Article
Immunology
Lauren E. Higdon, Claire E. Gustafson, Xuhuai Ji, Malaya K. Sahoo, Benjamin A. Pinsky, Kenneth B. Margulies, Holden T. Maecker, Jorg Goronzy, Jonathan S. Maltzman
Summary: Immune function changes with age, and infection with CMV accelerates these changes, resulting in increased mortality and impaired responses in elderly individuals. Following organ transplantation, CMV+ recipients show accelerated aging of CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Andreas Schroeter, Maximilian J. Roesel, Tomohisa Matsunaga, Yao Xiao, Hao Zhou, Stefan G. Tullius
Summary: This article provides a comprehensive update on the effects of aging on MDSC and discusses potential consequences on alloimmunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Isabella Pirozzolo, Zhipeng Li, Martin Sepulveda, Maria-Luisa Alegre
Summary: The microbiome plays a crucial role in shaping immune responses in transplantation, affecting various aspects such as cell modulation, immune response phases, and drug metabolism. The complex interactions between the microbiota and the host have significant implications for transplant outcomes and alloimmunity.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Surgery
Scott G. Westphal, Eric D. Langewisch, Amanda M. Robinson, Amber R. Wilk, Jianghu J. Dong, Troy J. Plumb, Ryan Mullane, Shaheed Merani, Arika L. Hoffman, Alexander Maskin, Clifford D. Miles
Summary: This study found that Kidney-alone transplant (KAT) candidates may face disadvantages due to the allocation priority given to multi-organ transplant (MOT) candidates. The analysis showed that next-sequential KAT candidates who missed out on receiving kidney offers were typically younger, more likely to be racial/ethnic minorities, and had higher sensitivities, leading to some candidates experiencing higher mortality rates and delays in transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Bob Z. Sun, Aaron Wightman, Douglas S. Diekema
Summary: This article examines ethical considerations of mandating COVID-19 vaccination for primary caregivers of solid organ transplant candidates. It highlights the potential improvement in overall utility in organ allocation and the need for sensitivity to the changing circumstances of disease severity, transmissibility, and vaccine effectiveness.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Public, Environmental & Occupational Health
Andre Karch, Daniela Schindler, Andrea Kuehn-Steven, Rainer Blaser, Klaus A. Kuhn, Lisa Sandmann, Claudia Sommerer, Markus Guba, Uwe Heemann, Jens Stroehaker, Stephan Gloeckner, Rafael Mikolajczyk, Dirk H. Busch, Thomas F. Schulz
Summary: The DZIF Transplant Cohort is a multicentre prospective cohort study focusing on infectious complications after solid organ and stem cell transplantation. It aims to understand the risk factors associated with infections, collect detailed data and biosamples to facilitate studies in infectious diseases and transplant medicine. The study has collected baseline data and biosamples from approximately 1400 patients as of January 2020, with plans to recruit 3500 patients by 2023 and continue follow-up visits and documentation of infectious events until at least 2025.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Review
Genetics & Heredity
Antero Salminen
Summary: Tissue-resident fibroblasts are mesenchymal cells that play a crucial role in maintaining the structural integrity of the extracellular matrix. Under various stresses, including those associated with aging, these fibroblasts can differentiate into myofibroblasts which not only contribute to tissue fibrosis but also interact with immune cells to regulate immune responses. The differentiation of myofibroblasts is induced by factors such as TGF-β cytokine and reactive oxygen species (ROS), which also play important roles in mediating signaling between immunosuppressive cells.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Review
Gastroenterology & Hepatology
Riccardo De Carlis, Paolo Muiesan, Burcin Taner
Summary: DCD grafts pose risks of complications and graft loss after liver transplantation due to prolonged functional donor warm ischaemia time. Improved outcomes have been achieved through stringent donor selection criteria and utilization of organ perfusion technologies. These technologies also enable liver function assessment and precise graft-recipient selection.
JOURNAL OF HEPATOLOGY
(2023)
Review
Immunology
Xuan Lu, Yun-Mei Yang, Yuan-Qiang Lu
Summary: Immunosenescence, the progressive immune dysfunction associated with aging, can worsen the immune disorder following sepsis and affect the organs. Immunosenescence exhibits similar characteristics to tissue pathology and functional decline after sepsis. A comprehensive understanding of the underlying mechanisms of immunosenescence after sepsis is crucial for the development of effective therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Nikolaus Kneidinger, Matthias Hecker, Vasiliki Bessa, Ina Hettich, Alexandra Wald, Sabine Wege, Anna-Barbara Nolde, Maike Oldigs, Zulfiya Syunyaeva, Heinrike Wilkens, Jens Gottlieb
Summary: This study aims to assess the outcome and associated factors in lung transplant recipients during the Omicron era of COVID-19, and found that age and glomerular filtration rate < 30 ml/min/1.73m(2) were independent risk factors for severe or critical COVID-19.
