Review
Biochemistry & Molecular Biology
Ziyu Kuang, Jingyuan Wu, Ying Tan, Guanghui Zhu, Jie Li, Min Wu
Summary: Doxorubicin (DOX) is a widely used chemotherapy drug for cancer treatment; however, its clinical utility is limited due to DOX-induced cardiotoxicity (DIC). Conventional detection methods are ineffective in early monitoring and detecting DIC. Therefore, there is a need for sensitive, accurate, and specific diagnostic and treatment methods. MicroRNAs (miRNAs) have been identified as stable and detectable molecules and are being studied as potential biomarkers and therapeutic targets for DIC. This review summarizes the current research on the diagnosis and treatment of miRNAs in DIC, discusses the feasibility and challenges of using miRNAs as diagnostic biomarkers and therapeutic targets, and provides recommendations for future studies.
Article
Oncology
Ying Chen, Yingjie Xu, Zhoufeng Deng, Yin Wang, Ying Zheng, Weihua Jiang, Li Jiang
Summary: This study used high-throughput deep-sequencing to analyze changes in global miRNA expression in Doxorubicin-induced cardiomyocytes, revealing the involvement of differentially expressed miRNAs in regulating key pathways including apoptosis, cell proliferation, oxidative stress, and lipid metabolism. These findings suggest that global wide miRNA profiling may provide new insights into understanding Doxorubicin-induced heart failure and cardiotoxicity, as well as identifying potential biomarkers and therapeutic targets.
Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Yanyan Jiang, Jing Chen, Yunchuang Sun, Fan Li, Luhua Wei, Wei Sun, Jianwen Deng, Yun Yuan, Zhaoxia Wang
Summary: The combination of salivary miR-29a-3p and miR-29c-3p shows potential as a diagnostic biomarker for idiopathic PD. The expression level of miR-29a-3p in PD patients was significantly lower than ET patients, but higher than MSA patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maia Segura-Wang, Bertrand Grenier, Suzana Ilic, Ursula Ruczizka, Maximiliane Dippel, Moritz Buenger, Matthias Hackl, Veronika Nagl
Summary: This study investigated the changes in miRNA expression induced by DON in porcine liver, jejunum, and serum. The serum miRNA response to DON increased over time and declined after removal of contaminated diets. Receiver operating curve analyses for individual miRNAs were significant, and a combination of four miRNAs increased the predictive capacity for DON exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Ji Hye Im, Tae Hoon Kim, Kyue-Yim Lee, Ho-Shin Gwak, Weiwei Lin, Jong Bae Park, Jong Heon Kim, Byong Chul Yoo, Seong-Min Park, Ji-Woong Kwon, Sang Hoon Shin, Heon Yoo
Summary: The study demonstrated the potential of extracellular microRNAs in cerebrospinal fluid as biomarkers for the diagnosis and pathogenesis study of leptomeningeal metastasis (LM). The unique miRNA profile in LM compared to brain metastasis (BM) suggests the importance of miRNAs in understanding LM pathogenesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Je-Jung Lee, So Young Kim, Songhee H. Kim, Seoyeon Choi, Bin Lee, Jeon-Soo Shin
Summary: In this study, the role of PD-L1 in cancer progression and its regulation of cancer prevention were investigated. It was found that PD-L1 depletion induced senescence in cancer cells by strongly inducing STING expression. Nuclear PD-L1 silencing increased STING promoter activity, indicating a negative regulation of STING expression by PD-L1 through transcriptional modulation. Furthermore, PD-L1 was shown to bind to the STING promoter region, directly controlling STING expression to promote cancer growth. Combining PD-L1 silencing with the senescence-inducing chemotherapeutic agent doxorubicin further enhanced the efficacy of PD-L1 targeting.
CELL DEATH & DISEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Palak Shah, Sean Agbor-Enoh, Pramita Bagchi, Christopher R. deFilippi, Angela Mercado, Gouqing Diao, Dave J. P. Morales, Keyur B. Shah, Samer S. Najjar, Erika Feller, Steven Hsu, Maria E. Rodrigo, Sabra C. Lewsey, Moon Kyoo Jang, Charles Marboe, Gerald J. Berry, Kiran K. Khush, Hannah A. Valantine, GRAfT Investigators
Summary: By analyzing and studying miR expression data in heart transplant patients, miR panels with high diagnostic accuracy for acute rejection can be developed, providing a new non-invasive method for clinical monitoring of heart transplant.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Cell Biology
Peter J. Kennel, P. Christian Schulze
Summary: MiRNA-regulated processes play a crucial role in cardiovascular homeostasis and disease, offering potential as biomarkers and therapeutic targets. Research on miRNA in heart failure diseases provides insight into new directions for heart failure treatment.
