cheol-Yong Hwang
Summary: A 6-year-old miniature Pinscher dog diagnosed with mucocutaneous lupus erythematosus (MCLE) showed improvement with initial treatment of oral prednisolone, mycophenolate mofetil (MMF) and tacrolimus. Despite side effects from high-dose prednisolone, the condition was successfully managed by gradually tapering the dosage and continuing with MMF and tacrolimus, highlighting their effectiveness as steroid-sparing agents in treating MCLE in dogs.
VETERINARY SCIENCES
(2021)
Article
Multidisciplinary Sciences
Youngmin Ko, Yu-Mee Wee, Sung Shin, Mi Joung Kim, Monica Young Choi, Dong Hyun Kim, Seong Jun Lim, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Duck Jong Han
Summary: The optimal dose of anti-thymocyte globulin (ATG) as an induction regimen in Asian living-donor kidney recipients is unclear. In a pilot study, patients undergoing living-donor kidney transplantation were randomly assigned to receive either 4.5 mg/kg or 6.0 mg/kg of ATG. The study found that the lower dose of ATG was associated with higher rates of acute rejection and graft failure.
Article
Multidisciplinary Sciences
Ye Eun Shim, Youngmin Ko, Jung Pyo Lee, Jin Seok Jeon, Heungman Jun, Jaeseok Yang, Myoung Soo Kim, Seong Jun Lim, Hye Eun Kwon, Joo Hee Jung, Hyunwook Kwon, Young Hoon Kim, Jungbok Lee, Sung Shin
Summary: Anti-thymocyte globulin (ATG) is commonly used as an induction regimen to prevent acute rejection after solid organ transplantation, but the optimal dose for Asian kidney recipients is unclear. A retrospective cohort study in South Korea compared different induction regimens in 4579 adult renal transplantation patients. The study found that high-dose ATG induction (>4.5 mg/kg) showed better graft and patient survival outcomes compared to basiliximab and low-dose ATG induction in Asian kidney transplant patients.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Lucy Meunier, Mathilde Sanavio, Jerome Dumortier, Magdalena Meszaros, Stephanie Faure, Jose Ursic Bedoya, Maxime Echenne, Olivier Boillot, Antoine Debourdeau, Georges Philippe Pageaux
Summary: The response rate to anti-SARS-CoV-2 vaccination is lower in liver transplant recipients, even after a booster dose. Mycophenolate mofetil is a major determinant of vaccine effectiveness in these patients.
LIVER INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Zhaohui Zheng, Haitao Zhang, Xiaomei Peng, Chun Zhang, Changying Xing, Gang Xu, Ping Fu, Zhaohui Ni, Jianghua Chen, Zhonggao Xu, Ming-Hui Zhao, Shaomei Li, Xiangyang Huang, Lining Miao, Xiaonong Chen, Bicheng Liu, Yongcheng He, Jing Li, Lijun Liu, Haishan Kadeerbai, Zhangsuo Liu, Zhihong Liu
Summary: This study evaluated the efficacy and safety of tacrolimus compared to IVCY as an initial therapy for LN in China. The results showed that tacrolimus was noninferior to IVCY in treating LN and had a more favorable safety profile.
Article
Gastroenterology & Hepatology
Pierluigi Toniutto, Annarosa Cussigh, Sara Cmet, Davide Bitetto, Ezio Fornasiere, Elisa Fumolo, Martina Fabris, Federica D'Aurizio, Carlo Fabris, Lucrezia Grillone, Assunta Sartor, Francesco Curcio, Edmondo Falleti
Summary: The third dose of the BNT16b2 vaccine increased the rate of positive anti-SARS-CoV-2 antibody response in liver transplant recipients, but some patients still did not respond. Predictors of antibody response failure after the third dose included higher dose of mycophenolate mofetil and lower estimated glomerular filtration rate.
