Testing Chemical Safety: What Is Needed to Ensure the Widespread Application of Non-animal Approaches?

Re-evaluation of animal numbers and costs for in vivo tests to accomplish REACH legislation requirements for chemicals - a report by the Transatlantic Think Tank for Toxicology (t4)

(2016) Costanza Rovida   ALTEX-Alternatives to Animal Experimentation

The application of 3D cell models to support drug safety assessment: Opportunities & challenges

(2014) Adrian Roth et al.   ADVANCED DRUG DELIVERY REVIEWS

Relevance of the 1-year dog study in assessing human health risks for registration of pesticides. An update to include pesticides registered in Japan

(2014) Werner Kobel et al.   CRITICAL REVIEWS IN TOXICOLOGY

Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials

(2014) Fiona Sewell et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A global initiative to refine acute inhalation studies through the use of ‘evident toxicity’ as an endpoint: Towards adoption of the fixed concentration procedure

(2014) Fiona Sewell et al.   TOXICOLOGY LETTERS

Reducing pre-clinical blood volumes for toxicokinetics: toxicologists, pathologists and bioanalysts unite

(2014) Kathryn Chapman et al.   Bioanalysis

Current standing and future prospects for the technologies proposed to transform toxicity testing in the 21st century

(2014) Erwin van Vliet   ALTEX-Alternatives to Animal Experimentation

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

(2014) Richard Judson   ALTEX-Alternatives to Animal Experimentation

Reducing safety-related drug attrition: the use of in vitro pharmacological profiling

(2012) Joanne Bowes et al.   NATURE REVIEWS DRUG DISCOVERY

Animal models of asthma: value, limitations and opportunities for alternative approaches

(2011) Anthony M. Holmes et al.   DRUG DISCOVERY TODAY

An Evidence-Based Medicine Methodology To Bridge The Gap Between Clinical And Environmental Health Sciences

(2011) Tracey J. Woodruff et al.   HEALTH AFFAIRS

A 1-year toxicity study in dogs is no longer a scientifically justifiable core data requirement for the safety assessment of pesticides

(2009) Werner Kobel et al.   CRITICAL REVIEWS IN TOXICOLOGY

Acute toxicity testing of chemicals—Opportunities to avoid redundant testing and use alternative approaches

(2009) Stuart Creton et al.   CRITICAL REVIEWS IN TOXICOLOGY