Review
Infectious Diseases
Fatima Allaw, Sara F. Haddad, Johnny Zakhour, Souha S. Kanj
Summary: Cytomegalovirus (CMV) is a common infection in immunocompromised patients, especially those undergoing allo-HSCT. Recent management strategies include pre-emptive treatment with frequent CMV PCR monitoring and the use of new drugs like letermovir. Treatment of CMV disease is challenging due to drug resistance, but promising results have been seen with maribavir and other alternative treatments such as immunotherapy, artesunate, and leflunomide.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Respiratory System
Peter Riddell, Ram Vasudevan-Nampoothiri, Jin Ma, Lianne G. Singer, Jeff H. Lipton, Stephen C. Juvet
Summary: This study found an increased risk of post-LTx mortality in recipients with previous allo-HSCT, especially related to infections. The 1-year survival rate post-LTx was similar to re-LTx recipients, but the conditional 1-year survival rate was lower. Therefore, optimization of post-LTx immunosuppressive and antimicrobial strategies should be considered in this patient population.
RESPIRATORY RESEARCH
(2021)
Review
Immunology
Yibo Wu, He Huang, Yi Luo
Summary: The high morbidity of HBV reactivation following allo-HSCT is partially due to complex therapeutic regimens and immunosuppression, which leads to HBV replication. Prophylactic antiviral therapy should be given to HBsAg positive recipients to reduce the risk of HBV reactivation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yuanfeng Zhang, Xin Chen, Donglin Yang, Aiming Pang, Rongli Zhang, Qiaoling Ma, Weihua Zhai, Yi He, Jialin Wei, Erlie Jiang, Mingzhe Han, Sizhou Feng
Summary: This study conducted a retrospective cohort analysis on patients with severe aplastic anemia (SAA) who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) to compare their survival between those with infection and those without infection. The study found that patients with infection before transplantation had inferior survival compared to those without infection, highlighting the importance of prophylaxis and complete control of infectious complications before transplantation among SAA patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yanfeng Liu, Yi Liu, Xuefeng Chen, Yan Jia
Summary: This study investigated the clinical characteristics and mortality risk factors of mixed bacterial infections (MBI) in hematopoietic stem cell transplantation (HSCT) recipients. The results showed that MBI has become a serious problem after HSCT, with a high mortality rate. Time interval from diagnosis to transplantation, ICU admission after transplantation, engraftment period, continuous renal replacement therapy, and septic shock were identified as independent risk factors for MBI acquisition and mortality. Clinicians should pay attention to MBI and formulate monitoring and treatment plans to improve patient prognosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Cell & Tissue Engineering
Davod Pashoutan Sarvar, Hosein Effatpanah, Parvin Akbarzadehlaleh, Karim Shamsasenjan
Summary: The study highlights the important role of MSC-derived extracellular vesicles (MSC-EVs) in hematopoietic regulation and immune response after transplantation. MSC-EVs directly fuse with hematopoietic stem cell membranes, affecting their fate, and regulate the proliferation and differentiation of hematopoietic stem cells through the release of various bioactive factors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yumiko Ohbayashi, Osamu Imataki, Makiko Uemura, Akihiro Takeuchi, Saki Aoki, Mao Tanaka, Yasuhiro Nakai, Fumi Nakai, Minoru Miyake
Summary: The comparison of oral and pathogenic microorganisms in bloodstream infections (BSIs) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) showed that oral microorganisms caused 46.2% of BSIs in patients. The incidence rate of BSIs was 27%, with coagulase-negative Staphylococci being the predominant microorganism.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Immunology
Tirthankar Sen, Rajkumar P. Thummer
Summary: The human microbiota plays a significant role in organ transplantation outcomes and rejection risk, with complex interactions existing between different microbiotas and the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Thais Guimaraes, Igor Carmo Borges, Fernanda de Souza Spadao, Livia Mariano, Marina de Mattos Nascimento, Hermes Higashino, Flavia Rossi, Vanderson Rocha, Silvia Figueiredo Costa
Summary: The non-use of fluoroquinolone prophylaxis during neutropenia can reduce antibiotic resistance in Gram-negative bacteria causing bloodstream infections (BSIs) in hematopoietic stem cell transplantation (HSCT) patients. However, it may also increase BSI incidence and mortality rates.
