Article
Biochemistry & Molecular Biology
Leonie Dopavogui, Florence Cadoret, Gaspard Loison, Sara El Fouikar, Francois-Xavier Frenois, Frank Giton, Sandrine Ellero-Simatos, Frederic Lasserre, Arnaud Polizzi, Clemence Rives, Nicolas Loiseau, Roger D. Leandri, Nicolas Gatimel, Laurence Gamet-Payrastre
Summary: Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, is considered to be involved in this reproductive disorder. This study found that exposure to a common pesticide mixture can disrupt folliculogenesis in mice, leading to abnormal ovarian structure and changes in hormone levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Bruno Garcia Montagnini, Simone Forcato, Karine Vandressa Pernoncine, Mariana Cunha Monteiro, Marina Rangel Ferro Pereira, Nathalia Orlandini Costa, Estefania Gastadello Moreira, Janete Aparecida Anselmo-Franci, Daniela Cristina Ceccatto Gerardin
Summary: The study found that TCS may act as an endocrine disruptor for the reproductive system. Exposure to TCS was shown to decrease sperm viability and motility, potentially related to the programming of reproductive cells during fetal/neonatal development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Yoo-Mi Kim, Han Hyuk Lim
Summary: This study found that inhalation of lavender oil may trigger early puberty in female rats and is associated with increased luteinizing hormone levels.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Julie Boberg, Tianyi Li, Sofie Christiansen, Monica K. Draskau, Pauliina Damdimopoulou, Terje Svingen, Hanna K. L. Johansson
Summary: A prevailing challenge in testing chemical substances for their potential to cause female reproductive toxicity is the lack of suitable toxicological test methods. This study suggests that starting a 28-day experiment at weaning and including assessment of vaginal opening can increase the sensitivity to detect endocrine disruptors.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christian Giommi, Hamid R. Habibi, Michela Candelma, Oliana Carnevali, Francesca Maradonna
Summary: This study investigated the impact of a probiotic mixture on BPA-induced effects on reproduction in zebrafish. The results demonstrated that in fish exposed to the combination of BPA and probiotic, most transcripts were closer to control or probiotic-treated levels, suggesting the potential of the probiotic mixture to counteract BPA toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Iman Al-Saleh
Summary: The study suggests that DEHP may contribute to PCOS, but further investigation is needed to understand the underlying mechanisms.
Article
Cell Biology
Matthew D. Hale, Therese Koal, Tuan Hai Pham, John A. Bowden, Benjamin B. Parrott
Summary: Interactions between the endocrine system and environmental contaminants can impair reproductive development and function. This study investigated the transcriptional and steroidogenic responses of juvenile alligators from a polluted lake and a reference site. The results showed that alligators from the polluted lake displayed hyperandrogenism and hyper-sensitive transcriptional responses to gonadotropin stimulation. Site-specific transcriptional differences were driven by distinct subsets of transcriptional regulators, indicating alterations to genetic pathways governing ovarian function. The findings provide a high-resolution mapping of transcriptional patterns and advance our understanding of impaired reproductive health due to environmental endocrine disruption.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Bailey A. Kermath, Lindsay M. Thompson, Justin R. Jefferson, Mary H. B. Ward, Andrea C. Gore
Summary: Endocrine-disrupting chemicals (EDCs) can lead to changes in endocrine and neurobehavioral functions, especially during gestation and early life. This study found that exposure to EDCs in different generations of rats resulted in unique and sex-specific behavioral phenotypes, including changes in body weight, uterine weight, and mating behavior.
Article
Environmental Sciences
Saira Amir, Manolis Tzatzarakis, Charalampos Mamoulakis, Jaafar Haris Bello, Syed Ali Musstjab Akber Shah Eqani, Elena Vakonaki, Markos Karavitakis, Sikandar Sultan, Faheem Tahir, Syed Tahir Abbas Shah, Aristidis Tsatsakis
Summary: Male infertility is a major issue with various pathological factors such as endocrine disruption due to environmental pollution. Organochlorine pollutants can disrupt the male reproductive system, with PCBs, DDTs, and HCB being major concerns. Serum samples are the best for assessing health outcomes related to exposure levels.
ENVIRONMENTAL RESEARCH
(2021)
Article
Cell Biology
Gemma Fabozzi, Paola Rebuzzini, Danilo Cimadomo, Mariachiara Allori, Marica Franzago, Liborio Stuppia, Silvia Garagna, Filippo Maria Ubaldi, Maurizio Zuccotti, Laura Rienzi
Summary: The gut microbiota plays an important role in both male and female fertility, and dysbiosis of the gut microbiota may contribute to reproductive issues. Exposure to endocrine-disrupting chemicals is a major cause of gut microbiota dysbiosis and can have significant effects on host health and potential transgenerational effects.
