Article
Surgery
Joao Batista Saldanha De Castro Filho, Jeferson De Castro Pompeo, Rafael Berlezi Machado, Luiz Felipe Santos Goncalves, Andrea Carla Bauer, Roberto Ceratti Manfro
Summary: This study examines the histological findings in surveillance biopsies of deceased donor kidney transplant recipients and identifies the risk factors for graft outcomes. The results indicate that acute tubular necrosis, acute rejection, and borderline findings are the main histological findings. Recipient age and DGF duration are independent risk factors for acute rejection, while antibody-induction therapy with ATG provides protective effects against rejection.
TRANSPLANT INTERNATIONAL
(2022)
Article
Health Care Sciences & Services
Estefania Tarazon, Lorena Perez-Carrillo, Manuel Portoles, Esther Rosello-Lleti
Summary: This study focuses on analyzing new ultrastructural findings in cardiac biopsy rejection through the observation of perinuclear clustering of mitochondria, which could complement and improve the diagnosis of rejection.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Anna Radajewska, Anna Krzywonos-Zawadzka, Iwona Bil-Lula
Summary: Kidney transplantation is the standard procedure for treating end-stage renal disease, and machine perfusion has been proven to be a better solution for organ preservation and monitoring.
Article
Transplantation
Eva Schrezenmeier, Mia Mueller, Frank Friedersdorff, Dmytro Khadzhynov, Fabian Halleck, Oliver Staeck, Michael Durr, Kun Zhang, Kai-Uwe Eckardt, Klemens Budde, Lukas J. Lehner
Summary: This study analyzed the severity of delayed graft function (DGF) and its impact on transplant outcomes in 627 deceased-donor kidney transplant recipients. The results showed that the duration of DGF had a significant effect on 10-year death-censored graft survival, especially in kidneys with a Kidney Donor Profile Index (KDPI) less than 85%. However, short duration DGF (0-1 day) had comparable results to no DGF.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Biochemistry & Molecular Biology
Nicola De Stefano, Alberto Calleri, Angelo Corso Faini, Victor Navarro-Tableros, Silvia Martini, Silvia Deaglio, Damiano Patrono, Renato Romagnoli
Summary: Extracellular vesicles (EVs) are small, membrane-bound vesicles that contain various bioactive molecules and play important roles in intercellular communication. In the field of liver disease research, EVs are emerging as a promising topic with potential applications in liver transplantation. This review provides an overview of the current understanding of the role of EVs in liver transplantation, including their potential as biomarkers and therapeutic agents, as well as their involvement in graft rejection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Paolo Vincenzi, Jeffrey J. Gaynor, Rodrigo Vianna, Gaetano Ciancio
Summary: Combined liver-kidney transplantation (CLKT) improves patient survival among liver transplant recipients with renal dysfunction. However, kidney delayed graft function (kDGF) still represents a common and challenging complication that can negatively impact clinical outcomes. This study analyzed the incidence, risk factors, and prognostic impact of kDGF development following CLKT and highlights the importance of prevention and improvement measures.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Joshua Hefler, Dayne Leon-Izquierdo, Braulio A. Marfil-Garza, Glenda Meeberg, Kevin Verhoeff, Blaire Anderson, Khaled Dajani, David L. Bigam, A. M. James Shapiro
Summary: Normothermic machine perfusion (NMP) is an effective tool for preserving liver allografts before transplantation. The University of Alberta's liver transplant program has successfully utilized NMP to extend preservation time in liver transplantation. NMP livers showed improved 30-day graft survival and no increase in complications compared with livers preserved using static cold storage (SCS).
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei-Chou Chang, Benjamin M. Yeh, Lisa Chu, So Yeon Kim, Kwun Wah Wen, Sung-Hua Chiu, Chien-Kuang Cornelia Ding, En-Haw Wu, John P. Roberts, Guo-Shu Huang, Hsian-He Hsu
Summary: CT findings of LPD and small portal vein diameters within 3 months of liver transplantation can predict graft failure within 1 year.
EUROPEAN RADIOLOGY
(2021)
Article
Engineering, Biomedical
Sergio Riveros, Carlo Marino, Gabriela Ochoa, Dagoberto Soto, Leyla Alegria, Maria Jose Zenteno, Sebastian San Martin, Alejandro Branes, Pablo Achurra, Rolando Rebolledo
Summary: Ex situ normothermic perfusion (NMP) using a customized machine can reduce hepatocellular damage and ischemia-reperfusion injury in liver transplantation, compared to static cold storage (SCS), while increasing bile production.
