Article
Immunology
Christos Gogos, Konstantinos Stamos, Nikolaos Tsanaxidis, Ioannis Styliadis, Ioanna Koniari, Sophia N. N. Kouni, Cesare de Gregorio, Nicholas G. G. Kounis
Summary: Kounis syndrome is a disease that affects the circulatory system and can result in spasms and blood clot formation. It can occur due to allergic or hypersensitivity reactions and involves the release of inflammatory mediators. The syndrome can affect various arteries, including the coronary arteries.
Article
Multidisciplinary Sciences
Ziya Isiksacan, Angelo D'Alessandro, Susan M. Wolf, David H. McKenna, Shannon N. Tessier, Erdem Kucukal, A. Aslihan Gokaltun, Nishaka William, Rebecca D. Sandlin, John Bischof, Narla Mohandas, Michael P. Busch, Caglar Elbuken, Umut A. Gurkan, Mehmet Toner, Jason P. Acker, Martin L. Yarmush, O. Berk Usta
Summary: Transfusion of red blood cells is a valuable and widespread treatment in modern medicine. Current practices in blood transfusion overlook the variability in stored red blood cell quality. It is necessary to rethink transfusion medicine workflows and utilize novel technologies for assessing red blood cell quality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Hematology
Dina Vara, Reiner K. Mailer, Anuradha Tarafdar, Nina Wolska, Marco Heestermans, Sandra Konrath, Manuela Spaeth, Thomas Renne, Katrin Schroeder, Giordano Pula
Summary: The study suggests that inhibiting NOXs has strong antithrombotic effects partially due to increased intracellular cGMP levels, while sparing hemostasis. NOXs are potential pharmacotherapeutic targets for developing new antithrombotic drugs without bleeding side effects.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Hematology
Eric A. Gehrie, Bipin N. Savani, Garrett S. Booth
Summary: Advancements in laboratory testing, pathogen reduction, and donor qualification have significantly reduced the risk of infection from blood transfusions. However, the prevention and recognition of hemolytic reactions, particularly due to donor-recipient incompatibility, have seen little recent progress. The article discusses the role of compatibility testing and transfusion practices in acute hemolysis, emphasizing clinical scenarios with increased risk and outlining initial clinical management for severe hemolytic reactions.
Article
Hematology
Yan Zheng, Deqing Pei, Lori Sweat, Missy Ryan, Mark A. Mestemacher, Maria Gann, Cheng Cheng, Terrence L. Geiger
Summary: Pediatric hematology-oncology patients frequently require platelet transfusions, but allergic transfusion reactions (ATRs) are common. This study found that an individual platelet donor caused repeated ATRs in multiple recipients, with certain recipient characteristics increasing the likelihood of ATRs. The study did not identify donor-specific risk factors for ATRs.
Article
Critical Care Medicine
Ander Dorken Gallastegi, Leon Naar, Apostolos Gaitanidis, Anthony Gebran, Charlie J. Nederpelt, Jonathan J. Parks, John O. Hwabejire, Jason Fawley, April E. Mendoza, Noelle N. Saillant, Peter J. Fagenholz, George C. Velmahos, Haytham M. A. Kaafarani
Summary: The study found that trauma patients receiving massive transfusion more often have unbalanced platelet (PLT) transfusion than unbalanced fresh frozen plasma (FFP) transfusion. As the RBC:PLT ratio increased, there was a gradual increase in 24-hour mortality, while balanced platelet and fresh frozen plasma transfusion lowered the risk of death.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2022)
Article
Veterinary Sciences
Barbara Steblaj, Jasmin Galli, Paul Torgerson, Annette Kutter
Summary: The aim of this retrospective study was to investigate the association between leukoreduction of packed red blood cell units and transfusion reactions in dogs. The results showed no correlation between leukoreduction and reduction in transfusion reactions or better outcomes.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Surgery
Amanda R. Phillips, Lillian Tran, Jill E. Foust, Nathan L. Liang
Summary: The study aimed to investigate the benefit of a greater ratio of plasma/packed red blood cells in patients with rAAAs. Some studies found that a higher ratio of plasma to packed red blood cells was associated with decreased mortality, but overall risk of bias was serious and evidence quality was very low.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Chemistry, Analytical
Masako Sugihara-Seki, Nozomi Takinouchi
Summary: In this study, platelet-sized fluorescent particles were used as platelet substitutes to investigate the cross-sectional distribution of particles in red blood cell suspensions flowing through microchannels. The results showed that in square channels, particles focused near the four corners, while in circular channels, particles accumulated uniformly adjacent to the channel wall.
