Review
Cell Biology
Florian Hermans, Lara Hemeryck, Ivo Lambrichts, Annelies Bronckaers, Hugo Vankelecom
Summary: Tooth development relies on interactions between dental epithelium and mesenchyme, regulated by molecular pathways including Wnt, BMP, FGF, and Shh. These signaling modules intertwine during tooth development, outlining specific cell populations' development pathways.Recent studies have uncovered crucial Wnt-Shh interactions during odontogenesis, showing conservation in developing ectodermal appendages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Marine & Freshwater Biology
Ting Zhang, Canchuan Zhang, Jin Zhang, Jiangtian Lin, Dongdong Song, Peng Zhang, Yang Liu, Lizhao Chen, Li Zhang
Summary: This study reveals the molecular mechanisms of cadmium toxicity on the early development of the swim bladder in zebrafish. Cadmium exposure inhibits Wnt and Hedgehog signaling pathways, disturbs surfactant lipid distribution, and impairs the formation of the swim bladder's tissue layers, leading to developmental defects.
AQUATIC TOXICOLOGY
(2022)
Correction
Neurosciences
I. Prajerova, P. Honsa, A. Chvatal, M. Anderova
Summary: There were errors in Fig. 3C and Supplementary Fig. S1 in the original article, involving the mistaken presentation of internal standard and the errors in presenting I3-catenin and active I3-catenin.
Article
Developmental Biology
Dong-Hoon Lee, Adam W. Olson, Jinhui Wang, Won Kyung Kim, Jiaqi Mi, Hong Zeng, Vien Le, Joseph Aldahl, Alex Hiroto, Xiwei Wu, Zijie Sun
Summary: This study utilized a mouse model to investigate the crucial role of stromal androgen signaling in prostate development at a single-cell level. The research revealed the importance of dynamic interactions between cells in driving early prostate development, shedding light on the molecular mechanisms involved in AR-initiated mesenchymal-epithelial interactions.
Review
Cell Biology
Sara Douceau, Tanya Deutsch Guerrero, Julien Ferent
Summary: A morphogen is a signaling molecule that induces cellular responses depending on its concentration. Sonic Hedgehog (Shh) is an important morphogen involved in various processes during embryonic development. This review discusses the sources of Shh during nervous system development, mechanisms of its distribution in surrounding tissues, and the consequences of disrupted distribution on neurodevelopmental disorders and cancers. Additionally, it highlights the use of contemporary techniques, like organoids, in re-examining the classical gradient model.
Article
Gastroenterology & Hepatology
Emilia J. Orzechowska-Licari, Agnieszka B. Bialkowska, Vincent W. Yang
Summary: This study reveals that upon ionizing radiation-induced injury, intestinal epithelial cells increase SHH secretion, stimulating stromal cells to secrete WNT ligands, which leads to the activation of reserve intestinal stem cells (rISCs) (marked by BMI1) and subsequent epithelial regeneration.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Genetics & Heredity
Sung-Eun Kim, Karla Robles-Lopez, Xuanye Cao, Kristyn Liu, Pooja J. Chothani, Nikitha Bhavani, Lauren Rahman, Saikat Mukhopadhyay, Bogdan J. Wlodarczyk, Richard H. Finnell
Summary: Gpr161 is a negative regulator of Sonic hedgehog signaling pathway and the absence of Gpr161 leads to structural defects in the neural tube and craniofacies. Gpr161 specifically impacts midbrain development and craniofacial bone formation during mouse embryogenesis.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Niraj Kumar Jha, Wei-Chih Chen, Sanjay Kumar, Rajni Dubey, Lung-Wen Tsai, Rohan Kar, Saurabh Kumar Jha, Piyush Kumar Gupta, Ankur Sharma, Rohit Gundamaraju, Kumud Pant, Shalini Mani, Sandeep Kumar Singh, Ricardo B. Maccioni, Tirtharaj Datta, Sachin Kumar Singh, Gaurav Gupta, Parteek Prasher, Kamal Dua, Abhijit Dey, Charu Sharma, Yasir Hayat Mughal, Janne Ruokolainen, Kavindra Kumar Kesari, Shreesh Ojha
Summary: Developmental signalling pathways play a central role in neuronal development and any aberration in these pathways can contribute towards neurological disorders. Extensive research has been conducted in the past decade on these pathways, revealing their potential as therapeutic targets for diseases.
