Transcriptional profiling to identify biomarkers of disease and drug response

Systematic Review: Gene Expression Profiling Assays in Early-Stage Breast Cancer

(2013) Luigi Marchionni et al.   ANNALS OF INTERNAL MEDICINE

HMG-CoA Reductase Inhibitor, Simvastatin Improves Reverse Cholesterol Transport in Type 2 Diabetic Patients with Hyperlipidemia

(2011) Jing-Zhi Guan et al.   Journal of Atherosclerosis and Thrombosis

Novel Blood Biomarkers of Pancreatic Cancer–Associated Diabetes Mellitus Identified by Peripheral Blood–Based Gene Expression Profiles

(2010) Hai Huang et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology

(2010) Keith A. Baggerly et al.   Annals of Applied Statistics

DNA Microarray Analysis of Whole Blood Cells and Insulin-Sensitive Tissues Reveals the Usefulness of Blood RNA Profiling as a Source of Markers for Predicting Type 2 Diabetes

(2010) Yasuhiro Hayashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil

(2010) Antonio Camargo et al.   BMC GENOMICS

Small RNA expression and strain specificity in the rat

(2010) Sam EV Linsen et al.   BMC GENOMICS

Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets

(2010) Bertalan Mesko et al.   BMC Medical Genomics

Circulating MicroRNAs in Patients With Coronary Artery Disease

(2010) Stephan Fichtlscherer et al.   CIRCULATION RESEARCH

Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans

(2010) Guo-Kun Wang et al.   EUROPEAN HEART JOURNAL

Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury

(2010) Barbara A. Wetmore et al.   HEPATOLOGY

Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes

(2010) Shlomit Radom-Aizik et al.   JOURNAL OF APPLIED PHYSIOLOGY

Expression of microRNA-208 is Associated With Adverse Clinical Outcomes in Human Dilated Cardiomyopathy

(2010) Mamoru Satoh et al.   JOURNAL OF CARDIAC FAILURE

Microarrays in the clinic

(2010) Guy W Tillinghast   NATURE BIOTECHNOLOGY

Evolution of biomarker qualification at the health authorities

(2010) Federico Goodsaid et al.   NATURE BIOTECHNOLOGY

Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium

(2010) Frank Dieterle et al.   NATURE BIOTECHNOLOGY

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

(2010)   NATURE BIOTECHNOLOGY

Gene-Expression Profiling for Rejection Surveillance after Cardiac Transplantation

(2010) Michael X. Pham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study

(2010) Helen Hermana M Hermsdorff et al.   Nutrition & Metabolism

Comparison of performance of one-color and two-color gene-expression analyses in predicting clinical endpoints of neuroblastoma patients

(2010) A Oberthuer et al.   PHARMACOGENOMICS JOURNAL

Assessment of variability in GWAS with CRLMM genotyping algorithm on WTCCC coronary artery disease

(2010) L Zhang et al.   PHARMACOGENOMICS JOURNAL

Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes

(2010) W Shi et al.   PHARMACOGENOMICS JOURNAL

Consistency of predictive signature genes and classifiers generated using different microarray platforms

(2010) X Fan et al.   PHARMACOGENOMICS JOURNAL

Variability in GWAS analysis: the impact of genotype calling algorithm inconsistencies

(2010) K Miclaus et al.   PHARMACOGENOMICS JOURNAL

An interactive effect of batch size and composition contributes to discordant results in GWAS with the CHIAMO genotyping algorithm

(2010) M Chierici et al.   PHARMACOGENOMICS JOURNAL

Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples

(2010) H Hong et al.   PHARMACOGENOMICS JOURNAL

Batch effects in the BRLMM genotype calling algorithm influence GWAS results for the Affymetrix 500K array

(2010) K Miclaus et al.   PHARMACOGENOMICS JOURNAL

k-Nearest neighbor models for microarray gene expression analysis and clinical outcome prediction

(2010) R M Parry et al.   PHARMACOGENOMICS JOURNAL

A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data

(2010) J Luo et al.   PHARMACOGENOMICS JOURNAL

Genomic indicators in the blood predict drug-induced liver injury

(2010) J Huang et al.   PHARMACOGENOMICS JOURNAL

MicroRNAs miR-17 and miR-20a Inhibit T Cell Activation Genes and Are Under-Expressed in MS Whole Blood

