Forward Genetic Screening Identifies a Small Molecule That Blocks Toxoplasma gondii Growth by Inhibiting Both Host- and Parasite-Encoded Kinases

TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production

(2013) Michael J. Brumlik et al.   EXPERIMENTAL PARASITOLOGY

Kinase Scaffold Repurposing for Neglected Disease Drug Discovery: Discovery of an Efficacious, Lapatanib-Derived Lead Compound for Trypanosomiasis

(2013) Gautam Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole

(2013) Julia D. Romano et al.   MOLECULAR BIOLOGY OF THE CELL

Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity

(2013) F. Imperi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1

(2013) Tatsuki Sugi et al.   International Journal for Parasitology-Drugs and Drug Resistance

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

(2012) Anjan Debnath et al.   NATURE MEDICINE

Fresh Approaches to Anti-Infective Therapies

(2012) C. Nathan   Science Translational Medicine

Failure of conventional treatment with pyrimethamine and sulfadiazine for secondary prophylaxis of cerebral toxoplasmosis in a patient with AIDS

(2011) B. Faucher et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

ATF6β is a host cellular target of theToxoplasma gondiivirulence factor ROP18

(2011) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Use of the Kinase Inhibitor Analog 1NM-PP1 Reveals a Role for Toxoplasma gondii CDPK1 in the Invasion Step

(2010) Tatsuki Sugi et al.   EUKARYOTIC CELL

Toxoplasma gondiiActivates Hypoxia-inducible Factor (HIF) by Stabilizing the HIF-1α Subunit via Type I Activin-like Receptor Kinase Receptor Signaling

(2010) Mandi Wiley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma

(2010) Sebastian Lourido et al.   NATURE

Tagging of Endogenous Genes in aToxoplasma gondiiStrain Lacking Ku80

(2009) My-Hang Huynh et al.   EUKARYOTIC CELL

Toxoplasma gondiiinfection and cerebral toxoplasmosis in HIV-infected patients

(2009) Vera Lucia Pereira-Chioccola et al.   Future Microbiology

A single polymorphic amino acid onToxoplasma gondiikinase ROP16 determines the direct and strain-specific activation of Stat3

(2009) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic Imaging of T Cell-Parasite Interactions in the Brains of Mice Chronically Infected with Toxoplasma gondii

(2009) Marie Schaeffer et al.   JOURNAL OF IMMUNOLOGY

Rapid whole-genome mutational profiling using next-generation sequencing technologies

(2008) D. R. Smith et al.   GENOME RESEARCH

Toxoplasma gondii Rhoptry Discharge Correlates with Activation of the Early Growth Response 2 Host Cell Transcription Factor

(2008) E. D. Phelps et al.   INFECTION AND IMMUNITY

Whole-genome sequencing and variant discovery in C. elegans

(2008) LaDeana W Hillier et al.   NATURE METHODS