Review
Surgery
James F. Crismale, Dalia Mahmoud, Jang Moon, M. Isabel Fiel, Kishore Iyer, Thomas D. Schiano
Summary: Intestinal transplantation is the preferred treatment for patients with intestinal failure, and endoscopy plays a critical role in the posttransplant management, particularly in the diagnosis and management of rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Tingting Chen, Xiaoyu Li, Jina Wang, Xuanchuan Wang, Tongyu Zhu, Ruiming Rong, Cheng Yang
Summary: A 66-year-old Chinese man underwent deceased donor kidney transplantation and developed BKV nephropathy and acute TCMR post-transplant. Treatment with basiliximab improved the kidney graft status.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Nissrin Alachkar, Nada Alachkar
Summary: Diagnosing kidney allograft rejection is complex and subjective, but an automated Banff classification could make assessment easier and improve accuracy.
Article
Urology & Nephrology
Thibaut Vaulet, Gillian Divard, Olivier Thaunat, Evelyne Lerut, Aleksandar Senev, Olivier Aubert, Elisabet Van Loon, Jasper Callemeyn, Marie-Paule Emonds, Amaryllis Van Craenenbroeck, Katrien De Vusser, Ben Sprangers, Maud Rabeyrin, Valerie Dubois, Dirk Kuypers, Maarten De Vos, Alexandre Loupy, Bart De Moor, Maarten Naesens
Summary: An international group of experts developed a consensus classification of kidney transplant rejection phenotypes known as the Banff classification. The data-driven clustering approach identified six clinically meaningful cluster phenotypes, significantly associated with graft failure, while eliminating intermediate and mixed phenotypes. This approach offers a more quantitative evaluation of rejection subtypes and severity.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Genetics & Heredity
Qianguang Han, Xiang Zhang, Xiaohan Ren, Zhou Hang, Yu Yin, Zijie Wang, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Ruoyun Tan, Min Gu, Xiaobing Ju
Summary: In this study, 32 differentially expressed transcripts were identified and a predictive model with five key transcripts was established for the prediction of biopsy-proven acute rejection (BPAR) after kidney transplantation. Functional enrichment analysis revealed the involvement of differential genes in chemokine signaling and immune cell infiltration. These findings provide valuable insights for early diagnosis and detection of BPAR.
FRONTIERS IN GENETICS
(2022)
Article
Infectious Diseases
Rita Eid, Maureen Assayag, Edouard Lefevre, Lelia Escaut, Marwa Laifi, Albane Brodin-Sartorius, Mohamad Zaidan, Renaud Snanoudj
Summary: Bacillary angiomatosis is a vascular proliferative disease caused by Bartonella henselae or Bartonella quintana, mainly observed in immunosuppressed patients. This case report focuses on a 75-year-old female kidney transplant recipient who presented with fever, chills, vomiting, and weight loss. Despite negative blood cultures and serological tests, a diagnosis of bacillary angiomatosis was confirmed through lymph node biopsy. This highlights the importance of maintaining a high clinical suspicion in immunocompromised patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Jean-Baptiste Woillard, Caroline Monchaud, Franck Saint-Marcoux, Marc Labriffe, Pierre Marquet
Summary: This study aimed to evaluate the intraindividual variability of the AUC/C0 ratio in renal transplant recipients and compare it with the variability of AUC, C0, AUC/dose, and C0/dose. The results showed that the AUC/C0 ratio had the lowest relative variation and could be used to calculate individualized C0 targets.
Article
Urology & Nephrology
Katelynn S. Madill-Thomsen, Georg A. Boehmig, Jonathan Bromberg, Gunilla Einecke, Farsad Eskandary, Gaurav Gupta, Luis G. Hidalgo, Marek Myslak, Ondrej Viklicky, Agnieszka Perkowska-Ptasinska, Philip F. Halloran
Summary: The study found that in kidney transplant patients classified as having no rejection, there are subtle increases in antibody-mediated rejection-related transcripts in biopsies that are positive for DSA. As the frequency of DSA increases, there is a gradient of increasing molecular ABMR-like transcript expression in these biopsies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Urology & Nephrology
Alexandre Loupy, Michael Mengel, Mark Haas
Summary: The Banff classification has become the main reference for the scoring of kidney allograft biopsies, gaining overwhelming international acceptance. Since its establishment in 1991, Banff conferences have been held every two years, resulting in continuous revisions and expansions of the classification, forming a multidisciplinary and international community.
