Article
Cardiac & Cardiovascular Systems
David Vivas, Jose Julio Jimenez, Roberto Martin-Asenjo, Esther Bernardo, Maria Aranzazu Ortega-Pozzi, Juan Carlos Gomez-Polo, Guillermo Moreno, Isidre Vilacosta, Julian Perez-Villacastin, Antonio Fernandez-Ortiz
Summary: Prasugrel and ticagrelor are more effective than aspirin in reducing cardiovascular events in acute coronary syndrome patients. Intravenous lysine acetylsalicylate (LA) achieves faster and more consistent platelet inhibition compared to oral aspirin. However, there is a lack of data on its effects in patients with ST-segment elevation myocardial infarction (STEMI).
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Multidisciplinary Sciences
Ibrahim M. El-Ashmawy, Marwa A. Ebeid, Moath S. M. Aljohani, Fahad A. Alhumaydhi, Abdullah S. M. Aljohani
Summary: This study found that Lysine Acetylsalicylate (LAS) has adverse effects on hepatorenal function and hematological parameters in a dose-dependent manner. Serum levels of several indicators increased while hematological parameters decreased. Additionally, histopathological changes were dose-dependent and persisted for 8 weeks at the higher dose.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Kuo-Ching Huang, Jui-Chen Li, Shu-Mei Wang, Chia-Hui Cheng, Chun-Hsiang Yeh, Li-Syun Lin, Hsin-Yi Chiu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The study found that CO-releasing molecules can reduce ROS generation and inflammation induced by Paraquat, thus decreasing the progression of lung fibrosis. CORM-3 and CORM-A1 have different effects on combating pulmonary fibrosis at different concentrations, suggesting a potential therapeutic approach for treating Paraquat toxicity.
Article
Biochemistry & Molecular Biology
Linlin Hou, Fang Yang, Yan Zhang, Yi Li, Hongyi Yan, Cuicui Meng, Yuqi Du, Huanzhou Zhu, Ding Yuan, Yanxia Gao
Summary: This study investigates the potential effects and mechanism of 2-methoxyestradiol (2ME) on PQ-induced pulmonary fibrosis. The results suggest that 2ME can ameliorate PQ-induced pulmonary fibrosis and inhibit the activation of the TGF-β/Smad2/3 signaling pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Review
Medicine, General & Internal
Angela Rizzi, Luca Gammeri, Raffaele Cordiano, Mariagrazia Valentini, Michele Centrone, Sabino Marrone, Riccardo Inchingolo, Franziska Michaela Lohmeyer, Carlo Cavaliere, Francesco Ria, Gabriella Cadoni, Sebastiano Gangemi, Eleonora Nucera
Summary: Chronic rhinosinusitis with nasal polyps (CRSwNP) is the most bothersome phenotype of chronic rhinosinusitis, characterized by Type 2 inflammatory reaction, comorbidities, and high rates of nasal polyp recurrence. Effective management includes anti-inflammatory treatment with local corticosteroids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Jingjing Xia, Zhuo Xiong, Jiaxuan Guo, Yongan Wang, Yuan Luo, Yangyang Sun, Zhongwei Guo, Bingchuan Lu, Ting Zhang, Wei Sun
Summary: Researchers designed a biomimetic multichannel micro-lung chip to mimic the interface between lung epithelium and interstitium for studying pulmonary fibrosis induced by PQ poisoning. The chip-based model showed decreased cell viability and significant changes in fibrosis-related proteins. Co-culturing A549 and MRC-5 cells in the chip induced severe epithelial-mesenchymal transition compared to the non-contact model. This novel co-culture micro-lung chip provides a new approach for studying lung fibrosis and drug development.
Article
Biochemistry & Molecular Biology
Nataliia Kovalchuk, Joseph L. Jilek, Laura S. Van Winkle, Nathan J. Cherrington, Xinxin Ding
Summary: The study used a lung-Cpr-null mouse model to investigate the role of lung POR in PQ-induced pulmonary fibrosis, finding that CPR plays a critical role in this process.
Article
Oncology
Feiya Jiang, Sha Li, Yu Jiang, Zhuo Chen, Tongtong Wang, Wen Liu
Summary: Fluorofenidone (AKF-PD) effectively alleviates paraquat (PQ)-induced pulmonary fibrosis by reducing oxidative stress and inflammatory factors, while inhibiting the PI3K/Akt/mTOR signaling pathway and upregulating autophagy.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Spectroscopy
An-Qi He, Qiang Li, Zhen-Qiang Yu, Jing Tian, Jun Song, Juan Feng, Yi-Zhuang Xu, Isao Noda, Yukihiro Ozaki
Summary: The interaction between bilirubin and terbium acetylsalicylate leads to energy transfer in the quenching process, significantly reducing luminescence.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Zohreh Mahmoudi, Hadi Kalantar, Esrafil Mansouri, Elaheh Mohammadi, Mohammad Javad Khodayar
Summary: This study evaluated the ameliorative effects of dimethyl fumarate (DMF) on lung damage induced by paraquat (PQ). The results demonstrated that DMF can mitigate PQ-induced lung damage through its antioxidant, anti-inflammatory, and antifibrotic activities.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marzieh Rashidipour, Bahram Rasoulian, Afshin Maleki, Behroz Davari, Naser Pajouhi, Ebrahim Mohammadi
Summary: In this study, it was found that encapsulation of paraquat in PEC/CS/TPP nanoparticles significantly reduced lung injury and fibrosis in a rat model of inhalation toxicity. Nanoencapsulation also led to lower apoptosis, oxidative stress, and alpha-SMA expression in lung tissue.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Zhou, Jin Liu, Lan-Lan Bu, Duan-Fang Liao, Shao-Wu Cheng, Xi-Long Zheng
Summary: The novel compound curcumin acetylsalicylate (CA) was found to extend the lifespan of Caenorhabditis elegans in a dose-dependent manner, decrease oxidative stress, and increase the expression of antioxidative genes. Activation of the DAF-16 transcription factor by CA may contribute to delaying aging in C. elegans.