Review
Biotechnology & Applied Microbiology
Soheila Montazersaheb, Ali Ehsani, Ezzatollah Fathi, Raheleh Farahzadi, Ilja Vietor
Summary: Autophagy is a fundamental process that helps cells adapt to metabolic stress by degrading and recycling intracellular components. It plays a crucial role in various aspects of allogeneic hematopoietic stem cell transplantation (HSCT), including the survival and function of hematopoietic stem cells, T-cell differentiation, antigen presentation, and responsiveness to cytokine stimulation. However, the overall role of autophagy in HSCT remains unclear, highlighting the need for further understanding to improve transplant outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Ashley M. Nelson, Alexandra A. Erdmann, Christopher L. Coe, Mark B. Juckett, Keayra Morris, Jennifer M. Knight, Peiman Hematti, Erin S. Costanzo
Summary: Increased synthesis and release of inflammatory signalling proteins are common among individuals with hematologic malignancies undergoing hematopoietic cell transplantation (HCT). This study examined the relationship between markers of inflammatory activity and depression symptoms following HCT. The results showed that patients with elevated levels of IL-6 and IL-10 reported more severe depression symptoms post-HCT, especially in terms of neurovegetative symptoms.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Pediatrics
Asmaa Ferdjallah, Jo-Anne H. Young, Margaret L. MacMillan
Summary: Opportunistic infections remain a major cause of morbidity and mortality after pediatric HCT, with risk factors including patient's disease, treatment history, donor graft source, pre-transplant therapy, and immunosuppressive agents. Infection risk changes over time and is greatly influenced by the degree of immunosuppression, highlighting the need for careful monitoring.
FRONTIERS IN PEDIATRICS
(2021)
Article
Immunology
Rebecca Isabel Wurm-Kuczera, Judith Buentzel, Julia Felicitas Leni Koenig, Tobias Legler, Jan-Jakob Valk, Justin Hasenkamp, Wolfram Jung, Jan-Gerd Rademacher, Peter Korsten, Gerald Georg Wulf
Summary: Sarcoidosis is a disease characterized by altered immune response and inflammatory granulomatous tissue infiltration. It may occur during immune reconstitution after HSCT, with glucocorticoid treatment resolving symptoms effectively. The HLA allele association reflects that observed in the general population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Tsung-Jang Yeh, Ching- Yang, Chien-Tzu Huang, Min-Hung Wang, Tzer-Ming Chuang, Ya-Lun Ke, Yuh-Ching Gau, Jeng-Shiun Du, Hui-Ching Wang, Shih-Feng Cho, Ching-Ping Lee, Chin-Mu Hsu, Hui-Hua Hsiao, Yi-Chang Liu
Summary: Infection is a major complication after allo-HSCT, especially CMV infection and IFI. Taiwan has a high CMV seroprevalence area. This study aimed to evaluate the incidence, risk factors, impact on survival of CMV infection, and the association of CMV infection and IFI in recipients after allo-HSCT.