Review
Biochemistry & Molecular Biology
Sheila I. Pena-Corona, Juan I. Chavez-Corona, Luis E. Perez-Caltzontzin, Dinorah Vargas-Estrada, C. Adriana Mendoza-Rodriguez, Edgar Ramos-Martinez, Jose L. Cerbon-Gutierrez, Jose A. Herrera-Barragan, David Quintanar-Guerrero, Gerardo Leyva-Gomez
Summary: Bisphenols are widely used plasticizers, but exposure to them is related to infertility and other pathologies. This study compared the protective effects of melatonin and vitamins against bisphenol-induced damage on reproductive variables. The results showed that melatonin improved sperm concentration and viability, while vitamins had negative effects on sperm concentration, testis weight, and testosterone levels. Molecular docking simulations suggested that vitamin E had the best binding affinity with androgen and estrogen receptors. These findings indicate that vitamins could act as endocrine disruptors, while melatonin is most effective in protecting against the toxic effects of bisphenols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Chelsea M. Cary, Talia N. Seymore, Dilpreet Singh, Kinal N. Vayas, Michael J. Goedken, Samantha Adams, Marianne Polunas, Vasanthi R. Sunil, Debra L. Laskin, Philip Demokritou, Phoebe A. Stapleton
Summary: This study assessed the toxicological consequences of inhalation exposure to polyamide micro- and nanoplastic particles (MNPs). The results showed that inhalation of MNPs can lead to inflammation, cardiovascular dysfunction, and endocrine disruption. These findings are important for understanding the toxicity of inhaled plastic particles.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Amanda E. Bries, Joseph L. Webb, Brooke Vogel, Claudia Carrillo, Aileen F. Keating, Samantha K. Pritchard, Gina Roslan, Joshua W. Miller, Kevin L. Schalinske
Summary: Letrozole-induced PCOS Sprague Dawley rats showed higher cumulative body weight gain compared to control, reduced time spent in proestrus, and increased time in metestrus. Furthermore, the ovarian abundance of Cbs mRNA and protein decreased in the early stages of PCOS in the letrozole-induced rats.
JOURNAL OF NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Monica Kam Draskau, Anna Kjerstine Rosenmai, Martin Scholze, Mikael Pedersen, Julie Boberg, Sofie Christiansen, Terje Svingen
Summary: Clotrimazole is a widely used antifungal drug, but studies have shown that its use during pregnancy can significantly alter hormone levels, potentially affecting the reproductive system of the fetus.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Microbiology
Tracey Bear, Nicole Roy, Julie Dalziel, Chrissie Butts, Jane Coad, Wayne Young, Shanthi G. Parkar, Duncan Hedderley, Hannah Dinnan, Sheridan Martell, Susanne Middlemiss-Kraak, Pramod Gopal
Summary: The relationship between microbiota profile and stress exposure is still unclear. A rat model of unpredictable chronic mild stress (UCMS) was used to investigate this relationship. Female Sprague Dawley rats showed atypical behaviors following UCMS, but no depressive-like behaviors were observed. The relative abundance of taxa from the Clostridiales order and Desulfovibrionaceae family correlated with anxiety-like behaviors and plasma cytokine concentrations, suggesting the brain-to-gut influence of mild anxiety with a microbiota profile that may involve inflammatory pathways.
Editorial Material
Veterinary Sciences
Midori G. Asakawa, Susan M. Lewis, Elizabeth L. Buckles, Tracy Stokol
VETERINARY CLINICAL PATHOLOGY
(2015)
Article
Veterinary Sciences
Emily A. Barrell, Midori Goto Asakawa, M. Julia B. Felippe, Thomas J. Divers, Tracy Stokol
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2017)
Editorial Material
Veterinary Sciences
Ashleigh W. Newman, Midori G. Asakawa, Tracy Stokol
VETERINARY CLINICAL PATHOLOGY
(2018)
Article
Fisheries
E. T. Anderson, S. Frasca, M. G. Asakawa, M. H. Fatzinger, J. Johnson, K. Marchetere, L. Goodale, G. R. Risatti, C. A. Harms
JOURNAL OF FISH DISEASES
(2012)
Article
Dermatology
Midori G. Asakawa, John M. Cullen, Keith E. Linder
VETERINARY DERMATOLOGY
(2013)
Article
Pathology
M. G. Asakawa, M. H. Goldschmidt, Y. Une, Y. Nomura
VETERINARY PATHOLOGY
(2008)
Article
Veterinary Sciences
Midori Goto Asakawa, Edward Mackillop, Natasha J. Olby, Ian D. Robertson, John M. Cullen
VETERINARY RADIOLOGY & ULTRASOUND
(2010)
Article
Veterinary Sciences
Kazushi Azuma, Makoto Asakawa, Toshiaki Konno, Shoko Fukuda, Midori Goto Asakawa
VETERINARY CLINICAL PATHOLOGY
(2019)
Article
Veterinary Sciences
Iori Koizumi, Daniela Hernandez-Muguiro, Shelley Ann Ash Chu, Tracy Stokol, Midori Goto Asakawa
FRONTIERS IN VETERINARY SCIENCE
(2020)
Article
Veterinary Sciences
Midori G. Asakawa, Marisa K. Ames, Yongbaek Kim
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
(2013)
Article
Pathology
M. Goto, Y. Nomura, Y. Une, M. H. Goldschmidt
VETERINARY PATHOLOGY
(2006)