Article
Agronomy
Zhenzhen Zhao, Lan Zhang, Yanning Zhang, Liangang Mao, Lizhen Zhu, Xingang Liu, Hongyun Jiang
Summary: The study investigated the enzymatic response of cytochrome P450 monooxygenase (CYP) and glutathione S-transferase (GST) genes after CPT treatment in the fat body cells of Spodoptera exigua. The effects of CPT on the growth and development of S. exigua larvae were also examined. The relative expression levels of selected CYP and GST genes changed significantly during the CPT treatment period, suggesting their involvement in CPT metabolism.
Article
Biochemistry & Molecular Biology
Vengai Mavangira, Matthew J. Kuhn, Angel Abuelo, Christophe Morisseau, Bruce D. Hammock, Lorraine M. Sordillo
Summary: Comparative analysis of sEH activity and oxidant status between healthy dairy cows and those with coliform mastitis revealed increased sEH activity in mammary tissue and elevated oxidant levels in milk of the mastitis group, suggesting potential therapeutic targets for coliform mastitis.
Article
Biochemistry & Molecular Biology
Dries Amezian, Ralf Nauen, Gaelle Le Goff
Summary: The genus Spodoptera is known for being polyphagous and destructive agricultural pests, with detoxification genes playing a crucial role in overcoming plant defense mechanisms. Despite a significant amount of expression data produced in the past decade for Spodoptera larvae in response to xenobiotics, the scattered information makes it difficult to clearly identify candidate genes involved in host plant adaptation and insecticide resistance. This review highlights the importance of detoxification genes in the genus and reveals a lack of genetic and biochemical information in some species, suggesting a need for further research in this area.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Dongqin Wei, Xin Tian, Longbo Zhu, Han Wang, Chao Sun
Summary: This study revealed the important role of ubiquitin-specific proteinase 14 (USP14) in the progression of nonalcoholic fatty liver disease (NAFLD). The overexpression of USP14 exacerbated the progression of NAFLD, while its knockdown had a mitigating effect. Furthermore, USP14 was found to promote lipid peroxidation and inflammation by regulating the protein level of cytochrome p4502E1 (CYP2E1). The study also demonstrated that USP14 facilitated the accumulation of CYP2E1 protein by inhibiting the degradation of heat shock protein 90 alpha family class A member 1 (HSP90AA1).
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Chandrima Shyam, Ednaldo A. Borgato, Dallas E. Peterson, Johanna Anita Dille, Mithila Jugulam
Summary: A Palmer amaranth population in Kansas has evolved resistance to six different herbicides, while remaining susceptible to others. The resistance is likely mediated by metabolic mechanisms involving cytochrome P450 and GST enzyme activity. Other management strategies may be needed to control such resistant populations.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Marie Perrin, Joffrey Moiroux, Sandrine Maugin, Jerome Olivares, Magali Rault, Myriam Siegwart
Summary: This study investigated the cross effects of temperature and insecticides on the survival of the codling moth and explored their underlying mechanisms. The results showed that high temperature reduced the effectiveness of emamectin and spinosad in controlling the codling moth, while temperature had no influence on the efficacy of chlorantraniliprole. Furthermore, the analysis of detoxification enzyme activities and gene expression revealed the complex biochemical responses of individuals facing multiple stresses.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Plant Sciences
Wei Tang, Shengnan Liu, Xiaoyue Yu, Yongjie Yang, Xiaogang Zhou, Yongliang Lu
Summary: Roegneria kamoji, a perennial monocot weed in winter wheat fields in China, shows high tolerance to metsulfuron-methyl and may enhance herbicide metabolism through GST and CytP450 enzymes, suggesting non-target-site mechanisms confer tolerance to metsulfuron-methyl.
Article
Plant Sciences
Xiaoyue Yu, Hanwen Wu, Jianping Zhang, Yongjie Yang, Wei Tang, Yongliang Lu
Summary: The resistant biotype of Polypogon fugax exhibits moderate resistance to metsulfuron-methyl herbicide and higher ALS enzyme activity. Additionally, GST and CYP-mediated metabolism play a role in the resistance mechanism. Malathion, a CYP inhibitor, has a synergistic effect with metsulfuron-methyl on the resistant biotype.
