Controversies in granzyme biology

Granzyme C Supports Efficient CTL-Mediated Killing Late in Primary Alloimmune Responses

(2014) Y. Getachew et al.   JOURNAL OF IMMUNOLOGY

NK Cell Protease Granzyme M Targets  -Tubulin and Disorganizes the Microtubule Network

(2014) N. Bovenschen et al.   JOURNAL OF IMMUNOLOGY

Human and mouse granzyme M display divergent and species-specific substrate specificities

(2011) Stefanie A.H. de Poot et al.   BIOCHEMICAL JOURNAL

FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade

(2011) S Wang et al.   CELL DEATH AND DIFFERENTIATION

A quarter century of granzymes

(2011) C L Ewen et al.   CELL DEATH AND DIFFERENTIATION

Mouse granzyme K has pro-inflammatory potential

(2011) L T Joeckel et al.   CELL DEATH AND DIFFERENTIATION

Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice

(2011) Paul R. Hiebert et al.   EXPERIMENTAL GERONTOLOGY

Human B cells differentiate into granzyme B-secreting cytotoxic B lymphocytes upon incomplete T-cell help

(2011) Magdalena Hagn et al.   IMMUNOLOGY AND CELL BIOLOGY

Unexpected Role for Granzyme K in CD56bright NK Cell-Mediated Immunoregulation of Multiple Sclerosis

(2011) W. Jiang et al.   JOURNAL OF IMMUNOLOGY

Genetic Variants of Human Granzyme B Predict Transplant Outcomes after HLA Matched Unrelated Bone Marrow Transplantation for Myeloid Malignancies

(2011) Luis J. Espinoza et al.   PLoS One

Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition

(2010) Tung-Chou Tsai et al.   BMC DEVELOPMENTAL BIOLOGY

Cleavage of Survivin by Granzyme M Triggers Degradation of the Survivin-X-linked Inhibitor of Apoptosis Protein (XIAP) Complex to Free Caspase Activity Leading to Cytolysis of Target Tumor Cells

(2010) Deqing Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Granzyme B-induced and Caspase 3-dependent Cleavage of Gelsolin by Mouse Cytotoxic T Cells Modifies Cytoskeleton Dynamics

(2010) Praxedis Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valosin-Containing Protein Cleavage by Granzyme K Accelerates an Endoplasmic Reticulum Stress Leading to Caspase-Independent Cytotoxicity of Target Tumor Cells

(2010) Y. Guo et al.   JOURNAL OF IMMUNOLOGY

A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis

(2010) D. A. Anthony et al.   JOURNAL OF IMMUNOLOGY

The structural basis for membrane binding and pore formation by lymphocyte perforin

(2010) Ruby H. P. Law et al.   NATURE

Perforin-Independent Extracellular Granzyme B Activity Contributes to Abdominal Aortic Aneurysm

(2009) Ciara M. Chamberlain et al.   AMERICAN JOURNAL OF PATHOLOGY

Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation

(2009) L Shi et al.   CELL DEATH AND DIFFERENTIATION

Defective γδ T-cell function and granzyme B gene polymorphism in a cohort of newly diagnosed breast cancer patients

(2009) Ameera Gaafar et al.   EXPERIMENTAL HEMATOLOGY

Ignition of p53 Bomb Sensitizes Tumor Cells to Granzyme K-Mediated Cytolysis

(2009) G. Hua et al.   JOURNAL OF IMMUNOLOGY

Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma

(2009) Wendy Anne Boivin et al.   LABORATORY INVESTIGATION

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

(2009) D. Kaiserman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genotypic Variation and Phenotypic Characterization of Granzyme B Gene Polymorphisms

(2009) Diana M. Girnita et al.   TRANSPLANTATION

Granzyme A Causes Detachment of Alveolar Epithelial A549 Cells Accompanied by Promotion of Interleukin-8 Release

(2008) Yumiko YOSHIKAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

(2008) Denis Martinvalet et al.   CELL

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

Nucleophosmin Is Cleaved and Inactivated by the Cytotoxic Granule Protease Granzyme M during Natural Killer Cell-mediated Killing

(2008) Sean P. Cullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity

(2008) Yuming Guo et al.   MOLECULAR IMMUNOLOGY

Granzyme B delivery via perforin is restricted by size, but not by heparan sulfate-dependent endocytosis

(2008) F. C. Kurschus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage

(2007) Qiang Hou et al.   MOLECULAR IMMUNOLOGY