Review
Microbiology
Paolo Rebulla, Daniele Prati
Summary: This article reviews the development of pathogen reduction technologies for platelets and describes complementary strategies recommended by the US FDA. The reviewed studies show significant progress in this field, but further efforts are needed.
Article
Medicine, General & Internal
Jan A. Graw, Victoria Buenger, Lorenz A. Materne, Alexander Krannich, Felix Balzer, Roland C. E. Francis, Axel Pruss, Claudia D. Spies, Wolfgang M. Kuebler, Steffen Weber-Carstens, Mario Menk, Oliver Hunsicker
Summary: This study investigated the effects of different storage durations of PRBCs on ARDS patients. The results showed that prolonged storage of PRBCs did not increase mortality in adults with ARDS, but transfusion of long-term stored PRBCs was associated with prolonged dependence on RRT in critically ill patients with ARDS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Preeti Maurya, Sara K. Ture, Chen Li, Kristin M. Scheible, Kathleen E. McGrath, James Palis, Craig N. Morrell
Summary: Platelet transfusions are commonly used in preterm neonates with thrombocytopenia to reduce the risk of bleeding, but there is limited clinical evidence to support this practice. This study found that adult and neonatal platelets have differential effects on monocyte immune functions, which may affect neonatal immune function and transfusion complications.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Medicine, General & Internal
Theresa Ackfeld, Thomas Schmutz, Youcef Guechi, Christophe Le Terrier
Summary: Blood transfusions have been crucial for life support, but they can also cause serious adverse effects. It is important for physicians to stay updated on the pathophysiology, management, and risks of transfusion reactions. Preventing unnecessary transfusions and maintaining a restrictive strategy is key, especially during the COVID-19 pandemic when blood supplies are affected.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Nicolas Malvaux, Anne Schuhmacher, Fanette Defraigne, Remy Jacob, Aicha Bah, Marcia Cardoso
Summary: The Luxembourg Red Cross implemented a fully automated system and pathogen reduction technology to improve safety and efficiency of blood component manufacture. The introduction of FAS and PRT has increased productivity and safety without compromising quality, transforming the daily routine of blood component supply.
TRANSFUSION AND APHERESIS SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Run Yao, Danyang Yan, Xiangjie Fu, Ying Deng, Xi Xie, Ning Li
Summary: This study investigates the association between plasma/red blood cells (RBCs) transfusion ratio and in-hospital mortality in patients with acute type A aortic dissection (AAAD). The findings suggest that a 1:1 plasma/RBCs transfusion ratio is associated with the lowest mortality in AAAD patients. Plasma transfusion is identified as an independent risk factor for in-hospital mortality. There is a non-linear relationship between plasma/RBCs transfusion ratio and mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Juan B. Gutierrez, Omar S. Harb, Jie Zheng, Daniel J. Tisch, Edwin D. Charlebois, Christian J. Stoeckert, Steven A. Sullivan
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Article
Biochemistry & Molecular Biology
Scott T. Small, Lisa J. Reimer, Daniel J. Tisch, Christopher L. King, Bruce M. Christensen, Peter M. Siba, James W. Kazura, David Serre, Peter A. Zimmerman
Article
Infectious Diseases
Ezekiel Mupere, LaShaunda Malone, Sarah Zalwango, Alphonse Okwera, Mary Nsereko, Daniel J. Tisch, Isabel M. Parraga, Catherine M. Stein, Roy Mugerwa, W. Henry Boom, Harriet K. Mayanja, Christopher C. Whalen
BMC INFECTIOUS DISEASES
(2014)
Review
Infectious Diseases
Scott T. Small, Daniel J. Tisch, Peter A. Zimmerman
INFECTION GENETICS AND EVOLUTION
(2014)
Article
Immunology
Ann M. Moormann, Peter Odada Sumba, Kiprotich Chelimo, Hua Fang, Daniel J. Tisch, Arlene E. Dent, Chandy C. John, Carole A. Long, John Vulule, James W. Kazura
