Article
Environmental Sciences
Megha Murali, T. Shivanandappa
Summary: Endosulfan exposure causes high levels of oxidative stress in the liver and brain, leading to reduced antioxidant enzyme activity and increased ROS and lipid peroxidation. The brain is more susceptible to oxidative stress than the liver, likely due to its lower antioxidant defenses and higher oxygen consumption.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Khadija Sossey Alaoui, Bernard Tychon, Sandrine Joachim, Alain Geffard, Katherine Nott, Sebastien Ronkart, Jean-Marc Porcher, Remy Beaudouin, Christelle Robert, Marie-Laure Fauconnier, Matthew Saive
Summary: The study aimed to assess the toxicity of a mixture of five pharmaceutical drugs using Fontinalis antipyretica as a bioindicator and bioaccumulator. Results showed that only carbamazepine and irbesartan were accumulated by the species, with bioaccumulation levels increasing with exposure time. Antioxidant enzymes were sensitive to the drug mixture, with higher activity observed in plants exposed to higher concentrations. Chlorophyll content decreased in exposed plants, but photosynthetic activity was restored after 5 months. Morphological characteristics were less impacted by the treatment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Plant Sciences
Alberto Gonzalez, Daniel Laporte, Alejandra Moenne
Summary: The study found that cadmium induced oxidative stress in Ulva compressa, which was mitigated by activating antioxidant enzymes and synthesizing glutathione and ascorbate. Calcium-dependent protein kinases, calmodulin-dependent protein kinases, calcineurin B-like protein kinases, and MAPKs are involved in cadmium accumulation and GSH and phytochelatin synthesis.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Lyubka Koleva, Aisha Umar, Nasim Ahmad Yasin, Anis Ali Shah, Manzer H. H. Siddiqui, Saud Alamri, Luqman Riaz, Ali Raza, Talha Javed, Zunera Shabbir
Summary: The application of nanoparticles has been proved to be an efficient technique for mitigating stress in plants. In this study, the synergistic effect of iron oxide nanoparticles and silicon nanoparticles in alleviating cadmium toxicity in Phaseolus vulgaris was elucidated. The results showed that nanoparticles enhanced growth and gas exchange in Cd-contaminated plants, and the synergistic application of iron oxide nanoparticles and silicon nanoparticles increased potassium content and polyamine biosynthesis, alleviating cadmium stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hanna Lesiewska, Alina Wozniak, Pawel Reisner, Krzysztof Czosnyka, Joanna Stachura, Grazyna Malukiewicz
Summary: Oxidative stress and depletion of antioxidant defenses may contribute to cataract incidence in patients under 60 years. This study measured antioxidant enzyme activity, vitamin concentrations, and oxidative stress markers in cataract patients and controls. The results showed lower activity of antioxidant enzymes and lower concentrations of vitamins A and E in cataract patients. Additionally, higher levels of lipid peroxidation and protein oxidation were observed, indicating increased oxidative stress in cataract patients. Supplementation with antioxidants could be beneficial for this group of patients.
Article
Environmental Sciences
Jie Zhang, Xiaoning Liang, Simin Xie, Yupeng Liang, Shuang Liang, Jihai Zhou, Yongjie Huang
Summary: Hydrogen sulfide (H2S) as a gas signal molecule plays a role in physiological and biochemical processes. This experiment studied the effects of different concentrations of H2S pretreatment on the growth of Miscanthus sacchariflorus under Cd stress. The results showed that low concentrations of H2S promoted resistance to Cd stress, while high concentrations inhibited growth. H2S pretreatment at a concentration of 50 μM had the best effect in regulating plant growth under Cd stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Ge-Zi Li, Ying-Ying Wang, Jin Liu, Hai-Tao Liu, Huai-Pan Liu, Guo-Zhang Kang
Summary: Melatonin (MT) can alleviate cadmium (Cd) toxicity in wheat plants by enhancing growth, reducing oxidative stress, and regulating Cd uptake and translocation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Salah A. Sheweita, Ahmed Abd El Rafea, Sabah G. Elbana
Summary: Exposure to cadmium is related to liver and kidney diseases. The mechanisms of cadmium's contribution to these diseases are unclear. This study found that cadmium exposure induced oxidative stress, inhibited antioxidant enzyme activities, and altered drug-metabolizing enzyme activities in the liver. Silymarin and garlic extract were found to protect against cadmium toxicity and restore enzyme activities to normal levels. This research has important implications for the protection and prevention of cadmium-related health effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Agronomy
Masoumeh Asadi Aghbolaghi, Mohammad Sedghi, Raouf Seyed Sharifi, Beata Dedicova
Summary: The pollution and accumulation of heavy metals pose significant environmental and health risks. This study investigates the impact of organic matter (humic acid) on the germination and biochemical changes of pumpkin seeds under cadmium stress conditions.
