Concise Review: New Insights Into the Role of Macrophages in β-Cell Proliferation

Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas

(2015) Naomi Van Gassen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Islet Microenvironment, Modulated by Vascular Endothelial Growth Factor-A Signaling, Promotes β Cell Regeneration

(2014) Marcela Brissova et al.   Cell Metabolism

Pancreatic duct cells as a source of VEGF in mice

(2014) Xiangwei Xiao et al.   DIABETOLOGIA

Beta cell regeneration after single-round immunological destruction in a mouse model

(2014) Jason M. Tonne et al.   DIABETOLOGIA

Activated Macrophages Create Lineage-Specific Microenvironments for Pancreatic Acinar- and β-Cell Regeneration in Mice

(2014) Angela Criscimanna et al.   GASTROENTEROLOGY

Transplantation of mesenchymal stem cells recruits trophic macrophages to induce pancreatic beta cell regeneration in diabetic mice

(2014) Xiaocang Cao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

(2014) Simona Chera et al.   NATURE

Pancreatic cell tracing, lineage tagging and targeted genetic manipulations in multiple cell types using pancreatic ductal infusion of adeno-associated viral vectors and/or cell-tagging dyes

(2014) Xiangwei Xiao et al.   Nature Protocols

M2 macrophages promote beta-cell proliferation by up-regulation of SMAD7

(2014) Xiangwei Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes

(2014) R Piran et al.   Cell Death & Disease

Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells

(2014) Wenxian Fu et al.   eLife

In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes

(2014) Weida Li et al.   eLife

Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway

(2014) Barak Blum et al.   eLife

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

(2013) F. C. Pan et al.   DEVELOPMENT

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

A Smad Signaling Network Regulates Islet Cell Proliferation

(2013) Y. El-Gohary et al.   DIABETES

G0-G1 Transition and the Restriction Point in Pancreatic  -Cells In Vivo

(2013) A. Hija et al.   DIABETES

Systemic Regulation of the Age-Related Decline of Pancreatic β-Cell Replication

(2013) Seth J. Salpeter et al.   DIABETES

 -Cells Are Not Generated in Pancreatic Duct Ligation-Induced Injury in Adult Mice

(2013) M. M. Rankin et al.   DIABETES

Macrophages and islet inflammation in type 2 diabetes

(2013) K. Eguchi et al.   DIABETES OBESITY & METABOLISM

Pancreatic Duct Ligation After Almost Complete β-Cell Loss: Exocrine Regeneration but No Evidence of β-Cell Regeneration

(2013) Claudia Cavelti-Weder et al.   ENDOCRINOLOGY

Neurogenin3 Activation Is Not Sufficient to Direct Duct-to-Beta Cell Transdifferentiation in the Adult Pancreas

(2013) Xiangwei Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

No evidence for β cell neogenesis in murine adult pancreas

(2013) Xiangwei Xiao et al.   JOURNAL OF CLINICAL INVESTIGATION

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

(2013) Luc Baeyens et al.   NATURE BIOTECHNOLOGY

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

(2013) Tony Jourdan et al.   NATURE MEDICINE

Efficient β-cell regeneration by a combination of neogenesis and replication following β-cell ablation and reversal of pancreatic duct ligation

(2013) Ergeng Hao et al.   STEM CELLS

TGF  Receptor Signaling Is Essential for Inflammation-Induced but Not  -Cell Workload-Induced  -Cell Proliferation

(2012) X. Xiao et al.   DIABETES

TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice

(2012) R. Menghini et al.   DIABETES

Alternatively Activated Macrophages in Types 1 and 2 Diabetes

(2012) Arlett Espinoza-Jiménez et al.   MEDIATORS OF INFLAMMATION

Beta Cell Count Instead of Beta Cell Mass to Assess and Localize Growth in Beta Cell Population following Pancreatic Duct Ligation in Mice

(2012) Marie Chintinne et al.   PLoS One

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Progenitor cell domains in the developing and adult pancreas

(2011) Janel L. Kopp et al.   CELL CYCLE

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas

(2011) D. Kopinke et al.   DEVELOPMENT

Duct Cells Contribute to Regeneration of Endocrine and Acinar Cells Following Pancreatic Damage in Adult Mice

(2011) Angela Criscimanna et al.   GASTROENTEROLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Ductal Origin Hypothesis of Pancreatic Regeneration under Attack

(2010) Jake A. Kushner et al.   Cell Metabolism

DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

(2010) Suneil K. Koliwad et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-17 Immunity in Human Type 1 Diabetes

(2010) J. Honkanen et al.   JOURNAL OF IMMUNOLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Pancreatic β-Cell Neogenesis by Direct Conversion from Mature α-Cells

(2010) Cheng-Ho Chung et al.   STEM CELLS

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

Adaptive  -Cell Proliferation Is Severely Restricted With Advanced Age

(2009) M. M. Rankin et al.   DIABETES

Protease-resistant human GAD-derived altered peptide ligands decrease TNF-α and IL-17 production in peripheral blood cells from patients with type 1 diabetes mellitus

(2009) Bernhard O. Boehm et al.   MOLECULAR IMMUNOLOGY

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

Restoring a functional β-cell mass in diabetes

(2008) D. Pipeleers et al.   DIABETES OBESITY & METABOLISM

In vivo reprogramming of adult pancreatic exocrine cells to β-cells

(2008) Qiao Zhou et al.   NATURE

Dendritic cells in islets of Langerhans constitutively present   cell-derived peptides bound to their class II MHC molecules

(2008) B. Calderon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation and Regeneration of Cells of the Liver and Pancreas

(2008) K. S. Zaret et al.   SCIENCE