Frontiers in Preclinical Safety Biomarkers

Gene Expression as Peripheral Biomarkers for Sporadic Alzheimer's Disease

(2017) Edna Grünblatt et al.   JOURNAL OF ALZHEIMERS DISEASE

MicroRNA changes in rat mesentery and serum associated with drug-induced vascular injury

(2012) Roberta A. Thomas et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Analytical aspects of microRNA in diagnostics: A review

(2011) Mariàngels de Planell-Saguer et al.   ANALYTICA CHIMICA ACTA

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

Quantitative miRNA Expression Analysis Using Fluidigm Microfluidics Dynamic Arrays

(2011) Jin Sung Jang et al.   BMC GENOMICS

MicroRNA profiling of diverse endothelial cell types

(2011) Matthew N McCall et al.   BMC Medical Genomics

Vesicle transfer and cell fusion

(2011) T. Kevin Howcroft et al.   CANCER BIOLOGY & THERAPY

MicroRNA Signatures: Novel Biomarker for Colorectal Cancer?

(2011) X. Luo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Cardiospecific microRNA Plasma Levels Correlate with Troponin and Cardiac Function in Patients with ST Elevation Myocardial Infarction, Are Selectively Dependent on Renal Elimination, and Can Be Detected in Urine Samples

(2011) Olof Gidlöf et al.   CARDIOLOGY

MicroRNA-145 in vascular smooth muscle cell biology: A new therapeutic target for vascular disease

(2011) Chunxiang Zhang   CELL CYCLE

Do Platform-Specific Factors Explain MicroRNA Profiling Disparities?

(2011) A. K. Watson et al.   CLINICAL CHEMISTRY

Circulating microRNAs as potential markers of human drug-induced liver injury

(2011) Philip J. Starkey Lewis et al.   HEPATOLOGY

Mitochondria Associate with P-bodies and Modulate MicroRNA-mediated RNA Interference

(2011) Lue Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome

(2011) Christian Widera et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

A specific miRNA signature in the peripheral blood of glioblastoma patients

(2011) Patrick Roth et al.   JOURNAL OF NEUROCHEMISTRY

Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages

(2011) Cecilia Lässer et al.   Journal of Translational Medicine

Body fluid derived exosomes as a novel template for clinical diagnostics

(2011) Sascha Keller et al.   Journal of Translational Medicine

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

The microRNA body map: dissecting microRNA function through integrative genomics

(2011) Pieter Mestdagh et al.   NUCLEIC ACIDS RESEARCH

Characterization of extracellular circulating microRNA

(2011) Andrey Turchinovich et al.   NUCLEIC ACIDS RESEARCH

Experimental strategies for microRNA target identification

(2011) D. W. Thomson et al.   NUCLEIC ACIDS RESEARCH

Transcriptional profiling to identify biomarkers of disease and drug response

(2011) Donna L Mendrick   PHARMACOGENOMICS

Impact of Cellular miRNAs on Circulating miRNA Biomarker Signatures

(2011) Radha Duttagupta et al.   PLoS One

Pre-microRNA and Mature microRNA in Human Mitochondria

(2011) Eric Barrey et al.   PLoS One

Exosomes Released from M.tuberculosis Infected Cells Can Suppress IFN-γ Mediated Activation of Naïve Macrophages

(2011) Prachi P. Singh et al.   PLoS One

Nuclear Outsourcing of RNA Interference Components to Human Mitochondria

(2011) Simonetta Bandiera et al.   PLoS One

Plasma miRNA as Biomarkers for Assessment of Total-Body Radiation Exposure Dosimetry

(2011) Wanchang Cui et al.   PLoS One

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microvesicles as mediators of intercellular communication in cancer—the emerging science of cellular ‘debris’

(2011) Tae Hoon Lee et al.   Seminars in Immunopathology

Identification of Urinary microRNA Profiles in Rats That May Diagnose Hepatotoxicity

(2011) Xi Yang et al.   TOXICOLOGICAL SCIENCES

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Transcriptional fingerprint of human whole blood at the site of coronary occlusion in acute myocardial infarction

(2011) Olivier Muller et al.   EuroIntervention

Small RNA and transcriptional upregulation

(2011) Victoria Portnoy et al.   Wiley Interdisciplinary Reviews-RNA

Cellular phenotype switching and microvesicles

(2010) Peter J. Quesenberry et al.   ADVANCED DRUG DELIVERY REVIEWS

MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction

(2010) Benjamin Meder et al.   BASIC RESEARCH IN CARDIOLOGY

On track with P-bodies

(2010) Meeta Kulkarni et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Whole blood-derived miRNA profiles as potential new tools for ovarian cancer screening

