Increased Aggregation Is More Frequently Associated to Human Disease-Associated Mutations Than to Neutral Polymorphisms

A Genome-Wide Sequence–Structure Analysis Suggests Aggregation Gatekeepers Constitute an Evolutionary Constrained Functional Class

(2014) Greet De Baets et al.   JOURNAL OF MOLECULAR BIOLOGY

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

α-Galactosidase Aggregation Is a Determinant of Pharmacological Chaperone Efficacy on Fabry Disease Mutants

(2012) Aleksandra Siekierska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folding without charges

(2012) M. Kurnik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging and the aggregating proteome

(2012) Della C. David   Frontiers in Genetics

Performance of mutation pathogenicity prediction methods on missense variants

(2011) Janita Thusberg et al.   HUMAN MUTATION

Hereditary lysozyme amyloidosis - phenotypic heterogeneity and the role of solid organ transplantation

(2011) P. T. Sattianayagam et al.   JOURNAL OF INTERNAL MEDICINE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants

(2011) G. De Baets et al.   NUCLEIC ACIDS RESEARCH

SMART 7: recent updates to the protein domain annotation resource

(2011) I. Letunic et al.   NUCLEIC ACIDS RESEARCH

An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins

(2011) Greet De Baets et al.   PLoS Computational Biology

Position-Dependent Electrostatic Protection against Protein Aggregation

(2009) Alexander K. Buell et al.   CHEMBIOCHEM

Functional impairment of p16INK4A due to CDKN2A p.Gly23Asp missense mutation

(2009) Maria Chiara Scaini et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer

(2009) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloidogenic Regions and Interaction Surfaces Overlap in Globular Proteins Related to Conformational Diseases

(2009) Virginia Castillo et al.   PLoS Computational Biology

Accurate Prediction of DnaK-Peptide Binding via Homology Modelling and Experimental Data

(2009) Joost Van Durme et al.   PLoS Computational Biology

The Zyggregator method for predicting protein aggregation propensities

(2008) Gian Gaetano Tartaglia et al.   CHEMICAL SOCIETY REVIEWS

Protein misfolding and disease: from the test tube to the organism

(2008) Leila M Luheshi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

(2008) Konstanze F Winklhofer et al.   EMBO JOURNAL