Review
Cell Biology
Yan Man, Xiangmei Yao, Tonghua Yang, Yajie Wang
Summary: The self-renewal and differentiation of hematopoietic stem cells are tightly controlled by various cells and cytokines in the bone marrow microenvironment. Changes in the niche composition can lead to hematological malignancies, and processes like homing, proliferation, and differentiation of HSCs are crucial for the success of hematopoietic stem cell transplantation. Single-cell sequencing and in vivo imaging are powerful tools for studying the bone marrow microenvironment in diseases like leukemia and after transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Hematology
Raphael Carapito, Nicolas Jung, Marius Kwemou, Meiggie Untrau, Sandra Michel, Angelique Pichot, Gaelle Giacometti, Cecile Macquin, Wassila Ilias, Aurore Morlon, Irina Kotova, Petya Apostolova, Annette Schmitt-Graeff, Anne Cesbron, Katia Gagne, Machteld Oudshoorn, Bronno van der Holt, Myriam Labalette, Eric Spierings, Christophe Picard, Pascale Loiseau, Ryad Tamouza, Antoine Toubert, Anne Parissiadis, Valerie Dubois, Xavier Lafarge, Myriam Maumy-Bertrand, Frederic Bertrand, Luca Vago, Fabio Ciceri, Catherine Paillard, Sergi Querol, Jorge Sierra, Katharina Fleischhauer, Arnon Nagler, Myriam Labopin, Hidetoshi Inoko, Peter A. von dem Borne, Juergen Kuball, Masao Ota, Yoshihiko Katsuyama, Mauricette Michallet, Bruno Lioure, Regis Peffault de latour, Didier Blaise, Jan J. Cornelissen, Ibrahim Yakoub-Agha, Frans Claas, Philippe Moreau, Noel Milpied, Dominique Charron, Mohamad Mohty, Robert Zeiser, Gerard Socie, Seiamak Bahram
Article
Immunology
Wei-Chen Huang, Nicholas J. Easom, Xin-Zi Tang, Upkar S. Gill, Harsimran Singh, Francis Robertson, Chiwen Chang, John Trowsdale, Brian R. Davidson, William M. Rosenberg, Giuseppe Fusai, Antoine Toubert, Patrick T. Kennedy, Dimitra Peppa, Mala K. Maini
JOURNAL OF IMMUNOLOGY
(2017)
Article
Hematology
Delphine Rea, Guylaine Henry, Zena Khaznadar, Gabriel Etienne, Francois Guilhot, Franck Nicolini, Joelle Guilhot, Philippe Rousselot, Francoise Huguet, Laurence Legros, Martine Gardembas, Viviane Dubruille, Agnes Guerci-Bresler, Aude Charbonnier, Frederic Maloisel, Jean-Christophe Ianotto, Bruno Villemagne, Francois-Xavier Mahon, Helene Moins-Teisserenc, Nicolas Dulphy, Antoine Toubert
Article
Oncology
Dominique Farge, Lucas C. M. Arruda, Fanny Brigant, Emmanuel Clave, Corinne Douay, Zora Marjanovic, Christophe Deligny, Guitta Maki, Eliane Gluckman, Antoine Toubert, Helene Moins-Teisserenc
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2017)
Article
Oncology
Anne-Sophie Chretien, Cyril Fauriat, Florence Orlanducci, Jerome Rey, Gaelle Bouvier Borg, Emmanuel Gautherot, Samuel Granjeaud, Clemence Demerle, Jean-Francois Hamel, Adelheid Cerwenka, Elke Pogge von Strandmann, Norbert Ifrah, Catherine Lacombe, Pascale Cornillet-Lefebvre, Jacques Delaunay, Antoine Toubert, Christine Arnoulet, Norbert Vey, Daniel Olive
Article
Hematology
Delphine Rea, Guylaine Henry, Zena Khaznadar, Gabriel Etienne, Francois Guilhot, Franck Nicolini, Joelle Guilhot, Philippe Rousselot, Francoise Huguet, Laurence Legros, Martine Gardembas, Viviane Dubruille, Agnes Guerci-Bresler, Aude Charbonnier, Frederic Maloisel, Jean-Christophe Ianotto, Bruno Villemagne, Francois-Xavier Mahon, Helene Moins-Teisserenc, Nicolas Dulphy, Antoine Toubert
Article
Oncology
Alexandra Frazao, Marina Colombo, Emmanuelle Fourmentraux-Neves, Meriem Messaoudene, Sylvie Rusakiewicz, Laurence Zitvogel, Eric Vivier, Frederic Vely, Florence Faure, Brigitte Dreno, Houssem Benlalam, Fanny Bouquet, Ariel Savina, Eric Pasmant, Antoine Toubert, Marie-Francoise Avril, Anne Caignard