Review
Medicine, General & Internal
Ruta Zulpaite, Povilas Miknevicius, Bettina Leber, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: Kidney transplantation is the gold standard treatment for patients with end-stage kidney disease, but the quality of donor organs poses limitations. Ex-vivo machine perfusion technology has great potential in maintaining kidney viability and optimizing organ treatment, serving as an important component of novel techniques in transplant surgery.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Jiyue Wu, Feilong Zhang, Xiang Zheng, Jiandong Zhang, Peng Cao, Zejia Sun, Wei Wang
Summary: This study identified two distinct clusters based on NET-related genes during the ischemia reperfusion injury (IRI) process in renal transplantation. Robust prediction strategies for delayed graft function (DGF) and long-term graft survival were constructed. The findings provide references for early prevention and individualized treatment of postoperative complications after renal transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Shivashankar Damodaran, Brenna Bullock, Obi Ekwenna, Mehdi Nayebpour, Naoru Koizumi, Puneet Sindhwani, Jorge Ortiz
Summary: Delayed graft function (DGF) is less common in living donor kidney transplantation but has a significant impact on graft survival. It is the greatest predictor of graft failure at three years, independent of rejection.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Urology & Nephrology
Ohad Guetta, Anton Osyntsov, Ruth Rahamimov, Ana Tobar, Moshe Israeli, Yasmin Masarwa, Michael Gurevich, Vladimir Tennak, Vadym Mezhybovsky, Aviad Gravetz, Sigal Eisner, Eviatar Nesher
Summary: Delayed graft function (DGF) after kidney transplantation is considered a risk factor for acute rejection. The common practice of performing sequential graft biopsies in DGF patients seems to provide little benefit, and further biopsies should be decided on a case-by-case basis.
Article
Genetics & Heredity
Qianguang Han, Xiang Zhang, Xiaohan Ren, Zhou Hang, Yu Yin, Zijie Wang, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Ruoyun Tan, Min Gu, Xiaobing Ju
Summary: In this study, 32 differentially expressed transcripts were identified and a predictive model with five key transcripts was established for the prediction of biopsy-proven acute rejection (BPAR) after kidney transplantation. Functional enrichment analysis revealed the involvement of differential genes in chemokine signaling and immune cell infiltration. These findings provide valuable insights for early diagnosis and detection of BPAR.
FRONTIERS IN GENETICS
(2022)
Review
Engineering, Biomedical
Sarah Bouari, Ozgur Eryigit, Ron W. F. de Bruin, Jan N. M. IJzermans, Robert C. Minnee
Summary: An updated overview of literature comparing normothermic with hypothermic machine perfusion in porcine kidneys showed mixed results, with some studies reporting significant advantages of normothermic machine perfusion in peak renal blood flow and creatinine clearance. However, the interpretation of these results should be cautious due to the heterogeneity in study design and sample sizes.
