Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors

Mycolic Acids: Structures, Biosynthesis, and Beyond

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Deciphering key features in protein structures with the new ENDscript server

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Mycobacterium tuberculosis Proteins Involved in Mycolic Acid Synthesis and Transport Localize Dynamically to the Old Growing Pole and Septum

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Structural analysis ofMycobacterium tuberculosisATP-binding cassette transporter subunit UgpB reveals specificity for glycerophosphocholine

(2013) Dunquan Jiang et al.   FEBS Journal

Progress in targeting cell envelope biogenesis inMycobacterium tuberculosis

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WHO's 2013 global report on tuberculosis: successes, threats, and opportunities

(2013) Alimuddin Zumla et al.   LANCET

Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

(2013) Chi Nguyen et al.   NATURE

Synthesis, Antitubercular Activity and Mechanism of Resistance of Highly Effective Thiacetazone Analogues

(2013) Geoffrey D. Coxon et al.   PLoS One

Structure analysis of the extracellular domain reveals disulfide bond forming-protein properties of Mycobacterium tuberculosis Rv2969c

(2013) Lu Wang et al.   Protein & Cell

Point Mutations within the Fatty Acid Synthase Type II Dehydratase Components HadA or HadC Contribute to Isoxyl Resistance in Mycobacterium tuberculosis

(2012) Laila Gannoun-Zaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Outwitting Evolution: Fighting Drug-Resistant TB, Malaria, and HIV

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Active Site Comparisons and Catalytic Mechanisms of the Hot Dog Superfamily

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Graphical tools for macromolecular crystallography inPHENIX

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A Common Mechanism of Inhibition of theMycobacterium tuberculosisMycolic Acid Biosynthetic Pathway by Isoxyl and Thiacetazone

(2012) Anna E. Grzegorzewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into the Mechanism and Inhibition of the β-Hydroxydecanoyl-Acyl Carrier Protein Dehydratase from Pseudomonas aeruginosa

(2012) Lucile Moynié et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutations in the essential FAS II β-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone inMycobacterium tuberculosisandMycobacterium kansasii

(2012) Juan M. Belardinelli et al.   MOLECULAR MICROBIOLOGY

The Mycobacterium Tuberculosis FAS-II Dehydratases and Methyltransferases Define the Specificity of the Mycolic Acid Elongation Complexes

(2011) Sylvain Cantaloube et al.   PLoS One

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

(2010) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases

(2010) Clinton R. Nishida et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Campylobacter jejuni fatty acid synthase II: Structural and functional analysis of β-hydroxyacyl-ACP dehydratase (FabZ)

(2009) Andrew S. Kirkpatrick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovering Potent Inhibitors Against the β-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) ofHelicobacter pylori: Structure-Based Design, Synthesis, Bioassay, and Crystal Structure Determination†

(2009) Lingyan He et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Past and Future of Tuberculosis Research

(2009) Iñaki Comas et al.   PLoS Pathogens

Three flavonoids targeting the β-hydroxyacyl-acyl carrier protein dehydratase fromHelicobacter pylori: Crystal structure characterization with enzymatic inhibition assay

(2008) Liang Zhang et al.   PROTEIN SCIENCE

The crystal structure of PfFabZ, the unique β-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum

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