CANCER IMMUNOLOGY RESEARCH
(2017)
Article
Immunology
Anne-Sophie Chretien, Cyril Fauriat, Florence Orlanducci, Claire Galseran, Jerome Rey, Gaelle Bouvier Borg, Emmanuel Gautherot, Samuel Granjeaud, Jean-Francois Hamel-Broza, Clemence Demerle, Norbert Ifrah, Catherine Lacombe, Pascale Cornillet-Lefebvre, Jacques Delaunay, Antoine Toubert, Emilie Gregori, Herve Luche, Marie Malissen, Christine Arnoulet, Jacques A. Nunes, Norbert Vey, Daniel Olive
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Meriem Messaoudene, Alexandra Frazao, Pierre Jean Gavlovsky, Antoine Toubert, Nicolas Dulphy, Anne Caignard
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Oncology
Alexandra Frazao, Meriem Messaoudene, Nicolas Nunez, Nicolas Dulphy, France Roussin, Christine Sedlik, Laurence Zitvogel, Eliane Piaggio, Antoine Toubert, Anne Caignard
CANCER IMMUNOLOGY RESEARCH
(2019)
Review
Immunology
Enrico Velardi, Emmanuel Clave, Lucas C. M. Arruda, Francesca Benini, Franco Locatelli, Antoine Toubert
Summary: The thymus plays a crucial role in T-cell development, but its function can be affected by various factors, including chemotherapy, conditioning regimen, graft-versus-host disease, and steroid therapy. Despite its remarkable capacity to recover after damage, the pathways governing its regeneration are poorly understood. Tools for measuring thymic output can help assess thymic function.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Immunology
Jihene Klibi, Claudine Joseph, Marc Delord, Aurelie Teissandier, Bruno Lucas, Christine Chomienne, Antoine Toubert, Deborah Bourc'his, Fabien Guidez, Kamel Benlagha
Summary: The study shows that acetylation-induced activation of PLZF affects the development of NKT cells, leading to a decrease in cell proportion and numbers, and blockage of transition from developmental stage 1 to stage 2. Acetylation of PLZF also alters NKT cell subset differentiation, inhibiting the development of NKT1 and NKT17 subsets while promoting the emergence of an NKT cell subset resembling cells in early developmental stages.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
A. Magnani, M. Semeraro, F. Adam, C. Booth, L. Dupre, E. C. Morris, A. Gabrion, C. Roudaut, D. Borgel, A. Toubert, E. Clave, C. Abdo, G. Gorochov, R. Petermann, M. Guiot, M. Miyara, D. Moshous, E. Magrin, A. Denis, F. Suarez, C. Lagresle, A. M. Roche, J. Everett, A. Trinquand, M. Guisset, J. Xu Bayford, S. Hacein-Bey-Abina, A. Kauskot, R. Elfeky, C. Rivat, S. Abbas, H. B. Gaspar, E. Macintyre, C. Picard, F. D. Bushman, A. Galy, A. Fischer, E. Six, A. J. Thrasher, M. Cavazzana
Summary: This article presents the long-term follow-up results of gene therapy for patients with Wiskott-Aldrich syndrome, showing that lentiviral gene therapy provides sustained clinical benefits for these patients.
Correction
Biochemistry & Molecular Biology
A. Magnani, M. Semeraro, F. Adam, C. Booth, L. Dupre, E. C. Morris, A. Gabrion, C. Roudaut, D. Borgel, A. Toubert, E. Clave, C. Abdo, G. Gorochov, R. Petermann, M. Guiot, M. Miyara, D. Moshous, E. Magrin, A. Denis, F. Suarez, C. Lagresle, A. M. Roche, J. Everett, A. Trinquand, M. Guisset, J. Xu Bayford, S. Hacein-Bey-Abina, A. Kauskot, R. Elfeky, C. Rivat, S. Abbas, H. B. Gaspar, E. Macintyre, C. Picard, F. D. Bushman, A. Galy, A. Fischer, E. Six, A. J. Thrasher, M. Cavazzana
Article
Hematology
Marie Roelens, Marc Delord, Caroline Ram-Wolff, Anne Marie-Cardine, Antonio Alberdi, Guitta Maki, Laurence Homyrda, Armand Bensussan, Martine Bagot, Antoine Toubert, Helene Moins-Teisserenc