Article
Biochemistry & Molecular Biology
Han-Mei Du, Chan Liu, Xin-Wu Jin, Cheng-Feng Du, Yan Yu, Shuai Luo, Wen-Zhu He, Su-Zhi Zhang
Summary: Aluminum (Al) toxicity is a major constraint for plant growth and cereal crop yield in acidic soils. This study identified a maize ALDH gene, ZmALDH, which is involved in protection against Al-induced oxidative stress. Overexpression of ZmALDH in Arabidopsis increased Al tolerance by promoting antioxidant mechanisms and reducing Al accumulation in roots.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Domenico Lapenna
Summary: Glutathione (GSH) is an important low-molecular weight thiol nucleophile and reductant with multiple functions, including antioxidant protection, detoxification, and cell signaling. It works in concert with GSH-dependent enzymes and its levels decline during aging, although elevated GSH levels in elderly individuals with good health suggest a potential link to increased healthspan and lifespan.
AGEING RESEARCH REVIEWS
(2023)
Article
Plant Sciences
Arnon Afonso de Souza Cardoso, Fabricio Teixeira de Lima Gomes, Joao Renato Rodrigues Antonio, Luiz Roberto Guimaraes Guilherme, Jiping Liu, Li Li, Maria Ligia de Souza Silva
Summary: The interaction between selenium and sulfur in plants and soils is important to study as it affects selenium nutrition and toxicity, crop composition and production, and the risk of toxicity to humans and animals. This study evaluated the impact of selenium exposure on rice plants grown under different sulfur supplies at different growth stages. The results showed that sulfate supply alleviated selenate toxicity, while soil clay content influenced selenate availability and adsorption capacity.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Agronomy
Agata Korbas, Jan Kubis, Magdalena Rybus-Zakjac, Tamara Chadzinikolau
Summary: The effects of short-term NaCl stress and spermidine level modification on polyamines level and antioxidant status in cucumber leaves were investigated. The results showed that salinity stress led to the accumulation of free polyamines in cucumber leaves, and application of spermidine improved the tolerance to salinity stress.
Review
Biochemistry & Molecular Biology
Evangelia Eirini Tsermpini, Una Glamoclija, Fulden Ulucan-Karnak, Sara Redensek Trampuz, Vita Dolzan
Summary: This article highlights the critical role of oxidative stress in COVID-19, discussing genetic variants within the oxidative stress pathway associated with the disease and exploring the use of antioxidant therapies in clinical trials for COVID-19 treatment, particularly glutathione and N-acetylcysteine.
Article
Plant Sciences
Ragia M. Mazrou, Sabry Hassan, Mei Yang, Fahmy A. S. Hassan
Summary: Exogenous melatonin (MT) treatment was found to extend the vase life of cut roses by maintaining relative water content and reducing stomatal aperture. In addition, MT treatment increased phenol content, enzyme activities, and radical scavenging capacity, while reducing H2O2 production and lipid peroxidation. This overall contributed to membrane stability maintenance and preservation of postharvest quality in cut flowers.
