Identification and Pathway Mapping of Furan Target Proteins Reveal Mitochondrial Energy Production and Redox Regulation as Critical Targets of Furan Toxicity

Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions

(2011) Moritz Marcinowski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The biology of lysine acetylation integrates transcriptional programming and metabolism

(2011) Jigneshkumar Patel et al.   Nutrition & Metabolism

Identification of Furan Metabolites Derived from Cysteine−cis-2-Butene-1,4-dial−Lysine Cross-Links

(2010) Ding Lu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats

(2010) C. Hamberger et al.   DRUG METABOLISM AND DISPOSITION

Low Doses of the Carcinogen Furan Alter Cell Cycle and Apoptosis Gene Expression in Rat Liver Independent of DNA Methylation

(2010) Tao Chen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

VDAC, a multi-functional mitochondrial protein regulating cell life and death

(2010) Varda Shoshan-Barmatz et al.   MOLECULAR ASPECTS OF MEDICINE

Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver

(2010) Angela Mally et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Targeting GRP78 to enhance melanoma cell death

(2010) Shaun Martin et al.   Pigment Cell & Melanoma Research

Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family

(2010) B. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Evidence of Oxidative Stress and Associated DNA Damage, Increased Proliferative Drive, and Altered Gene Expression in Rat Liver Produced by the Cholangiocarcinogenic Agent Furan

(2010) K. C. Hickling et al.   TOXICOLOGIC PATHOLOGY

Subchronic Oral Toxicity Study of Furan in Fischer-344 Rats

(2010) S. Gill et al.   TOXICOLOGIC PATHOLOGY

Induction and Progression of Cholangiofibrosis in Rat Liver Injured by Oral Administration of Furan

(2010) K. C. Hickling et al.   TOXICOLOGIC PATHOLOGY

Involvement of thio-, peroxi-, and glutaredoxins in cellular redox-dependent processes

(2009) E. V. Kalinina et al.   BIOCHEMISTRY-MOSCOW

Suppression of NF- B activity by NDRG2 expression attenuates the invasive potential of highly malignant tumor cells

(2009) A. Kim et al.   CARCINOGENESIS

A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress

(2009) S M Lee et al.   CELL DEATH AND DIFFERENTIATION

Degraded Protein Adducts ofcis-2-Butene-1,4-dial Are Urinary and Hepatocyte Metabolites of Furan

(2009) Ding Lu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protein Electrophile-Binding Motifs: Lysine-Rich Proteins Are Preferential Targets of Quinones

(2009) M. T. Labenski et al.   DRUG METABOLISM AND DISPOSITION

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

(2009) J. E. Laine et al.   XENOBIOTICA

Liver Disease in Alpha 1-Antitrypsin Deficiency: A Review

(2008) Kyrsten D. Fairbanks et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

ALDH-2 deficiency increases cardiovascular oxidative stress---Evidence for indirect antioxidative properties

(2008) Philip Wenzel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional and Clinical Evidence for NDRG2 as a Candidate Suppressor of Liver Cancer Metastasis

(2008) D. C. Lee et al.   CANCER RESEARCH

Biomarkers of Furan Exposure by Metabolic Profiling of Rat Urine with Liquid Chromatography-Tandem Mass Spectrometry and Principal Component Analysis

(2008) Marco Kellert et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Proteomic Analysis of Diaminochlorotriazine Adducts in Wister Rat Pituitary Glands and LβT2 Rat Pituitary Cells

(2008) G. P. Dooley et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protein Targets of Reactive Metabolites of Thiobenzamide in Rat Liver in Vivo

(2008) Keisuke Ikehata et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Filling and mining the reactive metabolite target protein database

(2008) Robert P. Hanzlik et al.   CHEMICO-BIOLOGICAL INTERACTIONS

NDRG2 suppresses cell proliferation through down-regulation of AP-1 activity in human colon carcinoma cells

(2008) Young Jun Kim et al.   INTERNATIONAL JOURNAL OF CANCER