In Sickness and in Health: The Role of TRAPP and Associated Proteins in Disease

VPS53mutations cause progressive cerebello-cerebral atrophy type 2 (PCCA2)

(2014) Miora Feinstein et al.   JOURNAL OF MEDICAL GENETICS

The PEG13-DMR and brain-specific enhancers dictate imprinted expression within the 8q24 intellectual disability risk locus

(2014) Franck Court et al.   Epigenetics & Chromatin

Recessive TRAPPC11 Mutations Cause a Disease Spectrum of Limb Girdle Muscular Dystrophy and Myopathy with Movement Disorder and Intellectual Disability

(2013) Nina Bögershausen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

(2013) Michael C. Bassik et al.   CELL

Aberrant and alternative splicing in skeletal system disease

(2013) Xin Fan et al.   GENE

A novel syndrome of hypohidrosis and intellectual disability is linked to COG6 deficiency

(2013) Ranad Shaheen et al.   JOURNAL OF MEDICAL GENETICS

Synbindin in Extracellular Signal-Regulated Protein Kinase Spatial Regulation and Gastric Cancer Aggressiveness

(2013) Xuan Kong et al.   JNCI-Journal of the National Cancer Institute

Regulation of ER-phagy by a Ypt/Rab GTPase module

(2013) Zhanna Lipatova et al.   MOLECULAR BIOLOGY OF THE CELL

The role of ERK2 in colorectal carcinogenesis is partly regulated by TRAPPC4

(2013) Yu-Rong Weng et al.   MOLECULAR CARCINOGENESIS

The wobbler mouse, an ALS animal model

(2013) Jakob Maximilian Moser et al.   MOLECULAR GENETICS AND GENOMICS

Expression and function of NIK- and IKK2-binding protein (NIBP) in mouse enteric nervous system

(2013) Y. Zhang et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Identification of novel determinants of resistance to lapatinib in ERBB2-amplified cancers

(2013) D Wetterskog et al.   ONCOGENE

The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway

(2013) D. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atrs20Mutation That Mimics an SEDT-Causing Mutation Blocks Selective and Non-Selective Autophagy: A Model for TRAPP III Organization

(2013) Stephanie Brunet et al.   TRAFFIC

Trs20 is Required for TRAPP II Assembly

(2013) David Taussig et al.   TRAFFIC

Trs20 is Required for TRAPP III Complex Assembly at the PAS and its Function in Autophagy

(2013) David Taussig et al.   TRAFFIC

The Unfolded Protein Response in Secretory Cell Function

(2012) Kristin A. Moore et al.   Annual Review of Genetics

TRAPPC9-related autosomal recessive intellectual disability: report of a new mutation and clinical phenotype

(2012) Giuseppe Marangi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A homozygous splice site mutation in TRAPPC9 causes intellectual disability and microcephaly

(2012) Naseebullah Kakar et al.   European Journal of Medical Genetics

Atg9 Vesicles Recruit Vesicle-tethering Proteins Trs85 and Ypt1 to the Autophagosome Formation Site

(2012) Soichiro Kakuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SEC23-SEC31 the Interface Plays Critical Role for Export of Procollagen from the Endoplasmic Reticulum

(2012) Sun-Don Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A BLOC-1 mutation screen reveals a novel BLOC1S3 mutation in Hermansky-Pudlak Syndrome type 8

(2012) Andrew R. Cullinane et al.   Pigment Cell & Melanoma Research

TRAPPC9 Mediates the Interaction between p150Glued and COPII Vesicles at the Target Membrane

(2012) Min Zong et al.   PLoS One

Sedlin Controls the ER Export of Procollagen by Regulating the Sar1 Cycle

(2012) R. Venditti et al.   SCIENCE

Trs130 Participates in Autophagy Through GTPases Ypt31/32 inSaccharomyces cerevisiae

(2012) Shenshen Zou et al.   TRAFFIC

Homozygosity mapping in 64 Syrian consanguineous families with non-specific intellectual disability reveals 11 novel loci and high heterogeneity

(2011) R Abou Jamra et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking

(2011) P. James Scrivens et al.   MOLECULAR BIOLOGY OF THE CELL

Sequential interactions with Sec23 control the direction of vesicle traffic

(2011) Christopher Lord et al.   NATURE

COPII and the regulation of protein sorting in mammals

(2011) Giulia Zanetti et al.   NATURE CELL BIOLOGY

A specific role for Arabidopsis TRAPPII in post-Golgi trafficking that is crucial for cytokinesis and cell polarity

