Article
Surgery
Shuhei Miura, Zahra A. Habibabady, Franziska Pollok, Madelyn Ma, Ivy A. Rosales, Kohei Kinoshita, Shannon Pratts, Gannon McGrath, Ryan Chaban, Siobhan Fogarty, Bernd Meibohm, Bruce Daugherty, Seth Lederman, Richard N. Pierson III
Summary: Blockade of the CD40/CD154 T cell costimulation pathway with a novel humanized anti-CD154 monoclonal antibody TNX-1500 showed promise in prolonging allograft survival, preventing alloantibody production, and inhibiting cardiac allograft vasculopathy in a nonhuman primate heart allotransplant model.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Endocrinology & Metabolism
Connie B. Newman, Jonathan A. Tobert
Summary: The discovery of PCSK9 as a therapeutic target for reducing LDL cholesterol has led to the development of monoclonal antibodies and gene silencing methods that effectively lower cholesterol levels. However, the use of these treatments in clinical practice is hindered by economic considerations.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Elena S. B. Campbell, Melanie M. Goens, Wenguang Cao, Brad Thompson, Leonardo Susta, Logan Banadyga, Sarah K. Wootton
Summary: Monoclonal antibodies (mAbs) are crucial in preventing and treating infectious diseases, especially when vaccines or therapies are lacking. Recent developments in mAb gene cloning have resulted in highly potent mAbs against various pathogens. Adeno-associated virus (AAV) vectors have been explored as a platform for delivering mAb genes, but further optimization is needed for improved therapeutic efficacy. This review summarizes the current landscape of AAV vectored immunoprophylaxis (VIP) in nonhuman primate (NHP) models and discusses major obstacles and implications for clinical translation.
Article
Cardiac & Cardiovascular Systems
Richard G. Lee, Anne Marie Mazzola, Maurine C. Braun, Colin Platt, Scott B. Vafai, Sekar Kathiresan, Ellen Rohde, Andrew M. Bellinger, Amit V. Khera
Summary: VERVE-101 is an investigational in vivo CRISPR base-editing medicine that can permanently lower low-density lipoprotein cholesterol by altering a single DNA base in the PCSK9 gene. The studies on nonhuman primates and mice demonstrated the efficacy, durability, tolerability, and lack of germline editing potential of VERVE-101.
Article
Multidisciplinary Sciences
Srinivas Kammanadiminti, Jason Comer, Gabriel Meister, Trevor Carnelley, Derek Toth, Shantha Kodihalli
Summary: In order to meet the requirements of the Animal Rule, the efficacy of monotherapy with ANTHRASIL was evaluated in blinded studies using rabbit and nonhuman primate models. The studies demonstrated that ANTHRASIL significantly improved survival rates in both animals, forming the basis for its approval by the FDA under the Animal Rule.
Review
Virology
Leonardo F. Ormundo, Carolina T. Barreto, Lilian R. Tsuruta
Summary: Antibody-based passive immunotherapy is effective in treating and preventing infectious diseases. Selecting neutralizing monoclonal antibodies (mAbs) and developing highly effective mAbs have become important strategies in combating emerging arbovirus infections.
Review
Biochemistry & Molecular Biology
Lin Ning, Hamza B. Abagna, Qianhu Jiang, Siqi Liu, Jian Huang
Summary: The global health crisis caused by the COVID-19 pandemic continues, with many therapeutic antibody treatments in development and authorized for emergency use by the FDA. Ongoing clinical trials worldwide have shown therapeutic antibody therapies to be a crucial part of COVID-19 treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Brian Effer, Isabela Perez, Daniel Ulloa, Carolyn Mayer, Francisca Munoz, Diego Bustos, Claudio Rojas, Carlos Manterola, Luis Vergara-Gomez, Camila Dappolonnio, Helga Weber, Pamela Leal
Summary: Cancer is a major cause of death and disease globally, and treatment options are continuously evolving. Monoclonal antibodies (mAbs) have been considered a fundamental aspect of modern cancer therapy in immunotherapy. To avoid side effects, it is important to identify specific molecular targets or biomarkers of therapy and/or diagnosis (theragnostic) when designing an appropriate immunotherapeutic regimen for any type of cancer. Additionally, understanding the mechanisms of action of currently employed mAbs in immunotherapy is crucial. This review provides a description of therapeutic targets used in cancer immunotherapy over the past 5 years, as well as emerging targets for potential therapeutic options in mAbs application for immunotherapy. It also explores the mechanisms of action of currently employed mAbs in immunotherapy.