KIDNEY INTERNATIONAL
(2022)
Article
Immunology
Yohan Park, Hanbi Lee, Sang Hun Eum, Hyung Duk Kim, Eun Jeong Ko, Chul Woo Yang, Byung Ha Chung
Summary: This study revealed that intrapatient variability (IPV) of tacrolimus (TAC) trough levels post-kidney transplantation significantly impacts allograft outcomes, emphasizing the importance of maintaining low TAC-IPV even with high mean TAC levels for improving transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pediatrics
Abigail Atlas-Lazar, Daniella Levy-Erez
Summary: In a child with acute kidney injury (AKI) after renal transplantation, it is crucial to diagnose the cause quickly and accurately in order to initiate timely treatment. This article provides a systematic review on the differential diagnosis of acute graft dysfunction in pediatric kidney transplant recipients, including rejection, infections, medication toxicity, and other potential causes. It also discusses current advancements in noninvasive methods of diagnosing rejection.
CURRENT OPINION IN PEDIATRICS
(2023)
Article
Urology & Nephrology
Young Hui Hwang, Hyunjung Kim, Kyungok Min, Jaeseok Yang
Summary: In clinically stable kidney transplant recipients, the tacrolimus trough levels standard deviation and coefficient of variation are sensitive to changes in tacrolimus dosage, requiring medical attention.
Article
Immunology
Tahm Spitznagel, Laurenz S. S. Matter, Yves L. L. Kaufmann, Jakob Nilsson, Seraina von Moos, Thomas Schachtner
Summary: HLA-derived epitope-mismatches can help predict histopathological changes of immune-related injury in kidney transplant recipients from the first indication biopsy to the follow-up biopsy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anaelle Chavant, Xavier Fonrose, Elodie Gautier-Veyret, Marie Noelle Hilleret, Matthieu Roustit, Francoise Stanke-Labesque
Summary: The study revealed that inflammation contributes to the variability of tacrolimus blood trough concentration and is associated with an increased risk of overexposure. It is suggested that inflammation should be considered for the correct interpretation of tacrolimus blood concentration.
Review
Medicine, General & Internal
Sami Alasfar, Lavanya Kodali, Carrie A. Schinstock
Summary: Despite advancements in immunosuppressive therapies, kidney transplant rejection remains a challenge. This article provides an overview of the diagnosis, current therapies, and management strategies for acute T-cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR). Corticosteroids are the primary treatment for TCMR, while plasmapheresis is commonly used for ABMR, although its efficacy is still debated. Optimizing immunosuppression and addressing adherence are crucial for managing both types of rejection, but further research is needed to explore newer therapeutics and evaluate their effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
G. Ciancio, P. Tryphonopoulos, J. J. Gaynor, G. Guerra, J. Sageshima, D. Roth, L. Chen, W. Kupin, A. Mattiazzi, L. Tueros, S. Flores, L. Hanson, R. H. Powell, P. Ruiz, R. Vianna, G. W. Burke
TRANSPLANTATION PROCEEDINGS
(2016)
Article
Immunology
Gaetano Ciancio, Jeffrey J. Gaynor, Giselle Guerra, Junichiro Sageshima, David Roth, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Sandra Flores, Lois Hanson, Phillip Ruiz, Rodrigo Vianna, George W. Burke
TRANSPLANT IMMUNOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ghaneh Fananapazir, Robert Benzl, Michael T. Corwin, Ling-Xin Chen, Junichiro Sageshima, Susan L. Stewart, Christoph Troppmann
Article
Immunology
Sandra K. Kabagambe, Ivonne P. Palma, Yulia Smolin, Tristan Boyer, Ivania Palma, Junichiro Sageshima, Christoph Troppmann, Chandrasekar Santhanakrishnan, John P. McVicar, Kuang-Yu Jen, Miriam Nuno, Richard Perez
Article
Surgery
Gaetano Ciancio, Jeffrey J. Gaynor, Giselle Guerra, Junichiro Sageshima, David Roth, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Phillip Ruiz, Rodrigo Vianna, George W. Burke
CLINICAL TRANSPLANTATION
(2018)
Editorial Material
Surgery
Christoph Troppmann, Chandrasekar Santhanakrishnan, Junichiro Sageshima, John McVicar, Richard Perez
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Surgery
Ghaneh Fananapazir, Gary Tse, Ryan Di Geronimo, John McVicar, Richard Perez, Chandrasekar Santhanakrishnan, Junichiro Sageshima, Christoph Troppmann
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Immunology
Christoph Troppmann, Chandrasekar Santhanakrishnan, Ghaneh Fananapazir, Junichiro Sageshima, Kathrin M. Troppmann, Richard Perez
Summary: Acute kidney injury in small pediatric donors affects early kidney graft function, but doesn't increase the risk of early graft loss and decreases long-term function. The high nonutilization rates for en bloc kidney grafts from very small pediatric donors with AKI seem unjustified, and the reluctance to transplant single kidneys from larger pediatric donors with AKI lacks a rational basis. Further prospective studies are needed for confirmation.