JOURNAL OF INFECTIOUS DISEASES
(2013)
Article
Infectious Diseases
Arlene E. Dent, Ann M. Moormann, Christopher T. Yohn, Rhonda J. Kimmel, Peter O. Sumba, John Vulule, Carole A. Long, David L. Narum, Brendan S. Crabb, James W. Kazura, Daniel J. Tisch
Article
Medicine, General & Internal
Lisa J. Reimer, Edward K. Thomsen, Daniel J. Tisch, Cara N. Henry-Halldin, Peter A. Zimmerman, Manasseh E. Baea, Henry Dagoro, Melinda Susapu, Manuel W. Hetzel, Moses J. Bockarie, Edwin Michael, Peter M. Siba, James W. Kazura
NEW ENGLAND JOURNAL OF MEDICINE
(2013)
Article
Multidisciplinary Sciences
Brajendra K. Singh, Moses J. Bockarie, Manoj Gambhir, Peter M. Siba, Daniel J. Tisch, James Kazura, Edwin Michael
Article
Hematology
Aaron A. R. Tobian, Alice K. Fuller, Kristin Uglik, Daniel J. Tisch, Prabhakar D. Borge, Richard J. Benjamin, Paul M. Ness, Karen E. King
Article
Public, Environmental & Occupational Health
James Matthias, Emily C. Zielinski-Gutierrez, Daniel J. Tisch, Danielle Stanek, Ronald E. Blanton, Michael S. Doyle, Robert B. Eadie, Elizabeth J. Gazdick, Andrea L. Leal, Kimberly J. Pattison, Carmen L. Perez-Guerra, Christopher J. Tittel, Jooi Vyas, Todd Wagner, Carina G. M. Blackmore
VECTOR-BORNE AND ZOONOTIC DISEASES
(2014)
Article
Infectious Diseases
Yi Wan Quah, Andreea Waltmann, Stephan Karl, Michael T. White, Ventis Vahi, Andrew Darcy, Freda Pitakaka, Maxine Whittaker, Daniel J. Tisch, Alyssa Barry, Celine Barnadas, James Kazura, Ivo Mueller
Article
Medicine, General & Internal
Maria Ome-Kaius, Johanna Helena Kattenberg, Sophie Zaloumis, Matthew Siba, Benson Kiniboro, Shadrach Jally, Zahra Razook, Daisy Mantila, Desmond Sui, Jason Ginny, Anna Rosanas-Urgell, Stephan Karl, Thomas Obadia, Alyssa Barry, Stephen J. Rogerson, Moses Laman, Daniel Tisch, Ingrid Felger, James W. Kazura, Ivo Mueller, Leanne J. Robinson
Article
Infectious Diseases
Livingstone Tavul, Moses Laman, Cade Howard, Bethuel Kotty, Anna Samuel, Catherine Bjerum, Kobie O'Brian, Steven Kumai, Matthew Amuga, Lina Lorry, Zebedee Kerry, Melvin Kualawi, Stephan Karl, Leo Makita, Lucy N. John, Sibauk Bieb, James Wangi, Gary J. Weil, Charles W. Goss, Daniel J. Tisch, William Pomat, Christopher L. King, Leanne J. Robinson
Summary: A community-based cluster-randomised trial in Papua New Guinea showed that the co-administration of ivermectin, diethylcarbamazine, and albendazole (IDA) was well-tolerated and more effective than diethylcarbamazine and albendazole (DA) for clearing microfilariae in lymphatic filariasis (LF) patients.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Moses Laman, Livingstone Tavul, Stephan Karl, Bethuel Kotty, Zebede Kerry, Stephen Kumai, Anna Samuel, Lina Lorry, Lincoln Timinao, S. Cade Howard, Leo Makita, Lucy John, Sibauk Bieb, James Wangi, Jeffrey M. Albert, Michael Payne, Gary J. Weil, Daniel J. Tisch, Catherine M. Bjerum, Leanne J. Robinson, Christopher L. King
Summary: Mass administration of a triple-drug regimen was more effective in reducing microfilariae prevalence in Papua New Guinea compared to a two-drug regimen, but did not significantly reduce circulating filarial antigen prevalence.
LANCET INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Darcy A. Freedman, Timothy H. Ciesielski, Owusua Yamoah, Elaine A. Borawski, Kristie R. Ross, Nora L. Nock, Eun Kyung Lee, Anastasia Dimitropoulos, Sonia Minnes, Kimberly Burkhart, Callie Ogland-Hand, Daniel J. Tisch
Summary: This study conducted a rapid-response research on childcare programs in Ohio during the COVID-19 pandemic. By evaluating passive surveillance data, conducting active surveillance with RT-PCR tests, and collecting feedback through focus groups, the study estimated the contribution of childcare settings to COVID-19 cases and emphasized the importance of expanding the incident reporting system for future health tracking.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)