Review
Biochemistry & Molecular Biology
Sotai Kimura, Tomoka Morita, Kosuke Hosoba, Hiroshi Itoh, Takashi Yamamoto, Tatsuo Miyamoto
Summary: Primary cilium is a non-motile, antenna-like structure on the cell surface that receives extracellular stimuli and initiates signal transduction. While primary cilia disappear in most cancers, some malignancies retain their primary cilia which play a role in tumorigenesis and tumor progression. Cholesterol enrichment in the ciliary membrane is crucial for Sonic hedgehog signaling, and targeting ciliary cholesterol may have therapeutic implications in progressive cancers.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kyungjoo Cho, Hyuk Moon, Sang Hyun Seo, Simon Weonsang Ro, Beom Kyung Kim
Summary: The study showed that the sonic hedgehog signaling pathway is up-regulated in cholangiocarcinoma (CCC), and that the sonic hedgehog inhibitor vismodegib has a significant inhibitory effect on CCC cells. In vivo experiments using a murine model of CCC confirmed the anti-cancer efficacy of vismodegib, suggesting that pharmacological inhibition of sonic hedgehog signaling could be an effective molecular target therapy for CCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Dominique Manikowski, Philipp Kastl, Sabine Schuermann, Kristina Ehring, Georg Steffes, Petra Jakobs, Kay Grobe
Summary: The study reveals that C-terminal cholesteroylation of Hedgehog is essential for early steps of production and maturation, but dispensable for signal reception at receiving cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Victor Martinez-Heredia, Danielle Blackwell, Sujith Sebastian, Timothy Pearson, Gi Fay Mok, Laura Mincarelli, Charlotte Utting, Leighton Folkes, Ernst Poeschl, Iain Macaulay, Ulrike Mayer, Andrea Munsterberg
Summary: Skeletal muscle stem cells play a crucial role in tissue homeostasis and repair. This study demonstrates that primary cilia and the Talpid3 gene are essential for self-renewal of muscle stem cells and proper muscle regeneration.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Andrew M. Hamilton, Olga A. Balashova, Laura N. Borodinsky
Summary: Research indicates that Hedgehog (Hh) signaling may be a useful target for driving regeneration, and non-canonical mechanisms of Hh signaling are necessary for spinal cord and muscle regeneration.
Article
Surgery
Ronan J. Kelly, Amir M. Ansari, Tomoharu Miyashita, Marianna Zahurak, Frank Lay, A. Karim Ahmed, Louis J. Born, Maryam K. Pezhouh, Kevan J. Salimian, Christopher Ng, Aerielle E. Matsangos, Anne-Heloise Stricker-Krongrad, Ken-ichi Mukaisho, Guy P. Marti, Christine H. Chung, Marcia I. Canto, Michelle A. Rudek, Stephen J. Meltzer, John W. Harmon
Summary: Itraconazole significantly reduces the development of esophageal adenocarcinoma and SHH expression in a preclinical animal model of Barrett's Metaplasia. In humans, BE tissue expresses higher levels of SHH, Indian Hedgehog, and bone morphogenic protein compared to normal squamous esophageal epithelium.
Review
Biochemistry & Molecular Biology
Marilyn D. Resh
Summary: This review discusses the role of Hedgehog acyltransferase (Hhat) in Hedgehog signaling, the importance of palmitoylation, and the potential involvement of Hhat in various cancers. Targeting hedgehog palmitoylation by inhibiting Hhat is considered a promising intervention in human disease.