Review
Environmental Sciences
Agnieszka Czyzowska, Anna Barbasz
Summary: Modern nanotechnology has made it possible to obtain zinc oxide nanomaterials with unique properties for a wide range of commercial applications. The toxicity of these nanoparticles to humans and plants is a subject of concern, but their use also has potential benefits depending on concentration and synthesis methods.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Environmental Sciences
Anna Barbasz, Barbara Kreczmer, Magdalena Skorka, Agnieszka Czyzowska
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2020)
Article
Toxicology
Agnieszka Czyzowska, Barbara Dyba, Elzbieta Rudolphi-Szydlo, Anna Barbasz
Summary: The study aimed to assess the toxic effects of ZnO-NPs on model human immune cells, focusing on their interaction with membrane lipids and the role of zinc ions. Results showed disruption in cell metabolism and lipid peroxidation, with zinc ions not being the main causative factor of toxicity. Using Langmuir technique, the interaction of nanoparticles with lipids was evaluated to understand the early stages of toxicity mechanism for a complete risk assessment and safer synthesis of nanomaterials.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Toxicology
Agnieszka Czyzowska, Anna Barbasz
Summary: This study assessed the toxicity of zinc oxide nanoparticles with two diameters on human immune cells, finding that they induce cell death, mitochondrial damage, membrane lipid peroxidation, and inflammation induction.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Biophysics
Ditta Ungor, Anna Barbasz, Agnieszka Czyzowska, Edit Csapo, Magdalena Ocwieja
Summary: This study focused on the comparative cytotoxicity investigations of protein-stabilized gold nanoclusters on lymphocytes B and T cells. It was found that gamma G-Au NCs induced the highest disorders in mitochondrial activity, while LYZ- and gamma G-Au NCs enhanced the secretion of malonic dialdehyde. Despite minor effects on cell viability, all Au NCs caused oxidative stress and could stimulate undesirable cellular processes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Toxicology
Anna Barbasz, Magdalena Ocwieja, Natalia Piergies, Dorota Duraczynska, Anna Nowak
Summary: The study investigated the toxicity of silver nanoparticles synthesized using antioxidants on human cells, finding that GAAgNPs were more toxic than AAgNPs, with the presence of stabilizing agents being the main factor influencing toxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Barbara Dyba, Elzbieta Rudolphi-Szydlo, Anna Barbasz, Agnieszka Czyzowska, Konrad Kamil Hus, Vladimir Petrilla, Monika Petrillova, Jaroslav Legath, Aleksandra Bocian
Summary: The study aimed to determine the effects of exogenous application of three-finger toxins on monocytes (U-937) and promyelocytes (HL-60) cells, focusing on membrane modifications under the influence of various doses of 3FTx protein fraction. The results showed that protein-lipid interactions depended on the presence of lipid polar parts and the degree of membrane saturation. Biochemical indicators reflecting the tested cells confirmed the results obtained from the model.
Article
Chemistry, Physical
Agnieszka Czyzowska, Anna Barbasz, Lilianna Szyk-Warszynska, Magdalena Ocwieja, Edit Csapo, Ditta Ungor
Summary: This study investigated the comprehensive toxicity mechanism of protein-stabilized gold nanoclusters (Au NCs) on HL-60 cells, revealing a minor toxic effect and enhanced apoptosis, especially with LYZ-stabilized Au NCs having the most negative impact on the cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Toxicology
Agnieszka Czyzowska, Anna Barbasz, Elzbieta Rudolphi-Szydlo, Barbara Dyba
Summary: Studies have shown that zinc oxide nanoparticles exhibit toxicity towards cell membranes, with different cell lines showing varying reactions to the nanoparticles. Analysis using a model membrane revealed that interaction with zinc oxide nanoparticles results in changes in the model membrane.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Barbara Kreczmer, Barbara Dyba, Anna Barbasz, Elzbieta Rudolphi-Szydlo
Summary: Quercetin, a polyphenolic compound, exhibits potential anticancer, antiinflammatory, and antioxidant properties, but may also have pro-oxidative and cytotoxic effects. Research suggests that quercetin's action in cells may be primarily through altering the stiffness/elasticity of cell membranes, impacting cellular processes associated with membrane functions.
Article
Toxicology
Anna Barbasz, Agnieszka Czyzowska, Natalia Piergies, Magdalena Ocwieja
Summary: Silver nanoparticles prepared and stabilized by various bioactive substances, particularly antioxidants, exhibit different toxicity levels on melanoma cells. Human skin melanoma cells are more sensitive to AgNPs than murine melanoma cells when exposed to different combinations of antioxidants.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