(2010) S F M Häusler et al.   BRITISH JOURNAL OF CANCER

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

(2010) Nobuyoshi Kosaka et al.   CANCER SCIENCE

Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs

(2010) Jacek Krol et al.   CELL

MicroRNAs in Angiogenesis and Vascular Smooth Muscle Cell Function

(2010) Susan Daubman   CIRCULATION RESEARCH

Circulating MicroRNAs in Patients With Coronary Artery Disease

(2010) Stephan Fichtlscherer et al.   CIRCULATION RESEARCH

Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes

(2010) Anna Zampetaki et al.   CIRCULATION RESEARCH

Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans

(2010) Tianrun Li et al.   CLINICA CHIMICA ACTA

Plasma MicroRNA-122 as a Biomarker for Viral-, Alcohol-, and Chemical-Related Hepatic Diseases

(2010) Y. Zhang et al.   CLINICAL CHEMISTRY

Robust MicroRNA Stability in Degraded RNA Preparations from Human Tissue and Cell Samples

(2010) M. Jung et al.   CLINICAL CHEMISTRY

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

Vascular microRNAs

(2010) Angelika Bonauer et al.   CURRENT DRUG TARGETS

Flow cytometric analysis of circulating microparticles in plasma

(2010) Aaron F. Orozco et al.   CYTOMETRY PART A

Insights into fetal and neonatal development through analysis of cell-free RNA in body fluids

(2010) Diana W. Bianchi et al.   EARLY HUMAN DEVELOPMENT

Circulating microRNAs are new and sensitive biomarkers of myocardial infarction

(2010) Yuri D'Alessandra et al.   EUROPEAN HEART JOURNAL

Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans

(2010) Guo-Kun Wang et al.   EUROPEAN HEART JOURNAL

Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis

(2010) F Reynier et al.   GENES AND IMMUNITY

Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury

(2010) Barbara A. Wetmore et al.   HEPATOLOGY

mir-17-92, a cluster of miRNAs in the midst of the cancer network

(2010) Virginie Olive et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Circulating miRNAs are correlated with tumor progression in prostate cancer

(2010) Jan C. Brase et al.   INTERNATIONAL JOURNAL OF CANCER

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA Loss Enhances Learning and Memory in Mice

(2010) W. Konopka et al.   JOURNAL OF NEUROSCIENCE

Cancer Biomarkers: Can We Turn Recent Failures into Success?

(2010) E. P. Diamandis   JNCI-Journal of the National Cancer Institute

Plasma microRNAs as potential biomarkers for non-small-cell lung cancer

(2010) Jun Shen et al.   LABORATORY INVESTIGATION

Expression profiling of microRNA using real-time quantitative PCR, how to use it and what is available

(2010) Vladimir Benes et al.   METHODS

mRNA and microRNA quality control for RT-qPCR analysis

(2010) C. Becker et al.   METHODS

In situ detection of microRNAs in paraffin embedded, formalin fixed tissues and the co-localization of their putative targets

(2010) Gerard J. Nuovo   METHODS

Robust one-day in situ hybridization protocol for detection of microRNAs in paraffin samples using LNA probes

(2010) Stine Jørgensen et al.   METHODS

Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR)

(2010) Evan M. Kroh et al.   METHODS

Serum microRNAs as non-invasive biomarkers for cancer

(2010) Jan C Brase et al.   Molecular Cancer

Towards consensus practices to qualify safety biomarkers for use in early drug development

(2010) Frank D Sistare et al.   NATURE BIOTECHNOLOGY

MicroRNA assassins: factors that regulate the disappearance of miRNAs

(2010) Zoya S Kai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Export of microRNAs and microRNA-protective protein by mammalian cells

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

Systemic miRNA-195 Differentiates Breast Cancer from Other Malignancies and Is a Potential Biomarker for Detecting Noninvasive and Early Stage Disease

(2010) H. M. Heneghan et al.   ONCOLOGIST

Whole Blood Transcriptomics in Cardiac Surgery Identifies a Gene Regulatory Network Connecting Ischemia Reperfusion with Systemic Inflammation

(2010) Orfeas Liangos et al.   PLoS One

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfiltration isolation of human urinary exosomes for characterization by MS

(2010) Michael L. Merchant et al.   Proteomics Clinical Applications

Time Course Characterization of Serum Cardiac Troponins, Heart Fatty Acid–binding Protein, and Morphologic Findings With Isoproterenol-induced Myocardial Injury in the Rat

(2010) Peter Clements et al.   TOXICOLOGIC PATHOLOGY

Circulating microRNAs, possible indicators of progress of rat hepatocarcinogenesis from early stages

(2010) Tokuo Sukata et al.   TOXICOLOGY LETTERS

Mechanism of MicroRNA-Target Interaction: Molecular Dynamics Simulations and Thermodynamics Analysis

(2010) Yonghua Wang et al.   PLoS Computational Biology

A translational approach to detecting drug-induced cardiac injury with cardiac troponins: Consensus and recommendations from the Cardiac Troponins Biomarker Working Group of the Health and Environmental Sciences Institute

(2009) Brian R. Berridge et al.   AMERICAN HEART JOURNAL

Effect of Hypoxia on Circulating Levels of Retina-Specific Messenger RNA in Type 2 Diabetes Mellitus

