ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations
Authors
Keywords
Biochemical simulations, Free energy, Alzheimers disease, Crystal structure, Protein structure, Salt bridges, Lipids, Thermal stability
Journal
PLoS Computational Biology
Volume 11, Issue 10, Pages e1004359
Publisher
Public Library of Science (PLoS)
Online
2015-10-28
DOI
10.1371/journal.pcbi.1004359
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk
- (2014) Leon M Tai et al. Molecular Neurodegeneration
- Extracellular Proteolysis of Apolipoprotein E (apoE) by Secreted Serine Neuronal Protease
- (2014) Irfan Y. Tamboli et al. PLoS One
- GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
- (2013) Sander Pronk et al. BIOINFORMATICS
- Impact of Apolipoprotein E on Alzheimer’s Disease
- (2013) Paul Hauser et al. Current Alzheimer Research
- Proteolytic Cleavage of Apolipoprotein E4 as the Keystone for the Heightened Risk Associated with Alzheimer’s Disease
- (2013) Troy Rohn INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
- (2013) Chia-Chen Liu et al. Nature Reviews Neurology
- Concerning the structure of apoE
- (2013) Carl Frieden et al. PROTEIN SCIENCE
- Small-Molecule Structure Correctors Target Abnormal Protein Structure and Function: Structure Corrector Rescue of Apolipoprotein E4–Associated Neuropathology
- (2012) Robert W. Mahley et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discrete Molecular Dynamics: An Efficient And Versatile Simulation Method For Fine Protein Characterization
- (2012) David Shirvanyants et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease
- (2012) C. Frieden et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hydrogen/Deuterium Exchange and Electron-Transfer Dissociation Mass Spectrometry Determine the Interface and Dynamics of Apolipoprotein E Oligomerization
- (2011) Richard Y-C. Huang et al. BIOCHEMISTRY
- Gaia: automated quality assessment of protein structure models
- (2011) Pradeep Kota et al. BIOINFORMATICS
- Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons
- (2011) Hung-Kai Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
- (2011) J. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discrete molecular dynamics
- (2011) Elizabeth A. Proctor et al. Wiley Interdisciplinary Reviews-Computational Molecular Science
- Wordom: A user-friendly program for the analysis of molecular structures, trajectories, and free energy surfaces
- (2010) Michele Seeber et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- Automated minimization of steric clashes in protein structures
- (2010) Srinivas Ramachandran et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Molecular Mechanism of Apolipoprotein E Binding to Lipoprotein Particles†
- (2009) David Nguyen et al. BIOCHEMISTRY
- Isoform-specific proteolysis of apolipoprotein-E in the brain
- (2009) David A. Elliott et al. NEUROBIOLOGY OF AGING
- Biophysical Analysis of Progressive C-Terminal Truncations of Human Apolipoprotein E4: Insights into Secondary Structure and Unfolding Properties
- (2008) Angeliki Chroni et al. BIOCHEMISTRY
- Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure
- (2008) Ning Zhong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
- (2008) Robert W. Mahley et al. JOURNAL OF LIPID RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now