Article
Biochemistry & Molecular Biology
Mohammad Z. Ahmed, Fahd A. Nasr, Wajhul Qamar, Omar M. Noman, Javed Masood Khan, Abdullah A. Al-Mishari, Ali S. Alqahtani
Summary: The study showed that janerin inhibits THP-1 cell proliferation in a dose-dependent manner by causing cell cycle arrest at the G2/M phase. Additionally, janerin promotes THP-1 cell death through apoptosis induction, which involves upregulation of pro-apoptotic markers and downregulation of anti-apoptotic marker. Furthermore, janerin treatment leads to the activation of P38-MAPK and ERK1/2 signaling pathways, suggesting its potential as a therapeutic agent for leukemia.
Article
Multidisciplinary Sciences
Changyin Zhou, Xue Zhang, Yilong Miao, Yu Zhang, Yu Li, Bo Xiong
Summary: Sororin functions as a regulator of meiotic G(2)-M transition and spindle assembly in mammalian oocytes, with its interactions with Cyclin B2 playing a crucial role in driving M phase entry and bipolar spindle formation in meiosis.
Article
Oncology
Ruixuan Wang, Tang Li, Guangren Li, Sheng-Xiang Lin
Summary: The upregulation of 17 beta-HSD7 in epithelial ovarian cancer cells leads to increased proliferation, which can be significantly reduced by knocking down the enzyme. Inhibition of 17 beta-HSD7 also results in negative feedback, lowering estradiol levels and increasing dihydrotestosterone levels, ultimately suppressing cell proliferation. Therefore, targeting 17 beta-HSD7 shows promise as a therapeutic strategy against malignant ovarian cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Wenshu Cong, Li Meng, Yuanjie Pan, Han Wang, Jiahui Zhu, Yuanyu Huang, Qingli Huang
Summary: Population aging is a global issue, and this study presents a novel approach using Pd-based single-atom nanozymes to improve mitochondrial function and attenuate aging. The nanozyme mimics enzyme activities in the mitochondrial respiratory chain and enhances mitochondrial activities and abundance. Additionally, it demonstrates excellent anti-aging and neuroprotective effects through the activation of the mitochondrial unfolded protein response (UPRmt) pathway.
Article
Biochemistry & Molecular Biology
Michal Jurasek, Jiri Rehulka, Lenka Hruba, Aleksandra Ivanova, Sona Gurska, Olena Mokshyna, Pavel Trousil, Lukas Huml, Pavel Polishchuk, Marian Hajduch, Pavel B. Drasar, Petr Dzubak
Summary: This study explored the effect of selected linkers on the biological activity of a dimer, and found that dimers with benzyl moieties substituted with one or more methoxy groups and longer branched structures were inactive, while other structures had comparable efficacy as the original dimer.
BIOORGANIC CHEMISTRY
(2023)
Article
Oncology
Yujie Huang, Yonghao Tian, Wenhao Zhang, Ruijuan Liu, Weifang Zhang
Summary: Rab12 was up-regulated in cervical cancer tissues and HPV+ cervical cancer cells. Knockdown of Rab12 enhanced radiosensitivity while overexpression of Rab12 promotes radioresistance. Rab12 regulates DNA double-strand breaks and DNA homologous recombination repair, affecting the radioresistance of cervical cancer cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shigeaki Sunada, Hiroko Saito, Doudou Zhang, Zeyu Xu, Yoshio Miki
Summary: CDK1 inhibitors regulate cellular sensitivity to DNA damage by controlling cell cycle progression and DNA repair inhibition, providing insights for developing clinical strategies targeting CDK1 inhibition in tumor cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Magdalena Delgado, Randall R. Rainwater, Billie Heflin, Alicja Urbaniak, Kaitlynn Butler, Mari Davidson, Reine M. Protacio, Giulia Baldini, Andrea Edwards, Megan R. Reed, Kevin D. Raney, Timothy C. Chambers
Summary: This study found that microtubule depolymerization induces different cell death pathways depending on the specific phase of the cell cycle. Cell death in M phase is associated with mitochondrial-mediated apoptosis, while cell death in G1 phase is associated with loss of mitochondrial transmembrane potential, parylation, nuclear translocation of apoptosis-inducing factor and endonuclease G, and supra-nucleosomal DNA fragmentation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Chih-Chiang Chien, Ming-Shun Wu, Shih-Wei Chou, Ganbolor Jargalsaikhan, Yen-Chou Chen
Summary: The study demonstrates the anti-cancer effects of evodiamine (EVO) on human anaplastic thyroid carcinoma (ATC) cells, with the endogenous p53 status affecting the sensitivity of cells to EVO-induced apoptosis and G2/M arrest. Mechanistically, EVO induces apoptosis and cell cycle arrest in cells by increasing p53 and downstream proteins, disrupting mitochondrial membrane potential, and increasing intracellular peroxide production.
