Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease

Title
Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease
Authors
Keywords
Trypanosoma cruzi, Chagas disease, Drug discovery, Parasitic diseases, Sterols, Drug metabolism, High throughput screening, Enzyme metabolism
Journal
PLoS Neglected Tropical Diseases
Volume 9, Issue 9, Pages e0004014
Publisher
Public Library of Science (PLoS)
Online
2015-09-23
DOI
10.1371/journal.pntd.0004014

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