LIVER INTERNATIONAL
(2023)
Article
Surgery
Jeffrey J. Gaynor, Gaetano Ciancio, Giselle Guerra, Junichiro Sageshima, David Roth, Michael J. Goldstein, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Sandra Flores, Lois Hanson, Phillip Ruiz, Rodrigo Vianna, George W. Burke
TRANSPLANT INTERNATIONAL
(2016)
Article
Surgery
Siegfredo Paloyo, Junichiro Sageshima, Jeffrey J. Gaynor, Linda Chen, Gaetano Ciancio, George W. Burke
TRANSPLANT INTERNATIONAL
(2016)
Article
Immunology
Elisa J. Gordon, Joe Feinglass, Paula Carney, Karina Vera, Maria Olivero, Anne Black, Kate O'Connor, Jessica MacLean, Shari Nichols, Junichiro Sageshima, Luke Preczewski, Juan Carlos Caicedo
Article
Immunology
G. Ciancio, P. Tryphonopoulos, J. J. Gaynor, G. Guerra, J. Sageshima, D. Roth, L. Chen, W. Kupin, A. Mattiazzi, L. Tueros, S. Flores, L. Hanson, R. H. Powell, P. Ruiz, R. Vianna, G. W. Burke
TRANSPLANTATION PROCEEDINGS
(2016)
Article
Immunology
Gaetano Ciancio, Jeffrey J. Gaynor, Giselle Guerra, Junichiro Sageshima, David Roth, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Sandra Flores, Lois Hanson, Phillip Ruiz, Rodrigo Vianna, George W. Burke
TRANSPLANT IMMUNOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ghaneh Fananapazir, Robert Benzl, Michael T. Corwin, Ling-Xin Chen, Junichiro Sageshima, Susan L. Stewart, Christoph Troppmann
Article
Immunology
Sandra K. Kabagambe, Ivonne P. Palma, Yulia Smolin, Tristan Boyer, Ivania Palma, Junichiro Sageshima, Christoph Troppmann, Chandrasekar Santhanakrishnan, John P. McVicar, Kuang-Yu Jen, Miriam Nuno, Richard Perez
Article
Surgery
Gaetano Ciancio, Jeffrey J. Gaynor, Giselle Guerra, Junichiro Sageshima, David Roth, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Phillip Ruiz, Rodrigo Vianna, George W. Burke
CLINICAL TRANSPLANTATION
(2018)
Editorial Material
Surgery
Christoph Troppmann, Chandrasekar Santhanakrishnan, Junichiro Sageshima, John McVicar, Richard Perez
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Surgery
Ghaneh Fananapazir, Gary Tse, Ryan Di Geronimo, John McVicar, Richard Perez, Chandrasekar Santhanakrishnan, Junichiro Sageshima, Christoph Troppmann
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Immunology
Christoph Troppmann, Chandrasekar Santhanakrishnan, Ghaneh Fananapazir, Junichiro Sageshima, Kathrin M. Troppmann, Richard Perez
Summary: Acute kidney injury in small pediatric donors affects early kidney graft function, but doesn't increase the risk of early graft loss and decreases long-term function. The high nonutilization rates for en bloc kidney grafts from very small pediatric donors with AKI seem unjustified, and the reluctance to transplant single kidneys from larger pediatric donors with AKI lacks a rational basis. Further prospective studies are needed for confirmation.
Article
Immunology
Kuang-Yu Jen, Samer Albahra, Felicia Yen, Junichiro Sageshima, Ling-Xin Chen, Nam Tran, Hooman H. Rashidi
Summary: In this study, an automated machine learning (ML) modeling pipeline was used to generate and optimize DGF prediction models en masse. The best performing models were based on neural network algorithms, with the highest area under the receiver operating characteristic curve of 0.7595. The performance of the ML models was comparable with classic logistic regression models.
Review
Immunology
Junichiro Sageshima, Jayanthi Chandar, Linda J. Chen, Rushi Shah, Ammar Al Nuss, Paolo Vincenzi, Mahmoud Morsi, Jose Figueiro, Rodrigo Vianna, Gaetano Ciancio, George W. I. I. I. I. I. I. Burke
Summary: Kidney transplantation is the best health option for patients with end-stage kidney disease, but multiple transplants may be needed. Surgical approach and immunologic concerns are key, and other factors such as thrombosis and posttransplant events should also be considered.
Article
Pediatrics
George W. Burke, Jayanthi Chandar, Junichiro Sageshima, Mariella Ortigosa-Goggins, Pooja Amarapurkar, Alla Mitrofanova, Marissa J. Defreitas, Chryso P. Katsoufis, Wacharee Seeherunvong, Alexandra Centeno, Javier Pagan, Lumen A. Mendez-Castaner, Adela D. Mattiazzi, Warren L. Kupin, Giselle Guerra, Linda J. Chen, Mahmoud Morsi, Jose M. G. Figueiro, Rodrigo Vianna, Carolyn L. Abitbol, David Roth, Alessia Fornoni, Phillip Ruiz, Gaetano Ciancio, Eduardo H. Garin
Summary: Podocyte B7-1 staining in biopsies of KTRs with post-transplant FSGS identifies a subset of patients who may benefit from abatacept.
PEDIATRIC NEPHROLOGY
(2023)
Letter
Surgery
Jacquelyn M. Yu, Junichiro Sageshima, Miriam A. Nuno, Neal M. Mineyev, Naeem Goussous, Peter A. Than, Richard V. Perez
Summary: This cohort study examines the survival of kidney grafts from small and very small pediatric donors in women compared to men with end-stage kidney disease.