Article
Oncology
Robert P. Carroll, Michael Boyer, Val Gebski, Bronwyn Hockley, Julie K. Johnston, Svjetlana Kireta, Hsiang Tan, Anne Taylor, Kate Wyburn, John RZalcberg
Summary: Maintaining baseline immunosuppression before treatment with an immune checkpoint inhibitor in kidney transplant recipients might not affect expected efficacy and might reduce the risk of allograft rejection mediated by immune checkpoint inhibitors.
Article
Cardiac & Cardiovascular Systems
Ersilia M. Defilippis, Mitchell A. Psotka, Prateeti Khazanie, Jennifer Cowger, Rebecca Cogswell
Summary: The majority of heart transplant clinicians surveyed expressed the need for modifications to the 2018 heart allocation system, citing concerns about the use of temporary mechanical circulatory support and changes in physician behavior under the new system. Suggestions for improvement included reevaluating criteria for patient status and establishing a heart allocation score.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Medicine, General & Internal
Felix J. Krendl, Franka Messner, Claudia Boesmueller, Stefan Scheidl, Benno Cardini, Thomas Resch, Annemarie Weissenbacher, Rupert Oberhuber, Manuel Maglione, Stefan Schneeberger, Dietmar Oefner, Christian Margreiter
Summary: The study evaluated the incidence and impact of post-transplant malignancies (PTMs) following pancreas transplantation, with skin cancers being the most common type. Patients with solid organ and hematologic malignancies had a significantly higher risk of death compared to those with skin cancers following pancreas transplantation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Philipp Lueckemeier, Aleksandar Radujkovic, Udo Holtick, Lars Kurch, Astrid Monecke, Uwe Platzbecker, Marco Herling, Sabine Kayser
Summary: This study compared patient characteristics, therapies, and outcomes of post-transplant lymphoproliferative disorders (PTLD) after allogeneic hematopoietic transplantation (allo-HSCT) and solid organ transplantation (SOT). The results showed that PTLD occurred earlier and had poorer treatment response and overall survival in the allo-HSCT group.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Syed A. Husain, Kristen L. King, David C. Cron, Nikole A. Neidlinger, Han Ng, Sumit Mohan, Joel T. Adler
Summary: This study investigated the impact of local market competition and/or organ availability on kidney procurement and utilization. The results showed that lower competition was associated with higher export, while market monopoly was weakly associated with lower discard. Higher organ availability was associated with both export and discard.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Rupert Oberhuber, Timm Heinbokel, Hector Rodriguez Cetina Biefer, Olaf Boenisch, Karin Hock, Roderick T. Bronson, Markus J. Wilhelm, Yoichiro Iwakura, Karoline Edtinger, Hirofumi Uehara, Markus Quante, Floris Voskuil, Felix Krenzien, Bendix Slegtenhorst, Reza Abdi, Johann Pratschke, Abdallah Elkhal, Stefan G. Tullius
Article
Surgery
F. Krenzien, M. Quante, T. Heinbokel, M. Seyda, K. Minami, H. Uehara, H. R. C. Biefer, J. M. Schuitenmaker, S. Gabardi, K. Splith, M. Schmelzle, A. K. Petrides, H. Azuma, J. Pratschke, X. C. Li, A. ElKhal, S. G. Tullius
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
Article
Multidisciplinary Sciences
Abdallah Elkhal, Hector Rodriguez Cetina Biefer, Timm Heinbokel, Hirofumi Uehara, Markus Quante, Midas Seyda, Jeroen M. Schuitenmaker, Felix Krenzien, Virginia Camacho, Miguel A. de la Fuente, Ionita Ghiran, Stefan G. Tullius
SCIENTIFIC REPORTS
(2016)
Review
Surgery
Hirofumi Uehara, Koichiro Minami, Markus Quante, Yeqi Nian, Timm Heinbokel, Haruhito Azuma, Abdala El Khal, Stefan G. Tullius
TRANSPLANT INTERNATIONAL
(2018)
Article
Allergy
Hector Rodriguez Cetina Biefer, Timm Heinbokel, Hirofumi Uehara, Virginia Camacho, Koichiro Minami, Yeqi Nian, Suresh Koduru, Rachid El Fatimy, Ionita Ghiran, Alexander J. Trachtenberg, Miguel A. de la Fuente, Haruhito Azuma, Omid Akbari, Stefan G. Tullius, Anju Vasudevan, Abdallah Elkhal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Immunology
Markus Quante, Timm Heinbokel, Karoline Edtinger, Koichiro Minami, Hirofumi Uehara, Yeqi Nian, Haruhito Azuma, Reza Abdi, Abdallah Elkhal, Stefan G. Tullius
Article
Surgery
Jeff Reeve, Georg A. Boehmig, Farsad Eskandary, Gunilla Einecke, Gaurav Gupta, Katelynn Madill-Thomsen, Martina Mackova, Philip F. Halloran
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Article