Article
Medicine, Research & Experimental
James Austerberry, John Edwards, Tim Eyes, Jeremy P. Derrick
Summary: The method involves using a synthetic peptide microarray to study the binding behavior of therapeutic proteins under different solution conditions. By analyzing peptide adhesion profiles, quantitative relationships between solution conditions can be established, enabling comparisons of monoclonal antibodies. Machine learning methods, such as neural networks, can be applied to train data on indicators of protein stability and self-association, providing insights into therapeutic protein formulation.
MOLECULAR PHARMACEUTICS
(2021)
Article
Allergy
Inge Van de Walle, Karen Silence, Kevin Budding, Liesbeth Van de Ven, Kim Dijkxhoorn, Elisabeth de Zeeuw, Cafer Yildiz, Sofie Gabriels, Jean-Michel Percier, Johanna Wildemann, Jan Meeldijk, Peter J. Simons, Louis Boon, Linda Cox, Rob Holgate, Rolf Urbanus, Henny G. Otten, Jeanette H. W. Leusen, Christophe Blanchetot, Hans de Haard, C. Erik Hack, Peter Boross
Summary: ARGX-117 is a promising new complement inhibitor that uniquely targets both the classical and lectin pathways by binding to the Sushi-2 domain of C2. It prevents complement-mediated cytotoxicity in in vitro models for autoimmune hemolytic anemia and antibody-mediated rejection of organ transplants.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Vincent Dussupt, Kayvon Modjarrad, Shelly J. Krebs
Summary: The unprecedented Zika outbreak in the Americas from 2015-2016 led to global concern and accelerated the deployment of vaccine and therapeutic countermeasures. Several potent neutralizing antibodies against Zika and related flaviviruses have been discovered in recent years. Structure-based approaches have helped identify species-specific and cross-protective epitopes with therapeutic value.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xihua Lian, Amy Scott-Thomas, John G. Lewis, Madhav Bhatia, Sean A. MacPherson, Yiming Zeng, Stephen T. Chambers
Summary: Invasive aspergillosis is a life-threatening fungal disease that poses challenges for early and accurate diagnosis and treatment. Current diagnostic techniques are inadequate, resulting in patients being diagnosed as possible or probable cases without confirmation. Therefore, more precise diagnostic techniques and targeted antifungal treatments are needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Guang Wu, Lan Li, Mengnan Liu, Chunyan Chen, Guangze Wang, Zewei Jiang, Yaqian Qin, Licai He, Hongzhi Li, Jiawei Cao, Haihua Gu
Summary: The generated HzMUC1-ADC demonstrated promising targeted therapy potential for pancreatic cancer, as it inhibited tumor cell growth, induced apoptosis, and significantly reduced xenograft tumor growth in vivo.
CANCER CELL INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Junyi Zhang, Jie Xiang, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: A highly sensitive method for detecting cancer therapeutic monoclonal antibody in diluted human serums was established, which can selectively discriminate the target antibody and has the potential for developing versatile sensing platforms.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Immunology
Rania Bouzeyen, Babak Javid
Summary: Tuberculosis is a deadly bacterial infection and drug resistance poses a threat to successful treatment. Therapeutic vaccination, as a new treatment modality, holds potential as a useful adjunct therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Alessander O. Guimaraes, Yi Cao, Kyu Hong, Oleg Mayba, Melicent C. Peck, Johnny Gutierrez, Felicia Ruffin, Montserrat Carrasco-Triguero, Jason B. Dinoso, Angelo Clemenzi-Allen, Catherine A. Koss, Stacey A. Maskarinec, Henry F. Chambers, Vance G. Fowler, Amos Baruch, Carrie M. Rosenberger
CLINICAL INFECTIOUS DISEASES
(2019)
Review
Pharmacology & Pharmacy
April Neal-Kluever, Jeffrey Fisher, Lawrence Grylack, Satoko Kakiuchi-Kiyota, Wendy Halpern
DRUG METABOLISM AND DISPOSITION
