Cellular-based therapies to prevent or reduce thrombocytopenia

Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes

(2011) Z.-J. Liu et al.   BLOOD

Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood

(2010) C. G. Brunstein et al.   BLOOD

Polyploid megakaryocytes can complete cytokinesis

(2010) Younes Leysi-Derilou et al.   CELL CYCLE

Individual and synergistic cytokine effects controlling the expansion of cord blood CD34+ cells and megakaryocyte progenitors in culture

(2010) Nicolas Pineault et al.   CYTOTHERAPY

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

(2010) Colleen Delaney et al.   NATURE MEDICINE

Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34+ cells are functionally active in an ex vivo flow model of thrombosis

(2009) I. I. Salles et al.   BLOOD

Improving outcomes of cord blood transplantation: HLA matching, cell dose and other graft- and transplantation-related factors

(2009) Vanderson Rocha et al.   BRITISH JOURNAL OF HAEMATOLOGY

Characterization and transplantation of induced megakaryocytes from hematopoietic stem cells for rapid platelet recovery by a two-step serum-free procedure

(2009) Te-Wei Chen et al.   EXPERIMENTAL HEMATOLOGY

Increased production of megakaryocytes near purity from cord blood CD34+ cells using a short two-phase culture system

(2008) Lucie Boyer et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Characterization of the Effects and Potential Mechanisms Leading to Increased Megakaryocytic Differentiation Under Mild Hyperthermia

(2008) Nicolas Pineault et al.   STEM CELLS AND DEVELOPMENT

Long–term platelet production assessed in NOD/SCID mice injected with cord blood CD34+ cells, thrombopoietin–amplified in clinical grade serum–free culture

(2007) Gianfranco Mattia et al.   EXPERIMENTAL HEMATOLOGY