Article
Immunology
Kuang-Yu Jen, Samer Albahra, Felicia Yen, Junichiro Sageshima, Ling-Xin Chen, Nam Tran, Hooman H. Rashidi
Summary: In this study, an automated machine learning (ML) modeling pipeline was used to generate and optimize DGF prediction models en masse. The best performing models were based on neural network algorithms, with the highest area under the receiver operating characteristic curve of 0.7595. The performance of the ML models was comparable with classic logistic regression models.
Review
Immunology
Junichiro Sageshima, Jayanthi Chandar, Linda J. Chen, Rushi Shah, Ammar Al Nuss, Paolo Vincenzi, Mahmoud Morsi, Jose Figueiro, Rodrigo Vianna, Gaetano Ciancio, George W. I. I. I. I. I. I. Burke
Summary: Kidney transplantation is the best health option for patients with end-stage kidney disease, but multiple transplants may be needed. Surgical approach and immunologic concerns are key, and other factors such as thrombosis and posttransplant events should also be considered.
Article
Pediatrics
George W. Burke, Jayanthi Chandar, Junichiro Sageshima, Mariella Ortigosa-Goggins, Pooja Amarapurkar, Alla Mitrofanova, Marissa J. Defreitas, Chryso P. Katsoufis, Wacharee Seeherunvong, Alexandra Centeno, Javier Pagan, Lumen A. Mendez-Castaner, Adela D. Mattiazzi, Warren L. Kupin, Giselle Guerra, Linda J. Chen, Mahmoud Morsi, Jose M. G. Figueiro, Rodrigo Vianna, Carolyn L. Abitbol, David Roth, Alessia Fornoni, Phillip Ruiz, Gaetano Ciancio, Eduardo H. Garin
Summary: Podocyte B7-1 staining in biopsies of KTRs with post-transplant FSGS identifies a subset of patients who may benefit from abatacept.
PEDIATRIC NEPHROLOGY
(2023)
Letter
Surgery
Jacquelyn M. Yu, Junichiro Sageshima, Miriam A. Nuno, Neal M. Mineyev, Naeem Goussous, Peter A. Than, Richard V. Perez
Summary: This cohort study examines the survival of kidney grafts from small and very small pediatric donors in women compared to men with end-stage kidney disease.
Review
Oncology
Joao Manzi, Camilla. O. O. Hoff, Raphaella Ferreira, Renata Glehn-Ponsirenas, Gennaro Selvaggi, Akin Tekin, Christopher. B. B. O'Brien, Lynn Feun, Rodrigo Vianna, Phillipe Abreu
Summary: The liver is a common primary tumor site, responsible for about 5% of all cancers and over 8% of cancer-related deaths worldwide. Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, accounting for approximately 75% of all primary liver tumors. Liver transplantation is a major therapeutic tool in the treatment of HCC, but it faces challenges of tumor recurrence and graft rejection. Cell-free DNA has emerged as a new tool for decision-making in the context of HCC treatment, and this article summarizes its main aspects, exploring its strengths and weaknesses.
Meeting Abstract
Urology & Nephrology
A. Dejmam, F. Cabeza, A. Torres, J. Gaynor, A. Schneegans, P. Ruiz, D. Roth, W. Kupin, G. Burke, G. Ciancio, L. Chen, R. Vianna, A. Mattiazzi, G. Guerra
AMERICAN JOURNAL OF KIDNEY DISEASES
(2016)
Meeting Abstract
Surgery
Zhobin Moghadamyeghaneh, Gennaro Selvaggi, Nishida Seigo, Rodrigo Vianna
AMERICAN JOURNAL OF TRANSPLANTATION
(2016)