Article
Chemistry, Medicinal
Zi-Wei Cai, Ting Ye, Pei-Wen Jiang, Yu-Jiao Liao, Lin Wang, Qing-Liang Zhang, Wen-Qian Du, Min Huang, Ping Yang, Min-Hui Li
Summary: This study aimed to investigate the inhibitory effect of alpha-momorcharin on the proliferation of multiple myeloma MM.1S cells. The results showed that alpha-momorcharin can inhibit the proliferation of MM.1S cells and induce cell death through cell cycle regulation and mitochondrial pathway-dependent apoptosis.
Article
Oncology
Yuhang Bao, Xiuxian Wu, Xinghua Jin, Akihiro Kanematsu, Michio Nojima, Yoshiyuki Kakehi, Shingo Yamamoto
Summary: Apigenin has inhibitory effects on renal cell carcinoma (RCC), suppressing cell growth and inducing cell cycle arrest. It shows potential as a novel therapeutic strategy for RCC treatment due to its anticancer activity and ability to modulate the cell cycle.
Article
Pharmacology & Pharmacy
Xun Zhang, Zhong Yao, Zhiyi Xue, Shuai Wang, Xuemeng Liu, Yaotian Hu, Yan Zhang, Jian Wang, Xingang Li, Anjing Chen
Summary: Resibufogenin (RB), a major component of traditional Chinese medicine Chansu, has shown potential in cancer treatment. This study found that RB induced G2/M phase arrest and inhibited invasion in glioblastoma cells. The mechanism involves the downregulation of CDC25C and upregulation of p21 through the MAPK/ERK pathway, as well as the elevation of intracellular Ca2+ to suppress the Src/FAK/Paxillin focal adhesion pathway. RB binds to ATP1A1, activating Na+-K+-ATPase and triggering the MAPK/ERK pathway and Ca2+-mediated Src/FAK/Paxillin pathway, resulting in G2/M phase arrest and inhibition of invasion in glioblastoma cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Limin Liu, Ting Liu, Rui Jia, Lizi Zhang, Zijian Lv, Yishan Qu, Shiren Sun, Fadao Tai
Summary: Hypoxia-regulated proximal tubular epithelial cells (PTCs) G2/M phase arrest/delay is involved in the production of renal tubulointerstitial fibrosis (TIF), which is a common pathological manifestation in patients with chronic kidney disease (CKD) and is often accompanied by lipid accumulation in renal tubules. However, the cause-effect relationship between hypoxia-inducible lipid droplet-associated protein (Hilpda), lipid accumulation, G2/M phase arrest/delay, and TIF remains unclear.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Food Science & Technology
Cheng Chen, Zhaobin Guo, Guoyuan Ma, Jibing Ma, Zhen Zhang, Qunli Yu, Ling Han
Summary: Lysosomal Fe2+ plays a crucial role in promoting postmortem tenderization of bovine muscles by facilitating mitochondrial-dysfunction-induced apoptosis.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guangya Xu, Xueling Yan, Zhongjia Hu, Lulu Zheng, Ke Ding, Yamei Zhang, Yi Qing, Tao Liu, Lijia Cheng, Zheng Shi
Summary: Glucocappasalin (GCP) from Descurainia sophia seeds shows potential antitumor activity in HeLa cervical carcinoma cells. GCP induces cell cycle G2/M-phase arrest, apoptosis, and autophagy by acting on the PI3K/AKT/mTOR signaling pathways, making it a promising agent for cervical cancer eradication.
FRONTIERS IN PHARMACOLOGY
(2021)