Review
Biochemistry & Molecular Biology
Maurizio J. Goetz, Sarah Kremer, Judith Behnke, Birte Staude, Tayyab Shahzad, Lena Holzfurtner, Cho-Ming Chao, Rory E. Morty, Saverio Bellusci, Harald Ehrhardt
Summary: BPD, a devastating consequence of preterm birth, is mainly caused by mechanical ventilation, oxygen toxicity, and bacterial infections. Therapeutic options for BPD are currently limited, but MSC-based therapies show promise in inhibiting inflammation and promoting lung development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nursing
Maria Schubert, Dietmar Ausserhofer, Helga Bragadottir, Christian. M. Rochefort, Luk Bruyneel, Renate Stemmer, Panayiota Andreou, Marcel Leppee, Alvisa Palese
Summary: This scoping review highlights the effectiveness of specific interventions in reducing rationed or missed nursing care, where structural interventions such as increased nurse staffing and improved nursing teamwork, as well as process interventions, have shown significant reductions in missed nursing care rates. The findings provide valuable insights for clinicians, managers and researchers to adapt and implement interventions aimed at reducing rationed and missed nursing care.
JOURNAL OF ADVANCED NURSING
(2021)
Review
Public, Environmental & Occupational Health
Julii Brainard, Natalia R. Jones, Isabel Catalina Swindells, Elizabeth J. Archer, Anastasia Kolyva, Charlotte Letley, Katharine Pond, Iain R. Lake, Paul R. Hunter
Summary: This study conducted a systematic review of observational and experimental studies worldwide to evaluate the effectiveness of indoor air treatment technologies in preventing respiratory or gastrointestinal infections. The results suggest that while some air treatment technologies, such as germicidal lights and high efficiency particulate air filtration, can reduce environmental and surface samples, robust evidence for their effectiveness in reducing infections in real world settings is still lacking.
PREVENTIVE MEDICINE
(2023)
Article
Engineering, Biomedical
Paolo Contessotto, Abhay Pandit
Summary: Myocardial infarction is a leading cause of global mortality, with different treatment approaches being evaluated through clinical trials. Current research focuses on therapeutic targets such as ischemia, inflammation, fibrosis, angiogenesis, and cellular stress. Novel biomaterial-based systems and unexplored translational studies offer promising avenues for future therapeutic strategies.
Article
Agriculture, Dairy & Animal Science
Ana Belen Garcia-Delgado, Rafael Campos-Cuerva, Cristina Rosell-Valle, Maria Martin-Lopez, Carlos Casado, Daniela Ferrari, Javier Marquez-Rivas, Rosario Sanchez-Pernaute, Beatriz Fernandez-Munoz
Summary: In this study, we developed an experimental model using human stem cells grown in vitro to form brain organoids, and evaluated their potential for assessing the safety of cell therapy products. Our results suggest that brain organoids provide valuable information in the evaluation of cell therapies, and can help reduce the use of animals in regulatory studies.
Editorial Material
Medicine, General & Internal
John T. Wilkins, Donald M. Lloyd-Jones
Summary: This article reviews different lipid-lowering therapies including traditional statins and ezetimibe, as well as new therapies like PCSK-9 inhibitors, bempedoic acid, icosapent ethyl, and inclisiran, prescribed to reduce cardiovascular risk.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Nutrition & Dietetics
Carlee Harris, Krzysztof Czaja
Summary: Type 2 diabetes (T2D) is caused by insulin resistance and poor diet. High frequency eating disrupts the circadian clock and gut microbiome, leading to T2D. An improved diet with meal consistency, avoiding late-night eating, low meal frequency, and fasting can improve metabolic health and T2D. Early time-restricted eating (TRE) is more beneficial than other fasting methods.
Review
Chemistry, Medicinal
Maria Eva Mingot-Castellano, Jose Maria Bastida, Gonzalo Caballero-Navarro, Laura Entrena Urena, Tomas Jose Gonzalez-Lopez, Jose Ramon Gonzalez-Porras, Nora Butta, Mariana Canaro, Reyes Jimenez-Barcenas, Maria Del Carmen Gomez Del Castillo Solano, Blanca Sanchez-Gonzalez, Cristina Pascual-Izquierdo
Summary: Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts and bleeding risk. Current treatments have limitations, and therefore a thorough review of novel therapies is necessary. The pathophysiology of ITP is complex, but it also presents an opportunity to uncover new treatment targets.
Review
Cell Biology
David H. Jang, Sarah Piel, John C. Greenwood, Johannes K. Ehinger, Todd J. Kilbaugh
Summary: CO poisoning can lead to serious neurological complications for survivors, with treatment primarily relying on hyperbaric oxygen and newer approaches such as succinate prodrugs showing promise. However, there is a lack of cellular-based therapies in this area, highlighting the need for further research and development to improve treatment efficacy for patients with CO poisoning.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Hematology
Firas El Chaer, Jeffery J. Auletta, Roy F. Chemaly
Summary: Patients with hematologic malignancies and recipients of HCT are at higher risk of severe COVID-19 and have suboptimal response to vaccines. Treatment options should be selected based on host factors, virus factors, and therapeutic considerations.
Review
Green & Sustainable Science & Technology
Andrea Winterstetter, Marie Grodent, Venkatesh Kini, Kim Ragaert, Karl C. Vrancken
Summary: The study evaluated 51 technological solutions for marine plastic litter, with most being collection systems. Some solutions involve processing technologies, 10% offer digital solutions, and the rest focus on waste management solutions. The study concludes that the most cost-effective solution is to tackle land-based sources of marine litter, combining technology, people-oriented practices, and an effective valorization plan for captured debris.
Article
Infectious Diseases
Hitoshi Kawasuji, Yasuhiro Tsuji, Chika Ogami, Makito Kaneda, Yushi Murai, Kou Kimoto, Akitoshi Ueno, Yuki Miyajima, Yasutaka Fukui, Ippei Sakamaki, Yoshihiro Yamamoto
Summary: The study demonstrated that initially reducing the dose of linezolid in hemodialysis patients can lower the risk of linezolid-induced thrombocytopenia.
Review
Immunology
Ting Ge, Yunyun Shao, Xiaofeng Bao, Wenxuan Xu, Chunfeng Lu
Summary: Cellular senescence is an irreversible state of cell cycle arrest, which can both contribute to organ repair and regeneration in physiological conditions and prime multiple chronic diseases in pathological conditions. In liver diseases, such as alcoholic liver disease, nonalcoholic fatty liver disease, liver fibrosis, and hepatocellular carcinoma, cellular senescence plays a significant role. This review focuses on the importance of cellular senescence in liver diseases and summarizes potential targets for regulating senescence, aiming to provide new insights for further research and therapeutic developments.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Chris Keyworth, Rory O'Connor, Leah Quinlivan, Christopher J. Armitage
Summary: The study explored the acceptability of the VHS among individuals who have previously self-harmed, finding higher acceptability among younger adults, White ethnic groups, and those without long-term health conditions. Recommendations for improvements include enhancing formatting, adding new situations and responses, and providing clearer instructions.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Environmental Sciences
Andreea-Iulia Dobrescu, Agnes Ebenberger, Julia Harlfinger, Ursula Griebler, Irma Klerings, Barbara Nussbaumer-Streit, Andrea Chapman, Lisa Affengruber, Gerald Gartlehner
Summary: This study summarized the evidence on the effectiveness of soil remediation to prevent or reduce lead exposure. It found that soil remediation can reduce blood lead levels in children when used as a single intervention. However, the incremental benefit of soil remediation when combined with other interventions is limited.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