Article
Surgery
Jeffrey J. Gaynor, Gaetano Ciancio, Giselle Guerra, Junichiro Sageshima, David Roth, Michael J. Goldstein, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Sandra Flores, Lois Hanson, Phillip Ruiz, Rodrigo Vianna, George W. Burke
TRANSPLANT INTERNATIONAL
(2016)
Article
Surgery
Siegfredo Paloyo, Junichiro Sageshima, Jeffrey J. Gaynor, Linda Chen, Gaetano Ciancio, George W. Burke
TRANSPLANT INTERNATIONAL
(2016)
Article
Immunology
Elisa J. Gordon, Joe Feinglass, Paula Carney, Karina Vera, Maria Olivero, Anne Black, Kate O'Connor, Jessica MacLean, Shari Nichols, Junichiro Sageshima, Luke Preczewski, Juan Carlos Caicedo
Article
Immunology
G. Ciancio, P. Tryphonopoulos, J. J. Gaynor, G. Guerra, J. Sageshima, D. Roth, L. Chen, W. Kupin, A. Mattiazzi, L. Tueros, S. Flores, L. Hanson, R. H. Powell, P. Ruiz, R. Vianna, G. W. Burke
TRANSPLANTATION PROCEEDINGS
(2016)
Article
Immunology
Gaetano Ciancio, Jeffrey J. Gaynor, Giselle Guerra, Junichiro Sageshima, David Roth, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Sandra Flores, Lois Hanson, Phillip Ruiz, Rodrigo Vianna, George W. Burke
TRANSPLANT IMMUNOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ghaneh Fananapazir, Robert Benzl, Michael T. Corwin, Ling-Xin Chen, Junichiro Sageshima, Susan L. Stewart, Christoph Troppmann
Article
Immunology
Sandra K. Kabagambe, Ivonne P. Palma, Yulia Smolin, Tristan Boyer, Ivania Palma, Junichiro Sageshima, Christoph Troppmann, Chandrasekar Santhanakrishnan, John P. McVicar, Kuang-Yu Jen, Miriam Nuno, Richard Perez
Article
Surgery
Gaetano Ciancio, Jeffrey J. Gaynor, Giselle Guerra, Junichiro Sageshima, David Roth, Linda Chen, Warren Kupin, Adela Mattiazzi, Lissett Tueros, Phillip Ruiz, Rodrigo Vianna, George W. Burke
CLINICAL TRANSPLANTATION
(2018)
Editorial Material
Surgery
Christoph Troppmann, Chandrasekar Santhanakrishnan, Junichiro Sageshima, John McVicar, Richard Perez
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Surgery
Ghaneh Fananapazir, Gary Tse, Ryan Di Geronimo, John McVicar, Richard Perez, Chandrasekar Santhanakrishnan, Junichiro Sageshima, Christoph Troppmann
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Immunology
Christoph Troppmann, Chandrasekar Santhanakrishnan, Ghaneh Fananapazir, Junichiro Sageshima, Kathrin M. Troppmann, Richard Perez
Summary: Acute kidney injury in small pediatric donors affects early kidney graft function, but doesn't increase the risk of early graft loss and decreases long-term function. The high nonutilization rates for en bloc kidney grafts from very small pediatric donors with AKI seem unjustified, and the reluctance to transplant single kidneys from larger pediatric donors with AKI lacks a rational basis. Further prospective studies are needed for confirmation.
Article
Immunology
Kuang-Yu Jen, Samer Albahra, Felicia Yen, Junichiro Sageshima, Ling-Xin Chen, Nam Tran, Hooman H. Rashidi
Summary: In this study, an automated machine learning (ML) modeling pipeline was used to generate and optimize DGF prediction models en masse. The best performing models were based on neural network algorithms, with the highest area under the receiver operating characteristic curve of 0.7595. The performance of the ML models was comparable with classic logistic regression models.
Review
Immunology
Junichiro Sageshima, Jayanthi Chandar, Linda J. Chen, Rushi Shah, Ammar Al Nuss, Paolo Vincenzi, Mahmoud Morsi, Jose Figueiro, Rodrigo Vianna, Gaetano Ciancio, George W. I. I. I. I. I. I. Burke
Summary: Kidney transplantation is the best health option for patients with end-stage kidney disease, but multiple transplants may be needed. Surgical approach and immunologic concerns are key, and other factors such as thrombosis and posttransplant events should also be considered.
Article
Pediatrics
George W. Burke, Jayanthi Chandar, Junichiro Sageshima, Mariella Ortigosa-Goggins, Pooja Amarapurkar, Alla Mitrofanova, Marissa J. Defreitas, Chryso P. Katsoufis, Wacharee Seeherunvong, Alexandra Centeno, Javier Pagan, Lumen A. Mendez-Castaner, Adela D. Mattiazzi, Warren L. Kupin, Giselle Guerra, Linda J. Chen, Mahmoud Morsi, Jose M. G. Figueiro, Rodrigo Vianna, Carolyn L. Abitbol, David Roth, Alessia Fornoni, Phillip Ruiz, Gaetano Ciancio, Eduardo H. Garin
Summary: Podocyte B7-1 staining in biopsies of KTRs with post-transplant FSGS identifies a subset of patients who may benefit from abatacept.
PEDIATRIC NEPHROLOGY
(2023)
Letter
Surgery
Jacquelyn M. Yu, Junichiro Sageshima, Miriam A. Nuno, Neal M. Mineyev, Naeem Goussous, Peter A. Than, Richard V. Perez
Summary: This cohort study examines the survival of kidney grafts from small and very small pediatric donors in women compared to men with end-stage kidney disease.