Article
Genetics & Heredity
Edward A. Mead, Nadia Boulghassoul-Pietrzykowska, Yongping Wang, Onaiza Anees, Noah S. Kinstlinger, Maximillian Lee, Shireen Hamza, Yaping Feng, Andrzej Z. Pietrzykowski
Summary: Alcohol Use Disorder (AUD) is a common mental disorder worldwide, and finding a reliable, cheap, and non-invasive biomarker for alcohol consumption is necessary. microRNAs can be detected in saliva and their expression is regulated by environmental factors. Analysis of microRNA expression in saliva of heavy alcohol abusers showed significant changes related to impaired immune system and development of epithelial cancer. Therefore, profiling microRNAs in saliva can serve as a non-invasive biomarker for monitoring alcohol abuse, alcohol-related inflammation, and early detection of cancer.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Dong-Sheng Pan, Bo Li, San-Long Wang
Summary: This study evaluated the changes in biomarkers during acute and chronic myocardial injury induced by the drug doxorubicin (DOX). The results showed that creatine kinase (CK), cardiac troponin I (cTnI), and fatty acid-binding protein 3 (FABP3) were relatively sensitive to DOX-induced acute myocardial injury, while cTnI and miR-146b were relatively sensitive to DOX-induced chronic myocardial injury. These findings suggest that these biomarkers can be useful for predicting and studying drug-induced cardiotoxicity.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Medicine, General & Internal
Sang Hoon Oh, Ho-Shik Kim, Kyu Nam Park, Sanghee Ji, Ji-Young Park, Seung Pill Choi, Jee Yong Lim, Han Joon Kim
Summary: Early circulating microRNAs (miRNAs) levels in cardiac arrest patients undergoing targeted temperature management (TTM) are associated with 6-month neurological outcomes. The predictive value of miRNAs is superior to protein biomarkers, especially when combined.
Article
Ophthalmology
Yingjie Zhang, Danyang Che, Yiting Cao, Yu Yue, Tianrui He, Yi Zhu, Jibo Zhou
Summary: This study aimed to identify differentially expressed microRNAs (miRNAs) in the aqueous humor of keratoconus (KC) eyes and explore their potential roles in KC pathophysiology. Next-generation sequencing revealed 14 differentially expressed miRNAs, with potential involvement in antigen processing, endocytosis, mismatch repair, and Hippo signaling. The concentrations of miR-222-3p, miR-3633p, and miR-423-5p in the aqueous humor could serve as potential KC biomarkers.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Oncology
Susan Swee-Shan Hue, Yu Jin, He Cheng, Muhammad Sufyan Bin Masroni, Lloyd Wei Tat Tang, Yong Howe Ho, Diana Bee-Lan Ong, Sai Mun Leong, Soo Yong Tan
Summary: It is challenging for pathologists to accurately diagnose small B-cell lymphomas due to overlapping morphological features and limitations of current ancillary testing. In this study, we identified and validated two sets of microRNA biomarkers that can distinguish small B-cell lymphomas from reactive lymphoid tissue and differentiate between the subtypes of these lymphomas. This study suggests that miRNA expression profiling may serve as a promising diagnostic tool for small B-cell lymphomas.
Article
Cardiac & Cardiovascular Systems
Luis M. Rincon, Macarena Rodriguez-Serrano, Elisa Conde, Val F. Lanza, Marcelo Sanmartin, Paz Gonzalez-Portilla, Marta Paz-Garcia, Jose Manuel Del Rey, Miriam Menacho, Maria-Laura Garcia Bermejo, Jose L. Zamorano
Summary: This study evaluated the prognostic value of circulating miRNAs for heart failure-related events among MI patients. It found that several miRNAs reliably predicted HF hospitalizations, cardiovascular mortality, and poor long-term NYHA status, improving current risk prediction methods.
Article
Pharmacology & Pharmacy
Varsha G. Desai, Taewon Lee, Carrie L. Moland, Vikrant Vijay, Tao Han, Sherry M. Lewis, Eugene H. Herman, James C. Fuscoe
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Letter
Reproductive Biology
Noriko Nakamura, Vikrant Vijay, Varsha G. Desai, Deborah K. Hansen, Tao Han, Ching-Wei Chang, Yu-Chuan Chen, Wafa Harrouk, Barry McIntyre, Paul M. Foster, James C. Fuscoe, Amy L. Inselman
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Immunology
Dong-Young Kim, Seung-Hwan Lee, Yan Fu, Feifeng Jing, Won-Young Kim, Sang-Bum Hong, Jung-A Song, Han Choe, Hyun Jin Ryu, Minjung Kim, Dahae Lim, Min-Seon Kim, Chae-Ok Yun, Taewon Lee, Hoon Hyun, Eun Young Choi
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Pharmacology & Pharmacy
James C. Fuscoe, Vikrant Vijay, Joseph P. Hanig, Tao Han, Lijun Ren, James J. Greenhaw, Richard D. Beger, Lisa M. Pence, Qiang Shi
DRUG METABOLISM AND DISPOSITION
(2020)
Article
Multidisciplinary Sciences
Jun Zhang, Gopalakrishnan Chandrasekaran, Wenting Li, Dong-Young Kim, In Young Jeong, So-Hyun Lee, Ting Liang, Jin Young Bae, Isaac Choi, Hyuno Kang, Jin-Soo Maeng, Myeong-Kyu Kim, Taewon Lee, Seung Woo Park, Min Jung Kim, Hyung-Seok Kim, Hyunju Ro, Yong Chul Bae, Hae-Chul Park, Eun Young Choi, Seok-Yong Choi
NATURE COMMUNICATIONS
(2020)
Article
Computer Science, Interdisciplinary Applications
Hangsuck Lee, Hongjun Ha, Taewon Lee
Summary: Modeling the interactions of competing risks that affect the occurrence of various decrements is crucial in survival analysis and actuarial science. This study discusses the conversion between probabilities of decrement and absolute rates under a general form of a distribution of fractional ages, and proposes a novel numerical algorithm for its solution. Extensive numerical experiments verify that the algorithm provides reliable results in terms of efficiency and accuracy.