Article
Plant Sciences
Weiwei Xu, Rui Peng, Siyu Chen, Congcong Wu, Xiaoxiao Wang, Ting Yu, Jiuying Jian, Ni Zhang, Siyang Zuo, Min Chen, Bing Guo, Lirong Liu
Summary: This study found that RTT extract has antifibrotic and anti-inflammatory effects on diabetic nephropathy, possibly through suppressing SMYD2 activation and H3K36me3 and H3K4me3 protein expression.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tongyu Wang, Jiahu Tian, Yuanzhe Jin
Summary: The study investigated the common mechanisms underlying ischemic heart disease and dilated cardiomyopathy, identifying the crucial role of vascular cell adhesion molecule 1 (VCAM1) in regulating different expressed genes, immune cell infiltration, and heart failure risk. Dysregulated VCAM1 expression was associated with heart failure risk, with implications for potential use as a biomarker or therapy target, linking to m6A RNA modification and immune regulation through the Wnt pathway.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Nasrin Shahabadi, Mohammad Moshiri, Ali Roohbakhsh, Mohsen Imenshahidi, Maryam Hashemi, Fatemeh Amin, Rezvan Yazdian-Robati, Zahra Salmasi, Leila Etemad
Summary: This study demonstrated that inhalation of SV-loaded PLGA NPs could effectively prevent the progression of PQ-induced pulmonary fibrosis, especially at a dose of 10 mg. Compared to the PQ group, this treatment significantly decreased inflammatory factors and contractile responses, showing promising results for the treatment of PQ poisoning.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rita Roque-Bravo, Rafaela Sofia Silva, Rui F. Malheiro, Helena Carmo, Felix Carvalho, Diana Dias da Silva, Joao Pedro Silva
Summary: Synthetic cannabinoids, a chemically diverse group of new psychoactive substances that target the endocannabinoid system, have more intense effects than cannabis and are increasingly being used recreationally. However, the rise in intoxications and deaths associated with synthetic cannabinoids poses a major public health concern and challenge for policy makers.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Toxicology
Ana Reis-Mendes, Felix Carvalho, Fernando Remiao, Emilia Sousa, Maria de Lourdes Bastos, Vera Marisa Costa
Summary: This study compares the cardiotoxicity of MTX and its metabolite NAPHT in an in vitro cardiac model and explores the role of metabolism in the cardiotoxic effects. The results show that MTX causes concentration-dependent cytotoxicity, affecting mitochondrial function and lysosome uptake, while NAPHT only exhibits concentration-dependent cytotoxicity. Inhibition or induction of metabolism has minimal impact on MTX-induced cytotoxicity, suggesting that metabolism is not a major contributor to MTX toxicity. However, autophagy is involved in MTX-induced cytotoxicity, potentially through the involvement of p62/LC3-II.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Sport Sciences
Laura Freitas, Andrea Bezerra, Tania Amorim, Ricardo J. Fernandes, Jose Duarte, Helder Fonseca
Summary: This study analyzed the effect of swimming on bone mass, cortical geometry, and trabecular microarchitecture. The results showed that swimmers have lower bone mass compared to athletes engaged in high-impact sports, but similar to those engaged in moderate- and non-impact sports as well as non-athletes. Swimmers' cortical geometry and trabecular microarchitecture were also found to be similar to those of athletes and non-athletes. However, the evidence was of poor quality.
GERMAN JOURNAL OF EXERCISE AND SPORT RESEARCH
(2023)
Review
Cell Biology
Beshoy Girgis, Davide Carvalho, Jose Alberto Duarte
Summary: The present review aimed to determine the efficacy and safety of high-voltage monophasic pulsed current (HVMPC) in treating diabetic ulcers. Thirty-two studies were included in the analysis, and HVMPC plus standard wound care (SWC) showed a likely increase in complete wound healing compared with sham/no stimulation plus SWC. Although conclusive evidence was not found, collateral evidence suggested a potential benefit of HVMPC. More research is needed to clarify the safe and effective application of electrical stimulation for wound healing.