(2019)
Article
Endocrinology & Metabolism
Michael T. Osborne, Amorina Ishai, Basma Hammad, Brian Tung, Ying Wang, Amos Baruch, Zahi A. Fayad, Jon T. Giles, Janet Lo, Lisa M. Shin, Steven K. Grinspoon, Karestan C. Koenen, Roger K. Pitman, Ahmed Tawakol
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Toxicology
Gautham K. Rao, Rodney A. Prell, Steven T. Laing, Stefanie C. M. Burleson, Allen Nguyen, Jacqueline M. McBride, Crystal Zhang, Daniel Sheinson, Wendy G. Halpern
TOXICOLOGICAL SCIENCES
(2019)
Article
Immunology
Alessander O. Guimaraes, Johnny Gutierrez, Stacey A. Maskarinec, Yi Cao, Kyu Hong, Felicia Ruffin, Montserrat Carrasco-Triguero, Melicent C. Peck, Vance G. Fowler, Amos Baruch, Carrie M. Rosenberger
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Immunology
Johnny Gutierrez, Alessander O. Guimaraes, Nicholas Lewin-Koh, Aklile Berhanu, Min Xu, Yi Cao, Janice Kim, Donghong Yan, Joanna K. Chang, Jason B. Dinoso, Catherine A. Koss, Angelo Clemenzi-Allen, Henry F. Chambers, Melicent C. Peck, Amos Baruch, Carrie M. Rosenberger
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Multidisciplinary Sciences
Chenguang Zhou, Hao Cai, Amos Baruch, Nicholas Lewin-Koh, Meng Yang, Fengxun Guo, Deming Xu, Rong Deng, Wouter Hazenbos, Amrita Kamath
Article
Veterinary Sciences
Adeyemi O. Adedeji, Vimala Vemireddi, Niraj Tripathi, Steffen Durinck, Jonathan M. Maher, Domagoj Vucic, Wendy Halpern
VETERINARY CLINICAL PATHOLOGY
(2020)
Article
Multidisciplinary Sciences
Irene Tom, Victoria C. Pham, Kenneth J. Katschke, Wei Li, Wei-Ching Liang, Johnny Gutierrez, Andrew Ah Young, Isabel Figueroa, Shadi Toghi Eshghi, ChingWei Lee, Jitendra Kanodia, Scott J. Snipas, Guy S. Salvesen, Phillip Lai, Lee Honigberg, Menno van Lookeren Campagne, Daniel Kirchhofer, Amos Baruch, Jennie R. Lill
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemical Research Methods
Gizette Sperinde, Meire Bremer, Henry R. Maun, Amos Baruch, Robert A. Lazarus, James T. Koerber, Rajesh Vij, Tangsheng Yi, Saloumeh K. Fischer, Tracy Staton
Article
Pathology
Justin D. Vidal, Karyn Colman, Manoj Bhaskaran, Eveline de Rijk, Darren Fegley, Wendy Halpern, Binod Jacob, Hitoshi Kandori, Balasubramanian Manickam, Sean McKeag, George A. Parker, Karen S. Regan, Benjamin Sefing, Michael Thibodeau, Vimala Vemireddi, Jonathan Werner, Aleksandra Zalewska
Summary: This article provides best practices for documenting the light microscopic assessment of sexual maturity in both rodent and nonrodent animals in nonclinical safety studies, aiming to assist study pathologists in accurately recording the sexual maturity status and providing a basis for further research.
TOXICOLOGIC PATHOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Harpreet S. Bhatia, Calvin Yeang, Amos Baruch, Xiaohong Yang, Erik S. G. Stroes, Sotirios Tsimikas
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Pathology
Wendy G. Halpern, April Kluever, Armando R. Irizarry Rovira
Summary: Postnatal development leads to changes in gastrointestinal tract and hepatic function, impacting drug metabolism and toxicity. Understanding these changes is crucial for evaluating drug toxicity and safe pediatric dosing.
TOXICOLOGIC PATHOLOGY
(2021)
Article
Pathology
Adeyemi O. Adedeji, Fiona Zhong, Jennifer A. Getz, Zoe Zhong, Wendy Halpern
Summary: The removal of core fucose from humanized monoclonal antibodies enhances their antibody-dependent cell cytotoxicity activities, but may lead to neutropenia. The presence of anti-drug antibodies (ADAs) may exacerbate this neutropenia in cynomolgus monkeys administered with afucosylated antibodies.
TOXICOLOGIC PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Amos Baruch, Chin Wong, Leslie W. Chinn, Anjali Vaze, Junichiro Sonoda, Thomas Gelzleichter, Shan Chen, Nicholas Lewin-Koh, Linda Morrow, Suresh Dheerendra, Richard Boismenu, Johnny Gutierrez, Eric Wakshull, Maria E. Wilson, Puneet S. Arora
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)