Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity

In vitro metabolism, disposition, preclinical pharmacokinetics and prediction of human pharmacokinetics of DNDI-VL-2098, a potential oral treatment for Visceral Leishmaniasis

(2014) Rao Mukkavilli et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Nitroimidazo-oxazole compound DNDI-VL-2098: an orally effective preclinical drug candidate for the treatment of visceral leishmaniasis

(2014) Suman Gupta et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Epidemiology of visceral leishmaniasis

(2014) Paul Ready   Clinical Epidemiology

TheREnantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis

(2013) Stephen Patterson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

(2013) Manu De Rycker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic Options for Visceral Leishmaniasis

(2013) Begoña Monge-Maillo et al.   DRUGS

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries

(2013) Carol A. Mulrooney et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections

(2013) ROB DON et al.   PARASITOLOGY

Leishmaniasis: clinical syndromes and treatment

(2013) B. S. McGwire et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

High Content Analysis of Primary Macrophages Hosting Proliferating Leishmania Amastigotes: Application to Anti-leishmanial Drug Discovery

(2013) Nathalie Aulner et al.   PLoS Neglected Tropical Diseases

Synthesis and Profiling of a Diverse Collection of Azetidine-Based Scaffolds for the Development of CNS-Focused Lead-like Libraries

(2012) Jason T. Lowe et al.   JOURNAL OF ORGANIC CHEMISTRY

A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes

(2012) Manu De Rycker et al.   PLoS Neglected Tropical Diseases

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

(2012) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Anti-infectives: Can cellular screening deliver?

(2011) Thomas H Keller et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

(2011) Geraldine De Muylder et al.   PLoS Neglected Tropical Diseases

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

(2010) Lisa A. Marcaurelle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets

(2010) Sivaraman Dandapani et al.   Nature Chemical Biology

Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds

(2010) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

In Vitro Susceptibilities of Leishmania donovani Promastigote and Amastigote Stages to Antileishmanial Reference Drugs: Practical Relevance of Stage-Specific Differences

(2009) M. Vermeersch et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapid fluorescent assay for screening drugs on Leishmania amastigotes

(2008) Orly Shimony et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Comparison of the expression profiles of promastigotes and axenic amastigotes in Leishmania donovani using serial analysis of gene expression

(2008) Qiaoli Li et al.   PARASITOLOGY RESEARCH

Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases

(2007) Ruth Brenk et al.   ChemMedChem

Retooling Leishmania metabolism: from sand fly gut to human macrophage

(2007) Doron Rosenzweig et al.   FASEB JOURNAL