Review
Biochemistry & Molecular Biology
Dries Amezian, Ralf Nauen, Gaelle Le Goff
Summary: Arthropods have evolved various strategies, including the induction of detoxification enzymes, to defend themselves against a wide array of chemicals in their environment. Studies using advanced genetic tools in insects have substantially contributed to our understanding of the genomic basis of their xenobiotic response. Signaling pathways such as nuclear receptors and transcription factors play crucial roles in the upregulation of detoxification enzymes and can impact insects' adaptive processes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Christophe Morisseau, Sean D. Kodani, Shizuo G. Kamita, Jun Yang, Kin Sing Stephen Lee, Bruce D. Hammock
Summary: Epoxy-fatty acids (EpFAs) are endogenous lipid mediators with diverse biological activities; soluble epoxide hydrolase (sEH) is the primary enzyme for degrading EpFAs in vivo; recent studies suggest that microsomal epoxide hydrolase and epoxide hydrolase-3 also play significant roles in the metabolism of EpFAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shasha Liu, Ruohan Cheng, Hui He, Kunming Ding, Rongmi Zhang, Yuanyuan Chai, Qinwei Yu, Xin Huang, Luyong Zhang, Zhenzhou Jiang
Summary: This study investigated the effect and mechanism of 8-methoxypsoralen (8-MOP) on acetaminophen (APAP)-induced hepatotoxicity in mice. It was found that treatment with different doses of 8-MOP reduced liver damage caused by APAP, as evidenced by decreased serum transaminase levels and histopathological liver necrosis area. 8-MOP achieved this by inhibiting the enzymatic activities of Cyp2e1 and reducing the production of the toxic metabolite APAP-CYS. The results suggest that 8-MOP could be a potential therapeutic agent for APAP-induced liver toxicity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Biochemistry & Molecular Biology
Zeqi Shi, Zuowen He, Dao Wen Wang
Summary: Inflammation plays a crucial role in various systemic illnesses, and EETs have been found to have anti-inflammatory effects, reducing inflammation and remodeling of blood vessels. EETs also play important roles in other pathological conditions. Manipulating the AA-CYP450-EETs-sEH pathway has shown potential in alleviating inflammatory diseases, highlighting the importance of this research field.
Editorial Material
Biochemistry & Molecular Biology
F. Peter Guengerich
Summary: The paper introduces the concept of cytochrome b(5) as an auxiliary protein facilitating cytochrome P450 reactions, providing important insights for future research.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Medicine, Research & Experimental
Yanfang Zhang, Liangcai Gao, Bingyi Yao, Shengbo Huang, Yuanjin Zhang, Jie Liu, Zongjun Liu, Xin Wang
Summary: Epoxyeicosatrienoic acids (EETs) play a crucial role in heart function and their metabolic pathway serves as an important target for drug development and prevention of cardiotoxicity, showing promising prospects for cardiovascular disease treatment.