COMPUTATIONAL STATISTICS & DATA ANALYSIS
(2021)
Article
Genetics & Heredity
Jung-Hwa Woo, Shukho Kim, Taewon Lee, Je-Chul Lee, Ji-Hyun Shin
Summary: This study revealed that antibiotic stress can induce the production of membrane vesicles (MVs) in L. monocytogenes, and MVs produced by L. monocytogenes exposed to sub-MIC of ampicillin can trigger strong pro-inflammatory responses by inducing TNF-alpha gene expression in host cells, potentially contributing to the pathology of listeriosis.
Article
Toxicology
Varsha G. Desai, Vikrant Vijay, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Taewon Lee, Kelly J. Davis, Levan Muskhelishvili, Kimo C. Stine, James C. Fuscoe
Summary: Research suggests that low doses of doxorubicin may lead to cardiotoxicity and subsequent cardiomyopathy. Experiments on mice showed that higher cumulative doses of DOX were associated with decreased cardiac function and increased cardiomyocyte apoptosis.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Editorial Material
Medicine, Legal
Joshua A. Harrill, Mark R. Viant, Carole L. Yauk, Magdalini Sachana, Timothy W. Gant, Scott S. Auerbach, Richard D. Beger, Mounir Bouhifd, Jason O'Brien, Lyle Burgoon, Florian Caiment, Donatella Carpi, Tao Chen, Brian N. Chorley, John Colbourne, Raffaella Corvi, Laurent Debrauwer, Claire O'Donovan, Timothy M. D. Ebbels, Drew R. Ekman, Frank Faulhammer, Laura Gribaldo, Gina M. Hilton, Stephanie P. Jones, Aniko Kende, Thomas N. Lawson, Sofia B. Leite, Pim E. G. Leonards, Mirjam Luijten, Alberto Martin, Laura Moussa, Serge Rudaz, Oliver Schmitz, Tomasz Sobanski, Volker Strauss, Monica Vaccari, Vikrant Vijay, Ralf J. M. Weber, Antony J. Williams, Andrew Williams, Russell S. Thomas, Maurice Whelan
Summary: Omics methodologies are widely used in toxicological research, but face challenges in gaining widespread regulatory acceptance due to lack of transparency in data processing methods and standardization in reporting. To foster further regulatory use of Omics data, the OECD's EAGMST launched a project to develop guidance for reporting Omics data.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Toxicology
Varsha G. Desai, Vikrant Vijay, Taewon Lee, Tao Han, Carrie L. Moland, Bounleut Phanavanh, Eugene H. Herman, Kimo Stine, James C. Fuscoe
Summary: The study identified miR-34a-5p as a potential circulating biomarker for early-onset cardiotoxicity caused by DOX, with its expression altered before the onset of myocardial injury and correlated with cardiac expression. Administration of a cardioprotective drug attenuated miR-34a-5p expression in both plasma and heart, suggesting its potential as an early biomarker. Higher expression of miR-34a-5p in plasma and heart also indicated its potential as an early biomarker of delayed-onset cardiotoxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Toxicology
Varsha G. Desai, Ana Azevedo-Pouly, Vikrant Vijay, Bounleut Phanavanh, Carrie L. Moland, Tao Han, Javier Revollo, Baikuntha Aryal, V. Ashutosh Rao, James C. Fuscoe
Summary: The present study found sexual dimorphism in cardiotoxicity induced by DOX, with more differentially expressed genes in males than females. The apelin-APJ pathway may play a critical role in sex-related differential DOX-induced cardiotoxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Toxicology
Noriko Nakamura, Vikrant Vijay, Daniel T. Sloper
JOURNAL OF TOXICOLOGICAL SCIENCES
(2020)