(2010) Mathew B. Cox et al.   PLoS One

Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures

(2010) Makoto Takahashi et al.   SCHIZOPHRENIA RESEARCH

Translational Medicine and the Value of Biomarker Qualification

(2010) F. M. Goodsaid et al.   Science Translational Medicine

Predose Blood Gene Expression Profiles Might Identify the Individuals Susceptible to Carbon Tetrachloride–Induced Hepatotoxicity

(2010) Jun-Won Yun et al.   TOXICOLOGICAL SCIENCES

The meaning of clinical remission in polyarticular juvenile idiopathic arthritis: Gene expression profiling in peripheral blood mononuclear cells identifies distinct disease states

(2009) Nicholas Knowlton et al.   ARTHRITIS AND RHEUMATISM

Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets

(2009) Thomas A. Griffin et al.   ARTHRITIS AND RHEUMATISM

Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral blood

(2009) Boryana S Stamova et al.   BMC Medical Genomics

Plasma miR-208 as a Biomarker of Myocardial Injury

(2009) X. Ji et al.   CLINICAL CHEMISTRY

A Family of microRNAs Encoded by Myosin Genes Governs Myosin Expression and Muscle Performance

(2009) Eva van Rooij et al.   DEVELOPMENTAL CELL

MicroRNA identification in plasma and serum: a new tool to diagnose and monitor diseases

(2009) Maria Angelica Cortez et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation

(2009) Rick D. Fannin et al.   HEPATOLOGY

A brief bout of exercise alters gene expression and distinct gene pathways in peripheral blood mononuclear cells of early- and late-pubertal females

(2009) Shlomit Radom-Aizik et al.   JOURNAL OF APPLIED PHYSIOLOGY

Brain and Blood microRNA Expression Profiling of Ischemic Stroke, Intracerebral Hemorrhage, and Kainate Seizures

(2009) Da-Zhi Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice

(2009) Thomas E. Callis et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of blood biomarkers for psychosis using convergent functional genomics

(2009) S M Kurian et al.   MOLECULAR PSYCHIATRY

Gene expression changes in blood as a putative biomarker for Huntington's disease

(2009) Luca Lovrecic et al.   MOVEMENT DISORDERS

Brief Bout of Exercise Alters Gene Expression in Peripheral Blood Mononuclear Cells of Early- and Late-Pubertal Males

(2009) Shlomit Radom-Aizik et al.   PEDIATRIC RESEARCH

Gene Expression Patterns in Peripheral Blood Correlate with the Extent of Coronary Artery Disease

(2009) Peter R. Sinnaeve et al.   PLoS One

Circulating microRNAs, potential biomarkers for drug-induced liver injury

(2009) K. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of the key innate genes related to individual variation in carbon tetrachloride-induced hepatotoxicity using a pre-biopsy procedure

(2009) Jun-Won Yun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Empirical Bayes accomodation of batch-effects in microarray data using identical replicate reference samples: application to RNA expression profiling of blood from Duchenne muscular dystrophy patients

(2008) Wynn L Walker et al.   BMC GENOMICS

Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF- B/iNOS

(2008) L. G. Mikael et al.   CARDIOVASCULAR RESEARCH

MicroRNAs: novel regulators in cardiac development and disease

(2008) T. Thum et al.   CARDIOVASCULAR RESEARCH

Correlation of Peripheral-Blood Gene Expression With the Extent of Coronary Artery Stenosis

(2008) James A. Wingrove et al.   Circulation-Cardiovascular Genetics

Gene Expression in Peripheral Blood Differs after Cardioembolic Compared with Large-Vessel Atherosclerotic Stroke: Biomarkers for the Etiology of Ischemic Stroke

(2008) Huichun Xu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identifying blood biomarkers for mood disorders using convergent functional genomics

(2008) H Le-Niculescu et al.   MOLECULAR PSYCHIATRY

Gene expression in blood of subjects with Duchenne muscular dystrophy

(2008) Brenda Wong et al.   NEUROGENETICS

Gene expression response in target organ and whole blood varies as a function of target organ injury phenotype

(2008) Edward K Lobenhofer et al.   GENOME BIOLOGY

Biomarkers of drug-induced adverse events

(2008) Donna L Mendrick et al.   Expert Review of Clinical Pharmacology

Effects of 30 min of aerobic exercise on gene expression in human neutrophils

(2007) Shlomit Radom-Aizik et al.   JOURNAL OF APPLIED PHYSIOLOGY

Genomic and genetic biomarkers of toxicity

(2007) Donna L. Mendrick   TOXICOLOGY