Article
Microbiology
Saurav Howlader, Min-Jung Kim, M. Rasheduzzaman Jony, Nguyen Phuoc Long, Yong-Soon Cho, Dong-Hyun Kim, Jae-Gook Shin
Summary: This study characterized the metabolic pathways and enzymes responsible for the metabolism of clofazimine in human liver microsomes. Eight metabolites, including oxidative metabolites, glucuronide conjugates, and sulfate conjugates, were identified. CYP1A2 and CYP3A were involved in the formation of oxidative metabolites, while UGT1A1, 1A3, 1A4, 1A9, and 2B4 were involved in the formation of glucuronide conjugates of oxidative metabolites of clofazimine.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Environmental Sciences
Hsiao-Chi Chuang, Li-Chen Chen, Yu-Chen Lei, Kuen-Yuh Wu, Po-Hao Feng, Tsun-Jen Cheng
ATMOSPHERIC ENVIRONMENT
(2015)
Article
Cardiac & Cardiovascular Systems
Hung-Ju Lin, Shu-Ting Chen, Hon-Yen Wu, Hsiu-Ching Hsu, Ming-Fong Chen, Yuan-Teh Lee, Kuen-Yuh Wu, Kuo-Liong Chien
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2015)
Article
Chemistry, Analytical
Hsin-Chang Chen, Charlene Wu, Kuen-Yuh Wu
Article
Biochemistry & Molecular Biology
Lars Barregard, Peter Moller, Trine Henriksen, Vilas Mistry, Gudrun Koppen, Pavel Rossner, Radim J. Sram, Allan Weimann, Henrik E. Poulsen, Robert Nataf, Roberta Andreoli, Paola Manini, Tim Marczylo, Patricia Lam, Mark D. Evans, Hiroshi Kasai, Kazuaki Kawai, Yun-Shan Li, Kazuo Sakai, Rajinder Singh, Friederike Teichert, Peter B. Farmer, Rafal Rozalski, Daniel Gackowski, Agnieszka Siomek, Guillermo T. Saez, Concha Cerda, Karin Broberg, Christian Lindh, Mohammad Bakhtiar Hossain, Siamak Haghdoost, Chiung-Wen Hu, Mu-Rong Chao, Kuen-Yuh Wu, Hilmi Orhan, Nilufer Senduran, Raymond J. Smith, Regina M. Santella, Yali Su, Czarina Cortez, Susan Yeh, Ryszard Olinski, Steffen Loft, Marcus S. Cooke
ANTIOXIDANTS & REDOX SIGNALING
(2013)
Article
Biochemical Research Methods
Yee Soon Ling, Hao-Jan Liang, Ming-Huan Lin, Chuan-Ho Tang, Kuen-Yuh Wu, Min-Liang Kuo, Ching Yu Lin
BIOMEDICAL CHROMATOGRAPHY
(2014)
Article
Chemistry, Medicinal
Chih-Chun Jean Huang, Chia-Fang Wu, Wei-Chung Shih, Yu-Syuan Luo, Ming-Feng Chen, Chien-Ming Li, Saou-Hsing Liou, Wen-Sheng Chung, Su-Yin Chiang, Kuen-Yuh Wu
CHEMICAL RESEARCH IN TOXICOLOGY
(2015)
Article
Environmental Sciences
Dalaijamts Chimeddulam, Kuen-Yuh Wu
Article
Environmental Sciences
Guang-Wen Lien, Ching-Chun Huang, Kuen-Yuh Wu, Mei-Huei Chen, Chien-Yu Lin, Chia-Yang Chen, Wu-Shiun Hsieh, Pau-Chung Chen
Article
Environmental Sciences
Kuan-Yen Tung, Kuen-Yuh Wu, Ching-Hui Tsai, Ming-Wei Su, Chien-Han Chen, Ming-Hung Lin, Yang-Ching Chen, Wen-Chia Wu, Yungling Leo Lee
ENVIRONMENTAL RESEARCH
(2013)
Article
Food Science & Technology
Yung-Lin Chu, Dalaijamts Chimeddulam, Lee-Yan Sheen, Kuen-Yuh Wu
FOOD AND CHEMICAL TOXICOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Yu-Wei Hsieh, Keh-Chung Lin, Mallikarjuna Korivi, Tsong-Hai Lee, Ching-Yi Wu, Kuen-Yuh Wu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2014)
Article
Public, Environmental & Occupational Health
Chu-Chih Chen, Yin-Han Wang, Kuen-Yuh Wu
Article
Environmental Sciences
Kyunghee Ji, Sungeun Kang, Gowoon Lee, Saeram Lee, Areum Jo, Kyunghee Kwak, Dohyung Kim, Dohyun Kho, Sangwoo Lee, Sunmi Kim, Sungkyoon Kim, Yuh-Fang Hiuang, Kuen-Yuh Wu, Kyungho Choi
SCIENCE OF THE TOTAL ENVIRONMENT
(2013)
Article
Engineering, Environmental
Chu-Chih Chen, Meng-Chiuan Shih, Kuen-Yuh Wu
STOCHASTIC ENVIRONMENTAL RESEARCH AND RISK ASSESSMENT
(2012)
Article
Clinical Neurology
Yu-wei Hsieh, Ching-yi Wu, Keh-chung Lin, Grace Yao, Kuen-yuh Wu, Ya-ju Chang