Surgery
Gunilla Einecke, Jeff Reeve, Gaurav Gupta, Georg A. Boehmig, Farsad Eskandary, Jonathan S. Bromberg, Klemens Budde, Philip F. Halloran
Summary: In this study, the focus was on clinical and molecular features of kidney transplant patients after indication biopsy to predict the risk of transplant failure. The results showed that factors such as estimated GFR, proteinuria, time posttransplant, donor-specific antibody, as well as molecular and histologic features reflecting injury were more important predictors of failure compared to rejection activity.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Timm Heinbokel, Markus Quante, Jasper Iske, Yeqi Nian, Ryoichi Maenosono, Koichiro Minami, Yang Liu, Haruhito Azuma, Abdallah Elkhal, Stefan G. Tullius
Summary: Elderly organ transplant recipients have shown reduced effectiveness of CTLA4-Ig treatment compared to young recipients, likely due to decreased CD28 expression in CD4(+)T cells and altered regulation of regulatory T cells (Tregs) with aging. These differences may have unique clinical implications for immunosuppression in elderly transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Multidisciplinary Sciences
Jasper Iske, Midas Seyda, Timm Heinbokel, Ryoichi Maenosono, Koichiro Minami, Yeqi Nian, Markus Quante, Christine S. Falk, Haruhito Azuma, Friederike Martin, Joao F. Passos, Claus U. Niemann, Tamara Tchkonia, James L. Kirkland, Abdallah Elkhal, Stefan G. Tullius
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Yeqi Nian, Jasper Iske, Ryoichi Maenosono, Koichiro Minami, Timm Heinbokel, Markus Quante, Yang Liu, Haruhito Azuma, Jinrui Yang, Reza Abdi, Hao Zhou, Abdallah Elkhal, Stefan G. Tullius
Summary: The study reveals that age affects T cell metabolic reprogramming, with elderly CD4(+) T cells relying more on glutaminolysis. Inhibiting glutaminolysis effectively suppresses immune responses and proliferation of old CD4(+) T cells, leading to prolonged allograft survival in elderly recipients.
Article
Surgery
Philip F. Halloran, Georg A. Bohmig, Jonathan S. Bromberg, Klemens Budde, Gaurav Gupta, Gunilla Einecke, Farsad Eskandary, Katelynn Madill-Thomsen, Jeff Reeve
Summary: The study found that certain injury elements in kidney transplant are selective for specific pathologic mechanisms, with Dimension 3 being a newly discovered dimension involving genes related to epithelial polarity.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Katelynn S. Madill-Thomsen, Georg A. Boehmig, Jonathan Bromberg, Gunilla Einecke, Farsad Eskandary, Gaurav Gupta, Luis G. Hidalgo, Marek Myslak, Ondrej Viklicky, Agnieszka Perkowska-Ptasinska, Philip F. Halloran
Summary: The study found that in kidney transplant patients classified as having no rejection, there are subtle increases in antibody-mediated rejection-related transcripts in biopsies that are positive for DSA. As the frequency of DSA increases, there is a gradient of increasing molecular ABMR-like transcript expression in these biopsies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Biology
Markus Quante, Jasper Iske, Timm Heinbokel, Bhavna N. Desai, Hector Rodriguez Cetina Biefer, Yeqi Nian, Felix Krenzien, Tomohisa Matsunaga, Hirofumi Uehara, Ryoichi Maenosono, Haruhito Azuma, Johann Pratschke, Christine S. Falk, Tammy Lo, Eric Sheu, Ali Tavakkoli, Reza Abdi, David Perkins, Maria-Luisa Alegre, Alexander S. Banks, Hao Zhou, Abdallah Elkhal, Stefan G. Tullius
Summary: The study found significantly reduced systemic levels of taurodeoxycholic acid (TDCA) and L-valine in obese mice, which were restored to levels comparable with lean mice after sleeve gastrectomy (SGx). Systemic treatment with TDCA and valine induced profound weight loss, similar to the effects observed after SGx, by reducing food intake through central inhibition of melanin-concentrating hormone (MCH).
Article
Surgery
Philip F. Halloran, Katelynn S. Madill-Thomsen, Shane Pon, Majid L. N. Sikosana, Georg A. Boehmig, Jonathan Bromberg, Gunilla Einecke, Farsad Eskandary, Gaurav Gupta, Luis G. Hidalgo, Marek Myslak, Ondrej Viklicky, Agnieszka Perkowska-Ptasinska
Summary: In 398 kidney transplant biopsies with molecular antibody-mediated rejection, the 150 DSA-negative cases are earlier, less intense, and mostly C4d-negative, but use identical molecular mechanisms and have the same risk of graft loss as the 248 DSA-positive cases.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