(2011) Xingyun Qi et al.   PLANT JOURNAL

TRAPPC4-ERK2 Interaction Activates ERK1/2, Modulates Its Nuclear Localization and Regulates Proliferation and Apoptosis of Colorectal Cancer Cells

(2011) Shu-Liang Zhao et al.   PLoS One

The Adaptor Function of TRAPPC2 in Mammalian TRAPPs Explains TRAPPC2-Associated SEDT and TRAPPC9-Associated Congenital Intellectual Disability

(2011) Min Zong et al.   PLoS One

Organization and Assembly of the TRAPPII Complex

(2011) Catherine Choi et al.   TRAFFIC

Tethering Factors as Organizers of Intracellular Vesicular Traffic

(2010) I-Mei Yu et al.   Annual Review of Cell and Developmental Biology

Moonlighting proteins: An intriguing mode of multitasking

(2010) Daphne H.E.W. Huberts et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cranio-lenticulo-sutural dysplasia associated with defects in collagen secretion

(2010) SA Boyadjiev et al.   CLINICAL GENETICS

Fatal outcome due to deficiency of subunit 6 of the conserved oligomeric Golgi complex leading to a new type of congenital disorders of glycosylation

(2010) J. Lubbehusen et al.   HUMAN MOLECULAR GENETICS

MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening

(2010) Hesso Farhan et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Molecular organization of the COG vesicle tethering complex

(2010) Joshua A Lees et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular architecture of the TRAPPII complex and implications for vesicle tethering

(2010) Calvin K Yip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SEDLIN Forms Homodimers: Characterisation of SEDLIN Mutations and Their Interactions with Transcription Factors MBP1, PITX1 and SF1

(2010) Jeshmi Jeyabalan et al.   PLoS One

Sec24D-Dependent Transport of Extracellular Matrix Proteins Is Required for Zebrafish Skeletal Morphogenesis

(2010) Swapnalee Sarmah et al.   PLoS One

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex

(2010) F. J. Perez-Victoria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy

(2010) Molly A. Lynch-Day et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation in Archain 1, a Subunit of COPI Coatomer Complex, Causes Diluted Coat Color and Purkinje Cell Degeneration

(2010) Xinjie Xu et al.   PLoS Genetics

Combination of Linkage Mapping and Microarray-Expression Analysis Identifies NF-κB Signaling Defect as a Cause of Autosomal-Recessive Mental Retardation

(2009) Orianne Philippe et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of Mutations in TRAPPC9, which Encodes the NIK- and IKK-β-Binding Protein, in Nonsyndromic Autosomal-Recessive Mental Retardation

(2009) Asif Mir et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Truncating Mutation of TRAPPC9 Is Associated with Autosomal-Recessive Intellectual Disability and Postnatal Microcephaly

(2009) Ganeshwaran H. Mochida et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Biochemical consequences of sedlin mutations that cause spondyloepiphyseal dysplasia tarda

(2009) Mei Y. Choi et al.   BIOCHEMICAL JOURNAL

A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway

(2009) Franz Wendler et al.   EMBO JOURNAL

Deficiency in COG5 causes a moderate form of congenital disorders of glycosylation

(2009) P. Paesold-Burda et al.   HUMAN MOLECULAR GENETICS

Golgi function and dysfunction in the first COG4-deficient CDG type II patient

(2009) Ellen Reynders et al.   HUMAN MOLECULAR GENETICS

mTrs130 Is a Component of a Mammalian TRAPPII Complex, a Rab1 GEF That Binds to COPI-coated Vesicles

(2009) Akinori Yamasaki et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II

(2009) Klaus Schwarz et al.   NATURE GENETICS

Identification of the Novel TRAPP Associated Protein Tca17

(2009) Ben Montpetit et al.   TRAFFIC

TRAPPC2L is a Novel, Highly Conserved TRAPP-Interacting Protein

(2009) P. James Scrivens et al.   TRAFFIC

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes

(2008) Yiying Cai et al.   CELL

Diversity in Structure and Function of Tethering Complexes: Evidence for Different Mechanisms in Vesicular Transport Regulation

(2008) D. Kummel et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development

(2008) A. K. Townley et al.   JOURNAL OF CELL SCIENCE

The TRAPP Complex: Insights into its Architecture and Function

(2008) Michael Sacher et al.   TRAFFIC