(2009) Amy Wong et al.   Annals of the New York Academy of Sciences

Stability of β-Actin mRNA in Plasma

(2009) N.C. Holford et al.   Annals of the New York Academy of Sciences

Optimization of Purification of Human Cell-Free mRNA from Plasma

(2009) Tadeja Dovc-Drnovsek et al.   Annals of the New York Academy of Sciences

MicroRNA isolation and stability in stored RNA samples

(2009) M. Mraz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Validation of extraction methods for total RNA and miRNA from bovine blood prior to quantitative gene expression analyses

(2009) Andrea Hammerle-Fickinger et al.   BIOTECHNOLOGY LETTERS

miRNAs in lung cancer - Studying complex fingerprints in patient's blood cells by microarray experiments

(2009) Andreas Keller et al.   BMC CANCER

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

MicroRNA-145, a Novel Smooth Muscle Cell Phenotypic Marker and Modulator, Controls Vascular Neointimal Lesion Formation

(2009) Yunhui Cheng et al.   CIRCULATION RESEARCH

A Necessary Role of miR-221 and miR-222 in Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

(2009) Xiaojun Liu et al.   CIRCULATION RESEARCH

Cardiac troponin may be released by ischemia alone, without necrosis

(2009) Peter E. Hickman et al.   CLINICA CHIMICA ACTA

MicroRNA Expression Ratio Is Predictive of Head and Neck Squamous Cell Carcinoma

(2009) M. Avissar et al.   CLINICAL CANCER RESEARCH

Plasma miR-208 as a Biomarker of Myocardial Injury

(2009) X. Ji et al.   CLINICAL CHEMISTRY

Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury

(2009) O. F. Laterza et al.   CLINICAL CHEMISTRY

The miR-430/427/302 Family Controls Mesendodermal Fate Specification via Species-Specific Target Selection

(2009) Alessandro Rosa et al.   DEVELOPMENTAL CELL

A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance

(2009) Eva van Rooij et al.   DEVELOPMENTAL CELL

Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening

(2009) E K O Ng et al.   GUT

MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets

(2009) Raffaele Baffa et al.   JOURNAL OF PATHOLOGY

Microfluidic isolation and transcriptome analysis of serum microvesicles

(2009) Chihchen Chen et al.   LAB ON A CHIP

C-Path sets diagnostics standard

(2009) Jim Roberts   NATURE BIOTECHNOLOGY

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

miRNA in situ hybridization in formaldehyde and EDC–fixed tissues

(2009) John T G Pena et al.   NATURE METHODS

Detection of Cancer with Serum miRNAs on an Oligonucleotide Microarray

(2009) Michael J. Lodes et al.   PLoS One

Expression Profile of MicroRNAs in Young Stroke Patients

(2009) Kay Sin Tan et al.   PLoS One

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-like off-target transcript regulation by siRNAs is species specific

(2009) J. Burchard et al.   RNA

Absolute quantification of microRNAs by using a universal reference

(2009) U. Bissels et al.   RNA

Qualification of Cardiac Troponin I Concentration in Mouse Serum Using Isoproterenol and Implementation in Pharmacology Studies to Accelerate Drug Development

(2009) Steven K. Engle et al.   TOXICOLOGIC PATHOLOGY

A Novel Strategy for the Invasive Toxin: Hijacking Exosome-Mediated Intercellular Trafficking

(2009) Fan Zhang et al.   TRAFFIC

Membrane array-based differential profiling of platelets during storage for 52 miRNAs associated with apoptosis

(2009) Meganathan Kannan et al.   TRANSFUSION

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Signal-Dependent Protein Synthesis by Activated Platelets

(2008) Guy A. Zimmerman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

MicroRNA biogenesis: there's more than one way to skin a cat

(2008) M FALLER et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Measuring microRNAs: Comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods

(2008) Robert A Ach et al.   BMC BIOTECHNOLOGY

Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases

(2008) Xi Chen et al.   CELL RESEARCH

hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

(2008) C. Camps et al.   CLINICAL CANCER RESEARCH

Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126

(2008) F. Kuhnert et al.   DEVELOPMENT

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform

(2008) Kimberly E. Resnick et al.   GYNECOLOGIC ONCOLOGY

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

(2008) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis

(2008) Coen van Solingen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Utility of Plasma Circulating mRNA as a Marker to Detect Hepatic Injury

(2008) Yuka KUDO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Serum MicroRNAs Are Promising Novel Biomarkers

(2008) Shlomit Gilad et al.   PLoS One

MicroRNA-directed transcriptional gene silencing in mammalian cells

(2008) D. H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

(2008) T. A. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normalization of microRNA expression levels in quantitative RT-PCR assays: Identification of suitable reference RNA targets in normal and cancerous human solid tissues

(2008) H. J. Peltier et al.   RNA

Degradation of microRNAs by a Family of Exoribonucleases in Arabidopsis

(2008) Vanitharani Ramachandran et al.   SCIENCE