WOUND REPAIR AND REGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Sandra I. Marques, Helena Carmo, Felix Carvalho, Susana I. Sa, Joao Pedro Silva
Summary: Immunohistochemical staining of brain samples provides valuable information on neurological mechanisms, but post-processing of DAB-stained photomicrographs is challenging. Traditionally, manual quantification of parameters in a large set of images is time-consuming and complex. This study presents an improved semi-automatic method using ImageJ's Skeletonize plugin and data processing software to quantify GFAP-labelled astrocytes in rat brain images, allowing faster and more efficient analysis of astrocyte size, number, branching, and activation indicators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Sport Sciences
Rita Pinho Ferreira, Jose Alberto Duarte
Summary: Skeletal muscle is a highly adaptable tissue that can change its mass and function in response to various stimuli. Protein synthesis and breakdown, regulated by multiple signaling pathways, play a crucial role in skeletal muscle mass. Different signaling pathways, such as Akt/mTOR signaling, ubiquitin-proteasome pathway, and autophagy, contribute differently to protein turnover and muscle mass depending on the condition and type of muscle. PGC-1α, by modulating mitochondria biogenesis, influences the cell's bioenergetic status and protein turnover. This review aims to provide an updated understanding of the molecular pathways involved in protein turnover regulation in skeletal muscle, with a focus on how lifestyle interventions, particularly exercise training, modulate various muscle proteins. An in-depth analysis of the anabolic effects of exercise programs will pave the way for personalized management of muscle wasting conditions.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Diana Nogueira, Ines Morais Caldas, Ricardo Jorge Dinis-Oliveira
Summary: This manuscript provides a comprehensive review on medication-related osteonecrosis of the jaw (MRONJ), including its pathophysiology, diagnosis, prevention, and other clinical and forensic aspects. The article also introduces a possible differential diagnosis and emphasizes the need for further research and consensus in treatment and management. Rating: 9/10.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Cell Biology
Ana Reis-Mendes, Mariana Ferreira, Ana Isabel Padrao, Jose Alberto Duarte, Margarida Duarte-Araujo, Fernando Remiao, Felix Carvalho, Emilia Sousa, Maria Lourdes Bastos, Vera Marisa Costa
Summary: This study assessed the short- and long-term cardiotoxicity of doxorubicin (DOX) in a mouse model and investigated the role of inflammation and antioxidant defenses in this cardiotoxicity. The results demonstrated that DOX induced adverse outcome pathways related to inflammation and oxidative stress, although activating different time-dependent response mechanisms.
Article
Pharmacology & Pharmacy
Vera Marisa Costa, Joao Paulo Capela, Maria Lourdes Bastos, Fernando Remiao, Kurt James Varner, Jose Alberto Duarte, Felix Carvalho
Summary: Prolonged overexposure to catecholamines causes toxicity due to continuous adrenoceptor stimulation, autoxidation, and reactive pro-oxidant species formation. This study investigated the contribution of oxidative stress in adrenaline-induced neurotoxicity using non-differentiated SH-SY5Y cells. Results showed that Adrenaline caused concentration- and time-dependent cytotoxicity in the cells, and N-acetyl-cysteine prevented the toxicity while the antioxidant Tiron was non-protective. Further analysis is needed to understand the involvement of these processes in catecholamine-induced peripheral neuropathy.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ana Sofia Almeida, Barbara Silva, Fernando Remiao, Carla Fernandes
Summary: This study presents the first determination of the permeability of MDPV across an intestinal epithelial cell monolayer. The enantiomers of MDPV were found to have high permeability across the Caco-2 monolayer. Enantioselectivity and efflux through a facilitated diffusion mechanism were also observed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Daniela Dantas, Ana I. Ribeiro, Filipe Carvalho, Eva Gil-Martins, Renata Silva, Fernando Remiao, Andrea Zille, Fatima Cerqueira, Eugenia Pinto, Alice M. Dias
Summary: This article describes a new route to obtain 2-aminoimidazole azo dyes with a unique substituent pattern in the heteroaryl unit that exhibit halochromic properties, changing from magenta to deep blue. The dyes also demonstrate potent antimicrobial properties against infectious yeasts. Cytotoxicity was not detected at concentrations lower than 16 μg mL(-1).
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Jessica Veiga-Matos, Ana I. Morales, Marta Prieto, Fernando Remiao, Renata Silva
Summary: This comprehensive review explores various models and techniques used to assess drug-induced P-gp modulation, highlighting the therapeutic implications of these modulators. Researchers present different approaches, including in vitro and in vivo experiments, and discuss their strengths and limitations. Additionally, the review focuses on the therapeutic significance of P-gp-mediated renal and intestinal elimination.
Review
Toxicology
Ana Dias-Carvalho, Susana Isabel Sa, Felix Carvalho, Eduarda Fernandes, Vera Marisa Costa
Summary: As life expectancy increases, the burden of neurologic disorders in the elderly has become a major challenge. Inflammation plays a crucial role in the development of aging and neurologic disorders, such as Alzheimer's, Parkinson's, and multiple sclerosis. Understanding the role of inflammation is essential for developing effective treatments and interventions to alleviate the social and economic burden of these diseases.
ARCHIVES OF TOXICOLOGY
(2023)